Perspective on control options forEchinococcus multiloculariswith particular reference to Japan

Parasitology ◽  
2003 ◽  
Vol 127 (S1) ◽  
pp. S159-S172 ◽  
Author(s):  
A. ITO ◽  
T. ROMIG ◽  
K. TAKAHASHI
Keyword(s):  
Close Contact ◽  
Integrated Control ◽  
Risk Behaviour ◽  
Control Measures ◽  
Domestic Dogs ◽  
Western China ◽  
Preventive Strategies ◽  
Preventive Chemotherapy ◽  
Information Campaigns ◽  
Control Options

Following a brief introduction of recent advances in molecular and immunological technology for detection of persons and animals infected withEchinococcus multilocularisand an overview of the current situation of alveolar echinococcosis (AE) in Japan, perspectives on control options are discussed with reference to different epidemiological situations. AE is considered the most serious parasitic zoonosis in temperate and arctic regions of the northern hemisphere. The number of human cases differs drastically among regions. While high numbers of patients are apparently associated with highE. multilocularisprevalence in domestic dogs, e.g. in parts of Alaska and western China, the number of cases is moderate or low in areas where the parasite is mainly transmitted by wild canid species (e.g. in central Europe or temperate North America). However, the severity of the disease, the absence of curative treatment for most cases, the high cost of long-term chemotherapy and the anxiety caused for the population in highly endemic areas call for the development of preventive strategies even in regions where human AE is rare. Furthermore, in view of (1) drastically increasing numbers and infection rates of foxes involved in transmission ofE. multilocularis, and (2) increasingly close contact between humans and foxes e.g. in Europe and Japan, there is considerable concern that AE incidences may in future increase in these regions. Control options depend on a variety of factors including the species of canid principally responsible for transmission and the socio-economic situation in the region. Where domestic dogs (stray or owned) are the principal hosts forE. multilocularis, control options can include those applicable toE. granulosus, i.e. reduction of the number of stray dogs, registration and regular preventive chemotherapy of owned dogs, and information campaigns for the population promoting low-risk behaviour for man and dogs. WhereE. multilocularisis mainly transmitted by wild canids, the situation is far more difficult with preventive strategies still being in trial stage. Integrated control measures could include prevention information campaigns, restricting access of pet animals (dogs and cats) to rodents, chemotherapy of foxes on local or regional scales, and strategies to minimize contacts between people and foxes.

scholarly journals Visceral leishmaniasis in northwest China from 2004 to 2018: a spatio-temporal analysis

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Canjun Zheng ◽  
Liping Wang ◽  
Yi Li ◽  
Xiao-Nong Zhou
Keyword(s):  
Visceral Leishmaniasis ◽  
Integrated Control ◽  
Sichuan Province ◽  
Gansu Province ◽  
Control Measures ◽  
Western China ◽  
Autonomous Region ◽  
Xinjiang Uygur Autonomous Region ◽  
Endemic Areas ◽  
Spatio Temporal

Abstract Background Although visceral leishmaniasis (VL), a disease caused by parasites, is controlled in most provinces in China, it is still a serious public health problem and remains fundamentally uncontrolled in some northwest provinces and autonomous regions. The objective of this study is to explore the spatial and temporal characteristics of VL in Sichuan Province, Gansu Province and Xinjiang Uygur Autonomous Region in China from 2004 to 2018 and to identify the risk areas for VL transmission. Methods Spatiotemporal models were applied to explore the spatio-temporal distribution characteristics of VL and the association between VL and meteorological factors in western China from 2004 to 2018. Geographic information of patients from the National Diseases Reporting Information System operated by the Chinese Center for Disease Control and Prevention was defined according to the address code from the surveillance data. Results During our study period, nearly 90% of cases occurred in some counties in three western regions (Sichuan Province, Gansu Province and Xinjiang Uygur Autonomous Region), and a significant spatial clustering pattern was observed. With our spatiotemporal model, the transmission risk, autoregressive risk and epidemic risk of these counties during our study period were also well predicted. The number of VL cases in three regions of western China concentrated on a few of counties. VL in Kashi Prefecture, Xinjiang Uygur Autonomous Region is still serious prevalent, and integrated control measures must be taken in different endemic areas. Conclusions The number of VL cases in three regions of western China concentrated on a few of counties. VL in Kashi Prefecture, Xinjiang Uygur Autonomous Region is still serious prevalent, and integrated control measures must be taken in different endemic areas. Our findings will strengthen the VL control programme in China.

scholarly journals Effectiveness of Epidemic Preventive Policies and Hospital Strategies in Combating COVID-19 Outbreak in Taiwan

2021 ◽  
Vol 18 (7) ◽  
pp. 3456
Author(s):  
Ting Wan Tan ◽  
Han Ling Tan ◽  
Man Na Chang ◽  
Wen Shu Lin ◽  
Chih Ming Chang
Keyword(s):  
Mortality Rate ◽  
Incidence Rate ◽  
Risk Ratio ◽  
Early Stage ◽  
Control Measures ◽  
Polymerase Chain Reaction Test ◽  
Effective Control ◽  
Nasopharyngeal Swab ◽  
Preventive Strategies ◽  
Epidemic Control

(1) Background: The implementation of effective control measures in a timely fashion is crucial to control the epidemic outbreak of COVID-19. In this study, we aimed to analyze the control measures implemented during the COVID-19 outbreak, as well as evaluating the responses and outcomes at different phases for epidemic control in Taiwan. (2) Methods: This case study reviewed responses to COVID-19 and the effectiveness of a range of control measures implemented for epidemic control in Taiwan and assessed all laboratory-confirmed cases between 11 January until 20 December 2020, inclusive of these dates. The confirmation of COVID-19 infection was defined as the positive result of a reverse-transcriptase–polymerase-chain-reaction test taken from a nasopharyngeal swab. Test results were reported by the Taiwan Centers for Disease Control. The incidence rate, mortality rate, and testing rate were compiled, and the risk ratio was provided to gain insights into the effectiveness of prevention measures. (3) Results and Discussion: This study presents retrospective data on the COVID-19 incidence rate in Taiwan, combined with the vital preventive control measures, in a timeline of the early stage of the epidemic that occurred in Taiwan. The implementation of multiple strategy control measures and the assistance of technologies to control the COVID-19 epidemic in Taiwan led to a relatively slower trend in the outbreak compared to the neighboring countries. In Taiwan, 766 confirmed patients were included, comprised of 88.1% imported cases and 7.2% local transmission cases, within the studied period. The incidence rate of COVID-19 in Taiwan during the studied period was 32 per million people, with a mortality rate of 0.3 per million people. Our analysis showed a significantly raised incidence risk ratio in the countries of interest in comparison to Taiwan during the study period; in the range of 1.9 to 947.5. The outbreak was brought under control through epidemic policies and hospital strategies implemented by the Taiwan Government. (4) Conclusion: Taiwan’s preventive strategies resulted in a drastically lower risk for Taiwan nationals of contracting COVID-19 when new pharmaceutical drug or vaccines were not yet available. The preventive strategies employed by Taiwan could serve as a guide and reference for future epidemic control strategies.

scholarly journals Effect of COVID-19 on childhood Mycoplasma pneumoniae infection in Chengdu, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ying Zhang ◽  
Yijie Huang ◽  
Tao Ai ◽  
Jun Luo ◽  
Hanmin Liu
Keyword(s):  
Public Health ◽  
Mycoplasma Pneumoniae ◽  
Close Contact ◽  
Serum Antibody ◽  
Pathogen Transmission ◽  
Western China ◽  
Public Health Response ◽  
The Public ◽  
Health Response ◽  
The Impact

Abstract Background Following the outbreak of the COVID-19 pandemic, a change in the incidence and transmission of respiratory pathogens was observed. Here, we retrospectively analyzed the impact of COVID-19 on the epidemiologic characteristics of Mycoplasma pneumoniae infection among children in Chengdu, one of the largest cities of western China. Method M. pneumoniae infection was diagnosed in 33,345 pediatric patients with respiratory symptoms at the Chengdu Women’s & Children’s Central Hospital between January 2017 and December 2020, based on a serum antibody titer of ≥1:160 measured by the passive agglutination assay. Differences in infection rates were examined by sex, age, and temporal distribution. Results Two epidemic outbreaks occurred between October-December 2017 and April-December 2019, and two infection peaks were detected in the second and fourth quarters of 2017, 2018, and 2019. Due to the public health response to COVID-19, the number of positive M. pneumoniae cases significantly decreased in the second quarter of 2020. The number of M. pneumoniae infection among children aged 3–6 years was higher than that in other age groups. Conclusions Preschool children are more susceptible to M. pneumoniae infection and close contact appears to be the predominant factor favoring pathogen transmission. The public health response to COVID-19 can effectively control the transmission of M. pneumoniae.

The effect of organic compost of Caryocar brasiliense waste against Meloidogyne javanica in two vegetable crops

Nematology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Fabíola de J. Silva ◽  
Regina C.F. Ribeiro ◽  
Adelica A. Xavier ◽  
Vanessa A. Gomes ◽  
Paulo V.M. Pacheco ◽  
...  
Keyword(s):  
Integrated Control ◽  
Meloidogyne Javanica ◽  
Control Measures ◽  
Vegetable Crops ◽  
Root Knot Nematode ◽  
Second Stage ◽  
Tomato Roots ◽  
Crop Development ◽  
Caryocar Brasiliense ◽  
Organic Compost

Summary Root-knot nematodes (Meloidogyne spp.) are responsible for various significant crop losses, which require taking integrated control measures. The present study aimed to identify a possible sustainable approach to the management of Meloidogyne javanica in vegetable crops using an organic compound based on pequi (Caryocar brasiliense) fruit residues. A pot experiment was conducted using cultivars of tomato and lettuce susceptible to M. javanica, with three amendments including inorganic fertiliser, cattle manure and five doses of organic compost with pequi residues. All treatments were inoculated with second-stage juveniles of M. javanica to simulate the root-knot nematode disease in field conditions. Increasing doses of organic compost with pequi residues from 5 kg m−3 to 30 kg m−3 promoted a significant decrease in the nematode population in both cultures evaluated. Organic compost (30 kg m−3) reduced the numbers of galls and eggs of M. javanica by 41.6 and 46.5% in tomato roots, and by 80.3 and 59.2% in lettuce roots, respectively, compared with non-treated control. Organic compost also increased crop development considerably. In general, there was a 43.0% increase in plant development compared to non-treated control. Hence, organic compost of pequi residues could be an alternative to toxic chemical nematicides and recommended as eco-friendly management of M. javanica in vegetable crops.

scholarly journals Seroprevalence and risk factors for canine visceral leishmaniasis in the endemic area of Dias D'Ávila, State of Bahia, Brazil

2010 ◽  
Vol 43 (4) ◽  
pp. 400-404 ◽  
Author(s):  
Laura Cristina Pinho de Oliveira ◽  
Rondinelli Ribeiro de Araújo ◽  
Carlos Roberto Alves ◽  
Eliame Mouta-Confort ◽  
Jorge Alberto López ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Indirect Immunofluorescence ◽  
Close Contact ◽  
Statistical Significance ◽  
Domestic Dogs ◽  
Mixed Breed ◽  
Rural Zone ◽  
Normochromic Anemia ◽  
Canine Infection ◽  
Immunoenzymatic Assays

INTRODUCTION: Visceral leishmaniasis (VL) is an important zoonosis in relation to public health systems. Dogs are the main domestic reservoir. This study aimed to investigate occurrences of canine VL in Dias D'Ávila, State of Bahia, Brazil. METHODS: The prevalence was evaluated by means of clinical and laboratory tests on a population of 312 domestic dogs from 23 localities in this municipality, using indirect immunofluorescence and immunoenzymatic assays. RESULTS: Among the animals examined, 3.2% and 6.7% showed signs of VL, confirmed by indirect immunofluorescence and immunoenzymatic assays, respectively, with a distribution of 29.9% (24 dogs) in the rural zone and 4.9% (288 dogs) in the urban zone (p = 0.001). The clinical evaluation on seropositive dogs showed both asymptomatic animals (2.4%) and symptomatic animals (47.6%), along with other abnormalities (e.g. normocytic and normochromic anemia, with leukocytosis and thrombocytopenia). Observations relating to phenotypic characteristics (e.g. sex, age, breed and hair) did not present statistical significance, although high seropositivity among male, short-haired and mixed-breed dogs was observed. CONCLUSIONS: The findings showed that VL was a predominantly rural zoonosis and that close contact between poultry and domestic dogs significantly increased the risk of canine infection in this region.

scholarly journals MASSER AF GRUNDE TIL USIKKER SEX: En undersøgelse af gode forklaringer

1996 ◽  
Author(s):  
Anders Dahl
Keyword(s):  
Sexual Behaviour ◽  
Risk Behaviour ◽  
Risk Groups ◽  
Sexual Risk Taking ◽  
Unsafe Sex ◽  
Information Campaigns ◽  
Culturally Informed ◽  
New Strategy ◽  
Sex With Men ◽  
Hiv Aids

Anders Dahl: Plenty of Reasons for Unsafe Sex. An Investigation of Good Explanations Information campaigns on HIV/AIDS have been running for more than ten years, but still it is difficult to demonstrate any changes in the sexual behaviour of the Danish population, except in regard of men who have sex with men. Analyses of dialogues of telephone counselling at the AIDS Hotline in Copenhagen give insights into the explanations that counselling-seeking persons themselves give conceming their unsafe sexual behaviour. It appears that safe sex is generally considered easy and simple, and therefore instances of unsafe sexual behaviour come to be regarded as “slips” and not as a pattem of behaviour. Choices of sexual behaviour are not determined by knowledge alone, but also by culturally informed personal experience and the context of the sexual act. The article points towards a new strategy in future HIV/AIDS-related work, putting greater emphasis on dialogue with people with risk behaviour, e.g. in connection with HIV-testing. The use of the data collected at the hotline demonstrates new paths in the difficult field of sex research. Also, it appears from the data that the study of the so-called risk groups for HIV is probably not the most useful way to reach an understanding of sexual risk taking, as reasons for unsafe sex transcend such groups.

scholarly journals Ophthalmic Workplace Modifications for the Post-COVID Era

2020 ◽  
Author(s):  
Hasan Naveed ◽  
Victor Leung ◽  
Mehran Zarei-Ghanavati ◽  
Christopher Leak ◽  
Christopher Liu
Keyword(s):  
At Risk ◽  
Healthcare Professionals ◽  
Scientific Evidence ◽  
Industrial Hygiene ◽  
Workplace Safety ◽  
Control Measures ◽  
Healthcare Sector ◽  
Exposure Control ◽  
Control Options

The COVID-19 pandemic necessitates implementation of exposure control measures in all facets of the healthcare sector. Healthcare professionals who work in busy ophthalmology clinics and theaters are amidst the highest at-risk of contracting COVID- 19. The authors review the up-to-date scientific evidence of SARS-CoV-2 transmission to demystify and explain the exposure control options available for ophthalmic workplace and offer insights from an industrial hygiene standpoint. As the we enter the post-COVID world, these measures will be critical to enhance workplace safety, and thus protect patients and staff alike.

scholarly journals Mathematical Modelling and Analysis of Corruption of Morals amongst Adolescents with Control Measures in Kenya

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Nathan Oigo Mokaya ◽  
Haileyesus Tessema Alemmeh ◽  
Cyrus Gitonga Ngari ◽  
Grace Gakii Muthuri
Keyword(s):  
Integrated Control ◽  
Equilibrium Points ◽  
Endemic Equilibrium ◽  
Control Measures ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Age Appropriate ◽  
Manifold Theory ◽  
Necessary And Sufficient ◽  
Well Posed

In the present paper, we formulate a new mathematical model for the dynamics of moral corruption with comprehensive age-appropriate sexual information and provision of guidance and counselling. The population is subdivided into three (3) different compartments according to their level of information on sexual matters. The model is proved to be both epidemiologically and mathematically well posed. The existence of unique morally corrupt-free and endemic equilibrium points is investigated. The basic reproduction number with respect to morally corrupt-free equilibrium is obtained using next generation matrix approach to monitor the dynamics of corrupt morals and ascertain its level in order to suggest effective intervention strategies to control this problem. The local as well as global asymptotic stability of these equilibrium points is studied. The analysis reveals a globally asymptotically stable morally corrupt-free equilibrium whenever ℛ 0 ≤ 1 and a globally asymptotically stable endemic equilibrium if otherwise. Further analysis, using center manifold theory, shows that the model exhibits forward bifurcation insinuating that the classical epidemiological requirement of ℛ 0 ≤ 1 is necessary and sufficient for elimination of moral corruption. A brief discussion on the graphical results using the available numerical procedures is shown. From numerical simulations, it was ascertain that integrated control strategy is the best approach to fight against moral corruption transmission. Lastly, some key parameters that show significance in the moral corruption elimination from the society are also exploited.

Mass SARS-CoV-2 Testing in a Dormitory-Style Correctional Facility in Arkansas

2021 ◽  
pp. e1-e10
Author(s):  
Lindsay K. Tompkins ◽  
Jayleen K. L. Gunn ◽  
Blake Cherney ◽  
Jason E. Ham ◽  
Roberta Horth ◽  
...  
Keyword(s):  
Infection Prevention ◽  
Close Contact ◽  
Correctional Facility ◽  
Mitigation Strategies ◽  
Control Measures ◽  
Infection Prevention And Control ◽  
Strict Enforcement ◽  
Prevention And Control Measures ◽  
And Control ◽  
Respiratory Specimens

Objectives. To assess SARS-CoV-2 transmission within a correctional facility and recommend mitigation strategies. Methods. From April 29 to May 15, 2020, we established the point prevalence of COVID-19 among incarcerated persons and staff within a correctional facility in Arkansas. Participants provided respiratory specimens for SARS-CoV-2 testing and completed questionnaires on symptoms and factors associated with transmission. Results. Of 1647 incarcerated persons and 128 staff tested, 30.5% of incarcerated persons (range by housing unit = 0.0%–58.2%) and 2.3% of staff tested positive for SARS-CoV-2. Among those who tested positive and responded to symptom questions (431 incarcerated persons, 3 staff), 81.2% and 33.3% were asymptomatic, respectively. Most incarcerated persons (58.0%) reported wearing cloth face coverings 8 hours or less per day, and 63.3% reported close contact with someone other than their bunkmate. Conclusions. If testing remained limited to symptomatic individuals, fewer cases would have been detected or detection would have been delayed, allowing transmission to continue. Rapid implementation of mass testing and strict enforcement of infection prevention and control measures may be needed to mitigate spread of SARS-CoV-2 in this setting. (Am J Public Health. Published online ahead of print March 18, 2021: e1–e10. https://doi.org/10.2105/AJPH.2020.306117 )

Isotope recycling in lactating dogs (Canis familiaris)

2000 ◽  
Vol 278 (3) ◽  
pp. R669-R676 ◽  
Author(s):  
Michael Scantlebury ◽  
Waring Hynds ◽  
Derek Booles ◽  
John R. Speakman
Keyword(s):  
Water Vapor ◽  
Energy Expenditure ◽  
Close Contact ◽  
Canis Familiaris ◽  
Domestic Dogs ◽  
Domestic Dog ◽  
Water Turnover ◽  
Energy Demands ◽  
Lactating Females ◽  
Peak Lactation

Isotope-based techniques for the measurement of water turnover, energy expenditure, and milk intake often assume that there is no recycling of isotopes once they have left the labeled animal. In experiments involving lactating females or their suckling offspring, there are several possible routes of isotope recycling. These include the consumption of labeled milk by offspring, the ingestion of labeled excreta, and the rebreathing of exhaled labeled CO2 or water vapor by both mother and offspring. Isotope recycling might be especially important during lactation because the offspring are in close contact with each other and their mother for prolonged periods. We show here in 24- to 30-day-old domestic dog Canis familiarispuppies that there was no detectable transfer of 18O or2H from labeled to unlabeled pups in two litters (16 pups, 8 labeled, 8 unlabeled) that were weaned early and independent of their mother. However, there was a significant transfer of both isotopes from labeled to unlabeled pups and from labeled pups to their mothers in nine equivalent nursing litters of the same age (27 labeled, 26 unlabeled pups). The increases in enrichment of isotopes in unlabeled offspring were greater than the increases in enrichment of the mothers. This indicates that maternal ingestion of offspring excreta and subsequent transfer of isotope in milk is not the sole pathway of recycling. Additional routes must also be important, such as exchange of isotope between pups on saliva-coated nipples and perhaps direct ingestion of excreta by unweaned young. Recycling is unlikely to be an important factor when determining maternal metabolic rate during peak lactation in domestic dogs. However, experiments that are designed to assess the energy demands of pups and isotope-based estimates of water turnover in offspring may need to take into account any effects of isotope recycling. In a theoretical example, removing the effects of recycling increased the measured energy expenditure in pups by up to 7% and increased the calculated elimination rates of both isotopes by up to 11.1% in 18oxygen and 10.9% in2hydrogen.

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