Marine polysaccharides: green and recyclable resources as wound dressings

2021 ◽  
Author(s):  
Xiaodong Jing ◽  
Yanzhen Sun ◽  
Xiaoli Ma ◽  
Hao Hu
Keyword(s):  
Renewable Resource ◽  
Wound Dressings ◽  
Environmental Friendliness ◽  
Good Biocompatibility ◽  
Recyclable Resources ◽  
Absolute Advantage

As a green and renewable resource, marine polysaccharides have inherent nontoxicity, good biocompatibility, biodegradability, and environmental friendliness. Compared to land-based polysaccharides, marine polysaccharides occupy an absolute advantage in the process...

scholarly journals Studies of the Sulfonated Hydrogenated Styrene–Isoprene–Styrene Block Copolymer and Its Surface Properties, Cytotoxicity, and Platelet-Contacting Characteristics

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 235
Author(s):  
Bin-Hong Tsai ◽  
Tse-An Lin ◽  
Chi-Hui Cheng ◽  
Jui-Che Lin
Keyword(s):  
Block Copolymer ◽  
Biomedical Applications ◽  
Human Life ◽  
Thermoplastic Elastomers ◽  
Wound Dressings ◽  
Tert Butyl ◽  
Soft Segments ◽  
Good Biocompatibility ◽  
Uv Ozone ◽  
Ozone Resistance

Styrenic thermoplastic elastomers (TPEs) consist of styrenic blocks. They are connected with other soft segments by a covalent linkage and are widely used in human life. However, in biomedical applications, TPEs need to be chemically hydrogenated in advance to enhance their properties such as strong UV/ozone resistance and thermal-oxidative stability. In this study, films composed of sulfonated hydrogenated TPEs were evaluated. Hydrogenated tert-butyl styrene–styrene–isoprene block copolymers were synthesized and selectively sulfonated to different degrees by reaction with acetyl sulfate. By controlling the ratio of the hydrogenated tert-butyl styrene–styrene–isoprene block copolymer and acetyl sulfate, sulfonated films were optimized to demonstrate sufficient mechanical integrity in water as well as good biocompatibility. The thermal plastic sulfonated films were found to be free of cytotoxicity and platelet-compatible and could be potential candidates in biomedical film applications such as wound dressings.

A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application

2021 ◽  
Vol 28 ◽  
Author(s):  
Bei He ◽  
Xinxin Liu ◽  
Shi Qi ◽  
Run Zheng ◽  
Minmin Chang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Application ◽  
Drug Loading ◽  
Cellulose Fibers ◽  
Dip Coating ◽  
Wound Dressings ◽  
Attractive Alternative ◽  
Natural Polymers ◽  
Insoluble Drugs ◽  
Good Biocompatibility

Background: Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years. Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized. Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment. Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.

scholarly journals Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2286 ◽  
Author(s):  
Sibusiso Alven ◽  
Xhamla Nqoro ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Wound Healing ◽  
Transmission Rate ◽  
Biological Activities ◽  
Drug Loading ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Microbial Invasion ◽  
Good Biocompatibility

Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

scholarly journals Research Progress on Chemical Modification and Application of Cellulose: A Review

2021 ◽  
pp. X
Author(s):  
Jinjie ZHANG ◽  
Yingping QI ◽  
Yongfeng SHEN ◽  
Hua LI
Keyword(s):  
Wastewater Treatment ◽  
Chemical Modification ◽  
Functional Groups ◽  
Polymer Material ◽  
Research Progress ◽  
Cellulose Derivatives ◽  
Natural Polymer ◽  
Environmental Friendliness ◽  
Grafting Modification ◽  
Good Biocompatibility

Cellulose is a rich natural polymer material, which has the characteristics of biodegradability, environmental friendliness and good biocompatibility. However, compared with conventional materials, there are some shortcomings in performance, such as intolerance corrosion, limited strength and so on. The chemical modification of cellulose not only retains its own excellent characteristics, but also introduces functional groups to endow it with specific properties. The chemical modification and utilization of cellulose has been the focus of research. In this paper, the latest advances in chemical modification of cellulose, such as esterification, etherification and grafting modification, are introduced. The research and application results of cellulose derivatives in food, wastewater treatment, medicine and papermaking in recent years are reviewed.

Current Applications of Biopolymer-based Scaffolds and Nanofibers as Drug Delivery Systems

2019 ◽  
Vol 25 (37) ◽  
pp. 3997-4012
Author(s):  
Tatiana Rita de Lima Nascimento ◽  
Marilia Mattar de Amoêdo Campos Velo ◽  
Camila Félix Silva ◽  
Sara Brito Silva Costa Cruz ◽  
Brenna Louise Cavalcanti Gondim ◽  
...  
Keyword(s):  
High Surface ◽  
Volume Ratio ◽  
Polymeric Materials ◽  
Renewable Resource ◽  
Bioactive Molecules ◽  
Wound Dressings ◽  
Natural Polymers ◽  
Implantable Medical Devices ◽  
Polymeric Nanofibers ◽  
Health Application

Background: The high surface-to-volume ratio of polymeric nanofibers makes them an effective vehicle for the release of bioactive molecules and compounds such as growth factors, drugs, herbal extracts and gene sequences. Synthetic polymers are commonly used as sensors, reinforcements and energy storage, whereas natural polymers are more prone to mimicking an extracellular matrix. Natural polymers are a renewable resource and classified as an environmentally friendly material, which might be used in different techniques to produce nanofibers for biomedical applications such as tissue engineering, implantable medical devices, antimicrobial barriers and wound dressings, among others. This review sheds some light on the advantages of natural over synthetic polymeric materials for nanofiber production. Also, the most important techniques employed to produce natural nanofibers are presented. Moreover, some pieces of evidence regarding toxicology and cell-interactions using natural nanofibers are discussed. Clearly, the potential extrapolation of such laboratory results into human health application should be addressed cautiously.

scholarly journals Graphene oxide-modified electrospun polyvinyl alcohol nanofibrous scaffolds with potential as skin wound dressings

RSC Advances ◽  
2017 ◽  
Vol 7 (46) ◽  
pp. 28826-28836 ◽  
Author(s):  
Qiang Zhang ◽  
Qiaoyue Du ◽  
Yanan Zhao ◽  
Feixiang Chen ◽  
Zijian Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Potential Application ◽  
Skin Wound ◽  
Wound Dressings ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Nanofibrous Scaffolds ◽  
Good Biocompatibility

Graphene oxide-modified electrospun polyvinyl alcohol nanofibrous scaffolds exhibit good biocompatibility and have potential application in skin tissue engineering.

scholarly journals Design of Chitosan Sterilization Agents by a Structure Combination Strategy and Their Potential Application in Crop Protection

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3250
Author(s):  
Weixiang Liu ◽  
Yukun Qin ◽  
Pengcheng Li
Keyword(s):  
Biological Activity ◽  
Potential Application ◽  
Crop Protection ◽  
Renewable Resource ◽  
Hydroxyl Groups ◽  
Combination Strategy ◽  
Chitosan Derivatives ◽  
Novel Structure ◽  
Activity Structure ◽  
Good Biocompatibility

Chitosan is the only cationic polysaccharide in nature. It is a type of renewable resource and is abundant. It has good biocompatibility, biodegradability and biological activity. The amino and hydroxyl groups in its molecules can be modified, which enables chitosan to contain a variety of functional groups, giving it a variety of properties. In recent years, researchers have used different strategies to synthesize a variety of chitosan derivatives with novel structure and unique activity. Structure combination is one of the main strategies. Therefore, we will evaluate the synthesis and agricultural antimicrobial applications of the active chitosan derivatives structure combinations, which have not been well-summarized. In addition, the advantages, challenges and developmental prospects of agricultural antimicrobial chitosan derivatives will be discussed.

Recent Insights on Biomedical Applications of Bacterial Cellulose based Composite Hydrogels

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei Liu ◽  
Haishun Du ◽  
Ting Zheng ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bacterial Cellulose ◽  
High Purity ◽  
Biomedical Applications ◽  
3D Structure ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Composite Hydrogels ◽  
Good Biocompatibility

Background: Bacterial cellulose (BC) and its derivatives are a rich source of renewable natural ingredients, which are of great significance for biomedical and medical applications but have not yet been fully exploited. BC is a high-purity, biocompatible, and versatile biomaterial that can be used alone or in combination with other ingredients such as polymers and nanoparticles to provide different structural organization and function. This review briefly introduces the research status of BC hydrogels, focusing on the preparation of BC based composite hydrogels and their applications in the field of biomedicine, particularly the wound dressings, tissue engineering scaffolds, and drug delivery. Methods: By reviewing the most recent literature on this subject, we summarized recent advances in the preparation of BC based composite hydrogels and their advances in biomedical applications, including wound dressings, tissue engineering, and drug delivery. Results: BC composite hydrogels have broadened the field of application of BC and developed a variety of BC-based biomaterials with excellent properties. BC-based hydrogels have good biocompatibility and broad application prospects in the biomedical field. Conclusion: BC based composite hydrogels with the advantages of 3D structure, non-toxicity, high purity, and good biocompatibility, have great prospects in the development of sustainable and multifunctional biomaterials for biomedical applications.

Evaluation the Manufacturing Process of Silk/Gelatin Electrospun Membrane

2008 ◽  
Vol 55-57 ◽  
pp. 321-324 ◽  
Author(s):  
Chieh Yu Chao ◽  
Ching Wen Lou ◽  
Chao Tsang Lu ◽  
Chao Chiung Huang ◽  
Jia Horng Lin
Keyword(s):  
Formic Acid ◽  
Volume Ratio ◽  
Average Diameter ◽  
High Specific Surface Area ◽  
Wound Dressings ◽  
High Porosity ◽  
Electrospun Membrane ◽  
Ultrafine Fibers ◽  
Silk Fibroins ◽  
Good Biocompatibility

Electrospinning is common used in manufacturing ultrafine fibers from a polymer solution. With a high specific surface area, high porosity and good biocompatibility, the elecrospun membranes have extensive applications as biomaterials such as tissue scaffolds and for drug delivery. Silk fibroins (SF), gelatin (G) both have good biocompatibility and are non-toxic. And in previous literature, gelatin nanofiber can be successfully prepared by electrospinning, which was dissolved in formic acid. Tencel, which is extracted from wood pulp, is biodegradable, has a smooth fiber structure, can protect wounds and is irritation-free. Consequently, SF, G and Tencel are widely used in biomedical applications, such as for wound dressings and scaffolds for tissue engineering and so on. In this study, we discussed the applications of different shapes of electrospun membrane such as film, web. After that, the electrospun membrane was combined with Tencel nonwoven to fabricate composite nonwoven. Electrospinning of SF/ G was performed using formic acid as the spinning solvent. Parameters, such as electrical field (15~11 kV), spinning distance (15~7 cm), and volume ratio of SF and G, were analyzed to investigate their effects on electrospinnability and morphology of nanofiber membranes. The morphology of electrospun SF/ G nanofibers was investigated by scanning electron microscopy (SEM). Analytical demonstrate that the optimal electrospinning condition was fibers with an average diameter of 200–300 nm.

French Panel Outlines Utility of Wound Dressings

2007 ◽  
Vol 38 (12) ◽  
pp. 6
Author(s):  
LEANNE SULLIVAN
Keyword(s):  
Wound Dressings
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