scholarly journals Defining Dysbiosis for a Cluster of Chronic Diseases

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lamont J. Wilkins ◽  
Manoj Monga ◽  
Aaron W. Miller
Keyword(s):  
Chronic Disease ◽  
Microbial Diversity ◽  
Chronic Diseases ◽  
Disease Risk ◽  
Antibiotic Use ◽  
Urinary Stone ◽  
Stone Disease ◽  
Cross Sectional ◽  
Disease States ◽  
Causative Effect

Abstract The prevalence of many chronic diseases has increased over the last decades. It has been postulated that dysbiosis driven by environmental factors such as antibiotic use is shifting the microbiome in ways that increase inflammation and the onset of chronic disease. Dysbiosis can be defined through the loss or gain of bacteria that either promote health or disease, respectively. Here we use multiple independent datasets to determine the nature of dysbiosis for a cluster of chronic diseases that includes urinary stone disease (USD), obesity, diabetes, cardiovascular disease, and kidney disease, which often exist as co-morbidities. For all disease states, individuals exhibited a statistically significant association with antibiotics in the last year compared to healthy counterparts. There was also a statistically significant association between antibiotic use and gut microbiota composition. Furthermore, each disease state was associated with a loss of microbial diversity in the gut. Three genera, Bacteroides, Prevotella, and Ruminococcus, were the most common dysbiotic taxa in terms of being enriched or depleted in disease populations and was driven in part by the diversity of operational taxonomic units (OTUs) within these genera. Results of the cross-sectional analysis suggest that antibiotic-driven loss of microbial diversity may increase the risk for chronic disease. However, longitudinal studies are needed to confirm the causative effect of diversity loss for chronic disease risk.

scholarly journals Efek Penyakit Kronis terhadap Gangguan Mental Emosional

2013 ◽  
Vol 7 (7) ◽  
pp. 309
Author(s):  
Giri Widakdo ◽  
Besral Besral
Keyword(s):  
Chronic Disease ◽  
Chronic Illness ◽  
Chronic Diseases ◽  
Emotional Disorders ◽  
Disease Risk ◽  
Standard Of Care ◽  
Cross Sectional Study ◽  
Emotional Disorder ◽  
Cross Sectional ◽  
Chronic Disease Risk

Hasil Riset Kesehatan Dasar tahun 2007 menunjukkan 11,6% penduduk Indonesia berumur 15 tahun ke atas mengalami gangguan mental emosional. Penelitian ini bertujuan untuk mengetahui efek penyakit kronis terhadap gangguan mental emosional. Desain penelitian ini adalah potong lintang mengggunakan data Riskesdas tahun 2007. Sebanyak 660.452 responden berusia di atas 15 tahun yang tidak mengalami gangguan jiwa dijadikan sampel. Gangguan mental emosional dinyatakan ada jika responden mem-punyai paling tidak enam dari 20 gangguan. Penyakit kronis seperti tuberculosis (TB) paru, hepatitis, jantung, diabetes, kanker, dan stroke diukur melalui wawancara yang didasarkan pada diagnosis petugas kesehatan. Hasil penelitian menunjukkan bahwa dari sepuluh penderita penyakit kronis, dua sampai lima penderita akan mengalami gangguan mental emosional. Analisis regresi logistik multivariat memperlihatkan bahwa risiko gangguan mental emosional semakin tinggi bersamaan dengan semakin banyak jumlah penyakit kronis yang diderita oleh responden. Responden yang menderita satu penyakit kronis berisiko 2,6 kali lebih besar untuk mengalami gangguan mental emosional, yang menderita dua penyakit kronis berisiko 4,6 kali, yang menderita tiga penyakit kronis atau lebih berisiko 11 kali. Kementerian Kesehatan disarankan untuk mengembangkan standar pelayanan penyakit kronis terkait dengan pengurangan dampak pada gangguan mental emosional dan dibentuknya tim bimbingan teknis pelayanan penyakit kronis.Basic Health Research (Riskesdas) year 2007 showed that 11.6 percent of Indonesia’s population aged 15 years and above suffering from mental emotional disorder. This study aimed to examine the effects of chronic illness to the mental emotional disorders. A cross-sectional study was performed that used Riskesdas 2007 data. Atotal of 660,452 respondents aged 15 years and over who are mentally health become sample of this study. Mental emotional disorders exist if they have at least six of the 20 disorder. Chronic diseases such as pulmonary tuberculosis, hepatitis, heart disease, diabetes, cancer, and stroke were measured based on diagnosis by health pro-fesional. The results showed that out of ten respondents with chronic illness, aproximately two to five will suffering from mental emotional disorder. Multivariat logistic regression analysis shows that the risk of developing mental emotional disorders higher as more number of chronic illnesses suffered by the respondent. Respondents suffering from one chronic disease were 2.6 times greater risk for emotional mental disorder, suffering from two chronic dis-ease have risk 4.6 times, which had three or more chronic disease risk have risk 11 times. It is suggested that the Ministry of Health to develop a standard of care of chronic diseases associated with reducing impact on the mental emotional disorders and establishment of teams for technical guidance chronic disease care.

scholarly journals Meta-analysis of Clinical Microbiome Studies in Urolithiasis Reveal Age, Stone Composition, and Study Location as the Predominant Factors in Urolithiasis-Associated Microbiome Composition

mBio ◽  
2021 ◽  
Author(s):  
Naveen Kachroo ◽  
Dirk Lange ◽  
Kristina L. Penniston ◽  
Joshua Stern ◽  
Gregory Tasian ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Environmental Factors ◽  
Chronic Diseases ◽  
Meta Analysis ◽  
Urinary Stone ◽  
Stone Disease ◽  
Stone Composition ◽  
Urinary Stone Disease ◽  
Microbiome Composition

Studies focused on the microbiome broadly support the hypothesis that the microbiome influences the onset of chronic diseases such as urinary stone disease. However, it is unclear what environmental factors shape the microbiome in ways that increase the risk for chronic disease.

scholarly journals Effects of supplementation with carnosine and other histidine-containing dipeptides on chronic disease risk factors and outcomes: protocol for a systematic review of randomised controlled trials

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020623 ◽  
Author(s):  
Kirthi Menon ◽  
Aya Mousa ◽  
Barbora de Courten
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Randomised Controlled Trials ◽  
Disease Risk ◽  
Primary Data ◽  
Controlled Trials ◽  
Chronic Disease Risk ◽  
Randomised Controlled

IntroductionAgeing of populations globally, coupled with the obesity epidemic, has resulted in the rising prevalence of chronic diseases including diabetes, cardiovascular diseases, cancers and neurodegenerative disorders. Prevention of risk factors that contribute to these diseases is key in managing the global burden of chronic diseases. Recent studies suggest that carnosine, a dipeptide with anti-inflammatory, antioxidative and antiglycating properties may have a role in the prevention of chronic diseases; however, no previous reviews have examined the effects of carnosine and other histidine-containing peptides (HCDs) on chronic disease risk factors and outcomes. We aim to conduct a comprehensive systematic review to examine the effects of supplementation with carnosine and other HCDs on chronic disease risk factors and outcomes and to identify relevant knowledge gaps.Methods and analysisElectronic databases including Medline, Cumulative Index of Nursing and Allied Health, Embase and all Evidence-Based Medicine will be systematically searched to identify randomised controlled trials (RCTs) and systematic reviews of RCTs, comparing supplementation with carnosine and/or other HCDs versus placebo, usual care or other pharmacological or non-pharmacological interventions. One reviewer will screen titles and abstracts for eligibility according to prespecified inclusion criteria, after which two independent reviewers will perform data extraction and quality appraisal. Meta-analyses, metaregression and subgroup analyses will be conducted where appropriate.Ethics and disseminationEthics approval is not required as this review does not involve primary data collection. This review will generate level-one evidence regarding the effects of carnosine supplementation on chronic disease risk factors and outcomes and will be disseminated through peer-reviewed publications and at conference meetings to inform future research on the efficacy of carnosine supplementation for the prevention of chronic diseases.PROSPERO registration numberCRD42017075354.

Red Meat and Health

2016 ◽  
pp. 131-177 ◽  
Author(s):  
Kate Marsh ◽  
Angela Saunders ◽  
Carol Zeuschner
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Disease Risk ◽  
Red Meat ◽  
Current Evidence ◽  
Processed Meat ◽  
Mortality Risks ◽  
Regular Consumption ◽  
Health And Disease ◽  
Nutritional Benefits

Despite its nutritional benefits, there is an increasing body of evidence to suggest that regular consumption of red meat may negatively impact health and disease risk, including the risk of most common chronic diseases. This chapter reviews the current evidence linking red and processed meat intakes with chronic disease, obesity and mortality risks and discusses possible mechanisms to explain these associations. Research on the health benefits of diets low in red meat, including vegetarian, vegan, Mediterranean and other plant-based diets, is also reviewed.

scholarly journals Prevalence of Chronic Diseases and Activity-Limiting Disability among Roma and Non-Roma People: A Cross-Sectional, Census-Based Investigation

2019 ◽  
Vol 16 (19) ◽  
pp. 3620 ◽  
Author(s):  
Vincze ◽  
Földvári ◽  
Pálinkás ◽  
Sipos ◽  
Janka ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Health Monitoring ◽  
Population Level ◽  
Sociodemographic Factors ◽  
Activity Limitations ◽  
Cross Sectional ◽  
Roma Ethnicity ◽  
Roma Health

The lack of recommended design for Roma health-monitoring hinders the interventions to improve the health status of this ethnic minority. We aim to describe the riskiness of Roma ethnicity using census-derived data and to demonstrate the value of census for monitoring the Roma to non-Roma gap. This study investigated the self-declared occurrence of at least one chronic disease and the existence of activity limitations among subjects with chronic disease by the database of the 2011 Hungarian Census. Risks were assessed by odds ratios (OR) and 95% confidence intervals (95% CI) from logistic regression analyses controlled for sociodemographic factors. Roma ethnicity is a risk factor for chronic diseases (OR = 1.17; 95% CI: 1.16–1.18) and for activity limitation in everyday life activities (OR = 1.20; 95% CI: 1.17–1.23), learning-working (OR = 1.24; 95% CI: 1.21–1.27), family life (OR = 1.22; 95% CI: 1.16–1.28), and transport (OR = 1.03; 95% CI: 1.01–1.06). The population-level impact of Roma ethnicity was 0.39% (95% CI: 0.37–0.41) for chronic diseases and varied between 0 and 1.19% for activity limitations. Our investigations demonstrated that (1) the Roma ethnicity is a distinct risk factor with significant population level impact for chronic disease occurrence accompanied with prognosis worsening influence, and that (2) the census can improve the Roma health-monitoring system, primarily by assessing the population level impact.

scholarly journals The relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men

2008 ◽  
Vol 100 (4) ◽  
pp. 883-889 ◽  
Author(s):  
Wildon R. Farwell ◽  
J. Michael Gaziano ◽  
Edward P. Norkus ◽  
Howard D. Sesso
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Disease Risk ◽  
Alcohol Ingestion ◽  
Health Study ◽  
Parameter Estimates ◽  
Total Plasma ◽  
The Relationship

Individual plasma carotenoids have been associated with various chronic diseases but little is known about the relationship between total plasma carotenoids and risk factors for chronic diseases. In the Physicians' Health Study, we examined 492 men free of CVD and cancer for the relationship between total plasma carotenoids (the sum of α-carotene, β-carotene, lycopene, zeaxanthin, lutein and β-cryptoxanthin) and a wide variety of factors that predict chronic disease. Multivariate linear and logistic regression was performed to calculate parameter estimates (95 % CI) and OR (95 % CI) for total plasma carotenoids. In linear regression models, BMI, hypertension, alcohol intake and plasma levels of each lipid parameter and α-tocopherol significantly predicted levels of total plasma carotenoids. Upon adjustment for multiple chronic disease risk factors, the OR for levels of total plasma carotenoids greater than or equal to the median ( ≥ 1·301 μmol/l) was statistically significant for current smoking (OR 0·21; 95 % CI 0·06, 0·77), weekly alcohol ingestion (OR 2·30; 95 % CI 1·06, 4·99), daily alcohol ingestion (OR 2·46; 95 % CI 1·29, 4·67), each 100 mg/l increase in total cholesterol (OR 0·73; 95 % CI 0·58, 0·91), LDL-cholesterol (OR 1·48; 95 % CI 1·17, 1·89) and HDL-cholesterol (OR 1·58; 95 % CI 1·26, 1·99), each 100 mg/ml increase in intercellular adhesion molecule-1 (OR 0·70; 95 % CI 0·53, 0·93) and each 10 μmol/l increase in α-tocopherol (OR 1·33; 95 % CI 1·12, 1·57), using logistic regression. Few lifestyle and clinical risk factors appear to be related to levels of total plasma carotenoids; however, levels of biomarkers such as plasma lipids and α-tocopherol may be strongly related.

scholarly journals A cross-sectional study on effect of non-communicable diseases on prevalent oral health conditions

2016 ◽  
Vol 4 (1) ◽  
pp. 246 ◽  
Author(s):  
Aasim Farooq Shah ◽  
Irfan Ashraf Baba ◽  
Subha Soumya Dany ◽  
Manu Batra
Keyword(s):  
Chronic Disease ◽  
Oral Health ◽  
Chronic Diseases ◽  
General Health ◽  
Dental Health ◽  
Cross Sectional Study ◽  
Communicable Diseases ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Communicable Diseases

Background: Non communicable diseases (NCDs) are defined as diseases of long duration, generally progress slowly and are the major cause of adult mortality and morbidity worldwide. NCDs mainly lead by four diseases which include: cardiovascular diseases, diabetes mellitus (DM), cancers and chronic respiratory diseases. Poor oral health reflects the general health, and several oral diseases are related to chronic diseases. The aim and objectives was to find casual association between NCDs with oral disease and further aims to provide evidence to health care providers regarding the significance of oral health while treating the patients for NCDs.Methods: The present cross sectional study was conducted to examine the oral health status of patients with NCD reporting to Dental OPD of Government Dental College and Hospital, Srinagar.  This hospital based study done through a convenience sampling technique, using a questionnaire and oral examination. A self-administered questionnaire was written in English language and was also translated in local language, first part of questionnaire was used to collect the demographic details, second part was designed regarding the medication history, oral habits such as smoking and consumption of betel nuts, medical history and earlier visit to dentist, cleaning of teeth, significance of dental health and its effect on general health and the third part of questionnaire was completely based on dental examination. The data was entered manually on Microsoft excel and then analyzed on statistical package SPSS version 20. Associations between different variables were assessed through application of χ2. The Data was analyzed using SPSS Statistics 20.0.Results: The present study was established with a sample of 300 participants. Male to female ratio was 2:3. Mean age of the participants was 46.6 years. It was observed that out of the total patients who visited the dentist, 42% (n=126) suffered from some chronic disease. 61% (n=183) were oblivious of the importance of dental health. When inquired if oral health affects general health 58.6% (n= 176) acknowledged its importance. 59 participants who lost more than three teeth who had chronic disease, 58.6% (n=176) respondents presented with bleeding gums, 66.3% (n=199) with food deposition, 52% (n=158) had halitosis, 26% (n= 78) had oral ulceration, 22.3% (n=67).Conclusions: It was concluded from this study that majority of participants with chronic diseases had poor oral health which requires immediate attention from the medical practitioners as well as dentists should counsel patients for maintenance and promotion of oral health.

scholarly journals Internet Devices and Desires: A Review of Randomized Controlled Trials of Interactive, Internet-mediated, In-home, Chronic Disease Monitoring Programs

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Anne-Marie Nicol ◽  
Corlann Gee Bush ◽  
Ellen Balka
Keyword(s):  
Chronic Disease ◽  
Randomized Controlled Trials ◽  
Chronic Diseases ◽  
Home Monitoring ◽  
Cost Savings ◽  
Monitoring Systems ◽  
Controlled Trials ◽  
Care Providers ◽  
Randomized Controlled ◽  
Disease States

Abstract:Background and Objectives: The advent of the Internet has made in-home monitoring a possibility for patients suffering from chronic disease, although few studies have examined this phenomena across different disease states. The goal of this review is to identify and evaluate studies where randomized control trials were used to evaluate Internet-mediated home monitoring systems designed to manage and support patients with chronic diseases.Methods and Results: We reviewed 454 abstracts of articles describing computerbased health interventions and read forty-three articles in depth. Seventeen articles met inclusion criteria and were selected for this review. Only completed randomized, controlled trials that reported physiological health outcomes of the intervention were included. Other results reviewed included the populations studied, the short and long term effectiveness of the interventions, costs and technology-related issues and health care provider communication. Internet-mediated home monitoring interventions appear to have some benefit for specific chronic diseases in specific circumstances. Few studies documented cost savings; none of those that did used consistent measures. Studies seldom addressed the challenges of introducing sophisticated interactive-monitoring systems into patients’ homes, the reasons for attrition from trials, or the effects of the intervention on the work of care providers or interprofessional practices.Conclusions: The interventions reviewed showed potential to enhance chronic disease management in some cases. However, the short duration of the studies made it difficult to generalize the results to wider home care settings or predict the effectiveness of such systems over the long and complicated courses of chronic diseases. Thus, despite hopes for significant cost and labour savings, Internet-mediated systems for monitoring chronic diseases in patients’ homes will likely complement rather than replace usual care.

Sign in / Sign up

Export Citation Format

Share Document