scholarly journals Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Xiao-Hong Li ◽  
Hai-Yan Lin ◽  
Li-Ying Guan ◽  
Hui Peng ◽  
Meng-Meng Wen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Association ◽  
Direct Bilirubin ◽  
Serum Total Bilirubin ◽  
Study Cohort ◽  
Cross Sectional ◽  
Chinese Men ◽  
Blood Institute ◽  
Indirect Bilirubin ◽  
Healthy Chinese

Background. Serum bilirubin is a potent endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies have reported that bilirubin was negatively associated with metabolic syndrome. However, in recent longitudinal studies, the relations between bilirubin and metabolic syndrome are inconsistent. Moreover, previous studies mainly focused on serum total bilirubin which is the sum of direct bilirubin and indirect bilirubin. For these reasons, the longitudinal effect of bilirubin subtypes on incident metabolic syndrome was evaluated in Chinese men. Methods. The study cohort involved 1339 Chinese men without metabolic syndrome. Metabolic syndrome was defined by the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, using BMI for the replacement of waist circumference. Results. There are 117 incident metabolic syndrome cases (8.7%) during 5 years of follow-up among 1339 metabolic syndrome-free participants at baseline. After adjusting for age, drinking, smoking, physical activity, TG, and LDL-C, the odd ratios (ORs) and 95% confidence intervals (CIs) for MetS incidence in the second, third, and fourth quartiles versus the first quartile of DBil concentration were 1.00 (0.61–1.63), 0.57 (0.32–1.02), and 0.51 (0.28–0.92) (Ptrend=0.031), respectively. Conclusions. Our findings support the negative association between direct bilirubin and incident metabolic syndrome in healthy Chinese men over 5-year period.

High Amounts of Sitting, Low Cardiorespiratory Fitness, and Low Physical Activity Levels: 3 Key Ingredients in the Recipe for Influencing Metabolic Syndrome Prevalence

2016 ◽  
Vol 32 (3) ◽  
pp. 587-594 ◽  
Author(s):  
Meghan K. Edwards ◽  
Paul D. Loprinzi
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Cardiorespiratory Fitness ◽  
Vigorous Physical Activity ◽  
Adult Population ◽  
Heart Association ◽  
Activity Levels ◽  
Cross Sectional ◽  
Blood Institute ◽  
National Heart Lung

Purpose: Limited research has evaluated the independent and additive associations of moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and cardiorespiratory fitness (CRF) with metabolic syndrome, which was the purpose of this study. Design: Cross-sectional. Setting: National Health and Nutrition Examination Survey 2003 to 2004. Sample: Three hundred seven adults aged 20 to 49 years. Measures: Moderate-to-vigorous physical activity and SB were assessed via accelerometer, whereas CRF was assessed via submaximal treadmill testing. Metabolic syndrome was assessed via the American Heart Association/National Heart, Lung, and Blood Institute guidelines. Analysis: Multivariable logistic regression. Results: A 10 min/d increase in MVPA was associated with a 45% reduced odds of metabolic syndrome (odds ratio [OR] = 0.55, 95% confidence interval [CI] = 0.40-0.76, P = .001), and a 10 mL/kg/min increase in CRF was associated with a 43% reduced odds of having metabolic syndrome (OR = 0.57, 95% CI = 0.37-0.87, P = .013). Additionally, a statistically significant combined association of MVPA, SB, and CRF with metabolic syndrome was present; individuals who had below-median SB and above-median MVPA and CRF had an 88% reduced odds of metabolic syndrome (OR = 0.12, 95% CI = 0.03-0.48, P = .005) when compared to those who had below-median MVPA and CRF and above-median SB. Conclusion: When considering MVPA, SB, and CRF, MVPA and CRF were both independently associated with metabolic syndrome (SB was not) among this young adult population and there was also evidence to support a combined association of all 3 parameters on metabolic syndrome.

scholarly journals Gender discrepancy in the predictive effect of metabolic syndrome and its components on newly onset cardiovascular disease in elderly from rural China

2020 ◽  
Author(s):  
Shasha Yu ◽  
Xiaofan Guo ◽  
GuangXiao Li ◽  
Hongmei Yang ◽  
Liqiang Zheng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Rural China ◽  
International Diabetes Federation ◽  
Heart Association ◽  
Population Based ◽  
Blood Institute ◽  
Effective Strategies ◽  
National Heart Lung ◽  
Predictive Effect

Abstract Background To evaluate the possible predictive effect of metabolic syndrome (MetS) and its components on cardiovascular disease (CVD) in a longitudinal analysis according to different criteria of MetS among rural Chinese elderly. Method A population-based sample of 2486 rural elderly Chinese residents aged ≥ 60 years at baseline were followed up from 2012–2013 to 2015–2017. CVD included stroke, coronary heart disease (CHD) diagnosed by clinicians were self-reported and were confirmed by medical records. MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and the international Diabetes Federation (IDF) criterion respectively. Result Hazard ratio adjusting for CHD, Stroke and CVD in those with MetS using NCEP ATP III criteria in female were 1.27 (95%CI 0.73, 2.21), 1.54 (95%CI 0.99, 2.40) and 1.45 (95%CI 1.00, 2.10); 1.33 (95%CI 0.77, 2.32), 1.44 (95%CI 0.92, 2.25) and 1.36 (95%CI 0.94, 1.97) with the AHA/NHLBI criteria; and 1.10 (95%CI 0.89,1.36), 1.62 (95%CI 1.03, 2.55) and 1.36 (95%CI 0.93, 1.97) with IDF criteria. Besides, abdominal obesity using the AHA/NHLBI criteria was significantly associated with the incidence of stroke (HR: 1.60; 95%CI 1.01, 2.52). However, among rural male elderly, neither MetS nor its components were capable of predicting newly onset CVD. Conclusion MetS is significantly associated with high incidence of CVD among rural female elderly only, and the incidence of CVD was evident only when MetS was defined using NCEP ATP III criterion. In order to reduce CVD among elderly in rural China, effective strategies to prevent, diagnose, and treating MetS should be made in time, especially among female.

scholarly journals The Metabolic Syndrome, Biomarkers, and the Acculturation–Health Relationship Among Older Mexican Americans

2011 ◽  
Vol 23 (7) ◽  
pp. 1101-1115 ◽  
Author(s):  
Hector M. González ◽  
Wassim Tarraf ◽  
Mary N. Haan
Keyword(s):  
Metabolic Syndrome ◽  
Acculturative Stress ◽  
Mexican Americans ◽  
Rating Scale ◽  
Negative Relationship ◽  
Heart Association ◽  
Foreign Born ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Developmental Health

Objective: To examine the acculturation–health relationship using metabolic syndrome biomarkers. Method: Cross-sectional sample data. Participants: 1,789 Mexican Americans (60 years and older) from northern California. Main Outcome: Biomarkers (waist circumference, blood pressure, fasting plasma glucose, triglycerides, and high-density lipids) were used to construct the metabolic syndrome indicator using American Heart Association criteria. Main Predictor: Acculturation Rating Scale for Mexican Americans-II scores. Results: Higher acculturation scores were associated with a significantly lower risk for the metabolic syndrome for foreign-born, but not U.S.-born, Mexican Americans. Conclusion: Immigrant health advantages over U.S.-born Mexican Americans are not evident in older adulthood. Higher acculturation was associated with lowered metabolic syndrome risk among older foreign-born Mexican Americans. This suggests that the prevailing acculturative stress hypothesis may not apply to the health of older adults and that any negative relationship between acculturation and health found in younger adults may yield to different developmental health influences in later adulthood.

scholarly journals Metabolic Syndrome Components and the Risk of Pulmonary Nodules: A Cross‐sectional Study in Northern China

2021 ◽  
Author(s):  
Chengshui Chen ◽  
Mingyang Zhu ◽  
Xueyu Chen ◽  
Yong Zhou ◽  
Xiaocheng Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Metabolic Syndrome ◽  
Pulmonary Nodules ◽  
Heart Association ◽  
Northern China ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Increased Risk

Abstract Objective: The components of metabolic syndrome have been shown to be associated with lung cancer. Pulmonary nodules (PNs), early predictors of lung cancer, have become common incidental findings with the widespread use of low-dose computed tomography (LDCT) but few epidemiological studies have been performed. The present study aimed to determine the association between MetS and/or its components with PNs in Chinese adults.Methods:A total of 3,340 participants (51.4% women) aged 18 years or older were included from the Jidong communities. MetS was defined by the criteria from the American Heart Association, and National Heart, Lung, and Blood Institute (AHA/NHLBI). PNs were detected using LDCT. Results:The prevalence rate of PNs was 19.2% in participants with MetS, while 12.8% in healthy controls (P<0.001). The odds ratio (OR) and 95% confidence internal (CI) for PNs in participants with elevated blood pressure (≥130/85 mmHg or on drugs for treatment of hypertension) was OR = 1.23, 95% CI: 1.01–1.51. Compared to individuals without MetS components, the ORs (95% CI) for PNs development among those with 1, 2, and ≥3 MetS components were 1.25 (0.94–1.67), 1.10 (0.82–1.48), and 1.43 (1.08–1.89), respectively (P for trend =0.04). Moreover, individuals with MetS had an approximately 30% increased risk of PNs than those who did not meet the MetS diagnostic criteria (number of MetS components<3) ( OR = 1.29, 95% CI: 1.03–1.61). Conclusion:The present study suggested that PNs was associated with abnormal MetS components in Chinese adults. Individuals with MetS might have a higher PNs risk than those without MetS.

Prevention and nutritional therapy of metabolic syndrome

2017 ◽  
Vol 7 (2) ◽  
pp. 100-104
Author(s):  
M. Rożniata ◽  
K. Zujko ◽  
M.E. Zujko
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Diagnostic Criteria ◽  
International Diabetes Federation ◽  
Heart Association ◽  
Hdl Cholesterol ◽  
Nutritional Therapy ◽  
Blood Institute ◽  
National Heart Lung ◽  
Definition Of

The term metabolic syndrome (MetS) defines the cooccurrence of the related risk factors of metabolic origin that promote the development of cardiovascular diseases with atherosclerotic background and type 2 diabetes. The diagnostic criteria of MetS have undergone modifications for years. Until now no clear definition of MetS has been established. The latest diagnostic criteria of MetS published in 2009 by a group of IDF (International Diabetes Federation) and AHA/NHLBI (American Heart Association/ National Heart, Lung and Blood Institute) experts discern three out of five risk factors: abdominal obesity (taking into consideration population differences), elevated level of triglycerides, reduced HDL cholesterol, hypertension and fasting hyperglycemia. Genetic predispositions and environmental factors, such as lack of physical activity and improper diet are considered to be responsible for MetS development. Therefore, prevention and treatment of MetS should be based first of all on a change in modifiable lifestyle factors, among which proper diet is of essential importance.

scholarly journals Association of Incidence between Pancreatic Adipose Infiltration and Metabolic Syndrome: A Literature Review and Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Zhang ◽  
Jing Li ◽  
Youqing Xu
Keyword(s):  
Metabolic Syndrome ◽  
Incidence Rate ◽  
Clinical Features ◽  
Case Control Study ◽  
Fasting Blood Glucose ◽  
Case Control ◽  
Cochrane Library ◽  
Study Cohort ◽  
Cross Sectional ◽  
Control Study

Objective. To investigate association of incidence between pancreatic adipose infiltration and metabolic syndrome (METS). Methods. We searched PubMed, Embase, Cochrane Library, and Web of Science databases up to July 2021. We compared incidence rate of METS between adults with and without pancreatic adipose infiltration, along with their clinical features, such as fasting blood glucose (FBG), triglyceride (TG), high-density lipoprotein (HDL), and hypertension (HTN). Cross-sectional study, cohort study, and case control study were included. Two investigators independently completed study selection, data extraction, and risk of bias assessment. Results. Eleven eligible studies that involved 17,127 patients were included, including 8 cross-sectional studies, 2 cohort studies, and 1 case control study. There was a trend of increasing in incidence rate of METS ( OR = 2.66 , 95% CI: 1.89-3.75) of adults with pancreatic adipose infiltration when compared to those without the disease. There was a trend of increasing in HTN ( OR = 1.68 , 95% CI: 1.32-2.13) and levels of FBG ( SMD = 0.54 , 95% CI: 0.35-0.72) and TG ( SMD = 0.39 , 95% CI: 0.25-0.53) of adults with pancreatic adipose infiltration, while there was a trend of decreasing in HDL level ( SMD = − 0.29 , 95% CI: -0.43~ -0.15). Conclusion. There was an association of incidence between pancreatic adipose infiltration and METS. Indicators of clinical features related to pancreatic adipose infiltration were more likely to arise, such as FBG and TG levels and HTN, but HDL level tended to decrease.

scholarly journals Prevalence, Characteristics, and In-Hospital Outcomes of Metabolic Syndrome among Patients with Acute Coronary Syndrome in the United Arab Emirates

2012 ◽  
Vol 6 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Abdulla Shehab ◽  
Bayan Al-Dabbagh ◽  
Wael Almahmeed ◽  
Nazar Bustani ◽  
Nicolaas Nagelkerke ◽  
...  
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Acute Coronary Syndrome ◽  
Hospital Mortality ◽  
United Arab Emirates ◽  
International Diabetes Federation ◽  
Heart Association ◽  
Hospital Outcomes ◽  
Blood Institute ◽  
Coronary Syndrome

Objective: To evaluate clinical profiles, management and in-hospital outcomes of acute coronary syndrome (ACS) patients with metabolic syndrome (MetS) in the United Arab Emirates (UAE). Methods: MetS was defined according to the criteria for its diagnosis by the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI). Participants were admitted to various hospitals in the UAE with a diagnosis of ACS in 2007 as part of the Gulf Registry of Acute Coronary Events (Gulf RACE) project. We compared baseline characteristics, treatment patterns, and in-hospital outcomes stratified by MetS status. Results: Of 1259 patients with ACS in the UAE (mean age: 52 ± 11 years, 88.8% males), the majority (n = 851, 67.6%) had MetS. MetS patients were more frequently males (86.4 vs 13.6%; P < 0.001). They were more obese (waist circumference and BMI, P < 0.001) as compared with non-MetS patients. MetS was more frequently associated with hypertension (51.1 vs 37.7%; P < 0.001) and diabetes mellitus (45.6 vs 24.3%; P < 0.001). After multivariate adjustment, certain MetS criteria rather than MetS itself were associated with higher in-hospital mortality and heart failure. Paradoxically, hypertension was associated with lower in-hospital mortality. Conclusions: Prevalence of MetS among patients with ACS in our study population was high. Certain MetS criteria were associated with higher in-hospital mortality and heart failure.

scholarly journals Gender discrepancy in the predictive effect of metabolic syndrome and its components on newly onset cardiovascular disease in elderly from rural China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shasha Yu ◽  
Xiaofan Guo ◽  
GuangXiao Li ◽  
Hongmei Yang ◽  
Liqiang Zheng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Rural China ◽  
International Diabetes Federation ◽  
Heart Association ◽  
Rural Elderly ◽  
Blood Institute ◽  
Hazard Ratios ◽  
Elderly Males ◽  
National Heart Lung

Abstract Background This study aimed to estimate whether metabolic syndrome (MetS) and its components could be used to predict cardiovascular disease (CVD) in a longitudinal analysis in a rural elderly Chinese population. Method At baseline during 2012–2013, a total of 2486 elderly from rural Chinese were enrolled and were followed up during 2015–2017. Stroke and coronary heart disease (CHD) were included in CVD and were diagnosed by clinicians. The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and the International Diabetes Federation (IDF) criteria were used to define MetS separately. Result Hazard ratios adjusting for CHD, stroke and CVD in those with MetS using the NCEP ATP III criteria in females were 1.27 (95 % CI 0.73, 2.21), 1.54 (95 % CI 0.99, 2.40) and 1.45 (95 % CI 1.00, 2.10), respectively; 1.33 (95 % CI 0.77, 2.32), 1.44 (95 % CI 0.92, 2.25) and 1.36 (95 % CI 0.94, 1.97), respectively, with the AHA/NHLBI criteria; and 1.10 (95 % CI 0.89,1.36), 1.62 (95 % CI 1.03, 2.55) and 1.36 (95 % CI 0.93, 1.97), respectively, with the IDF criteria. Additionally, abdominal obesity using the AHA/NHLBI criteria was significantly associated with the incidence of stroke (HR: 1.60; 95 % CI 1.01, 2.52). However, among rural elderly males, neither MetS nor its components predicted new-onset CVD. Conclusions MetS is correlated with high incidence of CVD among rural elderly female, and only using the NCEP ATP III criteria to define MetS could make the incidence of CVD obvious difference. In order to reduce rural elderly CVD, effective measures to prevent, diagnose, and treat MetS should be enacted in a timely manner, especially among females.

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