scholarly journals Regulation and function of capicua in mammals

2020 ◽  
Vol 52 (4) ◽  
pp. 531-537 ◽  
Author(s):  
Yoontae Lee
Keyword(s):  
Dna Sequences ◽  
Target Genes ◽  
Enterohepatic Circulation ◽  
High Mobility ◽  
Spinocerebellar Ataxia Type ◽  
Future Research ◽  
Physiological Processes ◽  
Systemic Autoimmunity ◽  
Future Research Directions ◽  
And Function

Abstract Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-mobility group (HMG) box that recognizes specific DNA sequences to regulate the expression of various target genes. CIC was originally identified in Drosophila melanogaster as a transcriptional repressor that suppresses the receptor tyrosine kinase signaling pathway. This molecule controls normal organ growth and tissue patterning as well as embryogenesis in Drosophila. Recent studies have also demonstrated its extensive functions in mammals. For example, CIC regulates several developmental and physiological processes, including lung development, abdominal wall closure during embryogenesis, brain development and function, neural stem cell homeostasis, T cell differentiation, and enterohepatic circulation of bile acids. CIC is also associated with the progression of various types of cancer and neurodegeneration in spinocerebellar ataxia type-1, systemic autoimmunity, and liver injury. In this review, I provide a broad overview of our current understanding of the regulation and functions of CIC in mammals and discuss future research directions.

Organizational Leadership and Health Care Reform

2016 ◽  
pp. 1043-1063
Author(s):  
T. Ray Ruffin ◽  
Joyce Marie Hawkins ◽  
D. Israel Lee
Keyword(s):  
Health Care ◽  
Organizational Leadership ◽  
Health Care Systems ◽  
Future Research ◽  
Health Care Reforms ◽  
Use Of Technology ◽  
Hitech Act ◽  
Care Systems ◽  
Future Research Directions ◽  
And Function

Policies, health, and government regulations affect various Health Care organizations and their members. One such policy, the Health Information Technology for Economic and Clinical Health (HITECH) Act, attempts to improve the performance of health care systems through the use of technology, such as Electronic Health Records (Bluementhal, 2010). The most critical task of leadership is to establish a mindset at the top of the organization and function to infuse a culture of excellence throughout the organization (Bentkover, 2012). Health organizations can only progress if their members share a set of values and are single-mindedly committed to achieving openly defined objectives (Bentkover, 2012). This chapter investigates organizational leadership in relation to health care reforms to include trends in health care leadership, Stratified Systems Theory (SST), Systems Thinking, and regulators perspectives. The chapter will consist of the following sections: background; issues controversies, and problems; solutions and recommendation; future research directions; and conclusion.

scholarly journals Role of co-regulators in metabolic and transcriptional actions of thyroid hormone

2016 ◽  
Vol 56 (3) ◽  
pp. R73-R97 ◽  
Author(s):  
Inna Astapova
Keyword(s):  
Thyroid Hormone ◽  
Transcriptional Repression ◽  
Target Genes ◽  
Thyroid Hormone Receptor ◽  
Retinoic Acid Receptor ◽  
Specific Response ◽  
Physiological Processes ◽  
Genome Wide ◽  
Wide Range ◽  
And Function

Thyroid hormone (TH) controls a wide range of physiological processes through TH receptor (TR) isoforms. Classically, TRs are proposed to function as tri-iodothyronine (T3)-dependent transcription factors: on positively regulated target genes, unliganded TRs mediate transcriptional repression through recruitment of co-repressor complexes, while T3binding leads to dismissal of co-repressors and recruitment of co-activators to activate transcription. Co-repressors and co-activators were proposed to play opposite roles in the regulation of negative T3target genes and hypothalamic–pituitary–thyroid axis, but exact mechanisms of the negative regulation by TH have remained elusive. Important insights into the roles of co-repressors and co-activators in different physiological processes have been obtained using animal models with disrupted co-regulator function. At the same time, recent studies interrogating genome-wide TR binding have generated compelling new data regarding effects of T3, local chromatin structure, and specific response element configuration on TR recruitment and function leading to the proposal of new models of transcriptional regulation by TRs. This review discusses data obtained in various mouse models with manipulated function of nuclear receptor co-repressor (NCoR or NCOR1) and silencing mediator of retinoic acid receptor and thyroid hormone receptor (SMRT or NCOR2), and family of steroid receptor co-activators (SRCs also known as NCOAs) in the context of TH action, as well as insights into the function of co-regulators that may emerge from the genome-wide TR recruitment analysis.

scholarly journals Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2

2020 ◽  
Vol 48 (7) ◽  
pp. 3869-3887 ◽  
Author(s):  
Linlin Hou ◽  
Yuanjie Wei ◽  
Yingying Lin ◽  
Xiwei Wang ◽  
Yiwei Lai ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Target Genes ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
High Mobility ◽  
Binding Motif ◽  
Dna And Rna ◽  
Somatic Cell Reprogramming ◽  
Double Stranded Dna

Abstract Some transcription factors that specifically bind double-stranded DNA appear to also function as RNA-binding proteins. Here, we demonstrate that the transcription factor Sox2 is able to directly bind RNA in vitro as well as in mouse and human cells. Sox2 targets RNA via a 60-amino-acid RNA binding motif (RBM) positioned C-terminally of the DNA binding high mobility group (HMG) box. Sox2 can associate with RNA and DNA simultaneously to form ternary RNA/Sox2/DNA complexes. Deletion of the RBM does not affect selection of target genes but mitigates binding to pluripotency related transcripts, switches exon usage and impairs the reprogramming of somatic cells to a pluripotent state. Our findings designate Sox2 as a multi-functional factor that associates with RNA whilst binding to cognate DNA sequences, suggesting that it may co-transcriptionally regulate RNA metabolism during somatic cell reprogramming.

scholarly journals Mini-Review of Studies Testing the Cardiorespiratory Hypothesis With Near-Infrared Spectroscopy (NIRS): Overview and Perspectives

2021 ◽  
Vol 15 ◽  
Author(s):  
Nounagnon Frutueux Agbangla ◽  
Pauline Maillot ◽  
Damien Vitiello
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Future Research ◽  
Brain Oxygenation ◽  
Research Directions ◽  
Future Research Directions ◽  
And Function ◽  
The Relationship

The cardiorespiratory hypothesis (CH) is one of the hypotheses used by researchers to explain the relationship between cardiorespiratory fitness and cognitive performance during executive functions. Despite the indubitable beneficial effect of training on brain blood flow and function that may explain the link between physical fitness and cognition and the recognition of the near-infrared spectroscopy (NIRS) as a reliable tool for measuring brain oxygenation, few studies investigated the CH with NIRS. It is still not well understood whether an increase in brain flow by training is translated into an increase in cerebral oxygenation. Thus, the objective of this mini-review was to summarize main results of studies that investigated the CH using the NIRS and to propose future research directions.

scholarly journals Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 918 ◽  
Author(s):  
Kinga Tóth ◽  
Dorottya Ádám ◽  
Tamás Bíró ◽  
Attila Oláh
Keyword(s):  
Therapeutic Potential ◽  
Endocannabinoid System ◽  
The Body ◽  
Future Research ◽  
Research Directions ◽  
Physiological Processes ◽  
Barrier Formation ◽  
The Central Nervous System ◽  
Future Research Directions ◽  
Pigmentation Disorders

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are related to the central nervous system and to immune processes, experimental efforts over the last two decades have unambiguously confirmed that cutaneous cannabinoid (“c[ut]annabinoid”) signaling is deeply involved in the maintenance of skin homeostasis, barrier formation and regeneration, and its dysregulation was implicated to contribute to several highly prevalent diseases and disorders, e.g., atopic dermatitis, psoriasis, scleroderma, acne, hair growth and pigmentation disorders, keratin diseases, various tumors, and itch. The current review aims to give an overview of the available skin-relevant endo- and phytocannabinoid literature with a special emphasis on the putative translational potential, and to highlight promising future research directions as well as existing challenges.

scholarly journals Is Extreme in the Eye of the Beholder? An Experimental Assessment of Extremist Cognitions

2020 ◽  
pp. 088626052095864
Author(s):  
Neil Shortland ◽  
Elias Nader ◽  
Lisa Thompson ◽  
Marek Palasinski
Keyword(s):  
Future Research ◽  
Personality Factors ◽  
Psychological Consequences ◽  
Research Directions ◽  
Personality Differences ◽  
Form And Function ◽  
Individual Personality ◽  
Future Research Directions ◽  
And Function

Scholars have extensively discussed the topic of “online radicalization,” often seeking to understand the form and function of online extremist material. However, this work has neglected to examine the role that the Internet plays alongside individual personality factors in the process through which someone develops violent extremist cognitions. This article aims to extend the understanding of the role of personality differences in the effect of exposure to extremist material online. In this study, we experimentally measure the short-term psychological consequences of exposure to extremist material on extremist cognitions. We use a between-group experimental design in which participants are shown extremist propaganda with either pre- or post-counter messages. Our results indicate that trait personality, and specifically aggression, may be more influential than exposure to extremist propaganda in influencing extremist cognitions. We discuss the implications of these results in the context of future research directions.

scholarly journals Protein and Proteome Atlas for Plants under Stresses: New Highlights and Ways for Integrated Omics in Post-Genomics Era

2019 ◽  
Vol 20 (20) ◽  
pp. 5222 ◽  
Author(s):  
Xuchu Wang
Keyword(s):  
Protein Identification ◽  
Target Genes ◽  
Protein Quantification ◽  
Plant Proteins ◽  
Post Translational Modifications ◽  
Physiological Processes ◽  
Integrated Omics ◽  
Response To Stress ◽  
And Function ◽  
Integrative Omics

In the post-genomics era, integrative omics studies for biochemical, physiological, and molecular changes of plants in response to stress conditions play more crucial roles. Among them, atlas analysis of plants under different abiotic stresses, including salinity, drought, and toxic conditions, has become more important for uncovering the potential key genes and proteins in different plant tissues. High-quality genomic data and integrated analyses of transcriptomic, proteomic, metabolomics, and phenomic patterns provide a deeper understanding of how plants grow and survive under environmental stresses. This editorial mini-review aims to synthesize the 27 papers including two timely reviews that have contributed to this Special Issue, which focuses on concluding the recent progress in the Protein and Proteome Atlas in plants under different stresses. It covers various aspects of plant proteins ranging from agricultural proteomics, structure and function of proteins, novel techniques and approaches for gene and protein identification, protein quantification, proteomics for post-translational modifications (PTMs), and new insights into proteomics. The proteomics-based results in this issue will help the readers to gain novel insights for the understanding of complicated physiological processes in crops and other important plants in response to stressed conditions. Furthermore, these target genes and proteins that are important candidates for further functional validation in economic plants and crops can be studied.

scholarly journals The Gut Microbiota-Derived Immune Response in Chronic Liver Disease

2021 ◽  
Vol 22 (15) ◽  
pp. 8309
Author(s):  
Sung-Min Won ◽  
Eunju Park ◽  
Jin-Ju Jung ◽  
Raja Ganesan ◽  
Haripriya Gupta ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Causative Factor ◽  
Chronic Liver ◽  
Intestinal Microbiome ◽  
Future Research ◽  
The Future ◽  
Future Research Directions ◽  
Excessive Intake ◽  
And Function

In chronic liver disease, the causative factor is important; however, recently, the intestinal microbiome has been associated with the progression of chronic liver disease and the occurrence of side effects. The immune system is affected by the metabolites of the microbiome, and diet is the primary regulator of the microbiota composition and function in the gut–liver axis. These metabolites can be used as therapeutic material, and postbiotics, in the future, can increase or decrease human immunity by modulating inflammation and immune reactions. Therefore, the excessive intake of nutrients and the lack of nutrition have important effects on immunity and inflammation. Evidence has been published indicating that microbiome-induced chronic inflammation and the consequent immune dysregulation affect the development of chronic liver disease. In this research paper, we discuss the overall trend of microbiome-derived substances related to immunity and the future research directions.

Survey about citation context analysis: Tasks, techniques, and resources

2015 ◽  
Vol 22 (3) ◽  
pp. 327-349 ◽  
Author(s):  
MYRIAM HERNÁNDEZ-ALVAREZ ◽  
JOSÉ M. GOMEZ
Keyword(s):  
Future Research ◽  
Context Analysis ◽  
Research Directions ◽  
Structural Problems ◽  
Citation Context ◽  
Perverse Incentives ◽  
Future Research Directions ◽  
And Function ◽  
Quality Assessments

AbstractBibliometric calculations currently used to assess the quality of researchers, articles, and scientific journals have serious structural problems; many authors have noted the weakness of citation counts, because they are purely quantitative and do not differentiate between high- and low-citing papers. If a paper’s reputation is simply evaluated according to the number of its citations, then incomplete, incorrect, or controversial articles may be promoted, regardless of their relevancy. Therefore, perverse incentives are generated for researchers who may publish many incorrect or incomplete papers to achieve high impact indexes. It is essential to improve the objective criteria for automatic article-quality assessments. However, to obtain these new criteria, it is necessary to advance the programmed detection of context, polarity, and function of bibliographic references.We present an overview of general concepts and review contributions to the solutions to problems related to these issues, with the purpose of identifying trends and suggesting possible future research directions.

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