Glycogenolytic rates and cAMP in livers of rats running at different treadmill speeds

1983 ◽  
Vol 245 (3) ◽  
pp. R353-R356
Author(s):  
W. W. Winder ◽  
M. A. Beattie ◽  
E. O. Fuller
Keyword(s):  
Liver Glycogen ◽  
Work Rate ◽  
Curvilinear Relationship ◽  
Camp Concentration ◽  
Running Speed ◽  
Cyclic Monophosphate ◽  
High Degree ◽  
The Relationship ◽  
Camp Levels ◽  
Liver Glycogenolysis

The purposes of this study were to determine the effect of different work rates on the rate of liver glycogenolysis and to determine the relationship between liver adenosine 3',5'-cyclic monophosphate (cAMP) levels and the glycogenolytic rate. Rats were run at treadmill speeds ranging from 10 to 34 m/min up a 15% grade for either 30 or 60 min. Both the magnitude of the decrease in liver glycogen and the increase in hepatic cAMP were dependent on the running speed and the duration of running. At the highest work rate a disproportionate acceleration in the liver glycogenolytic rate was observed compared with that at lower work loads, thus resulting in a curvilinear relationship between work rate and liver glycogenolytic rate. A high degree of correlation was found between the liver glycogenolytic rate and hepatic cAMP concentration (r = 0.98). This observation is consistent with the idea that hepatic glycogenolytic rates are determined by cAMP-mediated mechanisms.

Liver fructose 2,6-bisphosphate in rats running at different treadmill speeds

1988 ◽  
Vol 255 (1) ◽  
pp. R38-R41
Author(s):  
W. W. Winder ◽  
H. T. Yang ◽  
J. Arogyasami
Keyword(s):  
Blood Glucose ◽  
Time Course ◽  
Liver Glycogen ◽  
Work Rate ◽  
Rapid Decline ◽  
Cyclic Monophosphate ◽  
Significant Change ◽  
Rate Of Decline ◽  
All Speeds

To determine the effect of work rate on liver fructose 2,6-bisphosphate (fructose 2,6-P2), rats were run for 5 min on a treadmill up a 15% grade at 16, 21, 26, 31, and 36 m/min. The liver content of fructose 2,6-P2 decreased 25, 42, 50, 62, and 71% from resting values after 5 min of running at these work rates. The time course of the decline in liver fructose 2,6-P2 was also studied in rats run at 16 m/min for times ranging from 5 to 100 min, at 23 m/min for times ranging from 5 to 60 min, and at 31 m/min for times of 5, 10, and 20 min. The hepatic content of fructose 2,6-P2 declined significantly after 5 min in all three groups of rats. The rate of decline was greatest in rats run at 31 m/min. After 100 min of running, fructose 2,6-P2 in livers of rats running at 16 m/min declined to levels seen in rats run at 31 m/min for 20 min. Changes in fructose 2,6-P2 occurred before a detectable decline in liver glycogen and in the absence of any significant change in blood glucose. Liver adenosine 3',5'-cyclic monophosphate (cAMP) was elevated after 5 min of exercise in rats running at 23 and 31 m/min but not in rats running at 16 m/min. By the end of exercise, hepatic cAMP was elevated in rats running at all speeds. The rapid decline in fructose 2,6-P2 probably plays a role in decreasing hepatic glycolysis, thereby ensuring that glucose 6-phosphate derived from glycogenolysis is diverted to blood glucose.

An assessment of phosphodiesterase activity in situ after treatment of hepatocytes with hormones

1988 ◽  
Vol 254 (4) ◽  
pp. E449-E453
Author(s):  
T. W. Gettys ◽  
P. F. Blackmore ◽  
J. D. Corbin
Keyword(s):  
Phosphodiesterase Inhibitor ◽  
Intracellular Concentration ◽  
Detectable Change ◽  
Phosphodiesterase Activity ◽  
Camp Concentration ◽  
Cyclic Monophosphate ◽  
Camp Analogue ◽  
Camp Levels

The role of phosphodiesterase activation in controlling adenosine 3',5'-cyclic monophosphate (cAMP) levels within hepatocytes was investigated by preloading hepatocytes with the hydrolyzable cAMP analogue 8-para-chlorophenylthio-cAMP (8-pCl phi S-cAMP) and measuring disappearance of the analogue after treating the cells with various hormones. Incubation of hepatocytes with 15 nM 8-pCl phi S-cAMP increased the intracellular concentration of the analogue at 0.5 and 2 min, but by 5 min the concentration plateaued and remained constant or declined slightly at 7 and 10 min. Treatment of hepatocytes with 5 nM glucagon led to a rapid 50% decline in intracellular concentration of the analogue. However, 6 nM insulin produced no detectable change in analogue concentration, and a combination of 5 nM glucagon and 6 nM insulin produced no greater lowering of 8-pCl phi S-cAMP than did glucagon alone. Treatment of hepatocytes with the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (50 microM) blocked approximately 30% of the glucagon-mediated decrease in 8-pCl phi S-cAMP concentration, and in separate cell incubations, it blocked 50% of the cAMP lowering produced by 125 nM 8-pCl phi S-cAMP. Treatment of analogue-preloaded hepatocytes with effective concentrations of phenylephrine, vasopressin, or angiotensin resulted in no change in intracellular analogue or cAMP concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)

Gender Ideology and Fertility: Evidence for a Curvilinear Hypothesis

2020 ◽  
Author(s):  
Serena Stefani ◽  
Gabriele Prati
Keyword(s):  
Gender Ideology ◽  
Two Dimensions ◽  
Curvilinear Relationship ◽  
World Population ◽  
Fertility Rates ◽  
The World ◽  
And Gender ◽  
Using Data ◽  
National Analysis ◽  
The Relationship

Research on the relationship between fertility and gender ideology revealed inconsistent results. In the present study, we argue that inconsistencies may be due to the fact that such relationship may be nonlinear. We hypothesize a U- shaped relationship between two dimensions of gender ideology (i.e. primacy of breadwinner role and acceptance of male privilege) and fertility rates. We conducted a cross-national analysis of 60 countries using data from the World Values Survey as well as the World Population Prospects 2019. Controlling for gross domestic product, we found support for a U-shaped relationship between gender ideology and fertility. Higher levels of fertility rates were found at lower and especially higher levels of traditional gender ideology, while a medium level of gender ideology was associated with the lowest fertility rate. This curvilinear relationship is in agreement with the phase of the gender revolution in which the country is located. Traditional beliefs are linked to a complementary division of private versus public sphere between sexes, while egalitarian attitudes are associated with a more equitable division. Both conditions strengthen fertility. Instead, as in the transition phase, intermediate levels of gender ideology’s support are associated with an overload and a difficult reconciliation of the roles that women have to embody (i.e. working and nurturing) so reducing fertility. The present study has contributed to the literature by addressing the inconsistencies of prior research by demonstrating that the relationship between gender ideology and fertility rates is curvilinear rather than linear.

TO STUDY THE DYNAMICS OF IMMUNITY IN BLACK-AND-WHITE COWS DEPENDING ON AGE

2020 ◽  
pp. 49-52
Author(s):  
М.В. ДОВЫДЕНКОВА
Keyword(s):  
Bactericidal Activity ◽  
Phagocytic Activity ◽  
Physiological State ◽  
Age Groups ◽  
Statistical Processing ◽  
Natural Resistance ◽  
Black And White ◽  
Feeding Methods ◽  
High Degree ◽  
The Relationship

Проведена статистическая обработка сформированной базы данных показателей неспецифической резистентности MS «Excel» с целью изучения динамики иммунитета по параметрам бактерицидной, лизоцимной и фагоцитарной активности у крупного рогатого скота черно-пестрой породы разных возрастов. Было установлено, что средние значения показателей лизоцимной и бактерицидной активности у телят в 6 мес были ниже (47,89% и 49,09%, соответственно), чем у животных в 3—4 года (53,75% и 52,81%). Выведено уравнение регрессии, описывающее взаимосвязь между средними показателями фагоцитарной активности и возрастом при высокой степени достоверности (R2=0,90). Изменения лизоцимной и бактерицидной активности в зависимости от возраста были недостоверными (R2=0,58 и R2=0,49, соответственно). Установлена высокая корреляция между бактерицидной и лизоцимной активностью. Отмечена динамика изменения неспецифического иммунитета у коров различных возрастных групп. Создание баз данных и постоянный мониторинг основных показателей естественной резистентности в зависимости от различных факторов (породы, возраста, стадий лактации, кормления, способов содержания), которые влияют на данные показатели, необходимо для оценки физиологического состояния организма животных и их устойчивости к болезням. Statistical processing of the generated MS "Excel" on indicators of non-specific resistance database was carried out with the aim of studying the dynamics of the development of immunity in terms of bactericidal, lysozyme and phagocytic activity in black-and-white cattle of different ages. It was found that the average values of indicators of lysozyme and bactericidal activity in calves at 6 months were lower (47.89% and 49.09%, respectively) than in animals at the age of 3—4 years (53.75% and 52.81%). The equation of regression was derived, it describes the relationship between the average indicators of phagocytic activity and the age with a high degree of reliability (R2=0.90). The changes in lysozyme and bactericidal activity depending on age were dubious (R2=0.58 and R2=0.49, respectively). The high correlation between bactericidal and lysozyme activity was established. It was noticed that the cows of different age groups experienced the dynamics of changes in nonspecific immunity. The creation of databases and constant monitoring of the main indicators of natural resistance, depending on various factors (breed, age, stages of lactation, feeding, methods of keeping) that affect these indicators, is necessary for assessing the physiological state of the animals’ body of and their resistance to diseases.

scholarly journals Advertising Media Impact in Consumer Buying Behavior

2019 ◽  
Vol 8 ◽  
pp. 54-56
Author(s):  
Ashmita Dahal Chhetri
Keyword(s):  
Consumer Behavior ◽  
Young Male ◽  
Electronic Media ◽  
Buying Behavior ◽  
Media Impact ◽  
High Degree ◽  
The Impact ◽  
Buying Behaviors ◽  
The Relationship ◽  
Better Than

Advertisements have been used for many years to influence the buying behaviors of the consumers. Advertisements are helpful in creating the awareness and perception among the customers of a product. This particular research was conducted on the 100 young male and female who use different brands of product to check the influence of advertisement on their buying behavior while creating the awareness and building the perceptions. Correlation, regression and other statistical tools were used to identify the relationship between these variables. The results revealed that the relationship between media and consumer behavior is positive. The adve1tising impact on sales and there is positive and high degree relationship between advertising and consumer behavior. The impact on advertising of a product of electronic media is better than non-electronic media.

scholarly journals Evaluating the Relationship Between Initial Injury, Referral to A Pain Clinic, and Medical Retirement from the Army: A Retrospective Analysis

2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 502-505
Author(s):  
Justin J Stewart ◽  
Diane Flynn ◽  
Alana D Steffen ◽  
Dale Langford ◽  
Honor McQuinn ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Retrospective Analysis ◽  
Extended Period ◽  
Pain Clinic ◽  
Outcome Variable ◽  
Future Research ◽  
Curvilinear Relationship ◽  
The Impact ◽  
Pain Care ◽  
The Relationship

ABSTRACT Introduction Soldiers are expected to deploy worldwide and must be medically ready in order to accomplish their mission. Soldiers unable to deploy for an extended period of time because of chronic pain or other conditions undergo an evaluation for medical retirement. A retrospective analysis of existing longitudinal data from an Interdisciplinary Pain Management Center (IPMC) was used to evaluate the temporal relationship between the time of initial duty restriction and referral for comprehensive pain care to being evaluated for medical retirement. Methods Patients were adults (>18 years old) and were cared for in an IPMC at least once between May 1, 2014 and February 28, 2018. A total of 1,764 patients were included in the final analysis. Logistic regression was used to evaluate the impact of duration between date of first duty restriction documentation and IPMC referral to the outcome variable of establishment of a permanent 3 (P3) profile. Results The duration between date of first duty restriction and IPMC referral showed a curvilinear relationship to probability of a P3 profile. According to our model, a longer duration before referral is associated with an increased probability of a subsequent P3 profile with the highest probability peaking at 19 months. The probability of P3 declines gradually for those who were referred later. Discussion This is the first time the relationship between time of initial duty restriction, referral to an IPMC, and subsequent P3 or higher profile has been tested. Future research is needed to examine medical conditions listed on the profile to see how they might contribute to the cause of referral to the IPMC. Conclusion A longer duration between initial duty restriction and referral to IPMC was associated with higher odds of subsequent P3 status for up to 19 months. Referral to an IPMC for comprehensive pain care early in the course of chronic pain conditions may reduce the likelihood of P3 profile and eventual medical retirement of soldiers.

Sino-Japanese Reactive Diplomacy as Seen Through the Interplay of the Belt Road Initiative (BRI) and the Free and Open Indo-Pacific Vision (FOIP)

China Report ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 7-21
Author(s):  
Stephen Nagy
Keyword(s):  
Matrix Analysis ◽  
State Sovereignty ◽  
Pacific Region ◽  
Legal Perspective ◽  
Road Maps ◽  
Process Oriented ◽  
Development Trajectories ◽  
High Degree ◽  
The Relationship

The Indo-Pacific region is now home to at least two competing regionalism road maps, China’s Belt Road Initiative (BRI) and Japan’s Free and Open Indo-Pacific Vision (FOIP). Through comparing their respective development trajectories, this article examines the relationship between these two regionalisation initiatives. Key lines of enquiry include the following: Is the interaction between the BRI and the FOIP Vision reactive, proactive or both? Why has each initiative changed its trajectory? How can we characterise these competing initiatives? This article employs a regionalism matrix analysis that compares two different approaches, integration from a ‘rational-legal perspective’ with an emphasis on broad cooperation and state sovereignty from a ‘process-oriented perspective’ with a focus on exact goals. It finds that the BRI focuses on both a high degree of state sovereignty based on a ‘process-oriented perspective’ and exact cooperation. In contrast, FOIP stresses integration through a ‘rational-legal perspective’, broad cooperation and a shared rules-based order. Furthermore, there is a reactive interplay between these two regionalism frameworks that shapes their orientation and influences their focus.

When Religion Hurts: Structural Sexism and Health in Religious Congregations

2021 ◽  
pp. 000312242199668
Author(s):  
Patricia Homan ◽  
Amy Burdette
Keyword(s):  
General Social Survey ◽  
State Level ◽  
Religious Participation ◽  
Religious Institutions ◽  
Religious Congregations ◽  
Positive Health ◽  
Nationally Representative ◽  
Positive Health Outcomes ◽  
High Degree ◽  
The Relationship

An emerging line of research has begun to document the relationship between structural sexism and health. This work shows that structural sexism—defined as systematic gender inequality in power and resources—within U.S. state-level institutions and within marriages can shape individuals’ physical health. In the present study, we use a novel dataset created by linking two nationally representative surveys (the General Social Survey and the National Congregations Study) to explore the health consequences of structural sexism within another setting: religious institutions. Although religious participation is generally associated with positive health outcomes, many religious institutions create and reinforce a high degree of structural sexism, which is harmful for health. Prior research has not reconciled these seemingly conflicting patterns. We find that among religious participants, women who attend sexist religious institutions report significantly worse self-rated health than do those who attend more inclusive congregations. Furthermore, only women who attend inclusive religious institutions exhibit a health advantage relative to non-participants. We observe marginal to no statistically significant effects among men. Our results suggest the health benefits of religious participation do not extend to groups that are systematically excluded from power and status within their religious institutions.

The Impact of Organisational, Social Environmental and Job Content Stressors on the Work Related Strains of Probation Officers

2001 ◽  
Vol 34 (2) ◽  
pp. 193-203 ◽  
Author(s):  
Clare O'donnell ◽  
Christine Stephens
Keyword(s):  
New Zealand ◽  
Health And Safety ◽  
Workplace Stress ◽  
Probation Officers ◽  
Curvilinear Relationship ◽  
Work Stressors ◽  
Work Related ◽  
Job Content ◽  
The Impact ◽  
The Relationship

In recent years workplace stress has been seen as an important occupational health and safety problem and probation officers in New Zealand have been identified as suffering from increasing perceptions of stress. Accordingly, the present study was undertaken with a sample of 50 New Zealand Probation Officers in three offices to examine the relationship of individual, organisational and work stressors with work related strains. It was predicted that work stressors would be positively related to strains and that individual differences (e.g., age or gender) would have a moderating effect on the relationship between stressors and strains. The results showed that stressors caused by organisational problems, such as role boundary and overload, were related to strains, more strongly than job content problems, such as difficult clients. Secondly, age may have a curvilinear relationship to strains. Thirdly, the office, or place of work, moderates the stressor strain relationship.

Money Matters: Dissecting the Relationship Between Gender Equality and Female Homicide Victimization Rates in the European Union

2016 ◽  
Vol 13 (5) ◽  
pp. 435-455 ◽  
Author(s):  
Janet P. Stamatel
Keyword(s):  
European Union ◽  
Gender Equality ◽  
European Countries ◽  
Curvilinear Relationship ◽  
Violent Victimization ◽  
The European Union ◽  
Homicide Victimization ◽  
The Relationship ◽  
Gender Specific ◽  
Victimization Rates

This study utilized a fairly new measure of gender equality from the European Union to dissect the relationship between gender-specific homicide victimization rates and different forms of gender equality across a sample of European countries. Results showed support for a curvilinear relationship between financial equality and female and male homicide victimization, providing support for amelioration and backlash theories, but no support for absolute economic marginalization. While there were some similarities between the female and male models, there were enough differences to warrant further investigations of gendered theories of violent victimization.

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