Challenges for monitoring (trans)gene-flow in the environment.

2021 ◽  
pp. 39-55
Author(s):  
Sarah Zanon Agapito-Tenfen ◽  
Fern Wickson
Keyword(s):  
Wild Relatives ◽  
Detection Methods ◽  
Negative Results ◽  
Transgene Escape ◽  
Ongoing Development ◽  
Methodological Aspects ◽  
Future Work ◽  
The Impact ◽  
Transgene Detection ◽  
Mexican Maize

Abstract Monitoring the presence of transgenes in the environment depends on analytical detection methods and their measurement uncertainties. In this chapter, we aim to identify key methodological aspects and pinpoint the research bottlenecks and needs for building the capacity to effectively monitor transgene escape from genetically modified (GM) crops to wild relatives or landraces. We reviewed the iconic debate concerning the presence of transgenes in landraces of Mexican maize (with both positive and negative results for GM contamination shown over the years) to examine the impact of using different approaches to monitoring and detecting transgenes in landraces. Despite the lack of clear international guidelines that are specific for sampling and testing heterogeneous and dispersed landraces and wild relatives, transgene detection methods have developed significantly over the past decades. There is now an immensely valuable set of tools, approaches, and harmonized protocols that continue to develop and provide a way to evaluate transgene presence. To support this ongoing development and to steer it in directions that are particularly useful for addressing the challenges associated with detection in landraces and wild relatives, we offer lessons from our review for future work in this area particularly useful for addressing the challenges associated with detection in landraces and wild relatives, we offer lessons from our review for future work in this area.

scholarly journals Examining the impact of the number of regions used in cluster detection methods: An application to childhood asthma visits to a hospital in Manitoba, Canada

2018 ◽  
Vol 13 (2) ◽  
Author(s):  
Mahmoud Torabi ◽  
Katie Galloway
Keyword(s):  
Childhood Asthma ◽  
Spatial Aggregation ◽  
Detection Methods ◽  
Spatial Scan Statistic ◽  
Scan Statistic ◽  
Spatial Scan ◽  
The Right ◽  
Future Work ◽  
The Impact ◽  
Different Levels

The level of spatial aggregation is a major concern in cluster investigations. Combining regions to protect privacy may result in a loss of power and thus, can limit the information researchers can obtain. The impact of spatial aggregation on the ability to detect clusters is examined in this study, which shows the importance of choosing the correct level of spatial aggregation in cluster investigations. We applied the circular spatial scan statistic (CSS), flexible spatial scan statistic (FSS) and Bayesian disease mapping (BYM) approaches to a dataset containing childhood asthma visits to a hospital in Manitoba, Canada, using three different levels of spatial aggregation. Specifically, we used 56, 67 and 220 regions in the analysis, respectively. It is expected that the three scenarios will yield different results and will highlight the importance of using the right level of spatial aggregation. The three methods (CSS, FSS, BYM) examined in this study performed similarly when detecting potential clusters. However, for different levels of spatial aggregation, the potential clusters identified were different. As the number of regions used in the analysis increased, the total area identified in the cluster decreased. In general, potential clusters were identified in the central and northern parts of Manitoba. Overall, it is crucial to identify the appropriate number of regions to study spatial patterns of disease as it directly affects the results and consequently the conclusions. Additional investigation through future work is needed to determine which scenario of spatial aggregation is best.

The Impact of BRICS in Reconstructing the International Order

2020 ◽  
pp. 87
Author(s):  
Tareq Mohammed Dhannoon AL Taie
Keyword(s):  
International System ◽  
Political Influence ◽  
Active Role ◽  
International Order ◽  
First Century ◽  
International Affairs ◽  
Strategic Action ◽  
Brics Countries ◽  
Future Work ◽  
The Impact

The BRICS countries have a historical aspiration for global leadership, especially Russia and China, and other countries trying to have a position in the pyramid of international powers in the twenty-first century, especially Brazil, India and South Africa, they worked to unify their efforts, in order to achieve integration in the strategic action, activate its role in International affairs, ending American domination , and restructuring an international system that have an active role in its interactions.       The research hypothesis is based on the idea that the BRICS group, despite the nature of its economic composition and its long-term goals, but its political influence as a bloc, is greater than the proportion of its economic influence in restructuring the new international order. The BRICS group has the capabilities to reshape the international order, but disputes among some of its members represent a challenge to its future work. Its goals will not be achieved without teamwork. Third world countries, especially those that reject unipolarism, have regarded one of the pillars supporting multi-polarity, aiming of giving them freedom of movement in international relations. The ultimate goal of the BRICS is a political nature, as economic mechanisms are used to achieve political goals.

Relay Selection-aware Non-orthogonal Multiple Access Networks: Direct and Relaying Mode

2020 ◽  
Vol 13 (3) ◽  
pp. 348-354
Author(s):  
Dinh-Thuan Do ◽  
Minh-Sang V. Nguyen
Keyword(s):  
Relay Selection ◽  
Multiple Access ◽  
Decode And Forward ◽  
Selection Scheme ◽  
Fixed Power ◽  
Transmission Quality ◽  
Improved Performance ◽  
Outage Probabilities ◽  
Future Work ◽  
The Impact

Objective: In this paper, Decode-and-Forward (DF) mode is deployed in the Relay Selection (RS) scheme to provide better performance in cooperative downlink Non-orthogonal Multiple Access (NOMA) networks. In particular, evaluation regarding the impact of the number of multiple relays on outage performance is presented. Methods: As main parameter affecting cooperative NOMA performance, we consider the scenario of the fixed power allocations and the varying number of relays. In addition, the expressions of outage probabilities are the main metric to examine separated NOMA users. By matching related results between simulation and analytical methods, the exactness of derived formula can be verified. Results: The intuitive main results show that in such cooperative NOMA networks, the higher the number of relays equipped, the better the system performance can be achieved. Conclusion: DF mode is confirmed as a reasonable selection scheme to improve the transmission quality in NOMA. In future work, we will introduce new relay selections to achieve improved performance.

scholarly journals Early Detection Methods for Silicosis in Australia and Internationally: A Review of the Literature

2021 ◽  
Vol 18 (15) ◽  
pp. 8123
Author(s):  
Emma K. Austin ◽  
Carole James ◽  
John Tessier
Keyword(s):  
Early Detection ◽  
Literature Review ◽  
Detection Method ◽  
Detection Methods ◽  
X Rays ◽  
Review Of The Literature ◽  
Occupational Lung Disease ◽  
Work Related ◽  
Growing Body ◽  
Future Work

Pneumoconiosis, or occupational lung disease, is one of the world’s most prevalent work-related diseases. Silicosis, a type of pneumoconiosis, is caused by inhaling respirable crystalline silica (RCS) dust. Although silicosis can be fatal, it is completely preventable. Hundreds of thousands of workers globally are at risk of being exposed to RCS at the workplace from various activities in many industries. Currently, in Australia and internationally, there are a range of methods used for the respiratory surveillance of workers exposed to RCS. These methods include health and exposure questionnaires, spirometry, chest X-rays, and HRCT. However, these methods predominantly do not detect the disease until it has significantly progressed. For this reason, there is a growing body of research investigating early detection methods for silicosis, particularly biomarkers. This literature review summarises the research to date on early detection methods for silicosis and makes recommendations for future work in this area. Findings from this review conclude that there is a critical need for an early detection method for silicosis, however, further laboratory- and field-based research is required.

scholarly journals A Systematic Review of Landsat Data for Change Detection Applications: 50 Years of Monitoring the Earth

2021 ◽  
Vol 13 (15) ◽  
pp. 2869
Author(s):  
MohammadAli Hemati ◽  
Mahdi Hasanlou ◽  
Masoud Mahdianpari ◽  
Fariba Mohammadimanesh
Keyword(s):  
Time Series ◽  
Change Detection ◽  
Policy Development ◽  
Atmospheric Correction ◽  
Open Data ◽  
Detection Methods ◽  
Landsat 8 ◽  
Landsat Images ◽  
Detection Analysis ◽  
The Impact

With uninterrupted space-based data collection since 1972, Landsat plays a key role in systematic monitoring of the Earth’s surface, enabled by an extensive and free, radiometrically consistent, global archive of imagery. Governments and international organizations rely on Landsat time series for monitoring and deriving a systematic understanding of the dynamics of the Earth’s surface at a spatial scale relevant to management, scientific inquiry, and policy development. In this study, we identify trends in Landsat-informed change detection studies by surveying 50 years of published applications, processing, and change detection methods. Specifically, a representative database was created resulting in 490 relevant journal articles derived from the Web of Science and Scopus. From these articles, we provide a review of recent developments, opportunities, and trends in Landsat change detection studies. The impact of the Landsat free and open data policy in 2008 is evident in the literature as a turning point in the number and nature of change detection studies. Based upon the search terms used and articles included, average number of Landsat images used in studies increased from 10 images before 2008 to 100,000 images in 2020. The 2008 opening of the Landsat archive resulted in a marked increase in the number of images used per study, typically providing the basis for the other trends in evidence. These key trends include an increase in automated processing, use of analysis-ready data (especially those with atmospheric correction), and use of cloud computing platforms, all over increasing large areas. The nature of change methods has evolved from representative bi-temporal pairs to time series of images capturing dynamics and trends, capable of revealing both gradual and abrupt changes. The result also revealed a greater use of nonparametric classifiers for Landsat change detection analysis. Landsat-9, to be launched in September 2021, in combination with the continued operation of Landsat-8 and integration with Sentinel-2, enhances opportunities for improved monitoring of change over increasingly larger areas with greater intra- and interannual frequency.

scholarly journals A Qualitative Study of COVID-19 Distress in University Students

2021 ◽  
pp. 216769682110251
Author(s):  
Samantha G. Farris ◽  
Mindy M. Kibbey ◽  
Erick J. Fedorenko ◽  
Angelo M. DiBello
Keyword(s):  
University Students ◽  
Undergraduate Students ◽  
Mental Health Problems ◽  
Financial Strain ◽  
Public Response ◽  
Viral Spread ◽  
Future Work ◽  
The Impact ◽  
Viral Outbreak ◽  
Selection Of

The psychological effect of the pandemic and measures taken in response to control viral spread are not yet well understood in university students; in-depth qualitative analysis can provide nuanced information about the young adult distress experience. Undergraduate students ( N = 624) in an early US outbreak “hotspot” completed an online narrative writing about the impact and distress experienced due to the COVID-19 pandemic. Data were collected April-May 2020. A random selection of 50 cases were sampled for thematic analysis. Nine themes were identified: viral outbreak distress, fear of virus contraction/transmission, proximity to virus, dissatisfaction with public response, physical distancing distress, social distancing distress, academic and school-related distress, disruptive changes in health behavior and routines, financial strain and unemployment, worsening of pre-existing mental health problems, and social referencing that minimizes distress. Future work is needed to understand the persistence of the distress, in addition to developing methods for assessment, monitoring, and mitigation of the distress.

scholarly journals Screening for Melanoma and Other Skin Cancer Shows a Higher Early Melanoma Incidence: Social Educational Program “Life Fear-Free”

2021 ◽  
Vol 8 (1) ◽  
pp. 54-68
Author(s):  
Lev Demidov ◽  
Igor Samoylenko ◽  
Nina Vand ◽  
Igor Utyashev ◽  
Irina Shubina ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Screening Program ◽  
Excisional Biopsy ◽  
Skin Lesions ◽  
Detection Methods ◽  
Non Melanoma Skin Cancer ◽  
The Social ◽  
Educational Campaign ◽  
Skin Cancer Detection ◽  
The Impact

Background: The screening program Life Fear-Free (LFF) aimed at early diagnosis of cutaneous melanoma (CM) was introduced in Samara, Chelyabinsk, Yekaterinburg, and Krasnodar (Russia) in 2019. Objectives: To analyze the impact of the program on early CM and non-melanoma skin cancer (NMSC) detection. Methods: According to the social educational campaign, people were informed about CM risk factors and symptoms and were invited for skin examination. The program planned to involve 3200 participants in total. Participants with suspicious lesions were invited for excisional biopsy. Results: 3143 participants, including 75.4% women, were examined for skin lesions. The average age of the participants was 43.7 years. Mostly skin phototypes II and III were registered (48.2% and 41.0%, respectively); 3 patients had CM, 15 had basal cell carcinoma, and 1 had Bowen’s disease, which were confirmed histologically. All detected melanomas had Breslow’s thickness of 1 mm. Conclusion: The participants showed high interest in early skin cancer detection programs. The incidence rate of CM and NMSCs among the program participants was higher than in general public. The early disease grade was proven for the detected CMs and NMSCs. The study has shown that it is important to continue such programs.

scholarly journals Impact of a Series of Educational Talks Taught by Health Professionals to Promote Healthy Snack Choices among Children

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 203
Author(s):  
Víctor Arufe Giráldez ◽  
Javier Puñal Abelenda ◽  
Rubén Navarro-Patón ◽  
Alberto Sanmiguel-Rodríguez
Keyword(s):  
Nutritional Quality ◽  
Positive Impact ◽  
Total Sample ◽  
Overweight And Obesity ◽  
Healthy Habits ◽  
Quasi Experimental ◽  
Nutrition And Dietetics ◽  
Future Work ◽  
The Impact

Background: One of the great challenges facing today’s society is the need to combat overweight and obesity in schoolchildren. This study aimed to analyze the impact of a cycle of didactic talks—given to families by a specialist in pediatrics, a specialist in nutrition and dietetics and a specialist in physical exercise—on childrens’ snack choices and nutrition quality. Methods: A longitudinal, quasi-experimental and quantitative investigation was designed, working with a total sample of 50 students divided into control and experimental groups. The nutritional quality of daily snacks was recorded during the month before and the month after the cycle of talks given by health experts. Results: An increase in the nutritional quality of the snacks was observed in the days after the talk—but, after a week, values returned to normal. Conclusions: The giving of educational talks to promote healthy habits may have a positive impact on the nutritional quality of school snacks in the days immediately following the talks. However, some forgetfulness was detected over time, which reduced the nutritional quality of the snacks once more. For future work, it is recommended that researchers measure the impact produced by giving regular talks.

Health, happiness and your future: using a “men’s group” format to work with homeless men in London

2017 ◽  
Vol 13 (4) ◽  
pp. 403-418
Author(s):  
Kate Thompson ◽  
Pippa Brown ◽  
Stephanie Vieira
Keyword(s):  
Mental Health ◽  
Psychosocial Issues ◽  
Horn Of Africa ◽  
Content Type ◽  
Health And Wellbeing ◽  
Care Services ◽  
Homeless Men ◽  
Group Members ◽  
Future Work ◽  
The Impact

Purpose The purpose of this paper is to describe an intervention with a group of homeless men from the Horn of Africa, service users of the Horn of Africa Health and Wellbeing Project in London. The group was conceived by the second author who noted the presence of significant psychosocial issues for her clients, but equally their reluctance to access mainstream mental health or social care services. Design/methodology/approach Designing the group and introducing it to the men involved threw up some challenges which are explored, and the impact of the group on participants is evaluated. Findings Overall both the participants and the facilitators evaluated the group positively and it appeared to have led to lasting change for some of the group members, and this is described. The authors argue that this sort of group may be a more acceptable way to work on psychosocial issues than something more directly focused on mental health intervention. The group protocol is outlined along with suggestions for future work in this area. Originality/value This intervention represents a creative alternative to more mainstream psychological interventions for homeless or exiled men.

scholarly journals The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals

2021 ◽  
Vol 95 (3) ◽  
pp. 1103-1116
Author(s):  
Francesco Marchetti ◽  
Gu Zhou ◽  
Danielle LeBlanc ◽  
Paul A. White ◽  
Andrew Williams ◽  
...  
Keyword(s):  
Germ Cells ◽  
False Negative ◽  
Sampling Time ◽  
Male Germ Cells ◽  
Negative Results ◽  
False Negative Results ◽  
Detection Of Mutations ◽  
The Impact ◽  
Sampling Times

AbstractThe Organisation for Economic Co-Operation and Development Test Guideline 488 (TG 488) uses transgenic rodent models to generate in vivo mutagenesis data for regulatory submission. The recommended design in TG 488, 28 consecutive daily exposures with tissue sampling three days later (28 + 3d), is optimized for rapidly proliferating tissues such as bone marrow (BM). A sampling time of 28 days (28 + 28d) is considered more appropriate for slowly proliferating tissues (e.g., liver) and male germ cells. We evaluated the impact of the sampling time on mutant frequencies (MF) in the BM of MutaMouse males exposed for 28 days to benzo[a]pyrene (BaP), procarbazine (PRC), isopropyl methanesulfonate (iPMS), or triethylenemelamine (TEM) in dose–response studies. BM samples were collected + 3d, + 28d, + 42d or + 70d post exposure and MF quantified using the lacZ assay. All chemicals significantly increased MF with maximum fold increases at 28 + 3d of 162.9, 6.6, 4.7 and 2.8 for BaP, PRC, iPMS and TEM, respectively. MF were relatively stable over the time period investigated, although they were significantly increased only at 28 + 3d and 28 + 28d for TEM. Benchmark dose (BMD) modelling generated overlapping BMD confidence intervals among the four sampling times for each chemical. These results demonstrate that the sampling time does not affect the detection of mutations for strong mutagens. However, for mutagens that produce small increases in MF, sampling times greater than 28 days may produce false-negative results. Thus, the 28 + 28d protocol represents a unifying protocol for simultaneously assessing mutations in rapidly and slowly proliferating somatic tissues and male germ cells.

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