scholarly journals Using Threshold Regression as an Approach to Incorporate Informative Missingness in Long Life Family Study Data

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 671-672
Author(s):  
Ilya Zhbannikov ◽  
Konstantin Arbeev ◽  
Olivia Bagley ◽  
Yuriy Loika ◽  
Alexander Kulminski ◽  
...  
Keyword(s):  
Latent Variables ◽  
Genome Wide Association Study ◽  
Family Study ◽  
Physiological State ◽  
Age Groups ◽  
P Value ◽  
Threshold Regression ◽  
Biomarkers Of Aging ◽  
Variant Gene ◽  
Long Life

Abstract Genetics of aging is important since aging is a major risk factor in most diseases. Variables describing physiological state and cognitive functioning that influence morbidity and mortality risks can serve as biomarkers of aging. They change with increasing age and the ways in which these variables change can also influence these risks. Missing data due to dropout or death create problems in longitudinal studies producing biased results especially if the gap between exams is relatively long, as is the case in the Long Life Family Study (LLFS). We applied the threshold regression model to LLFS data to investigate the vitality and its rate, which are conceptualized as latent variables characterizing health and longevity, and to cope with such a problem. We performed genome-wide association study by sex and age groups to discover genetic signals on these phenotypes. We found 11 variants from the DACT2 gene, p-values < 1E-6 and variants rs12151399 (p-value = 8.43E-8, intron variant, gene AGAP1, in females), rs27958 (p-value = 8.39E-8, intron variant, gene ARHGAP26, in males) showing associations with the vitality. Olfactory receptors showed significant enrichment among the group of males over 80 years for the rate of aging phenotype. Results showed that vitality and its rate differ among sex and age groups. This work is an important step toward understanding the processes of aging linking the vitality with individual genetics using data from deceased and living individuals.

scholarly journals REDUCED COGNITIVE DECLINE WITH THE APOE ε2/ε2 GENOTYPE IN THE LONG LIFE FAMILY STUDY AND NEW ENGLAND CENTENARIAN STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S621-S621
Author(s):  
Benjamin Sweigart ◽  
Benjamin Sweigart ◽  
Stacy L Andersen ◽  
Stephanie Cosentino ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cognitive Decline ◽  
New England ◽  
Repeated Measures ◽  
Family Study ◽  
Reference Group ◽  
Cognitive Status ◽  
P Value ◽  
Long Life ◽  
Rate Of Decline

Abstract A growing body of evidence has suggested a protective effect on cognition of the ε2 allele of APOE. To determine if APOE ε2 is associated with protection against cognitive decline, we analyzed repeated measures of the Telephone Interview for Cognitive Status (TICS) from 2,933 Long Life Family Study subjects and 679 New England Centenarian Study subjects using a multivariable linear mixed effects model. The median age at first TICS administration was 73 (interquartile range [IQR] 64, 83). Subjects had a median of 3 TICS assessments (IQR 2, 4) and a median follow-up time of 5.0 years (IQR 2.9, 7.0). Carriers of the ε2/ε2 genotype had a significantly slower rate of decline in TICS score compared to the ε3/ε3 reference group (-0.05 points per annum for ε2/ε2 carriers compared with -0.15 points for ε3/ε3 carriers, p-value for difference 0.017). These results support a protective effect of the ε2 allele.

scholarly journals ASSESSING THE RELATIONSHIP BETWEEN SERUM IGF-1 AND ADIPOSITY BY AGE IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S257-S257
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
Total Sample ◽  
Age Cohorts ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
Underlying Mechanisms ◽  
The Relationship

Abstract Serum levels of insulin-like growth factor 1 (IGF-1) and measures of adiposity, such as body mass index (BMI), are associated with susceptibility to age-related diseases. Previous reports of the relationship between IGF-1 and BMI ranged from positive to negative to no relationship, perhaps because previous reports studied different age cohorts. Using data on 4270 participants (aged 24-110 years) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI overall and by age groups. IGF-1 and BMI were positively correlated in the total sample (β=0.161, r2= 0.0038, p=1.8-05). However, further analyses revealed that the relationship between IGF-1 and BMI varied by age quartile: in the 1st quartile (24-58yo) the relationship was negative (β=−0.204, r2= 0.011, p=0.0008); in the 2nd quartile (59-66yo) the relationship was negative but non-significant (β=−0.069, r2= 0.0012, p=0.28); in the 3rd quartile (67-86yo) the relationship was positive but non-significant (β=0.106, r2= 0.002, p=0.13); and in the 4th quartile (87-110yo) the relationship was positive (β=0.388, r2= 0.019, p=1.2−05). This pattern did not differ by sex. We also detected a similar age-related pattern between IGF-1 and BMI using an independent dataset (NHANES III), comprising 2550 men and women aged 20-90 years. Our results may clarify some of the inconsistency in previous literature about the relationship between IGF-1 and BMI. Additional studies of IGF-1 and adiposity measures are needed to better understand the underlying mechanisms involved.

scholarly journals Relationship Between Serum IGF-1 and BMI Differs by Age

2020 ◽  
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana V Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

Abstract Background Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Methods Using data on 4241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis. Results When stratified by age quartile, the relationship between IGF-1 and BMI varied: in the first quartile (Q1, 20–58 years) the relationship was negative (β = −0.2, p = .002); in Q2 (58–66 years) and Q3 (67–86 years) the relationship was negative (β = −0.07, β = −0.01, respectively) but nonsignificant; and in Q4 (87–110 years) the relationship was positive (β = 0.31, p = .0002). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey. Conclusions Our results that the relationship between IGF-1 and BMI differs by age may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

scholarly journals Genome-Wide Association Study of Personality Traits in the Long Life Family Study

2013 ◽  
Vol 4 ◽  
Author(s):  
Harold T. Bae ◽  
Paola Sebastiani ◽  
Jenny X. Sun ◽  
Stacy L. Andersen ◽  
E. Warwick Daw ◽  
...  
Keyword(s):  
Personality Traits ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Family Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Long Life

scholarly journals GENOME-WIDE ASSOCIATION STUDY OF A HEALTHY METABOLIC PHENOTYPE IN THE LONG LIFE FAMILY STUDY

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 272-272
Author(s):  
M Marron ◽  
I Miljkovic ◽  
M Wojczynski ◽  
R Boudreau ◽  
K Christensen ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Family Study ◽  
Genome Wide Association ◽  
Metabolic Phenotype ◽  
Genome Wide ◽  
Long Life

scholarly journals Assessing the Relationship between Serum IGF-1 and BMI by Age in the Long Life Family Study

2020 ◽  
Author(s):  
Rehab A. Sherlala ◽  
Candace M. Kammerer ◽  
Allison L. Kuipers ◽  
Mary K. Wojczynski ◽  
Svetlana V. Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

AbstractBackgroundSerum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies.MethodsUsing data on 4,241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis.ResultsWhen stratified by age quartile, the correlation between IGF-1 and BMI varied: in the 1st quartile (Q1, 24 y–58 y) the correlation was negative (r = −0.1, P = 0.0008); in Q2 (59 y– 66 y) it was negative (r = −0.035) but non-significant; in Q3 (67 y–86 y) it was positive (r = 0.045) but non-significant; and in Q4 (87 y–110 y) the correlation was positive (r = 0.14, P < 0.0001). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey.ConclusionsOur results, that the relationship between IGF-1 and BMI differs by age, may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

TO STUDY THE DYNAMICS OF IMMUNITY IN BLACK-AND-WHITE COWS DEPENDING ON AGE

2020 ◽  
pp. 49-52
Author(s):  
М.В. ДОВЫДЕНКОВА
Keyword(s):  
Bactericidal Activity ◽  
Phagocytic Activity ◽  
Physiological State ◽  
Age Groups ◽  
Statistical Processing ◽  
Natural Resistance ◽  
Black And White ◽  
Feeding Methods ◽  
High Degree ◽  
The Relationship

Проведена статистическая обработка сформированной базы данных показателей неспецифической резистентности MS «Excel» с целью изучения динамики иммунитета по параметрам бактерицидной, лизоцимной и фагоцитарной активности у крупного рогатого скота черно-пестрой породы разных возрастов. Было установлено, что средние значения показателей лизоцимной и бактерицидной активности у телят в 6 мес были ниже (47,89% и 49,09%, соответственно), чем у животных в 3—4 года (53,75% и 52,81%). Выведено уравнение регрессии, описывающее взаимосвязь между средними показателями фагоцитарной активности и возрастом при высокой степени достоверности (R2=0,90). Изменения лизоцимной и бактерицидной активности в зависимости от возраста были недостоверными (R2=0,58 и R2=0,49, соответственно). Установлена высокая корреляция между бактерицидной и лизоцимной активностью. Отмечена динамика изменения неспецифического иммунитета у коров различных возрастных групп. Создание баз данных и постоянный мониторинг основных показателей естественной резистентности в зависимости от различных факторов (породы, возраста, стадий лактации, кормления, способов содержания), которые влияют на данные показатели, необходимо для оценки физиологического состояния организма животных и их устойчивости к болезням. Statistical processing of the generated MS "Excel" on indicators of non-specific resistance database was carried out with the aim of studying the dynamics of the development of immunity in terms of bactericidal, lysozyme and phagocytic activity in black-and-white cattle of different ages. It was found that the average values of indicators of lysozyme and bactericidal activity in calves at 6 months were lower (47.89% and 49.09%, respectively) than in animals at the age of 3—4 years (53.75% and 52.81%). The equation of regression was derived, it describes the relationship between the average indicators of phagocytic activity and the age with a high degree of reliability (R2=0.90). The changes in lysozyme and bactericidal activity depending on age were dubious (R2=0.58 and R2=0.49, respectively). The high correlation between bactericidal and lysozyme activity was established. It was noticed that the cows of different age groups experienced the dynamics of changes in nonspecific immunity. The creation of databases and constant monitoring of the main indicators of natural resistance, depending on various factors (breed, age, stages of lactation, feeding, methods of keeping) that affect these indicators, is necessary for assessing the physiological state of the animals’ body of and their resistance to diseases.

The Prevalence of Insecticide Treated Net/malaria :cross section study (Preprint)

2019 ◽  
Author(s):  
Chanda Chalela
Keyword(s):  
Study Design ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Malaria Prevalence ◽  
Malaria Patient ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Itn Use ◽  
Structured Questionnaire

BACKGROUND ABSTRACT Introduction a study on prevalence of ITN use was carried out in Buchi community Kitwe Zambia from August to October 2019 OBJECTIVE Prevalence of ITN in BUchi METHODS Methodology: This was a cross sectional study design. A structured questionnaire was used to ascertain ownership and utilization and oral interviews, 200 households were targeted 844 individual covered across the 200 households. Data was analyzed with SPSS version 23. RESULTS ABSTRACT Introduction a study on prevalence of ITN use was carried out in Buchi community Kitwe Zambia from August to October 2019 Methodology: This was a cross sectional study design. A structured questionnaire was used to ascertain ownership and utilization and oral interviews, 200 households were targeted 844 individual covered across the 200 households. Data was analyzed with SPSS version 23. Findings: household ownership of at least an ITN was 52% and individual utilization at 37.6%, with 0.825 ITN/households and 0.195ITN /individual. Malaria prevalence of 52.4% /household and a 12.4% of the population. With 47.6% malaria patient coming from households with ITN and 60% of households with ITN have insufficient coverage.61% of malaria patient were female and 31 % male. however there was no significant relation between Gender and malaria prevalence in study area (p value was >0.05). Malaria cases distribution with age groups, 0-15yrs old represented 49.5%, 16-30 yrs., was at 27.6% and the over 30 yrs. case were at 22.9% .use of other preventive measures 23% used mosquito repellent ,others methods 1% with those not using any other methods 76%. CONCLUSIONS Conclusion The study showed clearly that malaria still poses a problem .the prevalence rate of malaria was still high 12.4% of the population and 52.4% of households. With high prevalence of malaria of 49.5% for 0-15yrs.the difference between ownership 52% and Utilization 37.6% showed that even household with ITN, the ITN were not sufficient.60% of households with ITN, the ITN were not sufficient for all occupants

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in hospitalized patients at a tertiary referral center in North India (Preprint)

2020 ◽  
Author(s):  
Dr. Animesh Ray ◽  
Dr. Komal Singh ◽  
Souvick Chattopadhyay ◽  
Farha Mehdi ◽  
Dr. Gaurav Batra ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Age Groups ◽  
Hospitalized Patients ◽  
North India ◽  
P Value ◽  
Care Hospital ◽  
Igg Antibodies ◽  
Igg Antibody ◽  
Increased Risk ◽  
Significant Difference

BACKGROUND Seroprevalence of IgG antibodies against SARS-CoV-2 is an important tool to estimate the true extent of infection in a population. However, seroprevalence studies have been scarce in South East Asia including India, which, as of now, carries the third largest burden of confirmed cases in the world. The present study aimed to estimate the seroprevalence of anti-SARS-CoV-2 IgG antibody among hospitalized patients at one of the largest government hospital in India OBJECTIVE The primary objective of this study is to estimate the seroprevalence of SARS-CoV-2 antibody among patients admitted to the Medicine ward and ICU METHODS This cross-sectional study, conducted at a tertiary care hospital in North India, recruited consecutive patients who were negative for SARS-CoV-2 by RT-PCR or CB-NAAT. Anti-SARS-CoV-2 IgG antibody levels targeting recombinant spike receptor-binding domain (RBD) protein of SARS CoV-2 were estimated in serum sample by the ELISA method RESULTS A total of 212 hospitalized patients were recruited in the study with mean age (±SD) of 41.2 (±15.4) years and 55% male population. Positive serology against SARS CoV-2 was detected in 19.8%patients(95% CI 14.7-25.8). Residency in Delhi conferred a higher frequency of seropositivity 26.5% (95% CI 19.3-34.7) as compared to that of other states 8% (95% CI 3.0-16.4) with p-value 0.001. No particular age groups or socio-economic strata showed a higher proportion of seropositivity CONCLUSIONS Around, one-fifth of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2. While there was no significant difference in the different age groups and socio-economic classes; residence in Delhi was associated with increased risk (relative risk of 3.62, 95% CI 1.59-8.21)

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