scholarly journals Estimating Cancer Latency Times Using a Weibull Model

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Diana L. Nadler ◽  
Igor G. Zurbenko
Keyword(s):  
Approximate Solutions ◽  
Weibull Model ◽  
Estimation Accuracy ◽  
Incidence Data ◽  
Different Types ◽  
Cancer Types ◽  
Trends Over Time ◽  
Cancer Latency ◽  
Cancer Incidence Data ◽  
Insight Into

Mathematical models can be useful tools in exploring population disease trends over time and can be used to gain insight into the fundamental mechanisms of cancer development. In this paper, we provide a systematic comparison between the exact and the approximate solutions for estimating the length of time between the biological initiation of cancer and diagnosis through the development of a Weibull-like survival model. A total of 1,608,484 malignant primary cancers were used in the analysis using cancer incidence data obtained from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program. We find that the approximate solution provides a reliable comparison of the latency periods for different types of cancer and has no significant effect on the estimation accuracy, which differs from the exact solution by 0% to 11.3%. Thirty-five of the 44 cancers in this analysis were found to progress silently for 10 years or longer prior to detection representing 89% of the patients in this analysis. The results of this analysis differentiate cancer types that progress undetected over a period of years to identify new opportunities for early detection which increases the likelihood of successful treatment and alleviates the ever-growing cancer burden.

Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types

2019 ◽  
Vol 21 (10) ◽  
pp. 771-783 ◽  
Author(s):  
Yin Wang ◽  
Zhenhao Liu ◽  
Baofeng Lian ◽  
Lei Liu ◽  
Lu Xie
Keyword(s):  
Clinical Analysis ◽  
System Level ◽  
Computational Pipeline ◽  
Biological Functions ◽  
Driver Genes ◽  
Different Types ◽  
Cancer Types ◽  
Survival Patterns ◽  
Functional Analyses ◽  
Insight Into

Aim and Objective: Integrating multi-omics data to identify driver genes and key biological functions for tumorigenesis remains a major challenge. Method: A new computational pipeline was developed to identify the Driver Mutation-Differential Co-Expression (DM-DCE) modules based on dysfunctional networks across 11 TCGA cancers. Results: Functional analyses provided insight into the properties of various cancers, and found common cellular signals / pathways of cancers. Furthermore, the corresponding network analysis identified conservations or interactions across different types of cancers, thus the crosstalk between the key signaling pathways, immunity and cancers was found. Clinical analysis also identified key prognostic / survival patterns. Conclusion: Taken together, our study sheds light on both cancer-specific and cross-cancer characteristics systematically.

The participation of Palestinian-Israeli politicians in public and commercial television and radio in Israel as capability

2021 ◽  
pp. 174804852199056
Author(s):  
Baruch Shomron ◽  
Amit Schejter
Keyword(s):  
Capabilities Approach ◽  
Media Representations ◽  
Community Members ◽  
Commercial Television ◽  
Radio Stations ◽  
Modes Of Representation ◽  
Current Affairs ◽  
Different Types ◽  
The Media ◽  
Insight Into

This study examines how media representations of Palestinian-Israeli politicians, can help community members realize their capabilities. The study’s database is comprised of 1,207 interviews conducted with Palestinian-Israeli politicians on news and current affairs programs on the three national television channels and the two national radio stations in Israel, for 24 months (2016-2017). We identified and analyzed the differences in the modes of representation between national and local Palestinian-Israeli politicians and between Palestinian-Israeli parliament members in the Joint List and Palestinian-Israeli parliament members in Zionist parties, all through the capabilities prism. In this study, we demonstrated how different types of Palestinian-Israeli politicians may potentially affect the realization of different political functions and capabilities. Analyzing political representations in the media through the theoretical framework of the ‘capabilities approach’ contributes to a more comprehensive insight into the roles the media can play promoting people’s wellbeing and human rights, relative to traditional media theories.

Double, triple or quadruple hits? Exploring the impact of cybercrime on victims in the Netherlands

2021 ◽  
pp. 026975802110106
Author(s):  
Raoul Notté ◽  
E.R. Leukfeldt ◽  
Marijke Malsch
Keyword(s):  
Public Opinion ◽  
Literature Review ◽  
The Netherlands ◽  
Public Discourse ◽  
Moral Judgments ◽  
Victim Blaming ◽  
High Prevalence ◽  
Different Types ◽  
The Impact ◽  
Insight Into

This article explores the impact of online crime victimisation. A literature review and 41 interviews – 19 with victims and 22 with experts – were carried out to gain insight into this. The interviews show that most impacts of online offences correspond to the impacts of traditional offline offences. There are also differences with offline crime victimisation. Several forms of impact seem to be specific to victims of online crime: the substantial scale and visibility of victimhood, victimisation that does not stop in time, the interwovenness of online and offline, and victim blaming. Victims suffer from double, triple or even quadruple hits; it is the accumulation of different types of impact, enforced by the limitlessness in time and space, which makes online crime victimisation so extremely invasive. Furthermore, the characteristics of online crime victimisation greatly complicate the fight against and prevention of online crime. Finally, the high prevalence of cybercrime victimisation combined with the severe impact of these crimes seems contradictory with public opinion – and associated moral judgments – on victims. Further research into the dominant public discourse on victimisation and how this affects the functioning of the police and victim support would be valuable.

scholarly journals Lights and Shadows in Immuno-Oncology Drug Development

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 691
Author(s):  
Milana Bergamino Sirvén ◽  
Sonia Pernas ◽  
Maggie C. U. Cheang
Keyword(s):  
Drug Development ◽  
Checkpoint Inhibitors ◽  
Late Phase ◽  
New Drugs ◽  
Successful Outcome ◽  
Different Types ◽  
Cancer Types ◽  
Clinical Trial Designs ◽  
Oncology Drug Development ◽  
Critical Aspects

The rapidly evolving landscape of immuno-oncology (IO) is redefining the treatment of a number of cancer types. IO treatments are becoming increasingly complex, with different types of drugs emerging beyond checkpoint inhibitors. However, many of the new drugs either do not progress from phase I-II clinical trials or even fail in late-phase trials. We have identified at least five areas in the development of promising IO treatments that should be redefined for more efficient designs and accelerated approvals. Here we review those critical aspects of IO drug development that could be optimized for more successful outcome rates in all cancer types. It is important to focus our efforts on the mechanisms of action, types of response and adverse events of these novel agents. The use of appropriate clinical trial designs with robust biomarkers of response and surrogate endpoints will undoubtedly facilitate the development and subsequent approval of these drugs. Further research is also needed to establish biomarker-driven strategies to select which patients may benefit from immunotherapy and identify potential mechanisms of resistance.

Small rodent communities (Muridae) in Gabonese savannas: species diversity and biogeographical affinities

Mammalia ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jean-François Mboumba ◽  
Maxime R. Hervé ◽  
Véronique Guyot ◽  
Frederic Ysnel
Keyword(s):  
Ecological Factors ◽  
Abundant Species ◽  
Small Rodent ◽  
Small Rodents ◽  
South West ◽  
New Information ◽  
Different Types ◽  
Mus Minutoides ◽  
Insight Into ◽  
Coastal Basin

Abstract The study contributes to the knowledge of species composition and biogeographical affinities of savannas rodent in Gabon. Unlike small rodents in Gabonese forests, there is little data on the diversity of small rodents in Gabonese savannas. The diversity and distribution of rodent murid communities was studied in four different types of savanna in Gabon: Coastal Basin (South-West), Lopé/Okanda (in the Center), Batéké Plateaux (Southeastern) and Ngougnié/ N’yanga (in the South). A total of 428 individuals representing six species were captured over 11,920 trap nights. Trap success was highly variable (2.2–6.9 %). The most abundant species were Mus minutoides (69%) followed by Lemniscomys striatus (21.5%). Indices of species richness varied from 2 to 5 and diversity (Shannon and Weaver) was low in the four savannas with the highest value at Ngougnié/N’yanga (H′ = 1.2). Species distributions show that Gabonese savanna small rodents conform to four distribution types, with one species known from Zambesian savannas exhibiting austral affinities (Pelomys campanae: occurs in three southern savannas). This new information provides important insight into the biogeography of small rodents at a local and regional level. Moreover, the correspondence analysis highlighted an influence of local ecological factors on population abundance.

EFFECT OF PERACETIC ACID OXIDATION ON N-CONTAINING COMPONENTS OF HUMIC MATERIALS

1980 ◽  
Vol 60 (3) ◽  
pp. 541-548 ◽  
Author(s):  
M. SCHNITZER ◽  
D. A. HINDLE
Keyword(s):  
Amino Acid ◽  
Peracetic Acid ◽  
Amino Sugar ◽  
Chemical Oxidation ◽  
Acid Oxidation ◽  
Mild Oxidation ◽  
Total N ◽  
Different Types ◽  
Humic Materials ◽  
Insight Into

Three humic and one fulvic acid were degraded by mild chemical oxidation with peracetic acid, with special emphasis on the effects of this type of oxidation on N-containing components. The different types of N that were considered were NH4+-N, amino acid-N, amino sugar-N, NO2−-N + NO3−-N, and by difference from total N, "unknown" N. The behaviour toward mild chemical oxidation of all four preparations was essentially similar: there were decreases in mino acid-N, amino sugar-N and "unknown" N, increases in NH4+-N, NO2−-N + NO3−-N with one material, and in N-gases. The "unknown" N was not inert. Between 16.6 and 59.1% of the latter appeared to be converted, as a result of mild chemical oxidation, to NH3 and N-gases which were expelled from the systems. The results presented provide an insight into what happens to N-containing humic components as a result of mild oxidation.

An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment

2021 ◽  
Vol 21 ◽  
Author(s):  
Parisa Dehghani ◽  
Monireh Esameili Rad ◽  
Atefeh Zarepour ◽  
Ponnurengam Malliappan Sivakumar ◽  
Ali Zarrabi
Keyword(s):  
Polymeric Nanoparticles ◽  
Synthetic Polymers ◽  
Diagnostic Methods ◽  
Diagnosis And Treatment ◽  
Diabetes Diagnosis ◽  
Transport Mechanisms ◽  
Different Types ◽  
Treatment And Diagnosis ◽  
Insight Into

: Diabetes mellitus (DM) is a type of chronic metabolic disease that has affected millions of people worldwide and is known with a defect in the amount of insulin secretion, insulin functions, or both. This deficiency leads to an increase in the amounts of glucose, which could be accompanied by long-term damages to other organs such as eyes, kidneys, heart, and nervous system. Thus, introducing an appropriate approach for diagnosis and treatment of different types of DM is the aim of several researches. By the emergence of nanotechnology and its application in medicine, new approaches were presented for these purposes. The object of this review article is to introduce different types of polymeric nanoparticles (PNPs), as one of the most important classes of nanoparticles, for diabetic management. To achieve this goal, at first, some of the conventional therapeutic and diagnostic methods of DM will be reviewed. Then, different types of PNPs, in two forms of natural and synthetic polymers with different properties, as a new method for DM treatment and diagnosis will be introduced. In the next section, the transport mechanisms of these types of nano-carriers across the epithelium, via paracellular and transcellular pathways will be explained. Finally, the clinical use of PNPs in the treatment and diagnosis of DM will be summarized. Based on the results of this literature review, PNPs could be considered one of the most promising methods for DM management.

Signals for a promoting action of radiation in cancer incidence data

2002 ◽  
Vol 22 (3A) ◽  
pp. A71-A74 ◽  
Author(s):  
W F Heidenreich
Keyword(s):  
Cancer Incidence ◽  
Incidence Data ◽  
Cancer Incidence Data

scholarly journals INS/GPS for High-Dynamic UAV-Based Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Junchuan Zhou ◽  
Stefan Knedlik ◽  
Otmar Loffeld
Keyword(s):  
Carrier Phase ◽  
Velocity Estimation ◽  
Estimation Accuracy ◽  
Processing Load ◽  
Estimation Errors ◽  
Integration Interval ◽  
Sequential Processing ◽  
Large Velocity ◽  
Different Types ◽  
High Dynamic

The carrier-phase-derived delta pseudorange measurements are often used for velocity determination. However, it is a type of integrated measurements with errors strongly related to pseudorange errors at the start and end of the integration interval. Conventional methods circumvent these errors with approximations, which may lead to large velocity estimation errors in high-dynamic applications. In this paper, we employ the extra states to “remember” the pseudorange errors at the start point of the integration interval. Sequential processing is employed for reducing the processing load. Simulations are performed based on a field-collected UAV trajectory. Numerical results show that the correct handling of errors involved in the delta pseudorange measurements is critical for high-dynamic applications. Besides, sequential processing can update different types of measurements without degrading the system estimation accuracy, if certain conditions are met.

Architecture of Evolution

2021 ◽  
Author(s):  
Alla Packevich
Keyword(s):  
Planetary System ◽  
Conflict Situation ◽  
Point Of View ◽  
Science Students ◽  
Present Stage ◽  
Male And Female ◽  
Different Types ◽  
New Energy ◽  
The One ◽  
Insight Into

The monograph, on the one hand, examines the period of development of the descending cycle of evolution and the associated progressive changes that show the irreversibility of the processes of formation of the planetary system. The end of one cycle and the beginning of another leads to the transformation of the system of life and the expansion of consciousness at a new energy level. On the other hand, the questions of potential opportunities for the development of the ascending phase of evolution, which goes both along the path of complexity of the organization and along the path of diversity, are considered. In the ascending evolutionary stream, what has been differentiated into the corresponding levels in the descending cycle is brought together and thus prepared to enter into new, more perfect forms of unity. It is shown that the development of humanity along its entire path depends on the interaction of energies of various forms and potentials. Understanding the relationships between different types of energy and their use provides insight into many important issues in the evolution of society. The material introduces the modern features of the existence of the male and female sexes from the energy point of view. The idea of a way out of the current conflict situation that has arisen between the sexes at the present stage of evolution is proposed. It will be useful for those interested in the problems of scientific knowledge, architects, philosophers,historians, physicists and methodologists of science, students and students of secondary schools.

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