scholarly journals Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression

2019 ◽  
Vol 30 (4) ◽  
pp. 2144-2156 ◽  
Author(s):  
Anders M Fjell ◽  
Donatas Sederevicius ◽  
Markus H Sneve ◽  
Ann-Marie Glasø de Lange ◽  
Anne CecilieSjøli Bråthen ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Sleep Problems ◽  
Older Individuals ◽  
Accumulation Pattern ◽  
Anatomical Distribution ◽  
Healthy Older Adults ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Cortical Regions ◽  
The Relationship

Abstract Sleep problems are related to the elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ). Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified in rodents. A major marker of sleep deprivation is Homer1a, a neural protein coded by the HOMER1 gene, which has also been implicated in brain Aβ accumulation. Here, we tested whether the relationship between cortical Aβ accumulation and self-reported sleep quality, as well as changes in sleep quality over 3 years, was stronger in cortical regions with high HOMER1 mRNA expression levels. In a sample of 154 cognitively healthy older adults, Aβ correlated with poorer sleep quality cross-sectionally and longitudinally (n = 62), but more strongly in the younger than in older individuals. Effects were mainly found in regions with high expression of HOMER1. The anatomical distribution of the sleep-Aβ relationship followed closely the Aβ accumulation pattern in 69 patients with mild cognitive impairment or AD. Thus, the results indicate that the relationship between sleep problems and Aβ accumulation may involve Homer1 activity in the cortical regions, where harbor Aβ deposits in AD. The findings may advance our understanding of the relationship between sleep problems and AD risk.

scholarly journals Longitudinal increase in sleep problems is related to amyloid deposition in cortical regions with high HOMER1 gene expression

2018 ◽  
Author(s):  
Anders M Fjell ◽  
Donatas Sederevicius ◽  
Markus H Sneve ◽  
Ann-Marie Glasø de Lange ◽  
Anne Cecilie Sjøli Bråthen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Older Adults ◽  
Sleep Quality ◽  
Molecular Mechanisms ◽  
Sleep Problems ◽  
Expression Patterns ◽  
Accumulation Pattern ◽  
Sleep Homeostasis ◽  
Cortical Regions ◽  
The Relationship

AbstractOlder adults who report more sleep problems tend to have elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ), but the mechanisms responsible for this relationship are largely unknown. Molecular markers of sleep problems are now emerging from rodent research, yielding opportunities to generate hypotheses about the causes of the sleep-Aβ relationship. A major molecular marker of sleep deprivation is Homer1a, a neural protein coded by the HOMER1 gene, involved in control of sleep homeostasis and also implied in Aβ accumulation. Here, in a sample of 109 cognitively healthy middle-aged and older adults, we tested whether the relationship between cortical Aβ accumulation and self-reported sleep quality, as well as changes in sleep quality over three years, was stronger in cortical regions with high HOMER1 mRNA expression levels. Aβ correlated with poorer sleep quality cross-sectionally and longitudinally. This relationship was stronger in the younger (50-67 years) than the older (68-81 years) participants. Effects were mainly found in regions with high expression of HOMER1, suggesting a possible molecular pathway between sleep problems and Aβ accumulation. The anatomical distribution of the sleep-Aβ relationships followed closely the Aβ accumulation pattern in 69 patients with mild cognitive impairment (MCI) or AD. Thus, the results indicate that the relationship between sleep problems and Aβ-accumulation may involve Homer1 activity in the cortical regions that harbor Aβ in AD. Analysis of cortical gene expression patterns represent a promising avenue to unveil molecular mechanisms behind the relationship between sleep problems and AD risk.

MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer’s Disease

2020 ◽  
Vol 17 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Dan Wang ◽  
Zhifu Fei ◽  
Song Luo ◽  
Hai Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Western Blot ◽  
Mrna Expression ◽  
Cognitive Deficits ◽  
Protein Levels ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Relationship

Objectives: Alzheimer's disease (AD), also known as senile dementia, is a common neurodegenerative disease characterized by progressive cognitive impairment and personality changes. Numerous evidences have suggested that microRNAs (miRNAs) are involved in the pathogenesis and development of AD. However, the exact role of miR-335-5p in the progression of AD is still not clearly clarified. Methods: The protein and mRNA levels were measured by western blot and RNA extraction and quantitative real-time PCR (qRT-PCR), respectively. The relationship between miR-335-5p and c-jun-N-terminal kinase 3 (JNK3) was confirmed by dual-luciferase reporter assay. SH-SY5Y cells were transfected with APP mutant gene to establish the in vitro AD cell model. Flow cytometry and western blot were performed to evaluate cell apoptosis. The APP/PS1 transgenic mice were used as an in vivo AD model. Morris water maze test was performed to assess the effect of miR- 335-5p on the cognitive deficits in APP/PS1 transgenic mice. Results: The JNK3 mRNA expression and protein levels of JNK3 and β-Amyloid (Aβ) were significantly up-regulated, and the mRNA expression of miR-335-5p was down-regulated in the brain tissues of AD patients. The expression levels of miR-335-5p and JNK3 were significantly inversely correlated. Further, the dual Luciferase assay verified the relationship between miR-335- 5p and JNK3. Overexpression of miR-335-5p significantly decreased the protein levels of JNK3 and Aβ and inhibited apoptosis in SH-SY5Y/APPswe cells, whereas the inhibition of miR-335-5p obtained the opposite results. Moreover, the overexpression of miR-335-5p remarkably improved the cognitive abilities of APP/PS1 mice. Conclusion: The results revealed that the increased JNK3 expression, negatively regulated by miR-335-5p, may be a potential mechanism that contributes to Aβ accumulation and AD progression, indicating a novel approach for AD treatment.

scholarly journals The Relationship Among Sleep Quality, the Stages of Change Readiness and Treatment Eagerness Scale, Abstinence Self-efficacy, and Quality of Life with Alcohol Use Disorder in South Korea

2020 ◽  
Vol 12 (4) ◽  
pp. 69
Author(s):  
EunJu Song
Keyword(s):  
Quality Of Life ◽  
Alcohol Use ◽  
Sleep Quality ◽  
Stages Of Change ◽  
Self Efficacy ◽  
Sleep Disturbances ◽  
Alcohol Use Disorder ◽  
Sleep Problems ◽  
The Relationship

Many patients with alcohol use disorder experienced insomnia or sleep disturbances. However, their sleep problems rarely addressed in the treatment process. It may prove beneficial if treatment programs should intend to help prevent the recurrence of alcohol use disorder by solving patients’ sleep-induced problems and accordingly include appropriate sleep interventions. The present study employed a descriptive design and conducted a cross-sectional survey to assess the relationship among sleep quality, score on the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES), abstinence self-efficacy, and quality of life in inpatients with alcohol use disorders. Data were collected from June to August 2018, from 117 patients admitted to the psychiatric ward for alcohol-use patients in two mental hospitals in South Korea. Sleep quality was significantly correlated with the SOCRATES score (r = .247, p = .007) and quality of life (r = -.346, p = .001). However, it showed no relationship with abstinence self-efficacy (r = -.066, p = .477). These findings suggest that abstinence programs need to employ a comprehensive approach instead of primarily focusing on maintaining abstinence and cessation of alcohol use. However, both sleep disturbances and alcohol abstinence require patience and prolonged treatment. Thus, it is a challenge to design concrete interventions to address the sleep problems experienced by patients with alcohol use disorder.

scholarly journals The relationship between sleep hygiene and sleep quality among residents of an elderly care institution in DKI Jakarta

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Mutia Annisa ◽  
Dwi Nurviyandari Kusuma Wati
Keyword(s):  
Sleep Quality ◽  
Sleep Problems ◽  
Elderly Care ◽  
Sleep Hygiene ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship ◽  
Purposive Sample

<p class="AbstractContent"><strong>Objective:</strong> Elderly are at risk of poor slepp quality and other health problems due to reduced sleep satisfaction. The objective of this study was to explore the association between sleep hygiene and sleep quality in elderly.</p><p class="AbstractContent"><strong>Methods: </strong>This was a descriptive study with cross sectional design. The study was conducted in four elderly care institutions in Jakarta, Indonesia, involving a purposive sample of 103 elderly aged 60 to 111 years old. Data were collected using Sleep Hygiene Index (SHI) and Pittsburgh Sleep Quality Index (PSQI).</p><p class="AbstractContent"><strong>Results:</strong> Over half of the residents had poor sleep hygiene (51.5%) and more than three quarter (81.6%) had poor sleep quality. The study revealed that there was a highly significant relationship between sleep hygiene and sleep quality (p = 0.001). The study also showed that those with poor sleep hygiene were 7.834 times more likely to have poor sleep quality.<strong></strong></p><p class="AbstractContent"><strong>Conclusion: </strong>Nurses need to include interventions that may address residents’ sleep problems. They also need to promote sleep hygiene and improve residents’ sleep quality.<strong></strong></p><strong>Keywords: </strong>elderly, institution, sleep hygiene, sleep quality

scholarly journals THE MODERATING EFFECT OF RAISING ONE’S GRANDCHILDREN ON THE RELATION BETWEEN SLEEP AND DEPRESSION

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S678-S678
Author(s):  
Melanie Stearns ◽  
Danielle K Nadorff
Keyword(s):  
Older Adults ◽  
Risk Factor ◽  
Depressive Symptoms ◽  
Sleep Quality ◽  
Sleep Problems ◽  
Depression Scale ◽  
Poor Sleep ◽  
Older Individuals ◽  
Poor Sleep Quality ◽  
Custodial Grandparents

Abstract Recent evidence has shown that poor quality sleep is associated with depression, particularly among older individuals (Bao et al., 2017; Nadorff, Fiske, Sperry, & Petts, 2012). Moreover, given the high prevalence of depressive symptoms among older adults, it is important to identify possible risk factors of poor sleep quality. One possible risk factor is being a custodial grandparent (raising one’s grandchildren), as increased caregiving responsivities are associated with increased depressive symptoms (Brand-Winterstein, Edelstein, & Bachner, 2018). Based upon these previous findings, the current study examines the effect of custodial status on the relation between sleep quality and depressive symptoms. The sample (N = 466) was a subset of individuals recruited in the second wave of the MIDUS biomarkers project completed in 2009 who answered the sleep, caregiving, and depressive symptoms variables of interest. Measures included the Center for Epidemiological Studies Depression Scale (CESD), the Pittsburgh Sleep Quality Index (PSQI), and a question regarding custodial grandparent status. The current study aimed to examine whether poor sleep quality might serve as a risk factor for experiencing depressive symptoms and how custodial grandparents might differ from other older adults. Moderation analyses were conducted using SPSS’ Process macro on the sample. The interaction between global sleep quality and custodial grandparent status was significant in predicting depressive symptoms, t (1, 465) = 3.90, p = .04, such that custodial grandparents reported a stronger positive correlation between greater global sleep problems and depressive symptoms than non-custodial grandparents. Implications, future directions, and limitations are discussed.

scholarly journals DNA methylation and cognitive functioning in healthy older adults

2011 ◽  
Vol 107 (5) ◽  
pp. 744-748 ◽  
Author(s):  
Olga J. G. Schiepers ◽  
Martin P. J. van Boxtel ◽  
Renate H. M. de Groot ◽  
Jelle Jolles ◽  
Frans J. Kok ◽  
...  
Keyword(s):  
Older Adults ◽  
Dna Methylation ◽  
Folic Acid ◽  
Cognitive Functioning ◽  
Cognitive Performance ◽  
Global Dna Methylation ◽  
Older Individuals ◽  
Healthy Older Adults ◽  
Study Results ◽  
The Relationship

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status and non-pathological cognitive functioning in human subjects has not yet been investigated. The present study investigated the associations between global DNA methylation and key domains of cognitive functioning in healthy older adults. Global DNA methylation, defined as the percentage of methylated cytosine to total cytosine, was measured in leucocytes by liquid chromatography–MS/MS, in 215 men and women, aged 50–70 years, who participated in the Folic Acid and Carotid Intima-Media Thickness (FACIT) study (clinical trial registration number NCT00110604). Cognitive performance was assessed by means of the Visual Verbal Word Learning Task, the Stroop Colour-Word Interference Test, the Concept Shifting Test, the Letter–Digit Substitution Test and the Verbal Fluency Test. Using hierarchical linear regression analyses adjusted for age, sex, level of education, alcohol consumption, smoking status, physical activity, erythrocyte folate concentration and 5,10-methylenetetrahydrofolate reductase 677 C → T genotype, we found that global DNA methylation was not related to cognitive performance on any of the domains measured. The present study results do not support the hypothesis that global DNA methylation, as measured in leucocytes, might be associated with cognitive functioning in healthy older individuals.

scholarly journals The Relationship Between a Baby's Age and Sleepiness in a Sample of Mothers

2021 ◽  
Vol 12 ◽  
Author(s):  
Mar Sánchez-García ◽  
María José Cantero ◽  
Eva Carvajal-Roca
Keyword(s):  
Sleep Quality ◽  
Sleep Duration ◽  
Daytime Sleepiness ◽  
Positive Relationship ◽  
Sleep Problems ◽  
Initial Period ◽  
Practical Importance ◽  
Sleep Disruption ◽  
Control Group ◽  
The Relationship

One question of great practical importance for the parents, and especially the mother, after the birth of a baby, refers to how long the time during which they have to go with less and more fragmented sleep actually lasts. Most of the studies only explore this issue up to 6 months of the newborn's life, and less is known about the sleep problems the mothers may have after this initial period. The objective of this study is to examine the relationship between the sleep disruption and daytime sleepiness of mothers with infants until 2 years old compared to a group of women currently not at care of babies. To this end, a sample of 113 women, 67 currently bringing up a baby of under 2 years old, and the remainder without a baby at their care under 6 years old, reported sleep duration, sleep interruptions, sleep quality, and responded to questionnaires of sleep quality and daytime sleepiness. The relationship between the age of the children and the comparison between the groups was used to highlight the sleep problems of the mothers taking care of the infant. The results showed that there was a positive relationship between the age of the infant and the duration of the sleep of the mothers and that the duration of sleep for them was similar to those of the women in the control group about 6 months after the infant was born. However, fragmentation of sleep, daytime sleepiness, and sleep problems were still higher than in the control group for mothers with children between 6 and 12 months old.

scholarly journals Good Sleep Quality Improves the Relationship Between Pain and Depression Among Individuals With Chronic Pain

2021 ◽  
Vol 12 ◽  
Author(s):  
Zoe Zambelli ◽  
Elizabeth J. Halstead ◽  
Antonio R. Fidalgo ◽  
Dagmara Dimitriou
Keyword(s):  
Chronic Pain ◽  
Sleep Quality ◽  
Sleep Problems ◽  
Pain Severity ◽  
Pain Interference ◽  
Poor Sleep ◽  
Regression Analyses ◽  
Cross Sectional Survey ◽  
The Relationship ◽  
Good Sleep

Individuals with chronic pain often experience co-existing sleep problems and depression-related states. Chronic pain, sleep problems, and depression interrelate, and have been shown to exacerbate one another, which negatively impacts quality of life. This study explored the relationships between pain severity, pain interference, sleep quality, and depression among individuals with chronic pain. Secondly, we tested whether sleep quality may moderate the relationship between pain and depression. A cross-sectional survey was completed by 1,059 adults with non-malignant chronic pain conditions (Mage 43 years, 88% identified as women) and collected measures related to pain severity, pain interference, sleep quality, and depression. Multiple regression analyses found that pain severity, pain interference, and sleep quality are all significantly associated with depression. Secondly, moderated regression analyses revealed that sleep quality moderates the relationship between pain interference and depression among individuals with chronic pain such that good sleep quality attenuates the effect of pain interference on depression, and poor sleep quality amplifies the effect of pain interference on depression. These findings suggest that sleep quality may be a relevant therapeutic target for individuals with chronic pain and co-existing depression.

scholarly journals Predictiveness of Covid-19 Anxiety and Emotion Regulation on Sleep Quality: The Moderator Effect of Gender

2021 ◽  
Vol 8 (4) ◽  
pp. 45-56
Author(s):  
İsmail YELPAZE
Keyword(s):  
Emotion Regulation ◽  
Sleep Quality ◽  
Online Survey ◽  
Sleep Problems ◽  
The Body ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Moderator Effect ◽  
The Relationship ◽  
Good Sleep

Prior research indicates that anxiety and emotion regulation are related to sleep quality. This study extends the body of research by investigating how people in different gender groups are affected by the coronavirus disease 2019 (Covid-19) anxiety and emotion regulation in terms of sleep quality. The present study examined gender as a potential moderating variable on the associations of Covid-19 anxiety and emotion regulation with sleep quality. University students were recruited via e-mail to participate in a brief online survey. Data were collected using the Pittsburgh Sleep Quality Index, Fear of COVID-19, and Emotion Management Skills Scale. The current study used SPSS PROCESS, an SPSS macro developed by Hayes. Results indicated that Covid-19 anxiety was related to poor sleep quality and emotion regulation was related to good sleep quality. Gender was a significant moderator for the relationship between Covid-19 anxiety and sleep quality, but not emotion regulation and sleep quality. The female gender presented a positive association between Covid-19 anxiety and poor sleep quality in comparison to the male gender. The relationship between emotion regulation and good sleep quality was found to be significant and positive for both genders. In the pandemic, Covid-19 anxiety should be reduced and people should have skills to manage their emotions. Otherwise, they will experience serious sleep problems.

scholarly journals CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders

Neurology ◽  
2018 ◽  
Vol 90 (12) ◽  
pp. e1038-e1046 ◽  
Author(s):  
David J. Irwin ◽  
Sharon X. Xie ◽  
David Coughlin ◽  
Naomi Nevler ◽  
Rizwan S. Akhtar ◽  
...  
Keyword(s):  
Lewy Body ◽  
Mean Difference ◽  
Csf Biomarkers ◽  
Cerebral Pathology ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Regression Diagnostic ◽  
Cortical Regions ◽  
And Control ◽  
T Tau

ObjectiveTo test the association of antemortem CSF biomarkers with postmortem pathology in Lewy body disorders (LBD).MethodsPatients with autopsy-confirmed LBD (n = 24) and autopsy-confirmed Alzheimer disease (AD) (n = 23) and cognitively normal (n = 36) controls were studied. In LBD, neuropathologic criteria defined Lewy body α-synuclein (SYN) stages with medium/high AD copathology (SYN + AD = 10) and low/no AD copathology (SYN − AD = 14). Ordinal pathology scores for tau, β-amyloid (Aβ), and SYN pathology were averaged across 7 cortical regions to obtain a global cerebral score for each pathology. CSF total tau (t-tau), phosphorylated tau at threonine181, and Aβ1-42 levels were compared between LBD and control groups and correlated with global cerebral pathology scores in LBD with linear regression. Diagnostic accuracy for postmortem categorization of LBD into SYN + AD vs SYN − AD or neocortical vs brainstem/limbic SYN stage was tested with receiver operating curves.ResultsSYN + AD had higher CSF t-tau (mean difference 27.0 ± 8.6 pg/mL) and lower Aβ1-42 (mean difference −84.0 ± 22.9 g/mL) compared to SYN − AD (p < 0.01, both). Increasing global cerebral tau and plaque scores were associated with higher CSF t-tau (R2 = 0.15–0.16, p < 0.05, both) and lower Aβ1-42 (R2 = 0.43–0.49, p < 0.001, both), while increasing cerebral SYN scores were associated with lower CSF Aβ1-42 (R2 = 0.31, p < 0.001) and higher CSF t-tau/Aβ1-42 ratio (R2 = 0.27, p = 0.01). CSF t-tau/Aβ1-42 ratio had 100% specificity and 90% sensitivity for SYN + AD, and CSF Aβ1-42 had 77% specificity and 82% sensitivity for neocortical SYN stage.ConclusionsHigher antemortem CSF t-tau/Aβ1-42 and lower Aβ1-42 levels are predictive of increasing cerebral AD and SYN pathology. These biomarkers may identify patients with LBD vulnerable to cortical SYN pathology who may benefit from both SYN and AD-targeted disease-modifying therapies.

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