Dietary Potential Renal Acid Load Is Positively Associated with Serum Uric Acid and Odds of Hyperuricemia in the German Adult Population

Purpose Recent studies have shown that hyperuricemia is a predictor of non-communicable disease and an increment of mortality rate. Also, elevated serum uric acid may be associated with obesity in the adult population. This study aims to evaluate the association between serum uric acid levels with metabolic parameters and risk of obesity in the Iranian population. Design/methodology/approach The cross-sectional study was done on 550 participants, who were referred to a hospital for elective angiography in Rasht, Iran; anthropometric indices (waist circumference (WC) and body mass index (BMI)) and hematological factors were measured using the standard approaches. Based to the angiography results, the severity of atherosclerosis was defined. Findings The mean (SD) concentration of serum uric acid for all participants was 5.15 (1.37) mg/dl. Individuals who were at the highest tertile had higher mean (SD) of weight (p = 0.004), creatinine and blood urea nitrogen (p < 0.001) lower fasting blood sugar (FBS) (p = 0.000) and HbA1c (p = 0.016), and they were mostly men compared with those in the lowest tertile. After adjusting for confounders, FBS (ß = –0.145, p = 0.001) and HbA1c (%) (ß = –0.130, p = 0.019) had inverse and weight (ß = 0.156, p = 0.001) had direct association with serum uric acid. After adjustment for additionally potential confounders subjects in the highest tertile of serum uric acid had 92 per cent higher chance of obesity compared with subjects in the lowest tertile (OR 1.92; 95 per cent CI 1.13, 3.23). Originality/value The present study has concluded that increase serum uric acid related to high risk of obesity and low mean of FBS and HbA1c.

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Role of Kalmegha (Andrographis paniculata (Burm.F.) Wall. Ex Nees) in treating Vatarakta (Gout)

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i6.2024 ◽

2018 ◽

Vol 8 (6) ◽

pp. 98-101

Author(s):

Harsh Sehgal ◽

Bhavna Singh ◽

Sanandan Thapliyal

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Skin Diseases ◽

Adult Population ◽

Gouty Arthritis ◽

Andrographis Paniculata ◽

P Value ◽

Objective Parameter ◽

Wide Range ◽

Anti Cancer

Andrographis paniculata (Burm.f.) Wall. Ex. Nees (A. Paniculata), i.e. Kalmegha is a medicinal plant traditionally used for various diseases such as fever, diarrhea, worm infestation, hepatic and skin diseases. Modern studies have also explicitly revealed that A. Paniculata has a wide range of pharmacological effects such as anti-inflammatory, anti-hyperglycemic, anti-diarrhoeal, anti-viral, anti-malarial, hepato-protective, anti-cancer, anti-human immunodeficiency virus (HIV), and also work as an immune stimulator. On the other hand, Gout (Vatarakta) is one common metabolic disorder which affects over 1% of the world’s adult population. Objective: To assess the clinical efficacy of A.Paniculata in Gouty Arthritis. Study Design: A clinical research, prospective in style, wherein a hypothesis, based on the previous studies on the various effects of A. Paniculata, was made; to assess its efficacy in treating Gout. Methodology: Randomly selected patients (n = 31) were administered powder of A. Paniculata, 2 gms thrice daily with water, for 45 days with a follow-up in every 15 days for one month. Assessment of the treatment was based on before treatment (BT) and after treatment (AT) effects of A. Paniculata on the parameters namely; subjective, i.e. the symptoms of Gout and objective, i.e. the levels of Serum Uric Acid. Results: In subjective parameters, Wilcoxon non-parametric test was used. The outcome shows that except the symptom i.e. Pallor (shwetata), in all other symptoms of Gout, p value was either < 0.05 or < 0.01, which is considered to be significant to highly significant. In objective parameter, Z test was used, in which the outcome of p value was < 0.01, which indicates that the effect of A.Paniculata on Serum Uric Acid is highly significant. Keywords: Kalmegha, Andrographis paniculata, Gout, Vatarakta, Serum Uric Acid, Clinical Studies

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Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults

Scientific Reports ◽

10.1038/s41598-021-99623-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Noyan Hossain Molla ◽

Rahanuma Raihanu Kathak ◽

Abu Hasan Sumon ◽

Zitu Barman ◽

Ananya Dutta Mou ◽

...

Keyword(s):

Uric Acid ◽

General Population ◽

Serum Uric Acid ◽

Liver Enzymes ◽

Multinomial Logistic Regression ◽

Adult Population ◽

Enzymes Activity ◽

Significant Difference ◽

The Mean ◽

The Relationship

AbstractSerum uric acid (SUA) level has been suggested to be associated with cardiovascular disease, diabetes and metabolic syndrome. However, little is known about the relationship between SUA and liver enzymes activity in the general population. The present study aimed to assess the relationship between SUA and serum liver enzymes in an adult population in Bangladesh. In this cross-sectional study, a total of 410 blood samples were collected from apparently healthy adults aged > 18 years. SUA, liver enzymes, lipid profile and other biochemical markers were measured in the collected samples by using standard methods. Multinomial logistic regression model was used to assess the relationship between SUA and elevated levels of liver enzymes among the participants. Overall, the prevalence of hyperuricemia was 30.1% with 32.2% in male and 18.6% in female participants. About 33% of the participants had at least one or more elevated levels of liver enzymes. The mean level of SUA was significantly higher in males (389.3 ± 96.9 µmol/L) than in the female (290.4 ± 89.8 µmol/L) subjects (p < 0.001). There was a significant difference in the mean levels of serum ALT and GGT between the male (34.5 ± 16.0 U/L and 26.7 ± 19.5 U/L, respectively) and female (25.0 ± 13.0 U/L and 19.5 ± 13.2 U/L, respectively) participants (p < 0.001 and p < 0.01, respectively). An increasing trend was observed in the mean levels of serum ALT and GGT across the SUA quartile groups (p < 0.001 and p < 0.01, respectively). SUA showed a positive and significant correlation with serum ALT (p < 0.001) and GGT (p < 0.01). In further statistical analysis after adjustment for potential confounders, SUA showed an independent and significant association with serum ALT and GGT in all regression models. In conclusion, SUA was strongly associated with serum levels of ALT and GGT after adjustment for potential confounders. More prospective studies are needed to clarify the complex relationship between SUA and liver enzymes in the general population.

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Dietary Acid Load and Potassium Intake Associate with Blood Pressure and Hypertension Prevalence in a Representative Sample of the German Adult Population

Nutrients ◽

10.3390/nu10010103 ◽

2018 ◽

Vol 10 (1) ◽

pp. 103 ◽

Cited By ~ 14

Author(s):

Danika Krupp ◽

Jonas Esche ◽

Gert Mensink ◽

Stefanie Klenow ◽

Michael Thamm ◽

...

Keyword(s):

Blood Pressure ◽

Representative Sample ◽

Adult Population ◽

Dietary Acid Load ◽

Potassium Intake ◽

Hypertension Prevalence ◽

Dietary Acid ◽

Acid Load ◽

German Adult

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Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

Journal of Clinical Hypertension ◽

10.1111/jch.13847 ◽

2020 ◽

Vol 22 (5) ◽

pp. 897-905

Author(s):

Alena Krajčoviechová ◽

Peter Wohlfahrt ◽

Jan Bruthans ◽

Pavel Šulc ◽

Věra Lánská ◽

...

Keyword(s):

Uric Acid ◽

Cardiovascular Risk ◽

Serum Uric Acid ◽

Adult Population ◽

General Adult Population

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Association of Hyperuricemia with Coronary Artery Disease in Gulab Devi Chest Hospital

The International Journal of Frontier Sciences ◽

10.37978/tijfs.v1i2.20 ◽

2017 ◽

Vol 1 (2) ◽

pp. 17-25

Author(s):

Aqsa Rasheed ◽

Majid Kaleem

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Heart Disease ◽

Coronary Artery ◽

Ischemic Heart Disease ◽

Serum Uric Acid ◽

Adult Population ◽

Ischemic Heart ◽

Cross Sectional ◽

Artery Disease

AbstractBackground: Coronary artery disease is the most common and life threatening cardiac emergency presenting to a hospital. Having significant mortality and morbidity are on the rise in Pakistan. The objective of the study is to examine the association of elevated level of serum uric acid with ischemic heart disease among adult population, to guide planning for primary and secondary prevention of this disease in community.Subjects and Methods: This cross-sectional study studied 110 consecutive patients from 20-80 years of age presenting with IHD (Myocardial infarction, unstable angina). All the subjects who were approached to participate in the study, gave their consent. Face-to-face interviews were conducted using a structured questionnaire followed by laboratory tests.Results: Association of serum uric acid were lined up as gender, smoking, hypertension, diabetes mellitus, menopause, dyslipidemia, family history and obesity. In this study, out of 110 patients 35 (32%) were females and 74 (68%) were males. Minimum Age of patients in this study was 30 years and maximum age was 70 years This study revealed that chest pain was the most occurring symptom which was observed in 39 patients which are 35.45% of the total patients and the second most occurring symptom was Dyspnea which was observed in 32 patients which 29.09% of the total patients. The study reveals that the major risk factor observed in CAD patients is ‘HTN’ which was found in 81 patients which are 73.64% of the total patients. However, ‘Smoking’ and ‘DM’ are proximate in occurrence and were found in 59 (53.64%) and 56 (50.91%) patients respectively. The study revealed that hyperuricemia was more in males that was 34(22.67) than in females.Conclusion: This study concluded that there was no significant association between hyperuricemia with ischemic heart disease.

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P6230Gender disparities in serum uric acid levels associated increased cardiovascular risk. The Czech Post-MONICA study

European Heart Journal ◽

10.1093/eurheartj/ehz746.0832 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

A Krajcoviechova ◽

J Bruthans ◽

P Wohlfahrt ◽

P Sulc ◽

R Cifkova

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Roc Curve ◽

Adult Population ◽

Risk Category ◽

Gamma Glutamyl Transferase ◽

Roc Curve Analysis ◽

The Past ◽

Glutamyl Transferase ◽

Very High

Abstract Background Recent European Society of Hypertension (ESH) guidelines have implemented serum uric acid (SUA) levels as cardiovascular (CV) risk factor and recommend routine SUA levels measurement in hypertensive patients. However, what is the appropriate SUA level threshold and whether all patients with so called asymptomatic hyperuricemia should be treated remain unclear. Objective To evaluate longitudinal trends and determinants of mean serum uric acid (SUA) levels in two representative Czech population surveys (2006–09 and 2015–18) and to determine the SUA levels associated with increased 10-year risk of cardiovascular (CV) death. Methods Two independent cross-sectional surveys of major CV risk factors were performed in the Czech Republic in 2006–09 and 2015–18; 1% percent random samples aged 25–64 years stratified by age and gender were examined. The number of participants was 3612 in 2006–09, and 2621 in 2015–18. Ten-year risk of CV death was categorized using the SCORE algorithm as low (<1%), intermediate (1% to <5%), high (≥5% to 10%), and very high (≥10%). Results Final analyses included 3542 individuals (48.2% men; mean age 47.1±11.3) in 2006–09, and 2304 individuals (47.4% men; mean age 47.9±10.9) in 2015–18. Over the past decade, there was a highly significant increase in SUA levels (μmol/l) from 344.6±81.1 to 374.4±73.3 in men, and from 250.1±73.8 to 278.9±66.1 in women. In gender-specific multivariate linear regression analyses conducted in the 2015–18 survey, SUA levels increased with use of diuretics, an increase in waist-to-height ratio, serum triglycerides, and aspartate aminotransferase, and a decrease in estimated glomerular filtration rate in both genders, whereas in men SUA levels increased also with an increase in quartiles of alcohol intake and gamma-glutamyl transferase, and a decrease in glycated haemoglobin. When analysing pooled data of the two surveys, mean SUA levels increased with each increase in 10-year CV risk category in women (P<0.001), but not in men (P=0.21). In receiver operating characteristic (ROC) curve analysis, the cut-off value of SUA levels discriminating between low/intermediate and high/very high CV risk category in women was 306 μmol/l (sensitivity 53%; specificity 82%; area under the ROC curve 0.713 [95% CI 0.683–0.743]). Conclusions Over the past decade, there was a significant increase in uricemia in the Czech adult population. However, increasing SUA levels were associated with increased 10-year CV death risk only in women. The SUA levels associated with high/very high CV risk were substantially lower in Czech women than the currently used cut-off values for hyperuricemia. Acknowledgement/Funding Grant number 15-27109A from Czech health research council

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Association of Serum Uric Acid Levels with Components of Metabolic Syndrome: A Cross-Sectional Analysis in a Saudi Adult Population

International Journal of Biomedicine ◽

10.21103/article10(4)_oa25 ◽

2020 ◽

Vol 10 (4) ◽

pp. 457-466

Author(s):

Manal Fawzy ◽

Baraah. Abu AlSel

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Adult Population ◽

Population Sample ◽

Cross Sectional Study ◽

Cross Sectional ◽

Mean Values ◽

Study Population ◽

Sectional Analysis

Background: This study aimed to investigate the possible relations between serum uric acid (UA) and metabolic syndrome (MetS) and its components in a Saudi adult population sample. Methods and Results: This cross-sectional study enrolled consecutive adult MetS and non-MetS subjects (90 subjects in each group). Glycemic control indices (fasting blood sugar (FBS), HbA1c, insulin, HOMA-IR index), lipid profile/ratios, and renal function tests were also evaluated. Findings showed that serum UA was significantly higher in the MetS group (322±98.9) than non-MetS group (286±61.2) μmol/L. The fourth quartile of serum UA showed a higher frequency of MetS (73.3%) and central obesity (82.2%), and higher mean values of TG and FBS as well as lower mean values for HDL-C relative to the first quartiles. Data stratification by sex showed consistent associations of BMI, abdominal obesity, HDL-C, TG/HDL-C, and serum creatinine levels with serum UA in both men and women. Serum UA at 310 μmol/L concentration might be a good predictor for MetS/its components in men. In contrast, at a cut-off level of 275.0 μmol/L, it could significantly predict only obesity and high FBS in women. Conclusion: Serum UA levels are associated with MetS and may predict MetS and/or its components at specific levels in a sex-dependent pattern in the study population.

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