scholarly journals Pleiotropic genetic influence on birth weight and childhood obesity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Suvo Chatterjee ◽  
Marion Ouidir ◽  
Fasil Tekola-Ayele
Keyword(s):  
Birth Weight ◽  
Childhood Obesity ◽  
Molecular Mechanisms ◽  
Genetic Correlations ◽  
Public Health Problem ◽  
Genetic Influence ◽  
Global Public Health ◽  
Functional Annotations ◽  
Global Public Health Problem ◽  
Shared Genetic

AbstractChildhood obesity is a global public health problem. Understanding the molecular mechanisms that underlie early origins of childhood obesity can facilitate interventions. Consistent phenotypic and genetic correlations have been found between childhood obesity traits and birth weight (a proxy for in-utero growth), suggesting shared genetic influences (pleiotropy). We aimed to (1) investigate whether there is significant shared genetic influence between birth weight and childhood obesity traits, and (2) to identify genetic loci with shared effects. Using a statistical approach that integrates summary statistics and functional annotations for paired traits, we found strong evidence of pleiotropy (P < 3.53 × 10–127) and enrichment of functional annotations (P < 1.62 × 10–39) between birth weight and childhood body mass index (BMI)/obesity. The pleiotropic loci were enriched for regulatory features in skeletal muscle, adipose and brain tissues and in cell lines derived from blood lymphocytes. At 5% false discovery rate, 6 loci were associated with birth weight and childhood BMI and 13 loci were associated with birth weight and childhood obesity. Out of these 19 loci, one locus (EBF1) was novel to childhood obesity and one locus (LMBR1L) was novel to both birth weight and childhood BMI/obesity. These findings give evidence of substantial shared genetic effects in the regulation of both fetal growth and childhood obesity.

4H-1,3-Benzothiazin-4-one a Promising Class Against MDR/XDR-TB

2019 ◽  
Vol 19 (8) ◽  
pp. 567-578 ◽  
Author(s):  
Marcus Vinicius Nora de Souza ◽  
Thais Cristina Mendonça Nogueira
Keyword(s):  
Treatment Time ◽  
Public Health Problem ◽  
New Drugs ◽  
Global Public Health ◽  
Synthesis Mechanism ◽  
Highly Active ◽  
Latent Disease ◽  
Resistant Strains ◽  
Chemical Class ◽  
Global Public Health Problem

Nowadays, tuberculosis (TB) is an important global public health problem, being responsible for millions of TB-related deaths worldwide. Due to the increased number of cases and resistance of Mycobacterium tuberculosis to all drugs used for the treatment of this disease, we desperately need new drugs and strategies that could reduce treatment time with fewer side effects, reduced cost and highly active drugs against resistant strains and latent disease. Considering that, 4H-1,3-benzothiazin-4-one is a promising class of antimycobacterial agents in special against TB-resistant strains being the aim of this review the discussion of different aspects of this chemical class such as synthesis, mechanism of action, medicinal chemistry and combination with other drugs.

A REVIEW ON GLOBAL TRENDS IN HEART FAILURE AND EVOLUTION OF ANGIOTENSIN–NEPRILYSIN INHIBITOR

2020 ◽  
pp. 32-37
Author(s):  
VEERENDRA UPPARA ◽  
SAISEKHAR KODIVANDLA ◽  
ASHIK ALI SHAIK
Keyword(s):  
Heart Failure ◽  
Public Health Problem ◽  
Global Public Health ◽  
Middle Income ◽  
Global Trends ◽  
Middle Income Countries ◽  
Health Loss ◽  
Neprilysin Inhibitor ◽  
Health Related ◽  
Global Public Health Problem

Heart failure (HF) is a major global public health problem irrespective of its causes. It generates an enormous clinical, societal, and economic, health loss burden with an increase in its prevalence reaching an epidemic proportion. The morbidity and mortality associated with heart failure are increasing the health-related burdens worldwide, especially in low- and middle-income countries. This review highlights the trends in HF burden, the clinical spectrum of HF, and the importance of neurohormonal pathways and the evolution of angiotensin receptor neprilysin inhibition in HF with updated clinical practice guidelines.

scholarly journals Medication Error in Anaesthesia – A Review

2016 ◽  
Vol 27 (1) ◽  
pp. 31-35
Author(s):  
Montosh Kumar Mondal ◽  
Beauty Rani Roy ◽  
Shibani Banik ◽  
Debabrata Banik
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Medication Error ◽  
Medication Errors ◽  
Health Problem ◽  
Preventive Measures ◽  
Medical Profession ◽  
Public Health Problem ◽  
Global Public Health ◽  
Global Public Health Problem

Medication error is a major cause of morbidity and mortality in medical profession . There is an increasing recognition that medication errors are causing a substantial global public health problem, as many result in harm to patients and increased costs to health providers.Anaesthesia is now safe and routine, yet anaesthetists are not immune from making medication errors and the consequences of their mistakes may be more serious than those of doctors in other specialties. Steps are being taken to determine the extent of the problem of medication error in anaesthesia. In this review, incidence, types, risk factors and preventive measures of the medication errors are discussed in detail.Journal of Bangladesh Society of Anaesthesiologists 2014; 27(1): 31-35

scholarly journals Término del embarazo de las adolescentes atendidas en el Hospital Verdi Cevallos Balda

2019 ◽  
Vol 3 (3) ◽  
pp. 12
Author(s):  
Betzabhé Pico Franco ◽  
Olga Pamela Cadena Orellana ◽  
Víctor Miguel Castro Bravo ◽  
Nicole Elizabeth Puga Miranda ◽  
Gustavo Iván Zambrano Intriago ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Teenage Pregnancy ◽  
Public Health Problem ◽  
Global Public Health ◽  
Cephalopelvic Disproportion ◽  
Postterm Pregnancy ◽  
Palabras Clave ◽  
First Time ◽  
The City ◽  
Global Public Health Problem

  El embarazo en adolescentes es un problema de salud pública mundial que altera la salud física, emocional, la condición educativa y económica de los futuros padres; asimismo, frecuentemente se afecta también al producto de la gestación. La investigación fue de tipo retrospectiva, correlacional y cuantitativa. La muestra fue 461 embarazadas adolescentes atendidas en el Hospital “Verdi Cevallos Balda” de la ciudad de Portoviejo durante el 2016. Los resultados de este estudio mostraron que la mayor tasa de embarazo en adolescentes se produjo en primigestas (88,72 %) de 18 años. La desproporción céfalo-pélvica fue el factor materno-fetal que ocupó el primer lugar como causa de cesárea, seguida de factores fetales como distocia de presentación y ruptura prematura de membranas.   Palabras clave: Parto espontáneo, cesárea, pretérmino, postérmino, embarazo.   Abstract Teenage pregnancy is a global public health problem that alters the physical, emotional, educational and economic condition of future parents; likewise, the gestation product is frequently affected. The research was retrospective, correlational and quantitative. The sample was 461 adolescent pregnant women treated at the Hospital "Verdi Cevallos Balda" of the city of Portoviejo during 2016. The results of this study showed that the highest rate of adolescent pregnancy occurred in first-time pregnant women (88.72 %) of 18 years. Cephalopelvic disproportion was the maternal-fetal factor that ranked first as a cause of caesarean section, followed by fetal factors such as presenting dystocia and premature rupture of membranes.   Keywords: Spontaneous delivery, cesarean section, preterm, postterm, pregnancy.

scholarly journals Vitamin D and COVID-19 infection; recent findings

2021 ◽  
Vol 7 (1) ◽  
pp. e19-e19
Author(s):  
Alireza Pouramini ◽  
Fatemeh Kafi ◽  
Shakiba Hassanzadeh
Keyword(s):  
Public Health ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Chronic Conditions ◽  
Public Health Problem ◽  
Global Public Health ◽  
Exact Role ◽  
Risk Of Death ◽  
Global Public Health Problem

COVID-19 infection increases the risk of death in patients with chronic conditions such as diabetes or obesity. The exact role of vitamin D in COVID-19 infection is unknown and controversial. Furthermore, the exact prevalence of vitamin D deficiency is still unknown but it affects individuals worldwide regardless of ethnicity and age. Herein, we give an overview of vitamin D deficiency as a global public health problem, the role of vitamin D in COVID-19 infection, and the proper approach to treating vitamin D deficiency.

scholarly journals COVID-19, neurovascular thrombotic problem and short summary on blood coagulation disorder: a brief review

2022 ◽  
Vol 58 (1) ◽  
Author(s):  
Rujittika Mungmunpuntipantip ◽  
Viroj Wiwanitkit
Keyword(s):  
Blood Coagulation ◽  
Public Health Problem ◽  
Coagulation Disorder ◽  
Global Public Health ◽  
Respiratory Viral Infection ◽  
Short Summary ◽  
Neurological Problem ◽  
Blood Coagulation Disorder ◽  
Neurological System ◽  
Global Public Health Problem

AbstractCOVID-19 is the present global public health problem. This respiratory viral infection can manifest atypical presentation including neurological presentations. An important neurological problem in COVID-19 is neurovascular thrombosis. The basic pathogenesis of thrombosis in neurological system is explainable by the basic principle of thrombohemostasis. A hypercoagulability is a possible problem seen in some COVID-19 cases. In this brief review, the authors summarize venous and arterial thrombosis of neurovascular system as a complication of COVID-19. The updated pathophysiology of COVID-associated blood coagulation disorder is discussed. In addition, consideration regarding new COVID-19 vaccine related thrombotic adverse event is also raised.

scholarly journals A CRITICAL REVIEW ARTICLE ON PANDU W.S.R. ANAEMIA

2021 ◽  
Vol 9 (9) ◽  
pp. 2144-2150
Author(s):  
Shivam Kumar Nigam ◽  
Rita Singh ◽  
Sanjay Srivastava
Keyword(s):  
Medical Science ◽  
Clinical Signs ◽  
Public Health Problem ◽  
Signs And Symptoms ◽  
Modern Medicine ◽  
Review Article ◽  
Global Public Health ◽  
The World ◽  
Clinical Signs And Symptoms ◽  
Global Public Health Problem

Pandu Roga is one of the diseases mentioned in Ayurveda characterized by the changes in the skin colour to white (Shweta), yellowish (Peeta), greenish (Harita) etc. which is one of the “Varnopalakshita Roga" i.e., a disease characterized by the change in the colour. The clinical condition of Pandu in Ayurveda can be co-related with Anaemia described in Modern Medical Science, due to the resemblance in the clinical signs and symptoms. In Modern Medicine, Pandu is a pale appearance which may be due to the decreased blood supply to the skin or de- creased visibility of oxyhemoglobin. Anaemia is a major global public health problem and the most prevalent nu- tritional deficiency disorder in the world. This article presents the Ayurvedic concept of Pandu Roga (Anaemia). Keywords: Pandu, Vyadhi, Srotas, Anaemia, Pallor,

scholarly journals The relationship between low birth weight and exposure to inhalable particulate matter

2013 ◽  
Vol 29 (6) ◽  
pp. 1101-1108 ◽  
Author(s):  
Rodrigo Romão ◽  
Luiz Alberto Amador Pereira ◽  
Paulo Hilário Nascimento Saldiva ◽  
Patricia Matias Pinheiro ◽  
Alfésio Luiz Ferreira Braga ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Public Health Problem ◽  
Sao Paulo ◽  
São Paulo ◽  
Global Public Health ◽  
Paulo State ◽  
São Paulo State ◽  
Adverse Pregnancy ◽  
The Relationship

Atmospheric pollution is a global public health problem. The adverse effects of air pollution are strongly associated with respiratory and cardiovascular diseases and, to a lesser extent, with adverse pregnancy outcomes. This study analyzes the relationship between exposure to PM10 and low birth weight in the city of Santo André, São Paulo State, Brazil. We included babies born to mothers resident in Santo André between 2000 and 2006. Data on daily PM10 levels was obtained from the São Paulo State Environmental Agency. We performed descriptive analysis and logistic regressions. The prevalence rate of low birth weight was 5.9%. There was a dose-response relationship between PM10 concentrations and low birth weight. Exposure to the highest quartile of PM10 (37,50µg/m³) in the third trimester of pregnancy increased the risk of low birth weight by 26% (OR: 1.26; 95%CI: 1.14-1.40) when compared to the first quartile. The same effect was observed in the remaining trimesters. This effect was observed for ambient particle concentrations that met the current air quality standards.

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