scholarly journals Magnetic Resonance Morphometry of Normal Cerebral Aqueduct in South Indian Population

2021 ◽  
Author(s):  
Veeramani Raveendranath ◽  
Prafulla Kumar Dash ◽  
Thangaraj Kavitha ◽  
Krishnan Nagarajan
Keyword(s):  
Adult Population ◽  
Age Groups ◽  
Mean Value ◽  
Cerebral Aqueduct ◽  
Normal Brain ◽  
South Indian Population ◽  
Endoscopic Neurosurgery ◽  
South Indian ◽  
Precise Knowledge ◽  
Significant Difference

Abstract Introduction Cerebral aqueduct (of Sylvius) connects the third and fourth ventricles of the brain, and the shape of the aqueduct varies. The aim of the study is to assess the morphometry of the cerebral aqueduct in normal south Indian adult population and to look for pattern by shape, if any. Materials and Methods One hundred and fifty normal brain MR images (75 males and 75 females) using 3D heavily T2-weighted sequence were analyzed for various normal parameters of cerebral aqueduct. Mean and standard deviation were calculated. Based on the shape of the aqueduct, an attempt was made to classify them. Unpaired t-test was used to assess any significant difference between age groups and gender. The intraclass coefficient correlation was used to analyze the interobserver variability. Results The mean value of the length of the cranial and caudal part of aqueduct in males were 0.69 cm and 0.86 cm and in females 0.65 cm and 0.80 cm, respectively. The length was more in males, and it was statistically significant (p = 0.006 and 0.02). There are four types of cerebral aqueduct based on shape. Conclusion MRI is considered as the investigation of choice for preoperative planning of brain operative procedures. The MR morphometric evaluation of cerebral aqueduct provides precise knowledge about the anatomy and may be of help in the diagnosis and treatment by endoscopic neurosurgery.

scholarly journals Skull Base Angle Morphometry in South Indian Population with Review on Terminology

2021 ◽  
Author(s):  
Veeramani Raveendranath ◽  
Prafulla Kumar Dash ◽  
Krishnan Nagarajan ◽  
Thangaraj Kavitha ◽  
Srinidhi Swathi
Keyword(s):  
Skull Base ◽  
Adult Population ◽  
Mean Value ◽  
South Indian Population ◽  
Basal Angle ◽  
South Indian ◽  
Significant Difference ◽  
Coefficient Corrélation ◽  
Males And Females ◽  
The Mean

Abstract Introduction Basal angle, Boogaard’s angle, and clival angle are frequently used in diagnosing the craniometric angle malformations either on radiography or now more on MRI. But anatomic and clinical studies have used varied terms for these parameters. We aimed to look for these parameters among a normal south Indian adult population to standardize the measurements and their terminology. Materials and Methods One hundred MRI images (50 males and 50 female) were studied retrospectively. MRI images that were reported as normal by neuroradiologist were taken up for the study. Mean and the standard deviation of males and females were calculated for basal angle, Boogaard’s angle, and clival angle, separately. Unpaired t-test was used to analyze the significant difference (p < 0.05) between the genders. The intraclass coefficient correlation was used to analyze the interobserver variability. Results The mean value of basal angle in males and females are 113°and 114°, respectively. The mean value of Boogaard’s angle in males and females are 120°and 121°, respectively. The mean value of clival angle in males and females are 157°and 155°, respectively. There was no statistically significant difference (p > 0.05) between males and females in all three angles. Conclusion Knowledge about the normal angles will be an important tool in understanding the normal and abnormal skull base. Since the type of skull varies in accordance with race, the normal craniometric angle also varies in accordance with race. The present study tried to standardize the parameters of normal skull base angles for appropriate correction of the anomalies and uniform usage of terminology.

Status of Vitamin B12 and Folate among the Urban Adult Population in South India

2015 ◽  
Vol 68 (2) ◽  
pp. 94-102 ◽  
Author(s):  
M. Sivaprasad ◽  
T. Shalini ◽  
N. Balakrishna ◽  
M. Sudarshan ◽  
P. Lopamudra ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin B12 ◽  
Wide Spectrum ◽  
Adult Population ◽  
Plasma Concentrations ◽  
Age Groups ◽  
Healthy Adults ◽  
Significant Difference ◽  
B12 Deficiency ◽  
Apparently Healthy

Background: Deficiency of vitamin B12 (B12) and folate (FA) leads to a wide spectrum of disorders that affect all age groups. However, reports on B12 and FA status in healthy adults in India are limited. Hence, we determined the plasma levels and dietary intake of B12 and FA in the adult population. Methods: We conducted a community-based cross-sectional study in an urban setup among 630 apparently healthy adults distributed into 3 age groups: 21-40, 41-60 and >60 years. Plasma concentrations of B12 and FA were analyzed by radio immunoassay and dietary intake by 24-hour recall method. Results: The overall prevalence of FA deficiency was 12%, but there was no significant difference in plasma FA concentrations among the groups. While the overall prevalence of B12 deficiency was 35%, it was significantly higher in the 21-40 (44%) and 41-60 age groups (40%) when compared with the >60 group (30%). B12 deficiency was higher in vegetarians (54%) compared to those consuming mixed diet (31%), and the reverse was the case with FA. However, the dietary intakes of FA and B12 were not significantly different among the groups. Conclusions: These results indicate a higher prevalence of B12 deficiency in apparently healthy adults in an urban setup.

scholarly journals ULTRASOUND;

2012 ◽  
Vol 19 (02) ◽  
pp. 187-192
Author(s):  
EJAZ HUSSAIN SIDDIQUI ◽  
SAAD SIDDIQUI ◽  
NOREEN SHAH
Keyword(s):  
Pediatric Population ◽  
Adult Population ◽  
Age Groups ◽  
X Rays ◽  
Geriatric Population ◽  
Cross Sectional ◽  
Study Results ◽  
Significant Difference ◽  
Ultrasound Findings ◽  
Hepatobiliary Diseases

Objectives: To assess common presenting features and the role of Ultrasound in evaluation of Hepatobiliary diseases in ourpopulation. Design: Cross sectional study. Setting: Khyber X rays, Khyber Medical Centre, Peshawar. Period: August 2010 to December2010. Material and Methods: Data from patients presenting for evaluation of Hepatobiliary diseases was analyzed for presenting complaintsand ultrasound findings according to objectives of the study. Results: In total 197 cases were included in the study. The age wise categorizationincluded pediatric population (6.1%) adult population (87.3%) and geriatric population (6.6%). Upper abdominal pain was the most commonpresenting feature in all age groups as well as in both genders. Cholelithiasis with or without cholecystitis was the most common ultrasoundfinding in all age groups. No statistically significant difference was found between presenting features or ultrasound findings in different agegroups as well as across gender. Conclusions: Hepatobiliary diseases are among major illnesses in our region. Ultrasound is a sensitive anduseful tool for screening and evaluation of Hepatobiliary disorders.

scholarly journals Ethnic differences in allele, genotype distributions and lung cancer risk of polymorphisms of gemcitabine metabolic pathway genes in south Indian population

2018 ◽  
Vol 7 (9) ◽  
pp. 1693
Author(s):  
Devika Tirumalasetty ◽  
Deepak Gopal Shewade ◽  
Biswajit Dubashi ◽  
Srinivasa Rao Katiboina
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Metabolic Pathway ◽  
Lung Cancer Risk ◽  
Allele Frequencies ◽  
Healthy Population ◽  
South Indian Population ◽  
Lung Cancer Patients ◽  
South Indian ◽  
Significant Difference

Background: Gemcitabine is a widely used cytotoxic drug in the treatment of a number of solid tumors, for instance, lung, pancreatic as well as breast cancer. As a consequence of the progressive genomic instability, the efficiency rates have eventually lowered. Genetic approach targeting one or several genes in drug targeting pathways facilitates substantially more valuable details in explaining the association between variants and also the efficacy of gemcitabine therapy. In addition, several researchers have reported ethnic discrepancies in clinical response to gemcitabine. Thus, the present study was aimed to establish the normative frequencies of genes associated with the metabolic pathway of Gemcitabine (RRM1 -37C>A (rs12806698), RRM1 -524T>C (rs11030918), CDA 79A>C (rs2072671) and CDA 435 C>T (rs1048977) in South Indian healthy population and compared with 1000 genome population. Additionally, the association of these SNPs with the risk of developing lung cancer was also evaluated.Methods: This study was carried out on 184 healthy subjects and 123 lung cancer patients of South Indian origin and genotyping was done using RT-PCR (Real Time Polymerase Chain Reaction). The frequencies of the above polymorphisms were in Hardy-Weinberg equilibrium (p >0 .05).Results: The minor allele frequencies of the SNPs RRM1 -37C>A (rs12806698), RRM1 -524T>C (rs11030918), CDA 79A>C (rs2072671) and CDA -435 C>T (rs1048977) were 31.3, 36.7, 24.5 and 22.0 respectively.Conclusions: There was a significant difference observed between the genotype and allele frequencies of south Indians with the 1000 genome populations. We also found that SNPs of RRM1 were significantly associated with lung cancer risk.

Prevalence of the optic disc anomalies in the adult South Indian population

2018 ◽  
Vol 103 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Shikha Talwar Bassi ◽  
Ronnie George ◽  
Swarnali Sen ◽  
Rashima Asokan ◽  
Vijaya Lingam
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Indian Population ◽  
Adult Population ◽  
Myelinated Nerve Fibre ◽  
South Indian Population ◽  
Optic Disc Pit ◽  
Myelinated Nerve ◽  
South Indian ◽  
Optic Disc Coloboma

PurposeTo determine the prevalence of congenitally abnormal disc (all anomalies) in an adult population in southern India.MethodsSubjects aged ≥40 years (n=6013) underwent a complete ophthalmic examination. Optic disc anomalies were diagnosed according to the definitions given in the article.ResultsOptic disc anomalies were found in 81 eyes of 66 (1.1%, 95% CIs 0.00834 to 0.01361) patients. The prevalence of each anomaly in the descending order was peripapillary myelinated nerve fibre (0.28%), epipapillary glial tissue on the optic disc (0.28%), peripapillary vascular loops (0.16%), tilted disc (0.09%), optic disc coloboma (0.08%), optic nerve hypoplasia (0.04%), optic disc pit (0.04%), optic disc pigmentation (0.03%), optic nerve head drusen (0.03%), Bergmeister’s papilla (0.03%), optic disc pit and coloboma (0.01%).ConclusionsThe prevalence of optic disc anomalies is 1.1% in the adult South Indian population.

scholarly journals Dietary profile of urban adult population in South India in the context of chronic disease epidemiology (CURES – 68)

2010 ◽  
Vol 14 (4) ◽  
pp. 591-598 ◽  
Author(s):  
Ganesan Radhika ◽  
Rangaswamy M Sathya ◽  
Anbazhagan Ganesan ◽  
Raghavan Saroja ◽  
Parthasarathy Vijayalakshmi ◽  
...  
Keyword(s):  
Dietary Intake ◽  
South India ◽  
Vegetable Consumption ◽  
Adult Population ◽  
Meat Products ◽  
Fats And Oils ◽  
Population Based ◽  
South Indian Population ◽  
Cross Sectional ◽  
South Indian

AbstractObjectiveFew dietary surveys have been done with reference to chronic diseases, such as diabetes, in India, which is considered to be the diabetes capital of the world. We report on the dietary intake of urban adults living in Chennai, South India.DesignA population-based cross-sectional study.SettingA representative population of urban Chennai in southern India.SubjectsThe study population comprised 2042 individuals aged ≥20 years selected from the Chennai Urban Rural Epidemiological Study (CURES). Dietary intake was measured using a validated and previously published interviewer-administered semi-quantitative meal-based FFQ.ResultsThe mean daily energy intake was 10 393 (sd 2347) kJ (male: 10953 (sd 2364) kJ v. female: 9832 (sd 233) kJ). Carbohydrates were the major source of energy (64 %), followed by fat (24 %) and protein (12 %). Refined cereals contributed to the bulk of the energy (45·8 %), followed by visible fats and oils (12·4 %) and pulses and legumes (7·8 %). However, energy supply from sugar and sweetened beverages was within the recommended levels. Intake of micronutrient-rich foods, such as fruit and vegetable consumption (265 g/d), and fish and seafoods (20 g/d), was far below the FAO/WHO recommendation. Dairy and meat products intake was within the national recommended intake.ConclusionsThe diet of this urban South Indian population consists mainly of refined cereals with low intake of fish, fruit and vegetables, and all of these could possibly contribute to the risk of non-communicable diseases such as diabetes in this population.

scholarly journals A Study on Oxidative stress and antioxidant status in Diabetic nephropathy

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 113-115
Author(s):  
Gurupavan kumar Ganta1 ◽  
Kedari G S R
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Glutathione Peroxidase ◽  
Glutathione Reductase ◽  
South Indian Population ◽  
Statistical Significant Difference ◽  
South Indian ◽  
Significant Difference ◽  
Anti Oxidant

Diabetes mellitus is the most common metabolic disorder in the world. The metabolic dysregulation of diabetes mellitus affects multiple organs like Kidneys, nerves, eyes and heart. Worldwide Among all diabetics, 20-40% of the people are suffering from Diabetic Nephropathy. Oxidative stress is increased by hyperglycemia in which Reactive Oxygen Species has been implicated in the pathology of these complications. The aim of our present study is one such attempt to find the role of oxidative stress by estimating the levels of oxidants and anti oxidant levels in diabetic nephropathy in ethnic south Indian population. 30 diagnosed cases of diabetic Nephropathy  were taken as cases and 30 age and sex matched Type 2 Diabetes mellitus patients were included as controls in the study. For oxidant levels Malondialdehyde (MDA) was estimated and for anti oxidant levels Super oxide Dismutase (SOD), Glutathione Peroxidase (GPx), Glutathione Reductase (GR) were measured. Statistically significant increase is observed in the levels of Malondialdehyde in cases when compared to controls. There is no statistical significant difference in the levels of Superoxide dismutase and Glutathione peroxidase between cases and controls. Whereas statistical significant difference is observed in the levels of Glutathione reductase in Diabetic Nephropathy cases when compared with controls.

scholarly journals Evaluation of deviation of the occlusal plane to three different points of the ala-tragus line among different age group in south Indian population

2020 ◽  
Vol 11 (4) ◽  
pp. 7728-7733
Author(s):  
Tandra Das T ◽  
Suresh Bhat V ◽  
Dhanraj Ganapathy
Keyword(s):  
Reference Point ◽  
Indian Population ◽  
Age Groups ◽  
External Auditory Meatus ◽  
Complete Denture ◽  
Occlusal Plane ◽  
South Indian Population ◽  
Age Group ◽  
Angle Measurements ◽  
South Indian

The aim of the study is to evaluate the deviation of the occlusal plane to three different points of the ala-tragus line among different age group in South Indian population. Incomplete denture prosthetics, there are four basic criteria that every satisfactory denture should achieve. They are aesthetics, phonetics, mastication and comfort. These requirements are attained by adopting proper techniques in complete denture construction. Thus, the exact determinations of the artificial occlusal plane in the upper occlusal rim while jaw registration procedures play an important role in attaining this objective. Considering the importance of the occlusal plane orientation in complete denture prostheses, planes which are steeper or inclined to the occlusal plane can be unaesthetic or cause difficulty in establishing balanced occlusion or centric occlusion, a study is done to evaluate the deviation of the occlusal plane to three different points of ala-tragus line among 15-20 years,20-30 years, 30-40 years age group individuals. Comparison of OP angle measurements with CP1, CP2 and CP3 within the four age groups. In the 15-20 years & 30-40 years age group, CP1 measurement was closest to OP followed by CP2. In the 20-30 year age groups, CP2 measurement was closest to OP followed by CP1. In the 40-50 year age groups, CP2 measurement was closest to OP followed by CP3. This study indicates or younger individual who is less than 40 years when the complete denture is constructed a superior point of external auditory meatus has to be taken as reference point & in an individual who is above 40 middlemost points of external auditory should be taken as reference point. 

scholarly journals Prevalence of diabetes in the adult population of Novosibirsk

2017 ◽  
Vol 20 (5) ◽  
pp. 329-334 ◽  
Author(s):  
Svetlana V. Mustafina ◽  
Oksana D. Rymar ◽  
Sofiya K. Malyutina ◽  
Diana V. Denisova ◽  
Liliya V. Shcherbakova ◽  
...  
Keyword(s):  
Adult Population ◽  
Population Sample ◽  
Age Groups ◽  
Epidemiological Studies ◽  
High Rate ◽  
Age Group ◽  
Men And Women ◽  
Younger Age ◽  
Significant Difference ◽  
High Prevalence

Aims. To estimate the prevalence of type 2 diabetes mellitus (T2DM) in different age groups of the adult population of Novosibirsk, according to epidemiological studies in 20032005 and 20132016. Methods. We examined a representative population sample (assessed in 20032005) of men and women aged 4569 years in two administrative districts of Novosibirsk, as a part of the international HAPIEE project. According to the tables of random numbers, representative samples of men and women aged 4569 years were formed, to which letters were sent, inviting them to pass for examination. During 20132016, a second population survey was conducted on a random representative sample of a population of 2544-year-olds of both sexes. Participants were residents of one of the districts of Novosibirsk. T2DM and impaired fasting glucose (IFG) were diagnosed using fasting plasma glucose (FPG) levels (diabetes: FPG 7.0 mmol/l; IFG: FPG 6.16.9 mmol/l). Results. The prevalence of T2DM among residents aged 4569 years was 11.3%, and overall, no significant difference in prevalence was found between females and males (11.3% vs. 11.0%). However, the overall prevalence of T2DM among residents aged 2544 years was 2.2%, and prevalence was higher in men (3.5%) than in women (1.1%), p 0.05. High prevalence of IFG was found in the 4569 age group (18.2%, in 20032005), and in the younger age group of 2544 years (21.6%, in 20132016). The high rate among young individuals is particularly alarming. Less than one half (4.8 out of 11.3%) of participants aged 4569 tested positive for T2DM, and only one in the age group 2544 years knew he/she had diabetes. This indicates a lack of knowledge among Siberians about their problem with diabetes. Conclusion. Approximately one in five adults had IFG. Among the adult population aged 4569 (in 20032005), 18.2% had IFG and 11.3% had T2DM. In individuals aged 2544 years in 20132016, IFG was observed in 21.6%, and 2.2% had T2DM (p0.05).

scholarly journals The Fitness Barometer: A Best Practice Example for Monitoring Motor Performance With Pooled Data Collected From Practitioners

2021 ◽  
Vol 9 ◽  
Author(s):  
Tanja Eberhardt ◽  
Klaus Bös ◽  
Claudia Niessner
Keyword(s):  
Motor Performance ◽  
Best Practice ◽  
Assessment Tool ◽  
Age Groups ◽  
Mean Value ◽  
Assessment Tools ◽  
Chi Square ◽  
Motor Test ◽  
Significant Difference ◽  
Chi Square Test

Introduction: Motor Performance (MP) in children is an important resource for their future active lifestyle and health. Monitoring of MP is crucial to derive information of trends and to implement specific programs on the base of current MP levels. A variety of MP assessment tools exist, making it difficult to determine a “gold-standard” for assessment and to compare the findings. In Germany, the German Motor Test 6–18 (GMT 6–18) and Kinderturntest Plus 3–10 (KITT+ 3–10) are widely used MP assessment tools. The aim of this paper is to show which key questions can be answered within the context of a best practice example of a MP assessment tool and what can be derived from this for a practical application (the Fitness Barometer).Methods: The raw data of the Fitness Barometer was collected with the MP assessment tools GMT 6–18 and KITT+ 3–10 from 2012 through 2020. Data was pooled anonymously with the e-Research infrastructure MO|REdata and categorized into percentiles for MP and BMI. Overall, we included data of 23,864 children for the statistical analyses. T-tests for independent samples, percentage frequency analysis, descriptive statistics (chi- square-test) and single analysis of variance were conducted.Results and Discussion: Children tested reached a mean value of 57.03 (SD = 18.85). Of the sample, 12.7% children were overweight or obese and there is a significant difference between age groups [χ(4)2 = 178.62, p &lt; 0.001, Cramer V = 0.09; n = 23.656]. The relationship between BMI category and mean value of MP was significant [F(4,19,523) = 224.81, p &lt; 0.001]. During 2020, the year of the COVID-19 pandemic, mean value of endurance and speed decreased [Welch's F(1,573) = 8.08, p = 0.005; Welch's F(1,610) = 35.92, p &lt; 0.001]. The GMT 6–18 and KITT+ 3–10 are valid, objective, reliable, and economic MP assessment tools for monitoring MP levels and derive added practical value. Specific programs and interventions should focus on the findings of these. The Fitness Barometer is a best practice example how a standardized assessment tool of monitoring MP point to trends on which practical evidence-based suggestions can be derived with many various partners and expertise.

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