scholarly journals Potential pathogenicity ofAeromonas hydrophilacomplex strains isolated from clinical, food, and environmental sources

2016 ◽  
Vol 62 (4) ◽  
pp. 296-306 ◽  
Author(s):  
Vicenta Albarral ◽  
Ariadna Sanglas ◽  
Montserrat Palau ◽  
David Miñana-Galbis ◽  
M. Carmen Fusté
Keyword(s):  
Extracellular Enzymes ◽  
The Elderly ◽  
Secretion Systems ◽  
Antibiotic Susceptibility Pattern ◽  
Cytopathic Effects ◽  
Pathogenic Factors ◽  
High Prevalence ◽  
Causative Agents ◽  
Complete Lysis ◽  
Potential Pathogenicity

Aeromonas are autochthonous inhabitants of aquatic environments, including chlorinated and polluted waters, although they can also be isolated from a wide variety of environmental and clinical sources. They cause infections in vertebrates and invertebrates and are considered to be an emerging pathogen in humans, producing intestinal and extra-intestinal diseases. Most of the clinical isolates correspond to A. hydrophila, A. caviae, and A. veronii bv. Sobria, which are described as the causative agents of wound infections, septicaemia, and meningitis in immunocompromised people, and diarrhoea and dysenteric infections in the elderly and children. The pathogenic factors associated with Aeromonas are multifactorial and involve structural components, siderophores, quorum-sensing mechanisms, secretion systems, extracellular enzymes, and exotoxins. In this study, we analysed a representative number of clinical and environmental strains belonging to the A. hydrophila species complex to evaluate their potential pathogenicity. We thereby detected their enzymatic activities and antibiotic susceptibility pattern and the presence of virulence genes (aer, alt, ast, and ascV). The notably high prevalence of these virulence factors, even in environmental strains, indicated a potential pathogenic capacity. Additionally, we determined the adhesion capacity and cytopathic effects of this group of strains in Caco-2 cells. Most of the strains exhibited adherence and caused complete lysis.

scholarly journals The Main Aeromonas Pathogenic Factors

2012 ◽  
Vol 2012 ◽  
pp. 1-22 ◽  
Author(s):  
J. M. Tomás
Keyword(s):  
Distribution Systems ◽  
Water Distribution ◽  
Extracellular Enzymes ◽  
Secretion Systems ◽  
Gastrointestinal Infections ◽  
Factors Associated ◽  
Pathogenic Factors ◽  
Different Types ◽  
Surface Polysaccharides ◽  
Systemic Infections

The members of the Aeromonas genus are ubiquitous, water-borne bacteria. They have been isolated from marine waters, rivers, lakes, swamps, sediments, chlorine water, water distribution systems, drinking water and residual waters; different types of food, such as meat, fish, seafood, vegetables, and processed foods. Aeromonas strains are predominantly pathogenic to poikilothermic animals, and the mesophilic strains are emerging as important pathogens in humans, causing a variety of extraintestinal and systemic infections as well as gastrointestinal infections. The most commonly described disease caused by Aeromonas is the gastroenteritis; however, no adequate animal model is available to reproduce this illness caused by Aeromonas. The main pathogenic factors associated with Aeromonas are: surface polysaccharides (capsule, lipopolysaccharide, and glucan), S-layers, iron-binding systems, exotoxins and extracellular enzymes, secretion systems, fimbriae and other nonfilamentous adhesins, motility and flagella.

scholarly journals Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression

2020 ◽  
pp. 1-10
Author(s):  
Ahmadshah Farhat ◽  
Gordon A. Ferns ◽  
Korosh Ashrafi ◽  
Mohammad-Hassan Arjmand
Keyword(s):  
Cancer Progression ◽  
Extracellular Enzymes ◽  
Lysyl Oxidase ◽  
Ecm Remodeling ◽  
Complex Process ◽  
High Prevalence ◽  
Different Types ◽  
Fibrotic Diseases ◽  
Gi Cancers ◽  
Improvement In Survival

<b><i>Background:</i></b> Malignancy is a complex process resulting from different changes such as extracellular matrix (ECM) remodeling and stiffness. One of the important enzymes that contribute to ECM remodeling is lysyl oxidase (Lox) that is overexpressed in different types of human cancers. Because of the high prevalence and poor survival of gastrointestinal (GI) malignancies in this review, we discuss the association between Lox activity and the progression of GI cancers. Lox proteins are a group of extracellular enzymes that catalyzed the cross-linking of collagen and elastin, so they have important roles in the control of structure and homeostasis of ECM. Abnormal activation and expression of the Lox family of proteins lead to changes in the ECM toward increased rigidity and fibrosis. Stiffness of ECM can contribute to the pathogenesis of cancers. <b><i>Summary:</i></b> Dysregulation of Lox expression is a factor in both fibrotic diseases and cancer. ECM stiffness by Lox overactivity creates a physical barrier against intratumoral concentration of chemotherapeutic drugs and facilitates cancer inflammation, angiogenesis, and metastasis. <b><i>Key Message:</i></b> Because of the roles of Lox in GI cancers, development targeting Lox protein isotypes may be an appropriate strategy for treatment of GI cancers and improvement in survival of patients.

High prevalence of suboptimal lipid management in the elderly: A call for new treatment guidelines

2015 ◽  
Vol 24 ◽  
pp. S188
Author(s):  
D. Colquhoun ◽  
I. Hamilton-Craig ◽  
K. Kostner ◽  
S. Woodhouse ◽  
M. d’Emden
Keyword(s):  
Treatment Guidelines ◽  
The Elderly ◽  
Lipid Management ◽  
High Prevalence ◽  
New Treatment

scholarly journals Seroepidemiology of Chlamydia Pneumoniae in Northern Greece

2009 ◽  
Vol 7 (3) ◽  
pp. 139-144
Author(s):  
D. Chatzidimitriou ◽  
M. Exidari ◽  
G. Gioula ◽  
P. Papakonstantinou ◽  
A. Melidou ◽  
...  
Keyword(s):  
Chlamydia Pneumoniae ◽  
The Elderly ◽  
Healthy Population ◽  
Serum Samples ◽  
Igg Antibody ◽  
Northern Greece ◽  
Specific Antibodies ◽  
High Prevalence ◽  
Iga Antibodies ◽  
One Year

The prevalence of IgG and IgA antibodies to Chlamydia pneumoniae was evaluated in a group of an apparently healthy population in northern Greece. Serum samples were obtained over a period of one year (June 2006 to May 2007) from 530 individuals (300 males and 230 females, aged from 1 month to 90 years). The sera were tested for specific antibodies to C. pneumoniae by two commercial methods, an ELISA and a micro-IF assay based on the principles of MIF. The prevalence of IgG and IgA antibodies to C. pneumoniae was 53.2% and 45.9%, respectively, and was found to be unrelated to gender, even in the elderly >61 years old. The IgG antibody prevalence was low in children under 5 years old (7.7%), sharply increased by the age of 20 (40%) and continued to increase, gradually, to reach 80.1% in the elderly. IgA antibodies also increased with similar kinetics to IgG, although at a lower level (3.8–66.1%). Our results show that infection with C. pneumoniae is common in northern Greece. The high prevalence of IgA specific antibodies reported in the present study is due to primary infection at a young age, while in the elderly is probably due to infection or reinfection, although the option of persistence cannot be excluded.

scholarly journals Aetiological Factors of Osteoarthritis: A Review Update

2015 ◽  
Vol 2 (1) ◽  
pp. 18-23
Author(s):  
M. Jahidul Islam ◽  
M. Shahadat Hossain ◽  
M. Ruhul Amin ◽  
Monzur Ahmed
Keyword(s):  
United States ◽  
Joint Damage ◽  
The Elderly ◽  
The United States ◽  
Common Type ◽  
High Rate ◽  
Lumbosacral Spine ◽  
First Metatarsal ◽  
High Prevalence ◽  
Wear And Tear

Osteoarthritis (OA) is no longer considered ‘degenerative’ or ‘wear and tear’ arthritis; rather involves dynamic biomechanical, biochemical and cellular process. Indeed, the joint damage that occurs in OA is the result of active remodeling involving all the joint structures. Although articular cartilage is at the center of change, OA is viewed as a disease of the entire joint. Traditionally, OA has been viewed as an inevitable degenerative condition of the cartilage. It is currently viewed as a biomechanical and biochemical inflammatory disease of the entire joints. Osteoarthritis (OA) is the most common type of arthritis. Its high prevalence, especially in the elderly, and the high rate of disability related to disease make it a leading cause of disability in the elderly. Because of the aging of Western populations and because obesity, a major risk factor, are increasing in prevalence, the occurrence of osteoarthritis is on the rise. In the United States, osteoarthritis prevalence will increase from 66–100% by the year 2020. OA affects certain joints, yet spares others. Commonly affected joints include the cervical and lumbosacral spine, hip, knee, and first metatarsal phalangeal joint (MTP). In the hands, the distal and proximal inter-phalangeal joints and the base of the thumb are often affected. Usually spared are the wrist, elbow, and ankle.Journal of Current and Advance Medical Research 2015;2(1):18-23DOI: http://dx.doi.org/10.3329/jcamr.v2i1.22584

scholarly journals Stroke death profiles in Brazil between the years 2010 and 2019

2021 ◽  
Author(s):  
Carolina Da Mota Iglesias ◽  
Liara Eickhoff Coppetti ◽  
Marcela Menezes Teixeira ◽  
Paula Loredo Siminovich ◽  
Bernardo Neuhaus Lignati ◽  
...  
Keyword(s):  
Continuous Improvement ◽  
Hospital Care ◽  
Formal Education ◽  
The Elderly ◽  
Abrupt Onset ◽  
Modifiable Risk Factors ◽  
Unified Health System ◽  
High Prevalence ◽  
Icd 10 ◽  
Stroke Death

Background: In most cases, strokes are events with an abrupt onset characterized by a neurological deficit attributed to a focal vascular cause. Such events can have ischemic or hemorrhagic origin with diagnosis attributed to clinical and imaging exams. In this work, we analyze the profile of deaths by stroke in the Brazilian population, outlining an overview of the disease in Brazil. Objective: Analyze stroke death profiles between the years 2010 and 2019. Methodology: We perform a descriptive documentary study based on the Mortality Information System (SIM) for the years 2010 to 2019, made available by the Brazilian Unified Health System (SUS) Information Department. Our study is delimited by age, starting from 15-year-olds, and considering the ICD-10 I64 pathologies. Results: In the analyzed period, 400.395 stroke deaths were registered. Over the years, these deaths showed a decrease of approximately 24.47% with 2011 being the year with the highest number of registered deaths (n=44 892). The southeast region registered most deaths with 38.18% of the total. The most affected groups were men (50.79%), whites (46.43%), over 80 years-old (41.80%) and with no formal education (27.31%). Conclusion: There is a decrease in stroke cases in Brazil between 2010 and 2019. The high prevalence of deaths from stroke in the elderly highlights the need for greater control of modifiable risk factors to reduce mortality. Thus, the continuous improvement of socioeconomic, educational, and hospital care conditions in Brazil is necessary.

scholarly journals Vulnerability in the elderly

2021 ◽  
Vol 64 (3) ◽  
pp. 62-67
Author(s):  
Ana Popescu ◽  
◽  
Gabriela Soric ◽  
Victoria Federiuc ◽  
Vitalie Ojovanu ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Functional Decline ◽  
The Elderly ◽  
Poor Quality ◽  
Important Target ◽  
Increased Risk ◽  
High Prevalence ◽  
Assessment Measures ◽  
Cognitive Problems

Background: Aging process involves an increased risk for the development of vulnerability, because senescence is a process characterized by a multitude of changes that influence the living conditions and health of the individuals. In geriatrics, the term “vulnerability” implies a multidimensional aspect, among which, multimorbidity, functional incapacity, socio-economic and cognitive problems in the elderly. The main objective of the article is to systematize data from the literature through the analysis of the concept and prevalence of vulnerability, assessed by the score Vulnerable Elders Survey-13 (VES-13) in the elderly. For this purpose, publications from the database GoogleSearch, PubMed, Hinari, etc. were analyzed. The information was systematized, highlighting the main aspects of the contemporary vision of the last 5 years.A series of studies (USA, Brazil, etc.) revealed a high prevalence of vulnerability in the elderly according to the VES-13 score, it was estimated in respondents aged > 65 years, between 40-50% of cases were vulnerable people, with a score ≥ 3 p. The vulnerability of the elderly results from different conditions, correlated with each other, especially biological, social and genetic factors. There was a functional decline between 13 and 24% of cases, especially in the elderly over 75 years, and an association with health problems, mobility and low autonomy in over 50% of cases, with a poor quality of life and increased risk of institutionalization. Conclusions: Vulnerability assessment measures are important for identifying older people at high risk of deteriorating health, which is an important target for interdisciplinary intervention.

scholarly journals Prevalence of falls in elderly in Brazil: a countrywide analysis

2011 ◽  
Vol 27 (9) ◽  
pp. 1819-1826 ◽  
Author(s):  
Fernando Vinholes Siqueira ◽  
Luiz Augusto Facchini ◽  
Denise Silva da Silveira ◽  
Roberto Xavier Piccini ◽  
Elaine Tomasi ◽  
...  
Keyword(s):  
Low Socioeconomic Status ◽  
Urban Areas ◽  
Female Gender ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Low Socioeconomic ◽  
The North ◽  
High Prevalence ◽  
Falls In Elderly

We conducted a cross-sectional study of a sample of 6,616 elderly living in urban areas of 100 municipalities in 23 Brazilian states, who responded to questions on the occurrence of falls in the 12 months prior to the interview, and occurrence of fractures due to the falls. The prevalence of falls among the elderly was 27.6% (95%CI: 26.5-28.7). Among those reporting falls, 11% had suffered fractures as a result. Of the elderly, 36% had received guidance about the precautions necessary to prevent falls, and about 1% had required surgery. Falls were associated with female gender, older age, low socioeconomic status, obesity and sedentary lifestyles. The prevalence of falls differed significantly between the North and other regions of Brazil. The study shows a high prevalence of falls, and underlines the need for preventive strategies targeting modifiable risk factors.

Short Note: Rape A Consequence of Covid-19 Quarantine on Children and The Elderly: A Call for Action

2021 ◽  
Vol SI ◽  
pp. 85-95
Author(s):  
Grace Emmanuel Kaka ◽  
Muhamad Helmi Md Said ◽  
Shahrul Mizan Ismail
Keyword(s):  
Domestic Violence ◽  
Short Note ◽  
The Elderly ◽  
Online News ◽  
News Reports ◽  
High Prevalence ◽  
The Government ◽  
Good Policy ◽  
Novel Coronavirus ◽  
The Impact

The novel coronavirus (Covid-19) led to a shift in the social structure of global cities leading to self-isolation and social/physical distancing to curb the spread of the virus. While these two are stand as good policy, they are greeted by domestic violence and rape as the most prevalent consequences. The researchers examined the impact of lockdown on domestic violence in Nigeria based on frequency of news reports using content analysis of two online news reports and discovered a high prevalence of rape on children (0 - 17 years) and elderly (60 years and above). Hence it is suggested that the government should always be prepared for emergencies. Also, future polices should consider the interest of the most vulnerable in the society by providing safety measures.

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