Sphincter of Oddi regulates flow by acting as a variable resistor to flow

1992 ◽  
Vol 263 (5) ◽  
pp. G683-G689 ◽  
Author(s):  
Y. F. Liu ◽  
G. T. Saccone ◽  
A. Thune ◽  
R. A. Baker ◽  
J. R. Harvey ◽  
...  

Two models of transsphincteric flow and a model evaluating pumping activity were established in the anesthetized Australian brush-tailed possum to determine whether the sphincter of Oddi (SO) acts as a resistor or as a pump. A simple model of transsphincteric flow (inflow only) demonstrated that at physiological common bile duct (CBD) pressure, 9.5 +/- 0.3 cmH2O (n = 7), transsphincteric flow occurred between SO pressure waves (n = 10). A second more complex transsphincteric flow model was established that permitted simultaneous measurements of inflow, outflow, CBD pressure, SO basal pressure, SO contraction frequency, and amplitude. At physiological CBD pressure, inflow always equaled outflow (157.0 +/- 11.2 and 156.4 +/- 11.4 microliters/min, respectively; n = 7). The SO displayed regular contractions superimposed on a basal pressure of 1.1 +/- 0.4 mmHg. Contraction amplitude was 12.6 +/- 3.0 mmHg and the frequency was 3.6 +/- 0.4 contractions/min (n = 7). Pressure waves recorded in the CBD corresponded to the SO contractions and reflected SO activity. Transsphincteric flow occurred between SO contractions and was obstructed by these contractions. Stimulation of SO activity (basal pressure and contraction frequency) with intra-arterial injections of motilin (200 ng/kg) or erythromycin (200 micrograms/kg) abolished transsphincteric flow. Reduction in SO contraction frequency to 72.7 +/- 7.2% (P < 0.01, paired t test) after administration of Cisapride (2 mg/kg iv) increased transsphincteric flow to 147.6 +/- 12.3% (n = 7, P < 0.05, paired t test). In six possums, possible SO pumping action was evaluated. A manometer was connected to the CBD, and a second manometer was connected to the duodenum surrounding the papilla.(ABSTRACT TRUNCATED AT 250 WORDS)

2020 ◽  
Vol 7 (2) ◽  
pp. 54-58
Author(s):  
Putri Andanawarih ◽  
Miftachul Jannah ◽  
Swasti Artanti

Complaints of dissmenorrhea occur in 60-90% of adolescents and are the most frequent causes of absenteeism from lectures and reduced daily activities. Dissmenorrhea that is felt in the form of pain or cyclic pain along with menstruation and often feels like cramps in the stomach and can spread to the back, accompanied by nausea and vomiting. Handling of dissmenorrhea can be done by means of the effleurage technique, the effleurage technique to stimulate the stimulation of the stomach that is experiencing pain which can provide a comfortable effect. This type of research used a quasi-experimental, quasi-experimental research design, the population in this study used a random sampling technique with a total of 15. The results of the normality test of menstrual pain data before treatment were 0.33 and after treatment was 0.14 which means p> 0.05. This shows that the data is normally distributed, so the statistical test used is the Paired T-test. Based on the Paired T-test significance test, it was found that the significance value (p) is 0.00 using the provision that the degree of error (α) is 5% or 0.05 so that there is a difference between menstrual pain before efflurage massage and after efflurage massage. In this study, it was found that there was a decrease in the level of menstrual pain after efflurage massage compared to before efflurage massage, this proves that massage with the efflurage technique can reduce pain.


2001 ◽  
Vol 281 (1) ◽  
pp. R140-R149 ◽  
Author(s):  
François Giuliano ◽  
Julien Allard ◽  
Sandrine Compagnie ◽  
Laurent Alexandre ◽  
Stéphane Droupy ◽  
...  

The understanding of the pathophysiology of female sexual dysfunction suffers from the lack of a convenient model for the study of female genital sexual response. In this study, systemic arterial blood pressure (BP) as well as partial oxygen tension, temperature, and blood engorgement of the vagina [using laser-Doppler flowmetry in arbitrary units (AU)] were measured in anesthetized, ovariectomized (1 wk before the start of the experiment) female rats. Vaginal sexual arousal was replicated by electrical stimulation of the pelvic nerve (PNS). PNS induced reproducible increases in the different vaginal parameters (from baseline value, respectively: 16 ± 10 to 30 ± 12 mmHg; 34.9 ± 0.6 to 36 ± 0.6°C; 450 ± 196 to 1,500 ± 360 AU; P < 0.05, paired t-test) and BP (90 ± 7 to 123 ± 13 mmHg, P < 0.05, paired t-test). Vaginal vascular resistance was significantly decreased during PNS (from 0.23 ± 0.15 to 0.08 ± 0.02 mmHg/AU). Vaginal wall tension was also measured with a force transducer. PNS induced an increase in vaginal wall tension (1.0 ± 0.2 g), followed by a decrease under the prestimulation value. Intravenous atropine sulfate (1 mg/kg) injection abolished the increase in vaginal wall tension without significantly affecting vaginal vascular resistance. Intravenous vercuronium bromide (2 mg/kg) injection abolished the decrease in vaginal wall tension. Concomitant electrical stimulation of the paravertebral sympathetic chain inhibited vaginal response induced by PNS. Electrical stimulation of the medial preoptic area of the hypothalamus induced a response qualitatively equivalent to PNS with a significant decrease of vaginal vascular resistance. These data support that vaginal contractions involve both smooth and striated muscles and indicate that neural control of vaginal sexual arousal have great similarities in male and female rats.


2019 ◽  
Vol 11 (4) ◽  
pp. 277-284
Author(s):  
Vitrianingsih Vitrianingsih ◽  
Sitti Khadijah

Studi memperkirakan emesis gravidarum terjadi pada 50-90% kehamilan. Mual muntah pada kehamilan memberikan dampak yang signifikan bagi tubuh dimana ibu menjadi lemah, pucat dan cairan tubuh berkurang sehingga darah menjadi kental (hemokonsentrasi). Keadaan ini dapat memperlambat peredaran darah dan berakibat pada kurangnya suplay oksigen serta makanan ke jaringan sehingga dapat membahayakan kesehatan ibu dan janin. Salah satu terapi yang aman dan dapat dilakukan untuk mengurangi keluahan mual muntah pada ibu hamil adalah pemberian aromaterapi lemon. Penelitian bertujuan untuk mengetahui efektifitas aroma terapi lemon untuk menangani emesis gravidarum. Penelitian ini menggunakan rancangan Quasi experiment  dengan  one group pre-post test design. Populasi penelitian adalah ibu hamil yang mengalami emesis gravidarum di Kecamatan Berbah, Sleman. Jumlah sampel 20 ibu hamil trimester pertama yang diambil dengan teknik purposive sampling. Pengukuran mual muntah dilakukan debelum dan setelah  pemberian aromaterapi lemon menggunakan Indeks Rhodes. Analisa data menggunakan uji Paired t-test. Hasil penelitian didapatkan rata-rata skor mual muntah sebelum pemberian aromaterapi lemon berdasarkan Indeks Rhodes pada Ibu Hamil dengan emesis gravidarum yaitu 22,1 dan terjadi penurunan skor setelah pemberian aromaterapi lemon menjadi 19,8. Ada pengaruh pemberian aromaterapi lemon dengan pengurangan mual muntah pada ibu hamil (p-value = 0.017). Berdasarkan hasil penelitian dapat disimpulkan pemberian aromaterapi lemon efektif untuk mengurangi emesis gravidarum pada ibu hamil trimester pertama.  Kata kunci: aromaterapi lemon, emesis gravidarum THE EFFECTIVENESS OF LEMON AROMATHERAPY FOR HANDLING EMESIS GRAVIDARUM   ABSTRACT Studies estimate that nausea and vomiting (emesis gravidarum) occur in 50 – 90% of pregnancies. Nausea and vomiting of pregnancy have a significant impact on the body in which it makes a mother becomes weak, pale, and decreasing body fluid so that the blood becomes thick (hemoconcentration). This situation can slow down blood circulation and inflict the lack of oxygen and food supplies to the body tissues so that it can endanger the health of the mother and fetus. One of the therapies that is safe and can be conducted to reduce nausea and vomiting of pregnancy is by giving the lemon aromatherapy treatment. The research aims to determine the effectiveness of the aroma of lemon therapy to deal with emesis gravidarum. This study applied quasi-experimental research with one group pretest-posttest design. The population of this study was pregnant women who experienced emesis gravidarum. Furthermore, samples were 20 mothers from Berbah, Sleman taken by using a purposive sampling technique. Nausea and vomiting were assessed between before and after giving lemon aromatherapy using the Rhodes Index. The data were analyzed using the paired t-test. The mean score of nausea and vomiting before giving lemon aromatherapy on mother with emesis gravidarum based on the Rhodes Index was 22.1. However, it decreased after given lemon aromatherapy treatment to 19.8. Therefore, there was an effect on giving lemon aromatherapy treatment toward the decrease of nausea and vomiting for pregnant women (p-value = 0.017). Lemon aromatherapy is effective to reduce emesis gravidarum.  Keywords: lemon aromatherapy, emesis gravidarum


2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Retno Issroviatiningrum ◽  
Shanti Wardaningsih ◽  
Novita Kurnia Sari

ABSTRAK Upaya untuk meningkatkan mutu pendidikan keperawatan khususnya untuk mendukung peserta didik menjadi perawat profesional memerlukan proses pembelajaran dengan menggunakan fasilitas keterampilan klinis. Practice based simulation model didasarkan pada teori belajar konstruktif yang menegaskan bahwa pengetahuan tidak pasif ditransfer dari pendidik kepada peserta didik, tetapi dibangun oleh peserta didik melalui pengolahan pengalaman dan interaksi dengan lingkungan mereka. Dengan metode simulasi di laboratorium dapat mendorong mahasiswa untuk menggunakan critical thinking dalam mengambil keputusan dalam mengatasi masalah tanpa merugikan pasien yang sebenarnya. Penelitian ini bertujuan untuk menganalisis pengaruh practice based simulation model terhadap critical thinking pada mahasiswa semester VI di FIK Unissula Semarang. Penelitian ini menggunakan metode Quasy – Experiment dengan pendekatan pretest-posttest with control group design. Pengambilan sampel dengan teknik  simple random sampling dengan jumlah 21 responden baik kelompok intervensi maupun kelompok kontrol. Analisis data menggunakan uji Paired T-Test dan Independent Samples T-Test. Hasil penelitian selisih peningkatan critical thinking pada kelompok intervensi sebanyak 11.95 poin dan pada kelompok kontrol 2.05. Practice based simulation model berpengaruh terhadap critical thinking dengan nilai p=0.00<0.05. Disimpulkan bahwa practice based simulation model mempengaruhi critical thinking pada mahasiswa semester VI FIK Unissula Semarang. Kata kunci: Practice based simulation model, critical thinking


2019 ◽  
Vol 2 (2) ◽  
pp. 107
Author(s):  
Umi Mahmudah

Latar Belakang: Anak-anak sekolah dasar merupakan salah satu kelompok rawan masalah gizi, baik pada gizi kurang maupun gizi lebih. Pendidikan gizi seimbang perlu diterapkan untuk mengatasi masalah gizi tersebut. Metode pendidikan mendorong peran serta dan keterlibatan anak untuk memberikan motivasi dalam belajar. Berbagai metode pendidikan yang menarik bagi anak antara lain permainan, tebak-tebakan, diskusi kelompok, serta peragaan. Tujuan: Untuk mengetahui pengaruh pendidikan gizi menggunakan media teka-teki silang (TTS) terhadap pengetahuan gizi seimbang pada anak sekolah dasar. Metode: Penelitian ini merupakan penelitian quasi experiment dengan rancangan pre-posttest with control group. Penelitian dilakukan pada anak Sekolah Dasar Negeri Donohudan I. Pengukuran pengetahuan gizi seimbang dilakukan sebanyak dua kali, yaitu pretest dan posttest. Penelitian ini dibagi menjadi dua kelompok, yaitu kelompok intervensi yang diberikan pendidikan gizi menggunakan teka-teki silang dan kelompok kontrol yang diberikan pendidikan gizi menggunakan ceramah. Pengukuran pengetahuan pretest dilakukan sebelum diberikan pendidikan gizi dan pengukuran pengetahuan posttest diberikan setelah dilakukan pendidikan gizi. Data dianalisis menggunakan Paired T-test dan Independent Sample T-test. Hasil: Terdapat perbedaan pengetahuan sebelum dan setelah dilakukan pendidikan gizi menggunakan media TTS dan media ceramah (p=0,010). Rerata peningkatan pengetahuan gizi menggunakan media TTS lebih tinggi dibandingkan dengan menggunakan metode ceramah pada anak sekolah dasar. Kesimpulan: Ada pengaruh pengetahuan gizi seimbang sebelum dan setelah diberikan pendidikan gizi, baik menggunakan media teka-teki silang maupun menggunakan media ceramah.


2020 ◽  
Vol 15 (2) ◽  
pp. 114-121
Author(s):  
Maryati . ◽  
Eka Rokhmiati Wahyu Purnamasari

Life Review Therapy merupakanterapi psikoterapi untuk menyelesaikan masalah pada lansia yang mengalami depresi, mengekspresikan perasaan yang disupresikan sehingga energy psikis tersebut dilepaskan. Tujuan penelitian ini untuk mengetahui pengaruh Life Review Therapy terhadap tingkat depresi lansia pada warga binaan sosial di PSTW Budi Mulia Jakarta Selatan.Metode yang digunakan adalah quasi experiment, dengan pendekatan Pre Test and Post Test Without Control design. Populasi dalam penelitian ini adalah lansia dengan jumlah sampel 20 orang dengan teknik purposivesampling. Analisis data menggunakan Paired T Test dengan tingkat signifikan (α0,05). Hasil menunjukan bahwa ada pengaruh Life Review Therapy terhadap tingkat depresi lansiadengan ρValue=0,000. Berdasarkan penelitian tersebut, terapi Life Reviewterbukti dapat menurunkan tingkat depresi sehingga terapi ini dapat dijadikan salah satu acuan terapi untuk menangani depresi pada lansia di PSTW


2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Tatiana Siregar ◽  
Nelly Febriani

Latar belakang: Kondisi sasaran pencapaian Indonesia Sehat 2015 dari program MDG’s yang belum tercapai, sehingga dilanjutkan dengan program SDGs menjadikan Indonesia harus banyak berperan dalam semua kegiatan khsusnya di bidang kesehatan. Proses pencapaian cakupan program kesehatan sangat dipengaruhi oleh Health education yang dilakukan petugas kesehatan kepada warga, kesehatan masyarakat. Tujuan: Penelitain ini bertujuan untuk mengetahui perubahan perilaku hidup bersih sehat yang  dilaksanakan warga setelah diberikan intervesi health education.  Metode: Metode penelitian dilaksanakan secara quasi experiment pre dan post test.  Teknik mengambil sampel secara purposive Sampling pada 30 reponden kelompook intervensi dan 26 responden kelompok kontrol. Analisa data dilakukan secara paired t test. Hasil: Hasil di dapat ada perbedaan yang bermakna antara pengetahuan dan perubahan perilaku hidup bersih sehat repsonden sebelum dan sesudah diberi penyuluhan p value = 0,000. Saran: Diharapkan pemerintah setempat menggerakkan petugas kesehatan bersama-sama dengan warga melakukan perilaku hidup bersih sehat dalam kehidupan sehari-hari dengan memfasilitasi  sarana penunjang untuk menjalankan perilaku hidup bersih sehat, dengan maksimal pada warga. Kata kunci: Health eduation,  Perilaku Hidup Bersih Sehat


2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Sinta Maria Dewi

Abstract: This research aims to know the Influence of Media Image on the ability of Writing Poetry students. The method used in this study is a random method that does not use posttes control group design method. The findings of this study show the average way of writing poetry on students by using the image media (experimental class) higher average poetry writing skills on students who were taught with conventional learning (control class). The average of pretest experiments obtained by experiment class is 63,75. The average pretest class of control class is 61,05. After the second class action, the average posttest of the experimental class is 79.45 and the control class is 74.95. Hypothesis calculation using t paired t test test and significance of 0.05 significant level indicates probability (significance) is 0,033. Because of the significance of 0.033


2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Hartin Suidah ◽  
Ninik Murtiyani ◽  
Arif Susanto ◽  
Yufi Aris Lestari ◽  
Shindy Sofyaning Fitra

ABSTRAKMasih tingginya penderita hipertensi merupakan salah satu masalah yang berpengaruh terhadap gaya hidup dan sikap yang mendorong timbulnya hipertensi. Untuk menangani tekanan darah pada penderita hipertensi umumnya minum obat-obatan dari puskesmas, rutinitas ini sering tidak disukai oleh penderita. Penelitian ini bertujuan untuk mengetahui efektifitas air rebusan daun seledri terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Desain penelitian ini Pre-Experimental dengan rancangan One- Group Pre-Post test design. Populasi dalam penelitian ini adalah semua lansia penderita hipertensi di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang sebanyak 30 responden. Sampel diambil dengan teknik total sampling. Variabel penelitian yaitu pemberian air rebusan daun seledri sebagai variabel independent dan tekanan darah sebagai variabel dependen. Data yang di dapat melalui lembar observasi tekanan darah kemudian di uji dengan menggunakan uji paired t Test.Hasil uji paired t Test menunjukkan bahwa p = 0,000 α= 0,05 Ho di tolak dan H1 diterima sehingga air rebusan daun seledri efektif terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Terdapat penurunan jumlah penderita hipertensi sebelum dan sesudah diberikan air rebusan daun seledri. Responden agar dapat meningkatkan informasi tentang pelaksanaan tekanan darah sehingga dapat mengurangi tekanan darah yang dialami dengan cara non formakologi sehingga responden tidak hanya menggantungkan pada obat-obatan farmakologi dalam menurunkan tekanan darah.Kata kunci : Air Rebusan Daun Seledri, Tekanan Darah, Lansia ABSTRACTStill high hypertension was  one of the problems that affect the lifestyle and attitudes that encourage the emergence of hypertension. To handle blood pressure in people with hypertension generally take  medication from puskesmas, this routine was often disliked by the patient. This study aims to determine the effectiveness of boiling water celery leaves on changes in blood pressure in the elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency.The design of this research was  Pre-Experimental with the design of One- Group Pre-Post test design. Population in this research was all elderly patient of hypertension in Posyandu Ngudi Konco Village Donomulyo District Donomulyo Malang Regency as many as 30 respondents. Samples were taken with total sampling technique. The research variable was giving boiled water of celery leaves as independent variable and blood pressure as dependent variable. The data can be through blood pressure observation sheet then tested by using paired t test.The result of paired t - test showed that p = 0.000 α = 0.05 Ho in rejection and H1 accepted so that boiling water celery leaf effective against blood pressure changes in elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency. There was a decrease in the number of hypertensive patients before and after being given boiled water of celery leaves. Respondents in order to improve information about the implementation of blood pressure so as to reduce blood pressure experienced by non-formakologi way so that respondents not only rely on pharmacological drugs in lowering blood pressure. Key Words: Water Stew of Celery leaves, Blood Pressure, Elderly


2019 ◽  
Author(s):  
Daniel Schiltz ◽  
Natalie Kiermeier ◽  
Dominik Eibl ◽  
Christoph Koch ◽  
Karolina Müller ◽  
...  

BACKGROUND Exact quantification of volumetric changes of the extremities is difficult. There are several direct and indirect methods to assess extremity volume. As water displacement volumetry is rarely viable in a clinical setting and circumference measurements are prone to errors due to poor reproducibility and high inter- and intra-observer variability, an objective and easily reproducible method is indispensable. OBJECTIVE The aim of this study was to establish a standardized method based on 3D scans with defined caudal and cranial landmarks of the lower leg which allows for measurements of exactly the same body area. Furthermore, this study tests the method in terms of reproducibility and evaluates volume changes after surgical therapy in patients suffering from lymphedema. METHODS 3D-scans of the lower limb were performed with a mobile 3D-scanner. Volumetric calculation was done digitally. “Repeatability“ and “Inter-observer reliability” of digital volumetry were tested. Furthermore, the method was applied on 31 patients suffering from chronic lymphedema. ANOVA (analyses of variance) was conducted to compare the digital volumetric measurements. To assess the sensitivity to changes in digital volumetry, the mean volume of 31 patients before and 3 months after therapy were compared by a paired t-Test. RESULTS Calculations of repeatability of the volume based on 20 3D-scans of the same lower leg showed a mean volume of 2,488 ± 0,011 liters (range: 2,470 – 2,510). The mean volume of the 7 measurements of the 3 examiners did not differ significantly (F(2,18) = 1,579, p = .233). The paired t-Test showed a significant mean volume decrease of 375ml (95% CI = 245/505ml) between pre and post treatment (t (30) =5,892, p < .001). CONCLUSIONS 3D-Volumetry is a noninvasive, easy and quick method to assess volume changes of the lower leg. Other than the costs, it is reproducible and precise and therefore ideal for evolution of therapy in lymphedema.


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