scholarly journals Development of Castor Oil Based Poly(urethane-esteramide)/TiO2Nanocomposites as Anticorrosive and Antimicrobial Coatings

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Mohammed Rafi Shaik ◽  
Manawwer Alam ◽  
Naser M. Alandis
Keyword(s):  
Castor Oil ◽  
Tap Water ◽  
Antimicrobial Properties ◽  
Gel Permeation Chromatography ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Spectroscopic Techniques ◽  
Condensation Polymerization ◽  
Agar Disc ◽  
Bacteria And Fungi

Castor oil based polyesteramide (CPEA) resin has been successfully synthesized by the condensation polymerization of N-N-bis (2-hydroxyethyl) castor oil fatty amide (HECA) with terephthalic acid and further modified with different percentages of 7, 9, 11, and 13 wt.% of toluene-2,4-diisocyanate (TDI) to obtain poly(urethane-esteramide) (UCPEA), via addition polymerization. TiO2(0.1, 0.2, 0.3, 0.4, and 0.5 wt%) nanoparticles were dispersed in UCPEA resin. The structural elucidation of HECA, CPEA, and UCPEA has been carried out using FT-IR,1H-NMR, and13C-NMR spectroscopic techniques while physicochemical and physicomechanical properties were investigated by standard methods. Thermal stability and molecular weight of UCPEA have been assessed by thermogravimetric analysis (TGA) and gel permeation chromatography (GPC), respectively. Furthermore, the corrosion behavior of UCPEA coatings on mild steel has been investigated by potentiodynamic polarization measurements in different corrosive environments (3.5 wt% HCl, 5 wt% NaCl, 3.5 wt% NaOH, and tap water) at room temperature and surface analysis by scanning electron microscope (SEM) and energy dispersive X-ray (EDX). The antibacterial activities of the UCPEA were tested against bacteria and fungi by agar disc diffusion method. The results of this study have revealed that UCPEA nanocomposite coatings exhibit good physicomechanical, anticorrosion and antimicrobial properties, which can be safely used up to 200°C.

scholarly journals Chemotherapeutic Potential of Carthamus Oxycantha Root Extract as Antidiarrheal and In Vitro Antibacterial Activities

Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 226 ◽  
Author(s):  
Muhammad Ikram ◽  
Amany Magdy Beshbishy ◽  
Muhammad Kifayatullah ◽  
Adedayo Olukanni ◽  
Muhammad Zahoor ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Castor Oil ◽  
Research Work ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Diffusion Method ◽  
Root Extract ◽  
Bacterial Strains

Our research work was designed to investigate the curative and preventive effects of Carthamus oxycantha root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, and Salmonella typhi, while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400 mg/kg (body weight, b.w) orally. The methanol extract of C. oxycantha significantly (p < 0.001) decreased the frequency of defecation, and wet stools in a dose depended on the manner of after receiving magnesium sulfate (2 g/kg (b.w)) and castor oil (1.0 mL/mice). Furthermore, the extract of C. oxycantha showed concentration-dependent antimicrobial properties against S. aureus followed by S. typhi, E. coli, and P. aeroginosa bacterial strains, with inhibitions ranging from 10.5–15 mm. These findings show significant results that C. oxycantha is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action.

scholarly journals Gas chromatographic and antimicrobial analyses of phenolic compounds in Senna alata (L.) Roxb. (Fabales: Fabaceae)

2016 ◽  
Vol 3 (6) ◽  
pp. 355-365
Author(s):  
Funmilayo Adelowo ◽  
Oluwole Oladeji
Keyword(s):  
Gas Chromatography ◽  
Phenolic Compounds ◽  
Antibacterial Activities ◽  
Bioactive Metabolites ◽  
Diffusion Method ◽  
Chemical Components ◽  
Bioactive Components ◽  
Antimicrobial Substances ◽  
Agar Disc ◽  
Senna Alata

This present work is aimed at determining the chemical components in Senna alata (L.) Roxb. (Fabales: Fabaceae), that contains a large array of phenolic compounds which make it useful as antifungal and antibacterial. Despite a notable success in the recent researches, yet, the quantification of the chemical components has not been actually specified. There is a claim by local people that S. alata can cure fungi and bacteria related diseases. Therefore, there is a need to ascertain this claim by examining the bioactive components present in the plant. The Gas Chromatography (GC) analysis was performed using a Clarus 500 Perkin Elmer gas chromatography equipped with an Elite-5 capillary column with the addition of an absolute alcohol. The antimicrobial analysis was carried out using Agar Disc Diffusion Method. In the GC chromatogram, four prominent peaks were observed in leaf chromatogram, three peaks in flower chromatogram and five peaks in fruit chromatogram, respectively. The flower contained the highest amount of cinnamic acid (52.91%) and the fruit contained the least (17.03%). The presence of some bioactive metabolites could be responsible for the observed antifungal and antibacterial activities on the susceptible organisms studied. It could be concluded that this plant is natural sources of antimicrobial substances of high importance and are useful in chemotherapy.

scholarly journals ONE-POT SYNTHESIS OF 2,4,5-TRIARYLIMIDAZOLES FROM KETO-OXIMES: CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY

2019 ◽  
pp. 263-270
Author(s):  
KRANTHI KUMAR T ◽  
SREENIVASULU R
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Antimicrobial Properties ◽  
Antimycobacterial Activity ◽  
Diffusion Method ◽  
Current Investigation ◽  
One Pot ◽  
Fungal Strains ◽  
Aryl Aldehydes ◽  
Agar Disc

Background and Objective: Imidazole scaffold is pervasive in pharmaceuticals and it possesses diverse type of biological activities, especially triarylimidazole derivatives are biologically prominent molecules which inspired the current investigation. The objective of the work is to synthesize 15 novel 2,4,5-triarylimidazole derivatives and evaluate their antimicrobial and antimycobacterial activity against selected bacterial and fungal strains. Methods: The title compounds 2,4,5-triaryl-imidazole were synthesized from the corresponding aryl aldehydes and keto-oximes through the cyclization to N-hydroxyimidazoles and reduced thermally to the different imidazole derivatives. Agar disc diffusion method is employed for the antimicrobial and antimycobacterial studies. Results: Fifteen novel 2,4,5-triarylimidazoles were synthesized in adequate yields and characterization of the molecules was done by detailed spectral analysis using advanced analytical support. Results disclosed that all the synthesized compounds were exhibiting antimicrobial properties. Compounds 3h, 3g, 3b, and 3m were stated to possess potent antimicrobial properties in the given bacterial and fungal strains. Conclusion: The current investigation results support the antimicrobial and antimycobacterial activity of the synthesized 2,4,5-triarylimidazole derivatives. Further, research is necessary to explore the mechanism involved in the antimicrobial activity.

scholarly journals Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS

2020 ◽  
Vol 21 (4) ◽  
Author(s):  
Siti Samiyarsih ◽  
NUR FITRIANTO ◽  
ELLY PROKLAMASININGSIH ◽  
JUWARNO ◽  
JUNI SAFITRI MULJOWATI
Keyword(s):  
Antimicrobial Activity ◽  
Catharanthus Roseus ◽  
Methanol Extract ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Diffusion Method ◽  
E Coli ◽  
Phytochemical Compounds ◽  
Dark Pink

Abstract. Samiyarsih S, Fitrianto N, Proklamasiningsih E, Juwarno, Muljowati JS. 2020. Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS. Biodiversitas 21: 1332-1344. Catharanthus roseus (L.) G is an important medicinal plant to evaluate the possibility of novel pharmaceuticals since most of the bacterial pathogens are developing resistance against antibiotics. This research aimed to determine the phytochemical diversity of methanol extract of eight cultivars of C. roseus and to evaluate for possible antimicrobial (antifungal and antibacterial) activities. It is the first research to compare phytochemicals and antimicrobial potential among C. roseus cultivars. The compound obtained was screened by Gas Chromatography-Mass Spectrometry (GC-MS) method. While agar-well disc diffusion method was employed to measure antimicrobial activity against Escherichia coli, Staphylococcus aureus, Aspergillus flavus and Aspergillus niger. Based on GC-MS analysis, a total of 18 significantly different metabolite compounds. The abundances of phytochemical compounds (18 classes total) in each cultivar were Dark Pink (66%), Pink (50%), Purple Pink (44%), Pale Pink (27%), White (44%), Milky White (50%), Whitish pink (50%) and Pinkish Red (55%). The leaves extracts showed antimicrobial activity with inhibition zones ranging from 6.40-22.00 mm and 3.35-8.20 mm, respectively. The best antimicrobial activity against E. coli, S. aureus, A. flavus, and A. niger with the zone of inhibition 16.10±1.67 mm, 22.00±0.33 mm, 6.05±0.67 mm and 8.20±0.50 mm respectively by Dark Pink cultivar.

scholarly journals Extraction and Isolation of Compound from Roots of Kniphofia pumila, and Its Antibacterial Activities in Combination with Zinc Chloride

2020 ◽  
Vol 17 (7) ◽  
pp. 631-638
Author(s):  
Dele ABDISSA ◽  
Gezahegn FAYE ◽  
Melkamu FAYERA ◽  
Shiferaw DEMISSIE
Keyword(s):  
Antibacterial Activity ◽  
Crude Extract ◽  
Pathogenic Bacteria ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Spectroscopic Techniques ◽  
Bacterial Strains ◽  
Pure Compound ◽  
Standard Drug ◽  
Isolated Compound

Kniphofia pumila has been traditionally used for the treatment of different diseases in Oromiya regional state, western part of Ethiopia. Thus, the main objective of this study was to extract bioactive natural products from the roots of K. pumila and perform in vitro antibacterial activity tests against selected pathogens. Extraction of compound from the roots of K. pumila was carried out by maceration method at room temperature and its antibacterial activity was done using agar disc diffusion method. The crude extracts alone and along with ZnCl2 were tested against pathogenic bacteria Escherichia coli (ATCC 25722), Klebsiella pneumoniae subsp. pneumoniae (DSM 19613), Staphylococcus aureus (ATCC 25925) and Salmonella Typhimurium (ATCC 13311). Following its promising activity, the acetone crude extract that have shown better antibacterial activity was subjected to column chromatography for isolation of pure compound. Hence, one pure compound (GZ-1) was obtained from acetone crude extract. Meanwhile, the antibacterial activities of the isolated compound alone and in combination with ZnCl2 were also performed against all aforementioned bacterial strains. Then, isolated compound was characterized by using NMR spectroscopic techniques such as 1H-NMR, 13C-NMR and, 2D NMR, so as to establish its structure as 3’-acetyl-2’,6’-dihydroxy-4-methoxyphenyl-1,8-dihydroxy-3-methylanthraquinone, trivial name knipholone. Finally, GZ-1 was isolated from the roots of K. pumila and it was noted that the antibacterial activities of ZnCl2 in combination with crude extract as well as with isolated compound against E. coli (ATCC 25722), S. aureus (ATCC 25925) and S. Typhimurium (ATCC 13311) bacterial strains showed remarkable results which were greater than the antibacterial activity of the positive standard drug (gentamycin). To sum up, from the chromatographic isolation of roots acetone extract of K. pumila one pure compound (knipholone) was obtained. Its antibacterial activity was also evaluated in combination with ZnCl2 salt and alone.

scholarly journals Vegetable-Oil-Based Hyperbranched Polyester-Styrene Copolymer Containing Silver Nanoparticle as Antimicrobial and Corrosion-Resistant Coating Materials

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Manawwer Alam ◽  
Mohammed Rafi Shaik ◽  
Naser M. Alandis
Keyword(s):  
Linolenic Acid ◽  
Silver Nanoparticle ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Spectroscopic Techniques ◽  
Hyperbranched Polyester ◽  
Coating Materials ◽  
Corrosion Resistant ◽  
Resistant Coating ◽  
Corrosion Resistant Coating

Pongamiaoil (PO) was converted toPongamiaoil hydroxyl (POH) via epoxidation process. The esterification of POH with linolenic acid was carried out to form hyperbranched polyester (HBPE), and further styrenation was performed at the conjugated double bond in the chain of linolenic acid. After styrenation, silver nanoparticle was added in different weight percentages (0.1–0.4 wt%). The structural elucidation of POH, HBPE, and HBPE-St was carried out by FT-IR,1H-NMR, and13C-NMR spectroscopic techniques. Physicochemical and physicomechanical analyses were performed by standard method. Thermal behavior of the HBPE-St was analyzed by using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The coatings of HBPE-St were prepared on mild steel strips. The anticorrosive behavior of HBPE-St resin-based coatings in acid, saline, and tap water was evaluated, and the molecular weight of HBPE-St was determined by gel permeation chromatography (GPC). The antibacterial activities of the HBPE-St copolymers were tested in vitro against bacteria and fungi by disc diffusion method. The HBPE-St copolymers exhibited good antibacterial activities and can be used as antimicrobial and corrosion-resistant coating materials.

scholarly journals Facile Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Activities of Biscoumarin Copolyester Bearing Pendant 3-(Trifluoromethyl)Styrene

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Narendran Kandaswamy ◽  
Nanthini Raveendiran
Keyword(s):  
Gel Permeation Chromatography ◽  
Inherent Viscosity ◽  
Proton Nuclear Magnetic Resonance ◽  
Diffusion Method ◽  
X Ray Diffraction ◽  
Anticancer Activities ◽  
Scanning Calorimetry ◽  
H Nmr ◽  
Agar Disc

Synthesis of random biscoumarin copolyester bearing pendant 3-(trifluoromethyl)styrene was prepared by the reaction of biscoumarin monomer 3 and hydroquinone 5 with azeloyl chloride. The influence of pendant 3-(trifluoromethyl)styrene unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and compared in detail. The inherent viscosity and polydispersity index of the copolyester were found to be 0.15 dL/g and 1.36, respectively. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The physical properties of copolyester were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and X-ray diffraction (XRD) technique. Agar disc diffusion method was employed to study the antimicrobial activity of the random copolyester. In vitro anticancer activity against lung cancer (Hep-2) cell line was also investigated.

scholarly journals Synthesis, Characterization, Antifungal and Antibacterial Activities of Novel Amide Derivatives of 1,3-Dioxolane

2019 ◽  
Vol 11 (1) ◽  
pp. 71
Author(s):  
Zahra Begum ◽  
Momin Khan ◽  
Sher Wali Khan ◽  
Muhammad Imran ◽  
Noor Rehman ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Partial Hydrolysis ◽  
Chromatographic Technique ◽  
Spectroscopic Techniques ◽  
Amide Derivatives ◽  
Bacteria And Fungi ◽  
Different Strains ◽  
Hydrolysis Of

L-Tartaric acid which is chiral compound and commercially available, was converted into 1,3-dioxolane. In the synthetic sequence, 1,3-dioxolane was first formed via protection and partial hydrolysis of L-tartaric acid. Treatment with altered substituted aromatic amines, 1,3-dioxolane gave the desired amides i.e. ethyl 2,2-dimethyl-5-(phenylcarbamoyl)-1,3-dioxolane-4-carboxylate 3a, 2-(4-(ethoxycarbonyl)-2,2-dimethyl-1,3-dioxolane-5-carboxamido)benzoic acid 3b, ethyl 5-(4-iodophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3c, ethyl 5-(2-chlorophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3d and ethyl 5-(2,4-dichlorophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3e. These chiral derivatives were purified through column chromatographic technique and characterized by different spectroscopic techniques i.e IR, 1H NMR, 13C NMR and EIMS. The antimicrobial activities of these compounds were determined at different concentrations against different strains of bacteria and fungi.

Antibacterial activity of the phenolic extract of wild virgin olive oil in vitro

2021 ◽  
Vol 18 ◽  
Author(s):  
Khalida Bouarroudj-Hamici ◽  
Soraya Mettouchi ◽  
Lynda Medjkouh-Rezzak ◽  
Romain Larbat ◽  
Abderezak Tamendjari
Keyword(s):  
Antibacterial Activity ◽  
Phenolic Compounds ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Antimicrobial Properties ◽  
Olive Tree ◽  
Diffusion Method ◽  
Phenolic Composition ◽  
Agar Disc

Background: The olive tree (Olea europaea L.), the most widespread plant species in the Mediterranean basin, includes two forms: cultivated (var Europaea) and wild (var Sylvestris). Wild olive trees or oleasters cover large areas in Algeria. It has been shown that oil from oleaster has a higher content of phenolic compounds, which could have antimicrobial properties. Objective:: The objective of this study was to assess the antibacterial activity of phenolic extracts from four Algerian oleaster oils and an extra virgin olive oil (EVOO) from Chemlal variety. Methods: Phenolic compounds were determined by UHPLC-MS. Antibacterial activity was tested against six referenced human enteropathogenic bacteria by the agar disc diffusion method by measuring the diameters of the zone of inhibition. Results: The results revealed a similarity between the phenolic composition of oleasters 1 and 3 and between oleaster 4 and EVOO; however, the phenolic composition of oleaster 2 that the poorer was markedly different with a higher content of free phenolic alcohols and lower in secoiridoids.

scholarly journals Antimicrobial Activity of Some Indigenous Plants of Bangladesh

1970 ◽  
Vol 7 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Mohammad S Rahman ◽  
Mohammed Z Rahman ◽  
Md Abdul Wahab ◽  
Rasheduzzaman Chowdhury ◽  
Mohammad A Rashid
Keyword(s):  
Antimicrobial Activity ◽  
Plant Extracts ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Indigenous Plants ◽  
Gram Negative ◽  
Agar Disc ◽  
Bacteria And Fungi

The antimicrobial activity of methanol extracts of 17 plant species of Bangladesh was evaluated by the agar disc diffusion method. Among those, eight plant extracts exhibited potent antimicrobial activity against a wide variety of Gram positive and Gram negative bacteria and fungi at a concentration of 400 μg /disc.Key words: Antimicrobial activity, Disc diffusion method.DOI = 10.3329/dujps.v7i1.1213Dhaka Univ. J. Pharm. Sci. 7(1): 23-26, 2008 (June)

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