scholarly journals Neutrophilia is associated with a poorer clinical outcome in dogs with chronic hepatitis

2020 ◽  
Vol 187 (6) ◽  
pp. 234-234
Author(s):  
Craig R Breheny ◽  
Ian Handel ◽  
Stephanie Banner ◽  
Elspeth M Milne ◽  
Linda R Morrison ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Clinical Outcome ◽  
Survival Time ◽  
The Other ◽  
Inclusion Criteria ◽  
Survival Times ◽  
Common Cause ◽  
The Relationship ◽  
Lower Count

BackgroundLiver disease is a common cause of morbidity and mortality in dogs. Currently, it is challenging to prognosticate in these cases. The aim of this study was to evaluate the utility of the haematological variables in dogs with chronic hepatitis.MethodsDogs with chronic hepatitis confirmed on histopathology had presenting haematological values retrospectively obtained and evaluated against survival time. Eighty-two dogs met the inclusion criteria and their data analysed.ResultsNeutrophilic patients, with a count greater than 12×109/l, controlled for sex and age, had a shorter survival time (P≤0.01). In dogs, neutrophilia at presentation predicted a poor outcome, whereas the other haematological parameters were not prognostically informative. When the dogs were split into even quarters on the basis of their neutrophil count, those within the higher quartiles had poorer survival times. Neutrophilia was associated with a poorer survival time in comparison to those patients with a lower count.ConclusionThe relationship between neutrophils, inflammation and clinical outcome is deserving of future study in dogs with chronic hepatitis.

scholarly journals Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Emily L. Heil ◽  
Mary L. Townsend ◽  
Kenneth Shipp ◽  
Amy Clarke ◽  
Melissa D. Johnson
Keyword(s):  
Chronic Hepatitis ◽  
Retrospective Study ◽  
Liver Disease ◽  
Clinic Visit ◽  
Primary Objective ◽  
Inclusion Criteria ◽  
Underlying Liver Disease ◽  
Severe Hepatotoxicity ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Introduction. Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease. This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases clinics.Methods. HIV/HCV co-infected adults were included in this retrospective study if they were PI or NNRTI naïve at their first clinic visit and were initiated on an NNRTI- and/or PI-based antiretroviral regimen. Patients were excluded if they had active or chronic hepatitis B virus (HBV). The primary objective was to determine the overall incidence of severe hepatotoxicity.Results. Fifty-six of the 544 patients identified met inclusion criteria. The incidence of severe hepatotoxicity was 10.7% (6/56 patients). Severe hepatotoxicity occurred with efavirenz (), nevirapine (), indinavir (), nelfinavir (), and saquinavir/ritonavir ().Conclusion. The incidence of severe hepatotoxicity appears to be low in this retrospective analysis of HIV/HCV co-infected patients receiving a PI-and/or NNRTI-based regimen.

Prognostic factors in dogs with osteosarcomas of the flat or irregular bones

1995 ◽  
Vol 31 (4) ◽  
pp. 321-326 ◽  
Author(s):  
AS Hammer ◽  
FR Weeren ◽  
SE Weisbrode ◽  
SL Padgett
Keyword(s):  
Body Weight ◽  
Prognostic Factors ◽  
Local Recurrence ◽  
Survival Time ◽  
Medical Records ◽  
Median Survival Time ◽  
Surgical Excision ◽  
Survival Times ◽  
Anatomic Site ◽  
Common Cause

The medical records of 45 dogs with histopathologically confirmed osteosarcomas arising from flat or irregular bones were reviewed. Thirty-five percent of the dogs eventually developed metastases. Telangectatic tumors and tumors arising from the rib and scapula had the highest prevalence of metastases. Survival times were short, with an overall median survival time of 120 days. Anatomic site, body weight, and completeness of surgical excision were found to be prognostic factors. Dogs with mandibular osteosarcomas in this study had shorter survival times than those times recently reported. 21 Local recurrence was the most common cause of death or euthanasia in this population of dogs.

scholarly journals Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marzanna Obrzut ◽  
Vitaliy Atamaniuk ◽  
Jun Chen ◽  
Bogdan Obrzut ◽  
Richard L. Ehman ◽  
...  
Keyword(s):  
Liver Disease ◽  
Magnetic Resonance ◽  
Liver Stiffness ◽  
Portal Blood Flow ◽  
Magnetic Resonance Elastography ◽  
Inclusion Criteria ◽  
Meal Intake ◽  
Before And After ◽  
The Relationship ◽  
H 30

AbstractMagnetic resonance elastography (MRE) is a reliable noninvasive method for assessment of hepatic stiffness. Liver stiffness is known to be affected by elevated postprandial portal blood flow in patients with chronic liver disease. The goal of this study was to determine whether food intake affects liver stiffness in the absence of known liver disease. We evaluated 100 volunteers (35 men and 65 women) who met inclusion criteria. The subjects had two MRE examinations, first while fasting and then 30 min after a test meal. Fourteen subjects also had two additional MRE exams 1 h 30 min and 2 h 30 min after the meal. Liver stiffness was measured by placing the largest possible polygon ROIs on the four widest liver slices and calculated as a mean of stiffness values from each slice. The correlation of liver stiffness values before and after the meal was assessed using a paired t-test. To evaluate the relationship between the change in postprandial liver stiffness and fasting liver stiffness values, linear regression was performed. The liver stiffness values in the fasting state ranged from 1.84 to 2.82 kPa, with a mean of 2.30 ± 0.23 kPa (95% CI 2.25–2.34). At 30 min after the meal, liver stiffness values ranged from 2.12 to 3.50 kPa, with a mean of 2.70 ± 0.28 kPa (95% CI 2.64–2.75), demonstrating a systematic postprandial increase by 0.40 ± 0.23 kPa (17.7 ± 3.5%). Meal intake significantly increases liver stiffness in healthy individuals, which persists for at least 2 h 30 min. Patients should fast for 3–4 h before MRE examinations to avoid fibrosis overstaging due to postprandial liver stiffness augmentation.

scholarly journals Survival and life-expectancy in a young-onset dementia cohort with six years of follow-up: the NeedYD-study

2019 ◽  
Vol 31 (12) ◽  
pp. 1781-1789 ◽  
Author(s):  
Adrie A.J. Gerritsen ◽  
Christian Bakker ◽  
Frans R.J. Verhey ◽  
Yolande A.L. Pijnenburg ◽  
Joany K. Millenaar ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Survival Time ◽  
Symptom Onset ◽  
Survival Times ◽  
Young Onset ◽  
Younger Age ◽  
Young Onset Dementia ◽  
The Relationship ◽  
Dementia Subtype

ABSTRACTObjectives:The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity.Design, Setting and Participants:Survival was examined in 198 participants in the Needs in Young-onset Dementia study, including participants with Alzheimer’s dementia (AD), vascular dementia (VaD) and frontotemporal dementia (FTD).Measures:The primary outcomes were survival time after symptom onset and after date of diagnosis. Cox proportional hazards models were used to explore the relationship between survival and age, sex, dementia subtype and comorbidity. Additionally, the impact on remaining life expectancy was explored.Results:During the six-year follow-up, 77 of the participants died (38.9%), 78 participants survived (39.4%) and 43 were lost to follow-up (21.7%). The mean survival time after symptom onset and diagnosis was 209 months (95% CI 185-233) and 120 months (95% CI 110-130) respectively. Participants with AD had a statistically significant shorter survival compared with VaD participants, both regarding survival after symptom onset (p = 0.047) as well as regarding survival after diagnosis (p = 0.049). Younger age at symptom onset or at diagnosis was associated with longer survival times. The remaining life expectancy, after diagnosis, was reduced with 51% for males and 59% for females compared to the life expectancy of the general population in the same age groups.Conclusion/Implications:It is important to consider the dementia subtype when persons with YOD and their families are informed about the prognosis of survival. Our study suggests longer survival times compared to other studies on YOD, and survival is prolonged compared to studies on LOD. Younger age at symptom onset or at diagnosis was positively related to survival but diagnosis at younger ages, nevertheless, still diminishes life expectancy dramatically.

scholarly journals Quantified ischemic core’s radiological hypodensity and risk of parenchymal hematoma in > 4.5 h-window stroke thrombectomy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alba Chavarría-Miranda ◽  
Bárbara Yugueros ◽  
Beatriz Gómez-Vicente ◽  
Miguel Schüller ◽  
Jorge Galván ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Hounsfield Unit ◽  
Hemorrhagic Transformation ◽  
Inclusion Criteria ◽  
Poor Clinical Outcome ◽  
Anterior Circulation ◽  
Unaffected Side ◽  
Logistic Regression Models ◽  
The Relationship

Abstract We aimed to study the relationship between the ischemic core’s (IC) radiological hypodensity and the risk of parenchymal haematoma after endovascular therapy (EVT) in acute ischemic stroke (AIS) presenting > 4.5 h from onset. We studied AIS patients with a proximal anterior circulation occlusion > 4.5 h from symptoms onset treated with primary EVT. The IC regions of interest (ROI) were manually delineated on pretreatment CT within the affected hemisphere and their specular ROIs on the unaffected side. IC hypodensity ratio was calculated by dividing mean Hounsfield Unit (HU) value from all ROIs in affected/unaffected hemisphere. Primary endpoint: parenchymal hematoma (PH) type hemorrhagic transformation. Secondary: poor long-term clinical outcome. From May 2015 to November 2018, 648 consecutive AIS patients received reperfusion therapies and 107 met all inclusion criteria. PH after EVT was diagnosed in 33 (31%) patients. In bivariate analyses, IC hypodensity ratio (p < 0.001) and minimum HU value (p = 0.008) were associated with PH. A lower IC hypodensity ratio [OR < 0.001 (< 0.001–0.116) p 0.016] predicted PH but not poor clinical outcome in multivariable logistic regression models. A lower IC radiological density predicted a higher risk of PH in > 4.5 h-window AIS patients treated with primary EVT, although it was not independently associated with a worse clinical outcome.

The Relationship Between Suicidal Thinking and Dating Violence in a Sample of Adolescent Abortion Patients

Crisis ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 246-253 ◽  
Author(s):  
Gretchen E. Ely ◽  
William R. Nugent ◽  
Julie Cerel ◽  
Mholi Vimbba
Keyword(s):  
Unintended Pregnancy ◽  
Dating Violence ◽  
Young Women ◽  
Psychosocial Problems ◽  
The Other ◽  
Assessment Scale ◽  
Adolescent Dating Violence ◽  
Adolescent Relationships ◽  
Suicidal Thinking ◽  
The Relationship

Background: The relationship between suicidal thinking and adolescent dating violence has not been previously explored in a sample of adolescent abortion patients. Aims: This paper highlights a study where the relationship between dating violence and severity of suicidal thinking was examined in a sample of 120 young women ages 14–21 seeking to terminate an unintended pregnancy. Methods: The Multidimensional Adolescent Assessment Scale and the Conflict in Adolescent Relationships Scale was used to gather information about psychosocial problems and dating violence so that the relationship between the two problems could be examined, while controlling for the other psychosocial problems. Results: The results suggest that dating violence was related to severity of suicidal thinking, and that the magnitude of this relationship was moderated by the severity of problems with aggression. Conclusions: Specifically, as the severity of participant’s general problems with aggression increased, the magnitude of the relationship between dating violence and severity of suicidal thinking increased. Limitations of the study and implications for practice are discussed.

Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

2010 ◽  
Vol 57 (5) ◽  
pp. 354-359 ◽  
Author(s):  
Melanie K. T. Takarangi ◽  
Deryn Strange
Keyword(s):  
Well Being ◽  
The Other ◽  
Personal Perspective ◽  
Emotional Impact ◽  
Potential Mechanism ◽  
Negative Experiences ◽  
Negative Memory ◽  
The Relationship ◽  
Negative Memories ◽  
Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Blood Lipids ◽  
The Other ◽  
The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

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