3485 Frailty Associated with Increased Rates of Acute Cellular Rejection Within 3 Months After Liver Transplantation

OBJECTIVES/SPECIFIC AIMS: There is currently a gap in the literature regarding the relationship between acute cellular rejection and frailty in LT patients. We aimed to evaluate the association between frailty and acute cellular rejection in LT patients. METHODS/STUDY POPULATION: Included were LT recipients from 2014-16 at a single center who had a frailty assessment prior to LT using the Liver Frailty index consisting of grip strength, chair stands, and balance. Frailty was defined by a Liver Frailty Index > 4.5. Data on acute cellular rejection at 3 months (primary outcome) and immunosuppression regimens were collected from medical chart review. Univariable and multivariable logistic regression assessed the associations between frailty and acute cellular rejection. RESULTS/ANTICIPATED RESULTS: A total of 241 LT recipients were included. Of these, 37% were female, 55% had Hepatitis C, and the median (IQR) age was 60 (54-65); 46 (19%) were classified as frail. 98% of patients were on a combination of mycophenolate, corticosteroids and tacrolimus on discharge compared to 80% by 3 months. Within the first 3 months post-LT, 7 (15%) of frail patients versus 10 (5%) (p = 0.02) of non-frail patients experienced acute cellular rejection. In univariable logistic regression, frailty was associated with a 3.3 times higher odds of acute cellular rejection at 3 months (95%CI 1.19, 9.26, p = 0.02); age (OR 0.91), Black race (OR 3.2), autoimmune disease (OR 2.3), and diabetes (OR 0.3) were also associated with acute cellular rejection at 3 months with a p-value<0.20. In a multivariate analysis, after adjusting for age, frailty remained significantly associated with rejection (OR 3.06, 95%CI 1.04, 9.01, p = 0.043). There were no significant differences in immunosuppression regimens or rates of mycophenolate dose reduction in the first 3 months between frail and non-frail patients. DISCUSSION/SIGNIFICANCE OF IMPACT: Frailty is associated with an increased rate of acute cellular rejection within 3 months post-LT, despite similar immunosuppression regimens and doses. Future studies should evaluate whether frailty should be considered in the management of immunosuppression in the early post-transplant period.

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HUBUNGAN INTELEGENSI DENGAN PERILAKU NERS TINGKAT II STIKES SANTA ELISABETH MEDAN

Elisabeth Health Jurnal ◽

10.52317/ehj.v1i1.185 ◽

2016 ◽

Vol 1 (1) ◽

pp. 21-30

Author(s):

Imelda Derang

Keyword(s):

Student Nurses ◽

Sampling Technique ◽

P Value ◽

Test Results ◽

Cross Sectional ◽

Intelligence Level ◽

Level Ii ◽

Study Population ◽

Cross Sectional Design ◽

The Relationship

Intelligence is the ability to apply the knowledge and experiences that have been gained into the effort tasks are challenging and flexible book. Behaviour is an action that involves aspects of affective, cognitive, and psychomotor. Goal: This study aims to determine the relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Method: This study uses correlation with cross sectional design. The study population was all students / i Ners Level II STIKes Santa Elisabeth Medan as 65. The samples used were 65 respondents, the sampling technique in this research is using purposive sampling. The instrument of this study using questionnaire and observation sheets by using product moment test person. Result: Intelligence students as many as 30 people (46.2%) classified as having an average level of intelligence. A total of 32 people (49.2%) classified as well-behaved students. Person product moment test results obtained p value = 0.172 where a significant level of p> 0.05 so that this value proves that the absence of a relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Conclusion: Recommended for institutions, motivating students in balancing the behavior and intelligence.

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Kejadian Hiperbilirubinemia Ditinjau dari Berat Badan Lahir

Cendekia Medika ◽

10.52235/cendekiamedika.v5i1.18 ◽

2020 ◽

Vol 5 (1) ◽

pp. 36-42

Author(s):

Yeviza Puspitasari

Keyword(s):

Random Sampling ◽

Statistical Tests ◽

Univariate Analysis ◽

Bivariate Analysis ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Study Population ◽

Relationship Of ◽

The Relationship

Hyperbilirubinemia is one of the clinical phenomena most often found in neonates occurring in the first week of life, which is also one of the factors causing infant death is influenced by the immature liver function of the baby to process erythrocytes (red blood cells), resulting in the accumulation of bilirubin. The purpose of this study was to determine the relationship of birth weight of infants with the incidence of hyperbilirubinemia in RSUD dr. Ibnu Soetowo Baturaja Ogan Komering Ulu Regency in 2019. This study uses analytic methods with a cross-sectional approach. The study population was all infants aged 0-7 days in the neonatal room at RSUD dr. Ibnu Soetowo Baturaja Ogan Komering Ulu Regency in 2019, with a random sampling. Data analysis uses univariate analysis and bivariate analysis using distribution tables and Chi-Square statistical tests, with a 95% confidence level. In the univariate analysis, of 203 respondents found 26.5% had hyperbilirubinemia and those without hyperbilirubinemia 72.5%, 24.6% of infants with LBW and non-LBW infants 75.4%. Bivariate analysis showed that there was an LBW relationship with the incidence of hyperbilirubinemia (p-value 0,000).

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Spiritual and Psychological Well-Being of Soldiers in Military Barracks: A Case Study in Iran

Journal of Archives in Military Medicine ◽

10.5812/jamm.108725 ◽

2020 ◽

Vol 8 (1) ◽

Author(s):

Mohammad Hosein Fadaei ◽

Mahya Torkaman ◽

Jamileh Farokhzadian

Keyword(s):

Military Service ◽

Well Being ◽

P Value ◽

Psychological Well Being ◽

Spiritual Well Being ◽

Study Population ◽

Combination Studies ◽

The Relationship ◽

Military Barracks

Background: Spiritual well-being is the newest dimension of health, which is placed along with the physical, mental, and social aspects of health. Since soldiers in military barracks are exposed to multiple psychological pressures, their psychological well-being can be affected. Objectives: This study aimed to evaluate the spiritual well-being and psychological well-being and the relationship between these two concepts among soldiers in military service. Methods: A descriptive-analytical study was conducted at a military barracks in Iran in 2019. The study population included 301 soldiers selected using a convenience sampling method. Data were collected using three questionnaires for data on sociodemographic, psychological well-being, and spiritual well-being. Results: The results showed that soldiers' spiritual well-being (Mean ± SD: 100.6 ± 12, 30, range: 50 – 120) and Psychological well-being (PWB) (Mean ± SD: 85.85 ± 7.91, range: 48 – 104) were at high levels. Furthermore, a significant correlation was observed between spiritual well-being and psychological well-being (P value< 0.001, r = 0.41). Conclusion: Considering the correlation between spiritual well-being and psychological well-being among soldiers in military service, it is possible to improve their psychological well-being by promoting spiritual well-being. In this regard, more interventional and combination studies are recommended in the field of psychological well-being and spiritual well-being.

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Malaria and the climate in Karachi: An eight year review

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.icon-suppl.1712 ◽

2019 ◽

Vol 36 (ICON-Suppl) ◽

Author(s):

Fivzia Herekar ◽

Sundus Iftikhar ◽

Ahsana Nazish ◽

Sabeen Rehman

Keyword(s):

Chart Review ◽

Climatic Factors ◽

Meteorological Data ◽

Climatic Variability ◽

Climate Variables ◽

Creative Commons ◽

Medical Chart Review ◽

Special Supplement ◽

The Relationship ◽

Open Access Article

Background and Objective: Malaria is an arthropod-borne infectious disease transmitted by the mosquito Anopheles and claims millions of lives globally every year. Reasons for failure to eradicate this disease are multifactorial. The seasonality of the malaria is principally determined by climatic factors conducive for breeding of the vector. We aimed to study the relationship between climatic variability and the seasonality of malaria over an eight-year duration. Methods: This was a retrospective medical chart review of 8,844 confirmed cases of malaria which presented to The Indus Hospital, Karachi from January 2008 to November 2015. Cases were plotted against meteorological data for Karachi to elicit monthly variation. Results: A secular incline and seasonality in malaria cases over the duration of 8 years was seen. More cases were reported in the summer, rainy season compared with the other three seasons in each year. There was significant association with specific climate variables such as temperature, moisture, and humidity. Conclusion: There is a marked seasonal variation of malaria in Karachi, influenced by various environmental factors. Identification of the ‘the concentrated period’ of malaria can be helpful for policymakers to deploy malaria control interventions. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1712 How to cite this:Herekar F, Iftikhar S, Nazish A, Rehman S. Malaria and the climate in Karachi: An eight year review. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S33-S37. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1712 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates

10.21203/rs.3.rs-154330/v1 ◽

2021 ◽

Author(s):

Yiyi Ding ◽

Shuo Wang ◽

Rui Guo ◽

Aizhen Zhang ◽

Yufang Zhu

Keyword(s):

Logistic Regression ◽

Blood Glucose ◽

Odds Ratio ◽

Exchange Transfusion ◽

Binary Logistic Regression ◽

P Value ◽

Bilirubin Encephalopathy ◽

Unbound Bilirubin ◽

Independent Variable ◽

The Relationship

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.

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Prevention of Nosocomial Infection through Application of Housekeeping

International Journal of Public Health Science (IJPHS) ◽

10.11591/.v6i1.6538 ◽

2017 ◽

Vol 6 (1) ◽

pp. 94 ◽

Cited By ~ 1

Author(s):

Qomariyatus Sholihah ◽

Aprizal Satria Hanafi

Keyword(s):

Nosocomial Infection ◽

P Value ◽

Test Results ◽

Treatment Room ◽

Study Population ◽

Prevention Of Nosocomial Infection ◽

Relationship Of ◽

The Relationship ◽

Paired T Test ◽

Point Class

The hospital has a high risk of nosocomial infection. Nosocomial infection can infect patients in hospital and can inhibit the patient's recovery, even worsen a patient. The purpose of this study was to determine the relationship of the application of housekeeping with the total number of germs floor as prevention nosocomial infection in the treatment room Roses in Ulin Hospital Banjarmasin, Indonesia. The study design was observational analytic. The study population was all Roses class treatment rooms. The samples were taken from the floor germs 4 point class treatment rooms in hospitals Rose Ulin. Sampling was conducted in the first week and the second week in November 2015. Paired t-test results showed no relationship between the applications of housekeeping with the total number of germs floor with a p-value 0.015.This study found there was decreasing the total number of germ on the floor in all rooms. It is hoped that the hospital to continue to pay attention to the condition of the hospital, especially in terms of hygiene in order to avoid transmission of germs or nosocomial infections due to bacteria originating from the floor.

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HUBUNGAN PENGETAHUAN IBU BALITA TENTANG GIZI BALITA DENGAN STATUS GIZI BALITA DI RW 07 KELURAHAN DAYEUH LUHUR WILAYAH KERJA PUSKESMAS BENTENG KOTA SUKABUMI

Jurnal Ilmiah Kebidanan (Scientific Journal of Midwifery) ◽

10.33023/jikeb.v6i1.536 ◽

2020 ◽

Vol 6 (1) ◽

pp. 38-44

Author(s):

Hana Haryani

Keyword(s):

Nutritional Status ◽

Health Centers ◽

P Value ◽

Maternal Knowledge ◽

Work Area ◽

Nutritional Enhancement ◽

Study Population ◽

Nutritional Status Of Children ◽

Relationship Of ◽

The Relationship

Malnutrition affects nearly 15% of the population and mostly from developing countries. The children are the ones who often suffer malnutrition. The purpose of this study was to determine the relationship of knowledge mother of toddler nutrition with nutritional status of children under five in RW 07 Dayeuh Sublime Work Area Health Center Fort Sukabumi. This type of research is kolerasional. The study population was as much as 131 mothers and 99 samples taken maternal, Slovin calculated by the formula. Validity test showed there were 26 valid items, and reliability values obtained r =0,789. Hypothesis testing using Shomer's formula with p-value =0,026. The results showed the majority of knowledge mother included in both categories as much as 92,6%, and toddlers with good nutritional status as much as 90,9%. Based on the results of the study there is a relationship between maternal knowledge about toddler nutrition toddler with nutritional status of children. The conclusion of this study is known the better knowledge of the mother, the more toddlers with good nutritional status, and health centers are expected to improve educational programs and nutritional enhancement.

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Relationship Between Sleep and Arthritis in a Middle-aged and Older Chinese Population- the China Health and Retirement Longitudinal Study

10.21203/rs.3.rs-253999/v1 ◽

2021 ◽

Author(s):

Chunnan Li ◽

Shang shaomei

Keyword(s):

Logistic Regression ◽

Longitudinal Study ◽

Protective Effect ◽

Sleep Duration ◽

Chinese Population ◽

P Value ◽

Confounding Factors ◽

Middle Aged ◽

Older Chinese ◽

The Relationship

Abstract Objective. To evaluate the relationship between sleep duration, sleep restless and arthritis in middle-aged and older Chinese population. Methods. A total of 4957 middle-aged and elderly people aged 45 years and above from The China Health and Retirement Longitudinal Study (CHARLS) wave 3 were included. Multivariable logistic regression was used to calculate adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) for arthritis. Results. Sleep duration was shown to have a U-shaped association with arthritis after adjusting confounding factors. Compared with <5h sleep duration per night, ORs (95 % CIs) of sleep duration 5-7,7-8 and 8-9 h per night for arthritis were 0.61 (0.52– 0.73, P value <0.001) ,0.47 (0.38-0.58, P value <0.001),0.50 (0.41,0.60, P value <0.001)and 0.50 (0.39–0.64, P value <0.001), respectively. Sleep restless was positively correlated with the prevalence of arthritis. After stratification according to sleep restless status, for those without sleep restless, 8-9 hours duration (OR=0.55, 95 % CI 0.39-0.78,P value=0.001)had the best protective effect on arthritis, while7-8 hours duration (OR=0.45, 95 % CI 0.34-0.60,P value <0.001)was best in people with sleep restless. Conclusion. In middle aged and old Chinese population, sleep duration is U-shaped associated with arthritis, and sleep restless affect the correlation.

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Sex Differences in Association Between Body Composition and Frailty or Physical Performance in Community-Dwelling Older Adults

10.21203/rs.3.rs-69908/v1 ◽

2020 ◽

Author(s):

Yunsoo Soh ◽

Chang Won Won

Keyword(s):

Body Composition ◽

Logistic Regression ◽

Cohort Study ◽

Physical Performance ◽

Fat Mass ◽

Frailty Index ◽

Community Dwelling ◽

Fat Free Mass ◽

Fat Mass Index ◽

The Relationship

Abstract BackgroundFrailty is a common geriatric condition due to aging, defined as a decrease in the functional reserve to maintain the homeostasis. As part of the aging process, body composition changes occur. This study investigated the relationship between body composition and frailty in a community-dwelling elderly Korean population.MethodsThis cross-sectional cohort study analyzed data of 2,385 elderly participants (aged 70–84 years, 1131 males and 1254 females) of the Korean Frailty and Aging Cohort Study from 2016 to 2017. Body composition, including total and trunk fat masses and fat-free mass, were measured with dual-energy X-ray absorptiometry. Fat mass index (FMI), trunk fat mass index (TFMI), and fat-free mass index (FFMI) represented total fat mass, trunk fat mass, and fat-free mass according to height. Based on the frailty index developed by Fried, we compared the frail and non-frail groups. Poor physical performance assessed with the short physical performance battery score of <9 is considered frailty. To evaluate the relationship between the variables, simple and fully adjusted multivariable logistic regression analyses were performed according to sex.ResultsAmong the participants, 462 (19.3%) were defined as the frail group, with a significantly high mean age of 77.9±4.0 years. In the logistic regression analysis of frailty based on body mass index (BMI) categories, underweight (BMI<18 kg/m2) participants showed a high incidence of frailty in both sexes. BMI showed an association with frailty only in males. In both sexes, FFMI was associated with a lower incidence of frailty, which was statistically significant in the fully adjusted models. In the female, fat-related indexes including body fat percentage, FMI, and TFMI showed a significant association with poor physical performance. In contrast, males with low FFMI only showed a significant association with poor physical performance.ConclusionsFrailty closely correlated with FFMI in both sexes. The poor physical performance associated with frailty correlated with fat-related body composition in females and fat-free mass in males owing to the difference in body composition between the sexes. In the assessment of frailty, body composition and sex-related differences should be analyzed.

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HUBUNGAN MENGONSUMSI MAKANAN KARIOGENIK DENGAN KEJADIAN KARIES PADA ANAK USIA SEKOLAH DI MI AL-HIDAYAH

JPKM: Jurnal Profesi Kesehatan Masyarakat ◽

10.47575/jpkm.v1i1.188 ◽

2020 ◽

Vol 1 (1) ◽

pp. 12-19

Author(s):

Karina Nur Ramadhanintyas

Keyword(s):

Dental Caries ◽

Alternative Hypothesis ◽

Simple Random Sampling ◽

Primary School Children ◽

School Age Children ◽

P Value ◽

Cross Sectional ◽

Study Population ◽

Spearman Test ◽

The Relationship

Teeth caries common in primary school children are caused by cariogenic food consumption habits. The children like to cousume cariogenik food, because it has a sweet and tasty. Dental caries is a disease of dental hard tissue (email, dentin). Objective of this study was to determine the relationship Cariogenik Consumption Eating Relations With Caries In School Age Children. This study uses correlation design with cross sectional approach. The study population are 105 students in grade I and II, sample 51 students whose teeth have not experienced loose teeth taken by simple random sampling method. The statistical test used the Spearman test.The results of this study showed respondents who frequently consume cariogenic foods as are 28 students (54.9%). Respondents who have dental caries are 37 students (72.5%) and respondents who did not happen dental caries are 14 students (27.5%). Results obtained spearman test p-value = 0.000 so that the alternative hypothesis is accepted. the Conclusion of this study, there is relationship between cariogenik consumption with caries is habits and caries.The from this study that the cariogenic foods can cause dental caries. So less consumption of cariogenic foods (candy, chocolate, ice cream and biscuits) can reduce the number of dental caries in MI AL-Hidayah Madiun.

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