Child’s Autism Risk Accelerates With Mother’s Age

ASHA Leader ◽  
2014 ◽  
Vol 19 (8) ◽  
pp. 18-18
Keyword(s):  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Saara Marttila ◽  
Leena E. Viiri ◽  
Pashupati P. Mishra ◽  
Brigitte Kühnel ◽  
Pamela R. Matias-Garcia ◽  
...  

Abstract Background Non-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the methylation pattern at the nc886 epiallele and how this methylation status associates with nc886 RNA expression. Furthermore, we investigated the associations between the nc886 methylation status or the levels of nc886 RNAs and metabolic traits in the YFS and KORA cohorts. The association between nc886 epiallele methylation and RNA expression was also validated in induced pluripotent stem cell (iPSC) lines. Results We confirm that the methylation status of the nc886 epiallele is mostly binomial, with individuals displaying either a non- or hemi-methylated status, but we also describe intermediately and close to fully methylated individuals. We show that an individual’s methylation status is associated with the mother’s age and socioeconomic status, but not with the individual’s own genetics. Once established, the methylation status of the nc886 epiallele remains stable for at least 25 years. This methylation status is strongly associated with the levels of nc886 non-coding RNAs in serum, blood, and iPSC lines. In addition, nc886 methylation status associates with glucose and insulin levels during adolescence but not with the indicators of glucose metabolism or the incidence of type 2 diabetes in adulthood. However, the nc886-3p RNA levels also associate with glucose metabolism in adulthood. Conclusions These results indicate that nc886 metastable epiallele methylation is tuned by the periconceptional conditions and it associates with glucose metabolism through the expression of the ncRNAs coded in the epiallele region.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Agung Dwi Laksono ◽  
Ratna Dwi Wulandari ◽  
Mursyidul Ibad ◽  
Ina Kusrini

Abstract Background Even though the Indonesian government have set regulations for maintaining exclusive breastfeeding practices, the coverage remains low. The study aims to analyze the effects of mother’s education level on the coverage of exclusive breastfeeding in Indonesia. Methods This study used data from the 2017 Nutrition Status Monitoring Survey. It covered data of 53,528 children under 5 years old (7–59 months) as the samples. Variables included exclusive breastfeeding status, mother’s education level, mother’s age, marital status, employment status, gender, residence, under five’s age and gender. A binary logistics regression was performed in the final test. Results Mothers who graduated from elementary school were 1.167 times more likely to perform exclusive breastfeeding compared to mothers who never attended schools. Additionally, those who graduated from junior high school had 1.203 times possibilities to give exclusive breastfeeding compared to mothers without educational records. While, mothers who graduated from high school were 1.177 times more likely to perform exclusive breastfeeding compared to those without educational records. Mothers who graduated from tertiary education had 1.203 times more possibilities to perform exclusive breastfeeding compared to mothers who were never enrolled to schools. Other variables also became affecting predictors on exclusive breastfeeding, such as mother’s age, mother’s employment status, child’s age, and residence. Conclusions The mother’s education level positively affects exclusive breastfeeding practice in Indonesia.


2021 ◽  
Vol 17 ◽  
Author(s):  
Mansoureh Refaei ◽  
Soodabeh Aghababaei ◽  
Mansoureh Yazdkhasti ◽  
Farideh Kazemi ◽  
Fatemeh Farahmandpour

Background: Several risk factors have been identified for postpartum hemorrhage, one of which being the duration of the third stage of labour. This stage refers to the interval between the expulsion of the fetus to the expulsion of the placenta. Some bleeding occurs in this stage due to the separation of the placenta Objective: This study aimed to identify the factors associated with the length of the third stage of labour. Methods: In this cross-sectional study, 300 women hospitalized for vaginal birth were selected via convenience sampling. The study data were collected using a researcher-made questionnaire. Then, the data were analyzed using univariate and multivariate linear regression analyses. Results: The mean (SD) age of the participants was 26.41 (6.26) years. Investigation of the relationship between the study variables and the time of placental separation indicated that a minute increase in the length of membranes rupture caused a 0.003minute decrease in the time of placental separation. However, this time increased by 2.75, 6.68, and 2.86 minutes in the individuals without the history of abortion, those with the history of stillbirth, and those who had not received hyoscine, respectively. The results of multivariate analysis indicated that suffering from preeclampsia or hypertension, history of stillbirth, not receiving hyoscine, and not receiving misoprostol increased the length of the third stage by 4.40, 8.55, 2.38, and 6.04 minutes, respectively. Conclusion: Suffering from preeclampsia and having the history of stillbirth increased and using hyoscine and misoprostol decreased the length of the third stage of labour. However, no significant relationship was found between the length of the third stage of labour and mother’s age, gestational age, parity, mother’s body mass index, mother’s chronic disorders, history of manual placenta removal, length of the first and second stages, membranes rupture, induction, amount of oxytocin after delivery, and infant’s weight and gender.


Author(s):  
Ravi Pachori ◽  
Jiratithigan Sillapasuwan

Background: Malnutrition in children occurs as a complex interplay among various factors like maternal health, dietary practices, hand washing and other hygiene practices, low birth weight, episode of diarrhoea and acute respiratory infection within the last 6 months are often associated with undernutrition in most developing nations including India. Objective of the study were to assess the determinants of maternal and child health, hygienic practice, health services for underweight and their association among apparently healthy children. Methods: The present study was hospital based descriptive cross-sectional study conducted from June 2019 to December 2019. The sample size calculated was 410, and accounting for 10% nonresponsive, the sample size calculated was 451. The data obtained were compiled and entered in MS-excel 2010 and analysed by using institutional SPSS (22.0). Results: Mother’s age at marriage <18 years belong to 68 (15.1%) children significantly low proportion as compared to marriage >18 years 383 (84.9%) including underweight 41 (22.5%) and mother’s age at child birth <18 years belong to 46 (10.2%) children significantly very low proportion in comparison to child birth >18 years including underweight 30 (16.6%). Birth weight <2.5 kg belongs to significantly 136 (30.1%) children including underweight 72 (39.8%) and significantly birth order >2 belong to 135 (29.9%) children including underweight 39 (21.6%). Exclusive breast feeding belongs to 149 (33.0%) children including underweight 62 (34.2%)Conclusions: Health education and its reinforcement especially in the area of maternal & child health care services is required.


2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Sri Aminingsih ◽  
Lucia Desi Puti

Background Breastfeeding will ensure babies stay healthy and start life in the most healthy. Breastfeeding is actually not only allows the baby to grow up to be healthy physically, but also more intelligent, stable had a emotional, spiritual development, and positivesocial development. Riskesdas 2010 coverage of exclusive breastfeeding in Indonesia is still far from the world average and still very far from the target of Healthy Indonesia 2010. In rural districts Pucanganom Giriwoyo of the initial interview 3 of 5 mothers to breastfeed exclusively, while 2 others are not breastfed exclusively with reasons having to work, lack of time and because of no discharge of breast milk.The purpose to find out the factors that affect the mother in exclusive breast feeding in the village of Pucanganom sub-district of Giriwoyo Regency Wonogiri.Method of this research is descriptive research. While the plan is cross sectional used to find out the factors that affect the mother in exclusive breast feeding. Then there searchers took data from respondents regarding the factors that affect breast feeding.The Result Factors that affect the exclusive breast feeding is the age of the mother, the mother's education, number of children,  mother's work and family income. The most exclusive breast feeding on mother's  age 26-45 years (83,33%), maternal education high school-undergraduate (70%), given on the first and second child(73,34%), employment of the mother as a homemaker (73,34%), and family income 1-3 million (76.67%).Conclusion the mother who does not work it's possible giving exclusive breast milk due to the considerable amount of time which can be used by the mother to nurture her baby even 24 hours time the mother could be given to her baby, therefore breast feeding can be done during the first 6 months of the birth ofthe baby.Keywords: Exclusive breast feeding


2018 ◽  
pp. 67-86
Author(s):  
Luca Salvati ◽  
Ilaria Zambon

Being more sensitive to economic fluctuations, childbearing postponement increased during the second demographic transition and was accompanied by a moderate decline in the number of children per woman and the progressive rise of mother’s age at first birth. Under the hypothesis that recessions have a marked influence on population dynamics, the present study investigates spatial changes in mother’s age at birth in Greece with the aim to assess the differential impact of economic crisis along the urban-rural gradient. The percent composition of births by mother's age class – considered a gross indicator of fertility under a changing socioeconomic context – was studied at 4 spatial scales (the whole country, administrative regions, prefectures and metropolitan areas or specific economic districts) over an economic cycle from expansion to recession (1980–2016). While stimulating childbearing postponement observed since the early 1980s, empirical results of this study indicate that the 2007 recession was quite neutral on fertility trends in Greece, consolidating the traditional divide between urban and rural areas.


2020 ◽  
Author(s):  
Rodrigue NDA'CHI DEFFO ◽  
Benjamin FOMBA KAMGA

Abstract Background: Among the eight Millennium Development Goals (MDGs), three were devoted to health. Two amongst which MDG4 in relation to the reduction of infant mortality has not been achieved in Least Developed Countries (LDC). In Africa, a significant part of infant mortality is due to vaccine-preventable diseases administered free of charge by the Extended Program on Immunization (EPI). As such, in the "social equity" pillar of Sustainable Development Goals (SDG), the MDGs related to health have yet been taken into account. The achievement of these objectives requires an understanding of the immunization behavior of children under five years of age through an analysis of immunization dynamics between 1991 and 2011.Methods: We use data from Demographic and Health Surveys (DHS) of 1991, 1998, 2004 and 2011 carried out by the National Institute of Statistics (NIS). The module concerning EPI vaccines was administered to 3350, 2317, 8125 and 25524 under 5 in 1991, 1998, 2004 and 2011 respectively. The Immunization analysis was made from the logistic model for complete immunization and the Oaxaca's decomposition to assess the contribution of the unexplained part, which is that of the strategies/programs implemented between 1991 and 2011 by the EPI to improve immunization.Results: In general, children with vaccination card are more than 7 times likely to be fully immunized than their counterparts who do not have any. This result was higher in 1991 (approximately 57) and lowest in 2011 (5). In addition, the child's birth order reduces his/her probability of being fully immunized and the impact increases with the latter's birth order. On the other hand, the mother's age as well as her level of education increase the child's likelihood of receiving all basic vaccines. Moreover, the contributions of EPI partners in terms of immunization support as well as strategies to promote immunization through communication for development are of a particular importance in increasing immunization coverage. They significantly explain 67.62% of the 0.105 gain recorded within the 2011-2004 period and 72.46% of the 0.069 gain recorded within the 2004-1998 period.Conclusion: The contribution of EPI partner organizations is fundamental for the achievement of EPI objectives. Since they contribute to increase the likelihood of fully immunized children. The link with child immunization is done through the specific characteristics to the mother.


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