scholarly journals Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset

2020 ◽  
Vol 8 (2) ◽  
pp. e001773
Author(s):  
Justyna Klusek ◽  
Ewelina Błońska-Sikora ◽  
Bartosz Witczak ◽  
Katarzyna Orlewska ◽  
Jolanta Klusek ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Diabetes Type 2 ◽  
Homozygous Deletion ◽  
Control Group ◽  
Diabetic Patients ◽  
Real Time Quantitative Pcr ◽  
Glutathione S Transferases ◽  
Design And Methods ◽  
And Control

IntroductionType 2 diabetes (T2D) is a multifactorial disease affecting mostly adults older than 40 years. The aim of the study was to examine GST gene polymorphism influence on the risk of T2D, especially in young adults.Research design and methods200 diabetic patients and 221 healthy controls participated in this study. Three GST gene polymorphism have been analyzed: GSTP1 (single-nucleotide polymorphism Ile105Val), homozygous deletion of GSTT1 (null/null) and GSTM1 (null/null), using TaqMan real-time quantitative PCR.ResultsThe distribution of examined polymorphisms was similar in patient group and control group. Statistically significant differences were demonstrated for the combination of GSTP1 Val/Val and GSTT1 null/null genotypes between patients diagnosed before 40 years of age and healthy people (12.5% vs 0.9%, p=0.016). Moreover, all three examined gene polymorphism together (GSTP1 Val/Val, GSTM1nul/null and GSTT1 null/null genotype) was observed in 12.5% of patients diagnosed before 40 years of age and in 0.5% of healthy individuals (p=0.013).ConclusionIn conclusion, the results suggest that GST polymorphism may be one of the risk factors for developing T2D at a younger age than the T2D population average.

scholarly journals Ethnic Foods Diet Program Improve Self-Efficacy and Diet Compliance Among Type 2 Diabetic Patients

Jurnal NERS ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 155
Author(s):  
Eka Mishbahatul Mar'ah Has ◽  
Amira Aulia ◽  
Tiyas Kusumaningrum ◽  
Ferry Efendi
Keyword(s):  
Treatment Group ◽  
Self Efficacy ◽  
Dietary Guidelines ◽  
Rank Test ◽  
Control Group ◽  
Diabetic Patients ◽  
Post Test ◽  
Diet Compliance ◽  
And Control

A well-balanced diet is one of the four pillars of diabetes self-management. Patient's culture strongly influences intake food. Diabetic dietary guidelines which fit with the patient's culture is expected to improve patient's self-efficacy and diet compliance. This study was aimed to analyze the effect of ethnic foods diet program in improving self-efficacy and diet compliance among Type-2 Diabetes Mellitus (T2DM) patients. This was quasy experiment research with pre and post-test control design. The population was 112 T2DM patients from Sasak Tribes, West Nusa Tenggara. Samples were 36 respondents, divided into intervention (18) and control (18) groups. The independent variable was the ethnic food diet (EFD) program, while the dependent variables were patient's self-efficacy and diet compliance. Data were collected using self-efficacy questionnaire and a 24-hour dietary recall form. Data were then analyzed using Wilcoxon Signed Rank Test and Mann Whitney U Test. The result showed differences in self-efficacy between pre and post-test in the treatment group (p=0,001), but there were no differences in the control group. There were differences in diet compliance in the treatment group (p=0,001), but there were no differences in the control group. There were differences between treatment and control groups on self-efficacy (p=0,000) and diet compliance (p=0,000). Ethnic foods diet program can improve self-efficacy and diet compliance among T2DM patients because more comfortable and easier to be applied. Nurses can apply ethnic foods diet program as an intervention to promote healthy diet for T2DM patients.

scholarly journals Intermuscular Fat Content in Young Chinese Men With Newly Diagnosed Type 2 Diabetes: Based on MR mDIXON-Quant Quantitative Technique

2021 ◽  
Vol 12 ◽  
Author(s):  
Fuyao Yu ◽  
Bing He ◽  
Li Chen ◽  
Fengzhe Wang ◽  
Haidong Zhu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Fat Content ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Group ◽  
Control Subjects ◽  
Intermuscular Fat ◽  
And Control

ObjectiveSkeletal muscle fat content is one of the important contributors to insulin resistance (IR), but its diagnostic value remains unknown, especially in the Chinese population. Therefore, we aimed to analyze differences in skeletal muscle fat content and various functional MRI parameters between diabetic patients and control subjects to evaluate the early indicators of diabetes. In addition, we aimed to investigate the associations among skeletal muscle fat content, magnetic resonance parameters of skeletal muscle function and IR in type 2 diabetic patients and control subjects.MethodsWe enrolled 12 patients (age:29-38 years, BMI: 25-28 kg/m2) who were newly diagnosed with type 2 diabetes (intravenous plasma glucose concentration≥11.1mmol/l or fasting blood glucose concentration≥7.0mmol/l) together with 12 control subjects as the control group (age: 26-33 years, BMI: 21-28 kg/m2). Fasting blood samples were collected for the measurement of glucose, insulin, 2-hour postprandial blood glucose (PBG2h), and glycated hemoglobin (HbAlc). The magnetic resonance scan of the lower extremity and abdomen was performed, which can evaluate visceral fat content as well as skeletal muscle metabolism and function through transverse relaxation times (T2), fraction anisotropy (FA) and apparent diffusion coefficient (ADC) values.ResultsWe found a significant difference in intermuscular fat (IMAT) between the diabetes group and the control group (p<0.05), the ratio of IMAT in thigh muscles of diabetes group was higher than that of control group. In the entire cohort, IMAT was positively correlated with HOMA-IR, HbAlc, T2, and FA, and the T2 value was correlated with HOMA-IR, PBG2h and HbAlc (p<0.05). There were also significant differences in T2 and FA values between the diabetes group and the control group (p<0.05). According to the ROC, assuming 8.85% of IMAT as the cutoff value, the sensitivity and specificity of IMAT were 100% and 83.3%, respectively. Assuming 39.25ms as the cutoff value, the sensitivity and specificity of T2 value were 66.7% and 91.7%, respectively. All the statistical analyses were adjusted for age, BMI and visceral fat content.ConclusionDeposition of IMAT in skeletal muscles seems to be an important determinant for IR in type 2 diabetes. The skeletal muscle IMAT value greater than 8.85% and the T2 value greater than 39.25ms are suggestive of IR.

Myocardial insulin resistance associated with chronic hypertriglyceridemia and increased FFA levels in Type 2 diabetic patients

2004 ◽  
Vol 287 (3) ◽  
pp. H1225-H1231 ◽  
Author(s):  
Lucilla D. Monti ◽  
Claudio Landoni ◽  
Emanuela Setola ◽  
Elena Galluccio ◽  
Pietro Lucotti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Insulin Resistance ◽  
Control Group ◽  
Diabetic Patients ◽  
Control Groups ◽  
Type 2 Diabetic Patients ◽  
Myocardial Insulin Resistance ◽  
And Control ◽  
Type 2 Diabetic

We evaluated the influence of chronic hypertriglyceridemia and endothelial dysfunction on myocardial glucose uptake (MGU) in Type 2 diabetic patients without coronary heart disease. Patients were divided into two groups according to fasting triglyceride (TG) levels: 5.4 ± 1.1 and 1.5 ± 0.3 mmol/l for high- and normal-TG groups, respectively. Five subjects were assigned to the high-TG group and 11 to the normal-TG group. Age, gender, body mass index, systolic and diastolic blood pressure, glucose, insulin, HbA1c, cholesterol, and HDL cholesterol were similar in the two groups, whereas free fatty acid (FFA) levels were higher in the high-TG group basally and at the end of the clamp. Furthermore, five healthy subjects were subjected to the same protocol and used as the control group. MGU was assessed by using 18F-labeled 2-fluoro-2-deoxy-d-glucose under hyperglycemic-hyperinsulinemic conditions. Basal endothelin-1 and nitric oxide levels were significantly higher in the high-TG group than in the normal-TG and control groups, and cGMP and maximal postischemic vasodilation were significantly decreased in the high-TG group compared with the normal-TG and control groups. However, significant alterations were found in the same parameters in the normal-TG group compared with the control group. By the end of the hyperglycemic clamp, in the high-TG group, MGU was ∼40 and 65% of that in the normal-TG and control groups. MGU negatively correlated with TG, FFA, and endothelin-1, whereas a positive correlation was found with cGMP and maximal postischemic vasodilation. In conclusion, increased TG and FFA levels are risks, in addition to Type 2 diabetes mellitus, for myocardial insulin resistance, endothelial dysfunction, and alteration of nitric oxide/cGMP levels.

scholarly journals Razões neutrófilos/linfócitos e plaquetas/linfócitos em pacientes diabéticos com ou sem disfunção renal

2018 ◽  
Vol 28 (3) ◽  
pp. 30376
Author(s):  
Anniely Carvalho Rebouças Oliveira ◽  
Brena Barros Mendes ◽  
Keila Correia De Alcântara
Keyword(s):  
Renal Damage ◽  
Absolute Number ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
And Control

AIMS: To compare the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) between patients with and without type 2 diabetes mellitus and between diabetic patients with and without renal dysfunction.METHODS: A cross-sectional retrospective study was performed at the Laboratory of Clinical Analyzes of the Hospital das Clínicas of the Federal University of Goiás between January and December 2016. Data from patients aged 40 years or older were included in the study. Those with a blood glucose ≥200 mg / dL and/or glycated hemoglobin ≥6.5% formed the diabetic group, and those who did not present these criteria for diabetes formed the control group, being matched by age and sex. The diabetic group was classified in one group with renal damage and another without renal damage, according to the 24-hour microalbuminuria. Calculations for NLR and PLR were performed from the absolute number of neutrophils, lymphocytes and platelets, and the medians were compared.RESULTS: A total of 122 subjects were included in the study, among which 52.5% were between 40 and 64 years of age and 63.9% were male. The median NLR was 2.1 (min 0.8 - max 5.3) in the diabetic group and 1.9 (min 0.6 - max 6.2) in the control group (p=0.16). The median PLR was 120.5 (min 63.5 - max 206.6) in the diabetic group and 119.7 (min 40.4 - max 215.1) in the control group (p=0.19). Considering the age group, there was no difference in the median NLR or PLR among the diabetic group and the control group; however, the NLR was higher for individuals 65 years of age or older, regardless of whether they were diabetic (median 2.2, min 1.0 - max 3.8, p=0.01) or not (median 2.4, min 0.9 - max 3.6, p=0.001). Among the participants, 38 patients presented renal damage, 24 (63.1%) of the diabetic group and 14 (36.9%) of the control group. The median NLR and PLR were similar among diabetic patients with renal damage, diabetics without renal damage and control group.CONCLUSIONS: NLR and PLR were similar between the diabetic group and the control group, as well as among diabetics with or without renal damage. RNL was higher for individuals 65 years of age or older, regardless of whether they were diabetic or not.

scholarly journals α-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Juan Pablo Aitken ◽  
Carolina Ortiz ◽  
Irene Morales-Bozo ◽  
Gonzalo Rojas-Alcayaga ◽  
Mauricio Baeza ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Control Group ◽  
Diabetic Patients ◽  
Promising Alternative ◽  
Positive Discrimination ◽  
And Control

Background. Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate thatα-2-macroglobulin levels are elevated in diabetic patients.Methods. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship betweenα-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated.Results. We found a positive correlation betweenα-2-macroglobulin and HbA1c (r=0.778andP<0.0001). Area under the receivers operating characteristic (ROC) curve ofα-2-macroglobulin indicated a positive discrimination threshold ofα-2-macroglobulin (AUC = 0.903, CI 95%: 0.847–0.959,P<0.0001) to diagnose glycemic control.Conclusions. Our data strongly suggest that the level of salivaα-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

scholarly journals Evaluation the Relationship Between Serum and Salivary Levels of 25(OH)Vit.D with Type II Diabetes in Newly Diagnosed Diabetics

2018 ◽  
Vol 8 (1) ◽  
pp. 108
Author(s):  
Hamidreza Abdolsamadi ◽  
Mohammad Vahedi ◽  
Shiva Borzouei ◽  
Alireza Soltanian ◽  
Ali Hosseini ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
The World ◽  
And Control ◽  
The Relationship ◽  
Vitamin D3 Deficiency

Introduction: The International Diabetes Federation (IDF) Announces 415 million people around the world are suffering from diabetes. There is a high proportion of UDM (undiagnosed diabetes) at the level of the world and particularly in developing countries. The number of people with UDM in Iran in 2015 are 2197.96 per 1000. Vitamin D3 deficiency is associated with increased risk of type 2 diabetes and for a long time, been recognized as a risk factor for glucose intolerance. Salivary composition, as the mirror of oral health, its use as a diagnostic tool is increasing and diabetes is also can be effective on the flow rate of saliva and its compounds. Analysis of saliva can be used as part of the evaluation of endocrine function. Material and Methods: In this case-control study in 2016 in Hamadan, we selected 57 newly diagnosed patients with type 2 diabetes mellitus with mean aged 47.73 years and 57 healthy controls with mean aged 45.36 years. By using Spitting method, 5ml of completely unstimulated saliva samples were collected from diabetic patients and control subjects. The serum and saliva 25(OH)Vit.Dconcentrations were measured by ELISA. The results are analyzed by SPSS 16.Results: Significant difference was found in serum concentrations between the two groups (p&lt;0.001). But in unstimulated whole salivary 1, 25(OH) 2D3 concentrations between the two groups, difference was not significant and the relationship, was reversed. There was a significant correlation (P=0.013) between serum and saliva 1, 25(OH) 2D3concentrations in the control group. In other words, the correlation was approximately 0.33. Correlation between serum and saliva 1, 25(OH) 2D3 concentrations in case group was not significant. Serum levels of 1, 25(OH) 2D3 in 21.1% of control group, showed the inadequate level (Vit.D3= 20-29ng/ml) and in the case group, showed the critical situation and overall 91.2% of the newly diagnosed diabetics, suffered from lack of vitamin D3. According to the salivary levels of 1, 25(OH) 2D3, in general, a total of 58% of the case group, have deficiency of vitamin D3.Conclusion: The results was confirmed vitamin D3 deficiency in participating in the study population (both case and control). The findings showed that there is lower concentration of 1, 25(OH) 2D3 in serum and after that in saliva in diabetic patients that newly diagnosed. Saliva would play a helpful diagnostic role in the early detection, the monitoring and progression of diabetes, but still serum is the better method for detecting vit.D3 levels and more research needs to be done on saliva for detecting Vit.D3 concentrations.

scholarly journals Android based Diabetic Manager to Enhance Compliance and to Control Blood Glucose Level among Type 2 Diabetic Patients in Magelang, Central Java, Indonesia

Webology ◽  
2021 ◽  
Vol 18 (1) ◽  
pp. 179-191
Author(s):  
Heru Supriyatno ◽  
Dwi Ari Murti Widigdo ◽  
Wiwin Renny Rahmawati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Patient Adherence ◽  
Control Group ◽  
P Value ◽  
Diabetic Patients ◽  
The Status ◽  
And Control

Android Based Diabetic Manager (ABDM) is an application used for diabetic patients to control their diet. This application is an easy way to remind them in consuming foods and giving them alert when its necessary calories have been achieved. This study was conducted in response to technological developments in the Era 4.0 to help people with Type 2 Diabetes Mellitus through diet control that can be done independently. This study was conducted in the city of Magelang aimed to evaluate whether using ABMD was effective to improve patients adherence in their diet and to control their blood glucose levels. This experimental study was using pre test and post test with control group design. By using simple random sampling, 52 people suffering from Type 2 Diabetes Mellitus recruited in this study devided into two groups, ABDM group and control group. The Pearson Chi-Square test result showed that there was significantly different between ABDM group and control group in the status of blood glucose control and patient adherence with p value was 0.048and 0.000 respectively (p value <0.05). This result indicated that H0 was rejected and H1 was accepted, which could be interpreted that Android based Diabetic Managerapplication influenced the status of blood sugar control and improved the patient adherence in managing their diet. Android based Diabetic Managerapplication influenced the status of blood sugar control and improved the patient adherence in managing their diet. Recomendation was made to conduct future study in the wider Diabetes community by adding more complete types of menu list and its variations in the Android based Diabetic Manager.

scholarly journals CORRELATION BETWEEN FATTY BINDING PROTEIN 1 (FABP1) AND DIABETES TYPE 2 (T2DM)

2021 ◽  
Vol 9 (06) ◽  
pp. 645-650
Author(s):  
Sofia Ashraf Abd Elhady ◽  
◽  
Asmaa Mohamed Mansour ◽  
Hassan Shalby ◽  
Naglaa Fawazy ◽  
...  
Keyword(s):  
Binding Protein ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Control Group ◽  
Diabetic Patients ◽  
Fasting Insulin ◽  
Fatty Acid Binding ◽  
Patients With Diabetes ◽  
Novel Biomarkers

Background: Diabetes mellitus is best described as a condition that is characterized by postprandial hyperglycemia that has two types; diabetes type 1 and type 2. Many patients with type 2 diabetes can be asymptomatic. There are many novel biomarkers for the detection of diabetes type 2, such as FABP1, which is investigated as a marker to detect patients with diabetes type 2. Aim: The aim of the study was to investigate FABP1 in Patients with diabetes type 2 and to find the correlations between FABP1 and fasting insulin in those patients. Methods: Samples were collected from 99 diabetic patients and 85 samples of healthy participants as the control group. All participants were subjected to liver enzymes (ALT and AST) lipid profile (triglycerides, HDL, LDL, and cholesterol), T-billirbun, Albumin, Alp, AFP, BMI, S-creatinine, Hb, Fatty acids, F. Insulin, CA19.9, HbA1c, and Fbs that were done by an autoanalyzer. The serum level of fatty acid-binding protein 1 was measured by SunRed human FABP1 Elisa kits. Results: Data was represented as mean ± standard deviation or median with statistically significant values of ALT, AST, ALP, PT, and INR (at P< 0.05). Findings revealed a significant positive correlation between our marker FABP1 and TG, cholesterol, LDL, Fasting insulin, and CA19.9, Conclusion: FABP1 can be used as a novel marker to detect patients with diabetes type 2.

scholarly journals Study of the Association between Serum Ferritin Levels and HbA1c in Patient with Type 2 Diabetes Mellitus in Jordanian Population Sample

2021 ◽  
pp. 1-5
Author(s):  
Saad AL-Fawaeir ◽  
Haytham M. Daradka ◽  
Ali Ahmad Abu Siyam
Keyword(s):  
Serum Ferritin ◽  
Population Sample ◽  
Positive Association ◽  
Control Group ◽  
Diabetic Patients ◽  
Biochemical Tests ◽  
Type 2 Dm ◽  
Significant Difference ◽  
And Control

Background/ aim: The most common endocrine disorder in the world is type 2 DM, affecting 85-90% of all people with diabetes. Several studies have found an association between serum ferritin levels and HbA1c, so the current study was undertaken to examine the association between serum ferritin levels and HbA1c in Jordanian patient’s sample with type 2 DM. Method:  120 patients with type 2 DM were enrolled into the current study, and control group consist of 20 healthy individuals, blood samples were collected after 14 h of fasting, 5 ml of fasting sample for FBS and ferritin, 4 ml whole blood taken in EDTA tube for Hb and HbA1c, sample centrifuged and biochemical tests were done in the same day. Results: The mean of serum ferittin was significantly higher in patients group (213.87±114.23 ng/ml) than control group (98.34±18.45 ng/ml, P < 0.05). There was a positive association between serum ferritin and HbA1c (P < 0.05). Also there was a significant correlation between serum ferritin and FBS P < 0.05. Among the two groups there was no significant difference regarding demographic features (sex, age and BMI). Conclusion: collected data showed that there is a significantly association between ferittin and type 2 DM, it was higher in comparison with healthy group, so it can give an indication of glycemic  control in diabetic patients.

scholarly journals Status of some Trace Elements in Type-2 Diabetic Patients and its Relationship with Lipid Profile

2016 ◽  
Vol 40 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Naznin Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Rashedul Alam
Keyword(s):  
Lipid Profile ◽  
Serum Magnesium ◽  
Control Group ◽  
P Value ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Serum Zn ◽  
And Control ◽  
Type 2 Diabetic

Investigation of the serum level of copper, zinc, magnesium and manganese in type-2 diabetes mellitus and their possible association with lipid profile was carried out. The comparative study included 100 type-2 diabetic patients in Gr-II and 100 non-diabetic as control in (Gr-I). Results indicated that there is a significant lower level (p < .001) of serum Zn, Cu, Mg and Mn in diabetic patients compared with the control group, showing p value < .001. In type-2 DM patients (Gr-II) there were significant correlations between serum Zn and TAG (r = 0.209) and between Zn and HDL-C level (r = .199) showing p value <.05. Non significant relationships were found in between Zn and lipid profile (TAG, Cholesterol, HDL-C and LDL-C) of control (Gr-I) group. Significant correlation was found between serum magnesium and TAG of control (Gr-I) where p < .01 and non significant correlations were found in serum Mg and total cholesterol, HDL-C, LDL-C of both type-2 diabetic (Gr-II) and control (Gr-I). Significant correlations were also found in between serum of Cu and Mn and TAG of control (Gr-I) where p < .05 and non significant correlations were found in other component of lipid profile of both cases (Gr-II) and control (Gr-I).Journal of Bangladesh Academy of Sciences, Vol. 40, No. 1, 79-85, 2016

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