Antimicrobial resistance in zoonotic bacteria: lessons learned from host-specific pathogens

2008 ◽  
Vol 9 (2) ◽  
pp. 177-186 ◽  
Author(s):  
Trudy M. Wassenaar ◽  
Peter Silley
Keyword(s):  
Antimicrobial Resistance ◽  
Bacterial Species ◽  
Lessons Learned ◽  
Animal Host ◽  
Relative Contribution ◽  
Single Animal ◽  
Resistance Patterns ◽  
Animal Hosts ◽  
Zoonotic Bacteria ◽  
Selection Of

AbstractThe relative contribution of veterinary and human clinical treatments to the selection of antimicrobial resistance in zoonotic pathogens remains controversial. In this review, we consider bacterial pathogens that differ in host specificity and address their resistance profiles: pathogens that only occur in the human host, pathogens that are specific to particular food-producing animals and pathogens that occur in both host types. Compared with those pathogens restricted to a single animal host, pathogens found in both human and animal hosts appear to have higher incidences of resistance. However, the most urgent and severe resistance problems occur with pathogens exclusively infecting humans. Differences exist in the available genetic repertoire of a bacterial species and these are reflected in the observed resistance patterns; it is important to note that different bacterial species do not automatically result in similarly resistant populations when they undergo comparable selection in different host species. Thus, within a bacterial species, prevalence of resistance can differ between populations isolated from different hosts. For some species, fluctuations in dominant subpopulations, for instance particular serotypes, can be the most important factor determining resistance. The frequently expressed opinion that veterinary use of antimicrobials is at the heart of many resistance problems may be an oversimplification of the complex forces at play.

Antimicrobial resistance and prudent drug use forStreptococcus suis

2013 ◽  
Vol 14 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Norma P. Varela ◽  
Pierre Gadbois ◽  
Claude Thibault ◽  
Marcelo Gottschalk ◽  
Paul Dick ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Preventive Measures ◽  
Economic Loss ◽  
Appropriate Use ◽  
Penicillin Binding Proteins ◽  
Resistance Patterns ◽  
The Impact ◽  
Unique Mechanism ◽  
Significant Economic Loss ◽  
Selection Of

AbstractThis paper reviews information on antimicrobial resistance patterns and prudent use of antimicrobials to reduce the impact and spread of resistantStreptococcus suisstrains.S. suisis an important pathogen in swine, which can cause significant economic loss. Prudent use of antimicrobials forS. suisis essential to preserve the therapeutic efficacy of broad-spectrum antimicrobials and to minimize selection of resistantS. suisstrains. Resistance ofS. suisto antimicrobials commonly used in swine, including lincosamides, macrolides, sulphonamides, and tetracycline, has been documented worldwide, with resistance in up to 85% of strains. Among antimicrobials examined, resistance ofS. suishas been demonstrated to be relatively low for penicillin (0–27%), ampicillin (0.6–23%), and ceftiofur (0–23%). For penicillin, this result may be due in part to the unique mechanism by which resistance is acquired through modifications in the structure of penicillin-binding proteins. Recommendations to controlS. suisinfection include focused and careful choice and appropriate use of antimicrobials, together with preventive measures intended to improve swine management.

Occurrence of Multiple-Drug Resistance bacteria and their antimicrobial resistance patterns in burn infections from southwest of Iran

2021 ◽  
Author(s):  
Mohammad Hashemzadeh ◽  
Reza Heydari ◽  
Aram Asareh Zadegan Dezfuli ◽  
Morteza Saki ◽  
Hossein Meghdadi ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Multiple Drug Resistance ◽  
Bacterial Species ◽  
Clinical Samples ◽  
Multiple Drug ◽  
Gram Negative Bacteria ◽  
Diverse Range ◽  
Gram Negative ◽  
Maximum Resistance ◽  
Resistance Patterns

Abstract Background Burn infection continues to be a major issue of concern globally and causes more harm to developing countries. This study aimed to identify the aerobic bacteriological profiles and antimicrobial resistance patterns of burn infections in three hospitals in Abadan, southwest Iran. Methods The cultures of various clinical samples obtained from 325 burn patients were investigated from January to December 2019. All bacterial isolates were identified based on the standard microbiological procedures. Antibiotic susceptibility tests were performed according to the CLSI. Results A total of 287 bacterial species were isolated burn patients.P. aeruginosa was the most frequent bacterial isolate in Gram-negative bacteria and S. epidermidis was the most frequent species isolated in Gram-positive bacteria. The maximum resistance was found to ampicillin, gentamicin, ciprofloxacin, while in Gram-negative bacteria, the maximum resistance was found to imipenem, gentamicin, ciprofloxacin, ceftazidime, and amikacin. The occurrence of multidrug resistance phenotype was as follows: P. aeruginosa (30.3 %), Enterobacter spp (11.1 %), Escherichia coli (10.5 %), Citrobacter spp (2.1 %), S. epidermidis (2.8 %), S. aureus, and S. saprophyticus (0.7 %). Conclusion Owing to the diverse range of bacteria that because burn wound infection, regular investigation, and diagnosis of common bacteria and their resistance patterns is recommended to determine the proper antibiotic regimen for appropriate therapy.

scholarly journals Distribution and antimicrobial resistance profiles of bacterial species in stray cats, hospital-visiting cats, and veterinary staff in South Korea

2019 ◽  
Author(s):  
Woo Kyung Jung ◽  
Sook Shin ◽  
Young Kyung Park ◽  
Suk-Kyung Lim ◽  
Dong-Chan Moon ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
South Korea ◽  
Pathogenic Bacteria ◽  
Bacterial Species ◽  
Coagulase Negative Staphylococci ◽  
Stray Cats ◽  
Enterococcus Spp ◽  
Health Concept ◽  
Resistance Patterns ◽  
Staphylococcus Spp

Abstract Background Antimicrobial resistance is becoming increasingly important in both human and veterinary medicine. According to the One Health concept, an important step is to monitor the resistance patterns of pathogenic bacteria. In this study, the antimicrobial susceptibility patterns and trends of bacteria isolated from stray cats, hospital-visiting cats, and veterinary staff in South Korea between 2017 and 2018 were investigated. Results The minimum inhibitory concentrations of different antibiotics for Staphylococcus spp., Enterobacteriaceae , and Enterococcus spp. were determined to establish representatives of different antibiotic classes relevant for treatment or surveillance. For Coagulase-positive and Coagulase-negative Staphylococci, resistance to fluoroquinolones was below 13%, but resistance to ampicillin and penicillin was high (20–88%). A total of 9.5%, 12.1%, and 40.3% of staphylococcal isolates from stray cats, hospital-visiting cats, and veterinary staff, respectively, were confirmed to be mecA positive. For Enterobacteriaceae , resistance to carbapenems, fluoroquinolones, and 3rd generation cephalosporins was low (0–11.1%). The Enterococcus spp. isolates showed no resistance to vancomycin. The antimicrobial resistance rates of the Staphylococcus spp. and Enterobacteriaceae isolates from stray cats were usually lower than those of isolates from hospital-visiting cats and veterinary staff, but the Enterococcus spp. isolates revealed the opposite. Thus, the antimicrobial resistance varied across bacterial species according to the source from which they were isolated. Conclusions Resistance to critically important compounds were low. These results emphasize the fact that more attention should be paid to the use of antimicrobials and the occurrence of antimicrobial resistance in cats.

scholarly journals Bacterial Pathogens and Their Antimicrobial Resistance Patterns of Inanimate Surfaces and Equipment in Ethiopia: A Systematic Review and Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-25
Author(s):  
Teklehaimanot Kiros ◽  
Shewaneh Damtie ◽  
Tahir Eyayu ◽  
Tegenaw Tiruneh ◽  
Wasihun Hailemichael ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antimicrobial Resistance ◽  
Outcome Measures ◽  
Bacterial Contamination ◽  
Bacterial Pathogens ◽  
Meta Analysis ◽  
Bacterial Species ◽  
Hospital Environment ◽  
Cochrane Library ◽  
Resistance Patterns

Background. Hospital-acquired infections have remained a serious cause of mortality, morbidity, and extended hospitalization. Bacterial contamination of inanimate surfaces of the hospital environment and equipment is considered a major contributing factor to the development of several nosocomial infections worldwide. The hospital environment and many devices are an important reservoir of many clinically important bacterial agents including multidrug-resistant pathogens. Therefore, this systematic review and meta-analysis are aimed at investigating bacterial pathogens and their antimicrobial resistance patterns of inanimate surfaces and equipment in Ethiopia. Methods. An exhaustive literature search was carried out using the major electronic databases including PubMed, Web of Science, MEDLINE, EMBASE, CINAHL, Google Scholar, Cochrane Library, Scopus, and Wiley online library to identify potentially relevant studies without date restriction. Original articles which address the research question were identified, screened, and included using the PRISMA flow diagram. Data extraction was prepared in Microsoft Excel, and data quality was assessed by using 9-point Joanna Briggs Institute critical appraisal tools. Then, data were exported to STATA 16.0 software for analyses of pooled estimation of outcome measures. Estimation of outcome measures at a 95% confidence interval was performed using DerSimonian-Laird’s random-effects model. Finally, results were presented via text, figures, and tables. Results. A total of 18 studies with 3058 bacterial isolates recovered from 3423 swab specimens were included for systematic review and meta-analysis. The pooled prevalence of bacterial contamination of inanimate surfaces and equipment was found 70% (95% CI: 59, 82). Among the Gram-negative bacterial species, the prevalence of ampicillin-resistant K. pneumoniae was the highest 80% (95% CI: 78, 92) followed by Citrobacter species 78% (95% CI: 57, 83). Conclusion. This study has shown a high prevalence of bacterial contamination of inanimate surfaces and equipment in Ethiopia.

scholarly journals Antimicrobial resistance of Pasteurella multocida strains isolated from pigs between 2010 and 2016

2018 ◽  
Vol 5 (1) ◽  
pp. e000293 ◽  
Author(s):  
Yoon-Hee Oh ◽  
Dong-Chan Moon ◽  
Young Ju Lee ◽  
Bang-Hun Hyun ◽  
Suk-Kyung Lim
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Pasteurella Multocida ◽  
Antimicrobial Treatment ◽  
Limited Information ◽  
Efficient Treatment ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Resistance Patterns ◽  
Selection Of

Pasteurella multocida is one of the significant causes of respiratory infection outbreaks in the Korean pig industry. Although antimicrobial treatment is an effective strategy for controlling respiratory diseases, limited information is available regarding the antimicrobial susceptibility of the pathogens infecting Korean pigs. Therefore, in this study, we evaluated the antimicrobial resistance of P multocida against widely used antimicrobials in order to enable the selection of appropriate drugs and to evaluate any trends in resistance. A total of 454 isolates of P multocida were collected from all provinces in Korea between 2010 and 2016. Antimicrobial susceptibility of all isolates was determined using a broth microdilution method. The most frequently observed resistance was to sulphadimethoxine (76.0 per cent), followed by oxytetracycline (66.5 per cent), chlortetracycline (36.8 per cent) and florfenicol (18.5 per cent). Although no consistent increase or decrease in resistance was observed for most antimicrobials, resistance to fluoroquinolones tended to increase over the study period. A variety of resistance patterns were observed, most frequently for tetracyclines and sulphonamides. These findings could provide information enabling the selection of optimal antimicrobials for efficient treatment of pneumoniae pasteurellosis in pig farms, which would impede the emergence of antimicrobial resistance.

scholarly journals Antimicrobial Resistance Patterns in Clostridioides difficile Strains Isolated from Neonates in Germany

Antibiotics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 481
Author(s):  
Friederike K. M. T. Tilkorn ◽  
Hagen Frickmann ◽  
Isabel S. Simon ◽  
Julian Schwanbeck ◽  
Sebastian Horn ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Longitudinal Survey ◽  
Resistance Testing ◽  
Clostridioides Difficile ◽  
Initial Cohort ◽  
Resistance Patterns ◽  
Stool Samples ◽  
Toxigenic Strains ◽  
Moderate Resistance ◽  
Selection Of

Young children are frequently colonized with Clostridioides (C.) difficile. Depending on their resistance patterns, antibiotic treatment can facilitate gastrointestinal spreading in colonized individuals, potentially leading to transmission to others. C. difficile was isolated from stool samples from infants born in two hospitals in Göttingen and Darmstadt, Germany. All isolates were subjected to phenotypic antimicrobial resistance testing, PCR-based screening for toxin genes and mass spectrometry-based exclusion of ribotypes 027 and 176. Within an initial cohort of 324 neonates with a longitudinal survey of C. difficile, 137 strains were isolated from 48 individuals. Antimicrobial resistance was recorded against metronidazole in one (0.7%), erythromycin in 16 (11.7%) and moxifloxacin in 2 (1.5%) of the strains, whereas no resistance was observed against vancomycin (0.0%) or rifampicin (0.0%). Newly observed resistance against erythromycin in children with detection of previously completely sensitive isolates was reported for C. difficile isolates from 2 out of 48 children. In 20 children (42%), non-toxigenic strains were detected, and from 27 children (56%), toxigenic strains were isolated, while both toxigenic and non-toxigenic strains were recorded for 1 child (2%). Ribotypes 027 or 176 were not observed. In conclusion, the German C. difficile strains isolated from the children showed mild to moderate resistance with predominance of macrolide resistance, a substance class which is frequently applied in children. The observed switches to the dominance of macrolide-resistant isolates suggests likely selection of resistant C. difficile strains already in children.

scholarly journals Antimicrobial resistance patterns of commensal Escherichia coli isolated from feces of non-diarrheic dogs in Grenada, West Indies

2019 ◽  
Vol 12 (12) ◽  
pp. 2070-2075 ◽  
Author(s):  
Victor A. Amadi ◽  
Harry Hariharan ◽  
Ozioma A. Amadi ◽  
Vanessa Matthew-Belmar ◽  
Roxanne Nicholas-Thomas ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Resistance Rate ◽  
Resistance Pattern ◽  
E Coli ◽  
Resistance Patterns ◽  
Antimicrobial Susceptibility Tests ◽  
Susceptibility Tests ◽  
Selection Of

Background and Aim: There is currently no published information on the prevalence and antimicrobial susceptibility patterns of commensal Escherichia coli in dogs of Grenada origin. Monitoring antimicrobial resistance helps in the empirical selection of antibiotics. This study determined the occurrence of E. coli including the O157:H7 serotype in feces of non-diarrheic dogs of Grenada origin and the antibiotic resistance pattern of the E. coli isolates. Materials and Methods: Fecal samples from 142 of the 144 (98.6%) dogs were culture positive for E. coli. Selection of up to three colonies from each of the 142 E. coli-positive samples yielded a total of 402 E. coli isolates, which were analyzed for the presence of non-sorbitol fermenting colonies, and O157-agglutination. Results: Of the 402 E. coli isolates, 30 (7.5%) were non-sorbitol fermenters. However, none of the 402 isolates gave a positive reaction (O157:H7) to the E. coli O157:H7 latex kit. Antimicrobial susceptibility tests against 12 antibiotics revealed low resistance rates to all the tested antibiotics except for tetracycline (Te) (23.4%), cephalothin (CF) (13.2%), and ampicillin (AM) (7.7%). Thirty-nine out of the 402 (9.7%), E. coli isolates were resistant to two or more antibiotics of different classes. Conclusion: This is the first report of isolation and antimicrobial susceptibilities of commensal E. coli from non-diarrheic dogs in Grenada. Some of the isolates (39/402 isolates, 9.7%) were resistant to multiple antibiotics. This study showed that presently, dogs in Grenada should not be considered a reservoir for the E. coli O157:H7 serotype and for multiple antibiotic-resistant E. coli strains. Among the 402 E. coli isolates, the resistance rate to drugs other than Te, CF, and AM was very low.

scholarly journals Replicon typing characterization of plasmids encoding resistance to gentamicin and apramycin inEscherichia coliandSalmonella typhimuriumisolated from human and animal sources in Belgium

1993 ◽  
Vol 111 (2) ◽  
pp. 229-238 ◽  
Author(s):  
P. Pohl ◽  
Y. Glupczynski ◽  
M. Marin ◽  
G. Van Robaeys ◽  
P. Lintermans ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Bacterial Species ◽  
Gene Encoding ◽  
E Coli ◽  
Molecular Weights ◽  
Electrophoretic Patterns ◽  
Rapid Spread ◽  
Hospital Patients ◽  
Resistance Patterns ◽  
Gentamicin Resistance

SummaryEscherichia coliand salmonella strains with plasmids conferring resistance to gentamicin and apramycin have been isolated with increasing frequency both from cattle and hospital patients in Belgium. The apramycin-gentamicin resistance plasmids were characterized in recipient strains by their profiles and molecular weights using agarose gel electrophoresis, by their antimicrobial resistance patterns and by replicon typing using a series of DNA probes specific for the genes controlling their systems of replication. Overall, most of the plasmids differed in their DNA electrophoretic patterns. Seventeen different antimicrobial resistance profiles were observed, and there were six different types of replicons. However, two replication genes predominated and had a preferential distribution in different bacterial species. The rep FIC.a plus rep Q multireplicon was found mainly in plasmids recovered from gentamicin- and apramycin-resistantE. coliwhile replicon of the type rep FIC.b largely prevailed inS. typhimurium. Identical replication genes were found in most animal and human strains, hence suggesting a high homology between apramycin- gentamicin plasmids in these communities. Finally, our results indicate that the rapid spread of apramycin-gentamicin-resistance in several species of Enterobacteriaceae isolated from animals and from humans in Belgium is not due to a single plasmid, but rather that the gene encoding AAC(3)-IV is carried by various replicons.

scholarly journals Distribution and antimicrobial resistance profiles of bacterial species in stray cats, hospital-visiting cats, and veterinary staff in South Korea

2019 ◽  
Author(s):  
Woo Kyung Jung ◽  
Sook Shin ◽  
Young Kyung Park ◽  
Suk-Kyung Lim ◽  
Dong-Chan Moon ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
South Korea ◽  
Pathogenic Bacteria ◽  
Bacterial Species ◽  
Coagulase Negative Staphylococci ◽  
Stray Cats ◽  
Enterococcus Spp ◽  
Health Concept ◽  
Resistance Patterns ◽  
Staphylococcus Spp

Abstract Background Antimicrobial resistance is becoming increasingly important in both human and veterinary medicine. According to the One Health concept, an important step is to monitor the resistance patterns of pathogenic bacteria. In this study, the antimicrobial susceptibility patterns and trends of bacteria isolated from stray cats, hospital-visiting cats, and veterinary staff in South Korea between 2017 and 2018 were investigated. Results The minimum inhibitory concentrations of different antibiotics for Staphylococcus spp., Enterobacteriaceae , and Enterococcus spp. were determined to establish representatives of different antibiotic classes relevant for treatment or surveillance. For Coagulase-positive and Coagulase-negative Staphylococci, resistance to fluoroquinolones was below 13%, but resistance to ampicillin and penicillin was high (20–88%). A total of 9.5%, 12.1%, and 40.3% of staphylococcal isolates from stray cats, hospital-visiting cats, and veterinary staff, respectively, were confirmed to be mecA positive. For Enterobacteriaceae , resistance to carbapenems, fluoroquinolones, and 3rd generation cephalosporins was low (0–11.1%). The Enterococcus spp. isolates showed no resistance to vancomycin. The antimicrobial resistance rates of the Staphylococcus spp. and Enterobacteriaceae isolates from stray cats were usually lower than those of isolates from hospital-visiting cats and veterinary staff, but the Enterococcus spp. isolates revealed the opposite. Thus, the antimicrobial resistance varied across bacterial species according to the source from which they were isolated. Conclusions Resistance to critically important compounds were low. These results emphasize the fact that more attention should be paid to the use of antimicrobials and the occurrence of antimicrobial resistance in cats.

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