scholarly journals Association between Dietary Lutein/Zeaxanthin Intake and Metabolic Syndrome Among U.S. Females: An Analysis of National Health and Examination Survey 2015–2018

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 82-82
Author(s):  
Yanqi Zhang ◽  
Linda Knol ◽  
Libo Tan
Keyword(s):  
Metabolic Syndrome ◽  
Intervention Studies ◽  
Smoking Status ◽  
Premenopausal Women ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Funding Sources ◽  
Separate Model ◽  
The Relationship ◽  
Dose Dependent

Abstract Objectives The prevalence of metabolic syndrome (MetS) is higher among U.S. females than males, mainly due to the higher prevalence of dyslipidemia and elevated fasting glucose levels. Lutein (L) and its isomer zeaxanthin (Z) are carotenoids that can alter the composition of lipoprotein, which may affect components of MetS. They also act as potent antioxidants that benefit metabolic health. Dietary intake of L and Z is inversely associated with MetS in U.S. males, however, this association is unclear in females. The purpose of this study was to investigate the relationship between dietary and supplemental intake of L/Z and MetS prevalence among U.S. females. Methods A sample of premenopausal women aged 20–50 years was drawn from NHANES 2015–2018. The diagnostic criteria of MetS was based on the National Cholesterol Education Program Adult Treatment Panel. Dietary L/Z intake was calculated from two 24-hour recalls. Supplemental L/Z intake was extracted from two 24-hour dietary supplements use files. Both dietary and supplemental L/Z intakes were divided into four quartiles. The association between MetS and quartile of L/Z intake was assessed using logistic regression analyses while adjusting for race, age, smoking status, and total energy intake. A separate model was run with the addition of supplemental L/Z. Results Among the 630 U.S. females included in these analyses, the prevalence of MetS was 22.84%. Mean dietary L/Z intakes by quartiles 1, 2, 3, and 4, respectively, were 0.30 mg/d, 0.64 mg/d, 1.16 mg/d, and 4.60 mg/d. When comparing the highest intake quartile to the lowest, women in the highest quartile had significantly lower risk of MetS after adjusting for covariates (OR: 0.38, 95% CI 0.15–0.97). The means of dietary plus supplemental L/Z intake by quartiles 1, 2, 3, and 4, respectively, were 0.33 mg/d, 0.64 mg/d, 1.21 mg/d, and 4.73 mg/d. No relationship was noted between the sum of dietary and supplemental L/Z intake and the odds of MetS. Conclusions When compared to participants with the lowest intake (quartile) of dietary L/Z, those in the highest quartile had significantly reduced odds of MetS. This relationship was not dose dependent suggesting extreme intakes of greater than 1.7 mg/d were related to a reduced risk. Further intervention studies are warranted to investigate the beneficial effects of dietary L/Z on risk factors of MetS in U.S. females. Funding Sources None.

scholarly journals Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study

2021 ◽  
Vol 9 (7) ◽  
pp. 1511
Author(s):  
Jia Yin ◽  
Yujie Song ◽  
Yaozhong Hu ◽  
Yuanyifei Wang ◽  
Bowei Zhang ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Physiological Function ◽  
Tryptophan Metabolism ◽  
Future Research ◽  
Beneficial Effects ◽  
First Time ◽  
The Relationship ◽  
Dose Dependent ◽  
Indole 3 Acetic Acid

Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism. However, the reciprocal interaction between tryptophan and Akkemansia is still unclear. Herein, for the first time, the possible effects of tryptophan and its derived metabolites on A. muciniphila were preliminarily investigated, including growth, physiological function, and metabolism. Obtained results suggested that 0.4 g/L of tryptophan treatment could significantly promote the growth of A. muciniphila. Notably, when grown in BHI with 0.8 g/L of tryptophan, the hydrophobicity and adhesion of A. muciniphila were significantly improved, potentially due to the increase in the rate of cell division. Furthermore, A. muciniphila metabolized tryptophan to indole, indole-3-acetic acid, indole-3-carboxaldehyde, and indole-3-lactic acid. Indoles produced by gut microbiota could significantly promote the growth of A. muciniphila. These results could provide a valuable reference for future research on the relationship between tryptophan metabolism and A. muciniphila.

scholarly journals The Relationship Between Leisure-Time Physical Activity and the Metabolic Syndrome: An Examination of NHANES III, 1988-1994

2005 ◽  
Vol 2 (4) ◽  
pp. 470-487 ◽  
Author(s):  
Katrina D. DuBose ◽  
Cheryl L. Addy ◽  
Barbara E. Ainsworth ◽  
Gregory A. Hand ◽  
J. Larry Durstine
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Smoking Status ◽  
Nhanes Iii ◽  
The Metabolic Syndrome ◽  
Low Hdl ◽  
The Relationship

Background:This study was performed to determine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome (MS) in 16,681 adults (43 ± 0.44 y) enrolled in NHANES III.Methods:LTPA was classified as regularly active (≥ 5 d/wk moderate and/or ≥ 3 d/wk vigorous), irregularly active (some LTPA), or inactive (no LTPA). The MS was positive with three or more conditions: 1) abdominal obesity, 2) low HDL-C, 3) hypertriglyceridemia, 4) elevated blood pressure, or 5) elevated glucose. Logistic regression examined the relationship between LTPA and the MS, adjusting for age, race, smoking status, and educational attainment stratified by gender.Results:In men only, irregular activity and inactivity was related to an increase in the MS (irregular: OR = 1.52 95% CI 1.11, 1.23; inactive: OR = 1.60, 95% CI 1.18, 1.98; test for trend P = 0.004). Inactivity increased the odds for abdominal obesity (P < 0.05).Conclusions:LTPA levels might influence the development of MS and abdominal obesity.

scholarly journals Chrysin in Combination with Insulin Promotes Glucose Uptake in Skeletal Muscle Cell: Impact of Combination Therapy in Diabetes Myopathy (P01-031-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Poonam Kalhotra ◽  
Veera Chandra Sekhar Reddy Chittepu ◽  
Guillermo Osorio-Revilla ◽  
Tzayhri Gallardo-Velazquez
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Glucose Uptake ◽  
Pathway Analysis ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
P Value ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Funding Sources

Abstract Objectives The objective of the current study was examining the beneficial effects of DPP4 inhibitor chrysin alone and in combination with insulin benefits diabetes myopathy. Methods Sulforhodamine B (SRB) protein-dye was used to determine the acute toxicity, and 1H NMR spectroscopy was used to identify and quantify glucose levels to assess glucose uptake on treatments chrysin and combination of chrysin with Insulin on differentiated skeletal muscle cells. Pathway analysis was carried out using omics net web server. All experiments were conducted in triplicates, and all data in the graph represent Mean ± S.D. Graph pad software was used to calculate One-way analysis of variance (ANOVA), computed p-value among different groups and values with P < 0.05 is significant. Results Results showed that 250 µM chrysin and combination (10 nM Insulin with 250 µM chrysin) treatments are not acutely toxic to skeletal muscle cells and proliferates the cells significant to insulin-treated skeletal muscle cells (Figure 1A). Glucose metabolite levels are studied as skeletal muscle cells adopted cell proliferative and to demonstrate our hypothesis on glucose metabolism. Significant differences were observed in skeletal muscle cells treated with insulin, chrysin, and combination (Figure 1B). It is observed that chrysin alone, combination increases glucose uptake significantly in comparison to control cells. Pathway analysis revealed that GPCR signaling and immune-related signaling plays a role in proliferating skeletal muscle cells to regulate glucose metabolism. Conclusions The results of this study propose the use of natural compound chrysin in combination with insulin to promote skeletal muscle health in diabetes mellitus. The combination identified herein must be considered for future therapies to control diabetic myopathy in preclinical and clinical studies. Chrysin can also be applied as a supplement in the diet as well, to control diabetic myopathy. Funding Sources Authors wish to express their gratitude to Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional (ENCB-IPN) for providing financial support for the present study. Supporting Tables, Images and/or Graphs

scholarly journals Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet

Antioxidants ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 79 ◽  
Author(s):  
Maria Guirro ◽  
Andreu Gual-Grau ◽  
Albert Gibert-Ramos ◽  
Juan Maria Alcaide-Hidalgo ◽  
Núria Canela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Sequencing Data ◽  
Global Epidemic ◽  
Beneficial Effects ◽  
Obesogenic Diet ◽  
Molecular Effects ◽  
Dose Dependent ◽  
And Oxidative Stress

Metabolic syndrome (MetS) is a global epidemic concern. Polyphenols are proposed as good candidates for its prevention, although their mechanisms are not fully understood. The gut microbiota seems to play a key role in polyphenol beneficial effects. Here, we assessed the effects of the citrus polyphenol hesperidin combining an untargeted metabolomics approach, which has an inherent potential to elucidate the host-microbiome interplay, with extensive anthropometric and biochemical characterizations and integrating metabolomics results with our previous 16S rRNA bacterial sequencing data. The rats were fed either a standard or an obesogenic cafeteria diet (CAF) for 17 weeks. After nine weeks, rats were supplemented with vehicle; low- (H1), or high- (H2) hesperidin doses. CAF animals developed MetS features. Hesperidin supplementation in CAF rats decreased the total cholesterol, LDL-C, and free fatty acids. The highest hesperidin dose also ameliorated blood pressure, insulin sensitivity, and decreased markers of arterial stiffness and inflammation. Metabolomics revealed an improvement of the lipidomic profile, decreases in circulating amino acids, and lower excretions of inflammation- and oxidative stress-related metabolites. Bacteroidaceae increases in the CAF-H2 group paralleled higher excretions of microbial-derived metabolites. Overall, our results provide detailed insights into the molecular effects of hesperidin on MetS and suggest that it is a promising prebiotic for the treatment of MetS and related conditions.

scholarly journals The Relationship Between Metabolic Syndrome with Incidence of Stroke

2016 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Fila Fatmisua Chrisna ◽  
Santi Martini
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Significant Relationship ◽  
Fasting Glucose ◽  
Hdl Cholesterol ◽  
Glucose Levels ◽  
The Third ◽  
The Metabolic Syndrome ◽  
The Relationship

Stroke is one of non-communicable diseases and affected by many risk factors. Some stroke risk factors have in common with the metabolic syndrome criteria, such as abdominal obesity, glucose intolerance, decreased HDL cholesterol, elevated triglyceride levels, and insulin resistance. The goals to analyze the relationship between the metabolic syndrome with the incidence of stroke. This research is analytic by using case-control design. The case groups were hospitalized patients of stroke and undergoing inpatient in dr. M. Soewandhie Surabaya. The case groups were 32 peoples and control group 32 peoples were selected at random. The variables studied were age, sex, metabolic syndrome, the first criteria, the second criteria of metabolic syndrome, and the third criteria of metabolic syndrome. The results showed that the majority of stroke patients in the age range 51-75 years (78%). Results of Chi-Square test indicates a significant relationship between the metabolic syndrome criteria first (abdominal obesity, triglycerides, and HDL cholesterol levels) p = 0,01 OR = 6,82 (95% CI = 1,23 to 68,17 ) and the second criteria of metabolic syndrome (HDL cholesterol, blood pressure, and fasting glucose levels) p= 0,007 OR = 5,80 (95% CI = 1,30 to 35,15) with the incidence of stroke. While for the third criteria of metabolic syndrome (fasting glucose levels, abdominal obesity, triglyceride  levels) there was no significant relationship to the incidence of stroke. It is expected for people, especially over the age of 35 years can do a lipid profile and circle abdominal measurements to detect of   metabolic syndrome and the risk of stroke.Keywords: Metabolic Syndrome, Stroke, Abdominal Obesity, Triglyceride, HDL

scholarly journals Antibodies against phosphorylcholine in hospitalized versus non-hospitalized obese subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amra Jujić ◽  
J. Korduner ◽  
H. Holm ◽  
G. Engström ◽  
E. Bachus ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Smoking Status ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Glucose Levels ◽  
History Of ◽  
Obese Subjects ◽  
Anti Inflammatory

AbstractObesity associates with reduced life expectancy, type 2 diabetes, hypertension and cardiovascular disease, and is characterized by chronic inflammation. Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein, dead cells and some microorganisms. Antibodies against PC (anti-PC) have anti-inflammatory properties. Here, we explored the role of anti-PC in hospitalized versus non-hospitalized obese. One-hundred-and-twenty-eight obese (BMI ≥ 30 kg/m2) individuals (59.8 (± 5.5) years, 53.9% women) from the Malmö Diet and Cancer Cardiovascular Cohort were examined and IgM, IgG1 and IgG2 anti-PC were analyzed by ELISA. Individuals with at least one recorded history of hospitalization prior to study baseline were considered hospitalized obese (HO). Associations between IgM, IgG1 and IgG2 anti-PC and HO (n = 32)/non-hospitalized obese (NHO) (n = 96), but also with metabolic syndrome and diabetes were analysed using logistic regressions. Both IgM and IgG1 anti-PC were inversely associated with HO, also after controlling for age and sex. When further adjusted for waist circumference, systolic blood pressure, glucose levels and smoking status, only IgG1 anti-PC remained significantly associated with HO. In multivariate models, each 1 standard deviation of increment in anti-PC IgG1 levels was inversely associated with prevalence of HO (odds ratio 0.57; CI 95% 0.33–0.98; p = 0.044). IgG2 anti-PC did not show any associations with HO. Low levels of IgM and IgG1 anti-PC are associated with higher risk of being a HO individual independent of sex and age, IgG1 anti-PC also independently of diabetes and metabolic syndrome. The anti-inflammatory properties of these antibodies may be related to inflammation in obesity and its complications.

scholarly journals The Relationship Between Metabolic Syndrome with Incidence of Stroke

2016 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Fila Fatmisua Chrisna ◽  
Santi Martini
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Significant Relationship ◽  
Fasting Glucose ◽  
Hdl Cholesterol ◽  
Glucose Levels ◽  
The Third ◽  
The Metabolic Syndrome ◽  
The Relationship

ABSTRACT Stroke is one of non-communicable diseases and affected by many risk factors. Some stroke risk factors have in common with the metabolic syndrome criteria, such as abdominal obesity, glucose intolerance, decreased HDL cholesterol, elevated triglyceride levels, and insulin resistance. The goals to analyze the relationship between the metabolic syndrome with the incidence of stroke. This research is analytic by using case-control design. The case groups were hospitalized patients of stroke and undergoing inpatient in dr. M. Soewandhie Surabaya. The case groups were 32 peoples and control group 32 peoples were selected at random. The variables studied were age, sex, metabolic syndrome, the first criteria, the second criteria of metabolic syndrome, and the third criteria of metabolic syndrome. The results showed that the majority of stroke patients in the age range 51-75 years (78%). Results of Chi-Square test indicates a significant relationship between the metabolic syndrome criteria first (abdominal obesity, triglycerides, and HDL cholesterol levels) p = 0,01 OR = 6,82 (95% CI = 1,23 to 68,17 ) and the second criteria of metabolic syndrome (HDL cholesterol, blood pressure, and fasting glucose levels) p= 0,007 OR = 5,80 (95% CI = 1,30 to 35,15) with the incidence of stroke. While for the third criteria of metabolic syndrome (fasting glucose levels, abdominal obesity, triglyceride  levels) there was no significant relationship to the incidence of stroke. It is expected for people, especially over the age of 35 years can do a lipid profile and circle abdominal measurements to detect of   metabolic syndrome and the risk of stroke. Keywords: Metabolic Syndrome, Stroke, Abdominal Obesity, Triglyceride, HDL

scholarly journals Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study

2020 ◽  
Vol 9 (12) ◽  
Author(s):  
Adebamike A. Oshunbade ◽  
Wondwosen K. Yimer ◽  
Karen A. Valle ◽  
Donald Clark ◽  
Daisuke Kamimura ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Smoking Status ◽  
Jackson Heart Study ◽  
Smoking Intensity ◽  
Heart Study ◽  
Increased Risk ◽  
Significant Difference ◽  
Never Smokers ◽  
The Relationship ◽  
Dose Dependent

Background Blacks are disproportionately affected by stroke compared with whites; however, less is known about the relationship between stroke and cigarette smoking in blacks. Therefore, we evaluated the relationship between cigarette smoking and all incident stroke in the JHS (Jackson Heart Study). Methods and Results JHS participants without a history of stroke (n=4410) were classified by self‐reported baseline smoking status into current, past (smoked at least 400 cigarettes/life), or never smokers at baseline (2000–2004). Current smokers were further classified by smoking intensity (number of cigarettes smoked per day [1–19 and ≥20]) and followed up for incident stroke (through 2015). Hazard ratios (HRs) for incident stroke for current and past smoking compared with never smoking were estimated with adjusted Cox proportional hazard regression models. After adjusting for cardiovascular risk factors, the risk for stroke in current smokers was significantly higher compared with never smokers (HR, 2.48; 95% CI, 1.60–3.83) but there was no significant difference between past smokers and never smokers (HR, 1.10; 95% CI, 0.74–1.64). There was a dose‐dependent increased risk of stroke with smoking intensity (HR, 2.28 [95% CI, 1.38–3.86] and HR, 2.78 [95% CI, 1.47–5.28] for current smokers smoking 1–19 and ≥20 cigarettes/day, respectively). Conclusions In a large cohort of blacks, current cigarette smoking was associated with a dose‐dependent higher risk of all stroke. In addition, past smokers did not have a significantly increased risk of all stroke compared with never smokers, which suggests that smoking cessation may have potential benefits in reducing the incidence of stroke in blacks.

scholarly journals Higher Chocolate Candy Intake Is Associated with Longer Telomere Length Among Adolescents (P01-018-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Li Chen ◽  
Haidong Zhu ◽  
Bernard Gutin ◽  
Howard Sesso ◽  
Yanbin Dong
Keyword(s):  
Telomere Length ◽  
Healthy Eating ◽  
Sexual Development ◽  
Intervention Studies ◽  
Healthy Eating Index ◽  
Cellular Aging ◽  
Leukocyte Telomere Length ◽  
Dietary Recall ◽  
Funding Sources ◽  
The Relationship

Abstract Objectives Chocolate intake has been shown to improve lipid profiles, which is associated with longer leukocyte telomere length (LTL). But the relationship between chocolate candy intake and cellular aging has not been investigated. We aimed to examine the association between chocolate intake and LTL in adolescents with comprehensive assessments of dietary, lifestyle, and clinical risk factors. Methods The dietary chocolate candy intake information were available in 660 adolescents aged from 14 to 18 years (51% girls and 48% blacks). The chocolate candy intake was estimated by seven independent 24 h dietary recalls and divided into three groups, which were none, less than 2 servings/week, and 2 servings/week or more. Multiple linear regression was performed to investigate the association between chocolate intake and LTL. Results Among the adolescents, 383 (58%) didn't take any chocolate during dietary recall periods, 165 (25%) consumed chocolate less than 2 servings/week (1.1 ± 0.5 servings/week), and 122 (17%) consumed chocolate of 2 servings/week or more (4.7 ± 4.0 servings/week). Body mass index (BMI) or % body fat was inversely related to chocolate intake in a dose-response fashion (ps < 0.01). Chocolate consumption was also positively associated with ApoA1 (P = 0.024) and ApoA1/HDL (P = 0.036). In addition, ApoA1 and ApoA1/HDL were positively associated with LTL (ps = 0.044 and 0.003, respectively). Compared to non-consumers, adolescents who consumed chocolate of ≥2 servings/week had 0.26 standard deviation longer LTL (P = 0.016) when adjusted for age, sex and race. The association remained significant after further adjustment of BMI, energy intake, the Alternate Healthy Eating Index (AHEI), non-chocolate candy intake, physical activity, family SES and sexual development. Conclusions Adolescents who consume 2 servings/week or more of chocolate have longer LTL compared with non-consumers, and ApoA1-HDL pathway might be underlying the chocolate-LTL relationship. Further intervention studies are warranted to verify the beneficial effect of chocolate candy intake on the cellular aging process. Funding Sources Study was in part supported by the National Institute of Health, grant number HL064157.

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