scholarly journals Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping

2018 ◽  
Vol 4 (10) ◽  
pp. eaau2426 ◽  
Author(s):  
Wonryung Lee ◽  
Shingo Kobayashi ◽  
Masase Nagase ◽  
Yasutoshi Jimbo ◽  
Itsuro Saito ◽  
...  

High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one of the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts with the surface of organs and to measure propagation of electrophysiological signals with high spatial-temporal resolution; however, plastic substrates have high Young’s modulus, causing difficulties in creating appropriate stretchability and blood compatibility for applying them on the dynamically moving and surgical bleeding surface of the heart. Here, we have successfully fabricated an active MEA that simultaneously achieves nonthrombogenicity, stretchability, and stability, which allows long-term electrocardiographic (ECG) monitoring of the dynamically moving hearts of rats even with capillary bleeding. Because of the active data readout, the measured ECG signals exhibit a high signal-to-noise ratio of 52 dB. The novel stretchable MEA is carefully designed using state-of-the-art engineering techniques by combining extraordinarily high gain organic electrochemical transistors processed on microgrid substrates and a coating of poly(3-methoxypropyl acrylate), which exhibits significant antithrombotic properties while maintaining excellent ionic conductivity.

2018 ◽  
Author(s):  
Satish Kodali ◽  
Liangshan Chen ◽  
Yuting Wei ◽  
Tanya Schaeffer ◽  
Chong Khiam Oh

Abstract Optical beam induced resistance change (OBIRCH) is a very well-adapted technique for static fault isolation in the semiconductor industry. Novel low current OBIRCH amplifier is used to facilitate safe test condition requirements for advanced nodes. This paper shows the differences between the earlier and novel generation OBIRCH amplifiers. Ring oscillator high standby leakage samples are analyzed using the novel generation amplifier. High signal to noise ratio at applied low bias and current levels on device under test are shown on various samples. Further, a metric to demonstrate the SNR to device performance is also discussed. OBIRCH analysis is performed on all the three samples for nanoprobing of, and physical characterization on, the leakage. The resulting spots were calibrated and classified. It is noted that the calibration metric can be successfully used for the first time to estimate the relative threshold voltage of individual transistors in advanced process nodes.


2015 ◽  
Vol 7 (3) ◽  
pp. 300-303
Author(s):  
Andrius Gudiškis

This paper proposes an algorithm to reduce the noise distortion influence in heartbeat annotation detection in electrocardiogram (ECG) signals. Boundary estimation module is based on energy detector. Heartbeat detection is usually performed by QRS detectors that are able to find QRS regions in a ECG signal that are a direct representation of a heartbeat. However, QRS performs as intended only in cases where ECG signals have high signal to noise ratio, when there are more noticeable signal distortion detectors accuracy decreases. Proposed algorithm uses additional data, taken from arterial blood pressure signal which was recorded in parallel to ECG signal, and uses it to support the QRS detection process in distorted signal areas. Proposed algorithm performs as well as classical QRS detectors in cases where signal to noise ratio is high, compared to the heartbeat annotations provided by experts. In signals with considerably lower signal to noise ratio proposed algorithm improved the detection accuracy to up to 6%. Širdies ritmas yra vienas svarbiausių ir daugiausia informacijos apie pacientų būklę teikiančių fiziologinių parametrų. Širdies ritmas nustatomas iš elektrokardiogramos (EKG), atliekant QRS regionų, kurie yra interpretuojami kaip širdies dūžio ãtskaitos, paiešką. QRS regionų aptikimas yra klasikinis uždavinys, nagrinėjamas jau keletą dešimtmečių, todėl širdies dūžių nustatymo iš EKG signalų metodų yra labai daug. Deja, šie metodai tikslūs ir patikimi tik esant dideliam signalo ir triukšmo santykiui. Kai EKG signalai labai iškraipomi, QRS aptiktuvai ne visada gali atskirti QRS regioną, o kartais jį randa ten, kur iš tikro jo būti neturėtų. Straipsnyje siūlomas algoritmas, kurį taikant sumažinama triukšmo įtaka nustatant iš EKG signalų QRS regionus. Tam naudojamas QRS aptiktuvas, kartu prognozuojantis širdies dūžio atskaitą. Remiamasi arterinio kraujo spaudimo signalo duomenimis, renkama atskaitų statistika ir atliekama jos analizė.


Author(s):  
Ananya Dastidar ◽  
Damodar Panigrahy

The Fetal Electrocardiogram (FECG) signal reflects the electrical activity of the fetal heart. It contains information about the health status of the Fetus and therefore, an early diagnosis of any cardiac defects before delivery increases the effectiveness of the appropriate treatment. This paper proposes the use of Adaptive Neuro Fuzzy Inference Systems (ANFIS) for Fetal Electrocardiogram (FECG) extraction from two ECG signals recorded at the Thoracic and Abdominal areas of the mother’s skin. Wavelet transform is performed on ANFIS output to extract pure FECG with high Signal to Noise Ratio (SNR) and low error rate. The effectiveness of this technique is underlined in this paper.


2020 ◽  
Vol 64 (1-4) ◽  
pp. 951-958
Author(s):  
Tianhao Liu ◽  
Yu Jin ◽  
Cuixiang Pei ◽  
Jie Han ◽  
Zhenmao Chen

Small-diameter tubes that are widely used in petroleum industries and power plants experience corrosion during long-term services. In this paper, a compact inserted guided-wave EMAT with a pulsed electromagnet is proposed for small-diameter tube inspection. The proposed transducer is noncontact, compact with high signal-to-noise ratio and unattractive to ferromagnetic tubes. The proposed EMAT is designed with coils-only configuration, which consists of a pulsed electromagnet and a meander pulser/receiver coil. Both the numerical simulation and experimental results validate its feasibility on generating and receiving L(0,2) mode guided wave. The parameters for driving the proposed EMAT are optimized by performance testing. Finally, feasibility on quantification evaluation for corrosion defects was verified by experiments.


Nanophotonics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 2569-2576 ◽  
Author(s):  
Lu Li ◽  
Lihui Pang ◽  
Qiyi Zhao ◽  
Yao Wang ◽  
Wenjun Liu

AbstractTransition metal dichalcogenides have been widely utilized as nonlinear optical materials for laser pulse generation applications. Herein, we study the nonlinear optical properties of a VS2-based optical device and its application as a new saturable absorber (SA) for high-power pulse generation. Few-layer VS2 nanosheets are deposited on the tapered region of a microfiber to form an SA device, which shows a modulation depth of 40.52%. After incorporating the microfiber-VS2 SA into an Er-doped fiber laser cavity, passively Q-switched pulse trains could be obtained with repetition rates varying from 95 to 233 kHz. Under the pump power of 890 mW, the largest output power and shortest pulse duration are measured to be 43 mW and 854 ns, respectively. The high signal-to-noise ratio of 60 dB confirms the excellent stability of the Q-switching state. To the best of our knolowdge, this is the first illustration of using VS2 as an SA. Our experimental results demonstrate that VS2 nanomaterials have a large potential for nonlinear optics applications.


2021 ◽  
Vol 11 (4) ◽  
pp. 1591
Author(s):  
Ruixia Liu ◽  
Minglei Shu ◽  
Changfang Chen

The electrocardiogram (ECG) is widely used for the diagnosis of heart diseases. However, ECG signals are easily contaminated by different noises. This paper presents efficient denoising and compressed sensing (CS) schemes for ECG signals based on basis pursuit (BP). In the process of signal denoising and reconstruction, the low-pass filtering method and alternating direction method of multipliers (ADMM) optimization algorithm are used. This method introduces dual variables, adds a secondary penalty term, and reduces constraint conditions through alternate optimization to optimize the original variable and the dual variable at the same time. This algorithm is able to remove both baseline wander and Gaussian white noise. The effectiveness of the algorithm is validated through the records of the MIT-BIH arrhythmia database. The simulations show that the proposed ADMM-based method performs better in ECG denoising. Furthermore, this algorithm keeps the details of the ECG signal in reconstruction and achieves higher signal-to-noise ratio (SNR) and smaller mean square error (MSE).


2021 ◽  
Vol 13 (1) ◽  
pp. 168781402098732
Author(s):  
Ayisha Nayyar ◽  
Ummul Baneen ◽  
Syed Abbas Zilqurnain Naqvi ◽  
Muhammad Ahsan

Localizing small damages often requires sensors be mounted in the proximity of damage to obtain high Signal-to-Noise Ratio in system frequency response to input excitation. The proximity requirement limits the applicability of existing schemes for low-severity damage detection as an estimate of damage location may not be known  a priori. In this work it is shown that spatial locality is not a fundamental impediment; multiple small damages can still be detected with high accuracy provided that the frequency range beyond the first five natural frequencies is utilized in the Frequency response functions (FRF) curvature method. The proposed method presented in this paper applies sensitivity analysis to systematically unearth frequency ranges capable of elevating damage index peak at correct damage locations. It is a baseline-free method that employs a smoothing polynomial to emulate reference curvatures for the undamaged structure. Numerical simulation of steel-beam shows that small multiple damages of severity as low as 5% can be reliably detected by including frequency range covering 5–10th natural frequencies. The efficacy of the scheme is also experimentally validated for the same beam. It is also found that a simple noise filtration scheme such as a Gaussian moving average filter can adequately remove false peaks from the damage index profile.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Francesco Giganti ◽  
Alex Kirkham ◽  
Veeru Kasivisvanathan ◽  
Marianthi-Vasiliki Papoutsaki ◽  
Shonit Punwani ◽  
...  

AbstractProstate magnetic resonance imaging (MRI) of high diagnostic quality is a key determinant for either detection or exclusion of prostate cancer. Adequate high spatial resolution on T2-weighted imaging, good diffusion-weighted imaging and dynamic contrast-enhanced sequences of high signal-to-noise ratio are the prerequisite for a high-quality MRI study of the prostate. The Prostate Imaging Quality (PI-QUAL) score was created to assess the diagnostic quality of a scan against a set of objective criteria as per Prostate Imaging-Reporting and Data System recommendations, together with criteria obtained from the image. The PI-QUAL score is a 1-to-5 scale where a score of 1 indicates that all MR sequences (T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced sequences) are below the minimum standard of diagnostic quality, a score of 3 means that the scan is of sufficient diagnostic quality, and a score of 5 implies that all three sequences are of optimal diagnostic quality. The purpose of this educational review is to provide a practical guide to assess the quality of prostate MRI using PI-QUAL and to familiarise the radiologist and all those involved in prostate MRI with this scoring system. A variety of images are also presented to demonstrate the difference between suboptimal and good prostate MR scans.


Nanophotonics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 3443-3450 ◽  
Author(s):  
Wei-Nan Liu ◽  
Rui Chen ◽  
Wei-Yi Shi ◽  
Ke-Bo Zeng ◽  
Fu-Li Zhao ◽  
...  

AbstractSelective transmission or filtering always responds to either frequency or incident angle, so as hardly to maximize signal-to-noise ratio in communication, detection and sensing. Here, we propose compact meta-filters of narrow-frequency sharp-angular transmission peak along with broad omnidirectional reflection sidebands, in all-dielectric cascaded subwavelength meta-gratings. The inherent collective resonance of waveguide-array modes and thin film approximation of meta-grating are employed as the design strategy. A unity transmission peak, locating at the incident angle of 44.4° and the center wavelength of 1550 nm, is demonstrated in a silicon meta-filter consisting of two-layer silicon rectangular meta-grating. These findings provide possibilities in cascaded meta-gratings spectroscopic design and alternative utilities for high signal-to-noise ratio applications in focus-free spatial filtering and anti-noise systems in telecommunications.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yazhou Wang ◽  
Yuyang Feng ◽  
Abubakar I. Adamu ◽  
Manoj K. Dasa ◽  
J. E. Antonio-Lopez ◽  
...  

AbstractDevelopment of novel mid-infrared (MIR) lasers could ultimately boost emerging detection technologies towards innovative spectroscopic and imaging solutions. Photoacoustic (PA) modality has been heralded for years as one of the most powerful detection tools enabling high signal-to-noise ratio analysis. Here, we demonstrate a novel, compact and sensitive MIR-PA system for carbon dioxide (CO2) monitoring at its strongest absorption band by combining a gas-filled fiber laser and PA technology. Specifically, the PA signals were excited by a custom-made hydrogen (H2) based MIR Raman fiber laser source with a pulse energy of ⁓ 18 μJ, quantum efficiency of ⁓ 80% and peak power of ⁓ 3.9 kW. A CO2 detection limit of 605 ppbv was attained from the Allan deviation. This work constitutes an alternative method for advanced high-sensitivity gas detection.


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