scholarly journals Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L.

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Mohamed Marouane Saoudi ◽  
Jalloul Bouajila ◽  
Rami Rahmani ◽  
Khaled Alouani
Keyword(s):  
Phenolic Compounds ◽  
Biological Activities ◽  
Dry Weight ◽  
Biological Properties ◽  
Cytotoxic Activities ◽  
Chemical Compositions ◽  
Meoh Extract ◽  
Rumex Crispus ◽  
Polar Extracts ◽  
New Compounds

Rumex crispus L. (R. crispus) is regarded as an aromatic plant. It was used for its excellent biological properties in traditional medicine. The aerial part was extracted successively by maceration with three solvents increasing polarity (cyclohexane (CYH), dichloromethane (DCM), and methanol (MeOH)) to evaluate their chemical compositions and biological activities. The extracts were rich in phenolic compounds (13.0 to 249.8 mg GAE/g of dry weight (dw)). The MeOH extract has presented remarkable IC50 = 6.2 μg/mL for anti-DPPH and 31.6 μg/mL for anti-AChE. However, the DCM extract has the highest cytotoxic activity against the two cancer cells (HCT-116 and MCF-7) (69.2 and 77.2% inhibition at 50 μg/mL, respectively). Interestingly, GC-MS analysis enabled to identify three new compounds in R. crispus extracts, such as L-(−)-arabitol (5), D-(−) fructopyranose (7) detected only in MeOH extract, and 2, 5-dihydroxyacetophenone (3) detected in all extracts. For HPLC chromatograms, cardamonin (8), 5-hydroxy-3′-methoxyflavone (17), and 3′-hydroxy-b-naphthoflavone (18) showed the highest concentrations of 74.0, 55.5, and 50.4 mg/g of dw, respectively, among others who are identified. Some phenolic compounds were identified and quantified by HPLC in more than one organic extract, such as 4′, 5-dihydroxy-7-methoxyflavone (13), 4′, 5-dihydroxy-7-methoxyflavone (14), 5-hydroxy-3′-methoxyflavone (17), and 3′-hydroxy-b-naphthoflavone (18), were found for the first time in the R. crispus extracts. Our results showed that the biological activities of this plant might be linked to their phenolic compounds and that the polar extracts could be considered as new natural supplements to be used in food and pharmaceuticals.

scholarly journals Recent Progress of Propolis for Its Biological and Chemical Compositions and Its Botanical Origin

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Viviane Cristina Toreti ◽  
Helia Harumi Sato ◽  
Glaucia Maria Pastore ◽  
Yong Kun Park
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Phenolic Compounds ◽  
Recent Progress ◽  
Biological Activities ◽  
Folk Medicine ◽  
Chemical Compounds ◽  
Biological Properties ◽  
Chemical Compositions ◽  
Botanical Origin

Propolis is the generic name given to the product obtained from resinous substances, which is gummy and balsamic and which is collected by bees from flowers, buds, and exudates of plants. It is a popular folk medicine possessing a broad spectrum of biological activities. These biological properties are related to its chemical composition and more specifically to the phenolic compounds that vary in their structure and concentration depending on the region of production, availability of sources to collect plant resins, genetic variability of the queen bee, the technique used for production, and the season in which propolis is produced. Many scientific articles are published every year in different international journal, and several groups of researchers have focused their attention on the chemical compounds and biological activity of propolis. This paper presents a review on the publications on propolis and patents of applications and biological constituents of propolis.

scholarly journals Bunias erucago L.: Glucosinolate Profile and In Vitro Biological Potential

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 741 ◽  
Author(s):  
Ivica Blažević ◽  
Azra Đulović ◽  
Vedrana Čikeš Čulić ◽  
Franko Burčul ◽  
Ivica Ljubenkov ◽  
...  
Keyword(s):  
Degradation Products ◽  
Dry Weight ◽  
Mediterranean Area ◽  
Biological Properties ◽  
Glucosinolate Content ◽  
Cytotoxic Activities ◽  
Plant Parts ◽  
Biological Potential ◽  
Glucosinolate Profile

Bunias erucago belongs to the Brassicaceae family, which represents a forgotten crop of the Euro-Mediterranean area. The aim of the present study was to determine the glucosinolate profile in different plant parts and biological properties (antioxidant, anticholinesterase, and cytotoxic activities) of the isolates containing glucosinolate breakdown products. The chemical profiles were determined by using HPLC-PDA-MS/MS of desulfoglucosinolates and GC-MS of glucosinolate degradation products. The analysis of B. erucago showed the presence of seven glucosinolates: gluconapin (1), glucoraphasatin (2), glucoraphenin (3), glucoerucin (4), glucoraphanin (5), glucotropaeolin (6), and glucosinalbin (7). The total glucosinolate content ranged from 7.0 to 14.6 µmol/g of dry weight, with the major glucosinolate glucosinalbin in all parts. The antioxidant activity of all volatile isolates was not notable. At a tested concentration of 227 μg/mL, flower hydro-distillate (FH) showed good AChE inhibition, i.e., 40.9%, while root hydro-distillate (RH) had good activity against BChE, i.e., 54.3%. FH showed the best activity against both tested human bladder cancer cell lines, i.e., against T24 after 72 h, which have IC50 of 16.0 μg/mL, and against TCCSUP after 48 h with IC50 of 7.8 μg/mL, and can be considered as highly active. On the other hand, RH showed weak activity against tested cancer cells.

scholarly journals Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells

Marine Drugs ◽  
2020 ◽  
Vol 18 (7) ◽  
pp. 364 ◽  
Author(s):  
Rebeca Alvariño ◽  
Eva Alonso ◽  
Louis Bornancin ◽  
Isabelle Bonnard ◽  
Nicolas Inguimbert ◽  
...  
Keyword(s):  
Ring Opening ◽  
Biological Activities ◽  
Neuroblastoma Cells ◽  
Marine Cyanobacteria ◽  
Cytotoxic Activities ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Ampk Phosphorylation ◽  
Induction Of Apoptosis ◽  
New Compounds

Laxaphycins are a family of non-ribosomal lipopeptides that have been isolated from several cyanobacteria. Some of these compounds have presented cytotoxic activities, but their mechanism of action is poorly understood. In this work, the already described laxaphycins B and B3, and acyclolaxaphycins B and B3 were isolated from the marine cyanobacteria Anabaena torulosa. Moreover, two new acyclic compounds, [des-(Ala4-Hle5)] acyclolaxaphycins B and B3, were purified from the herviborous gastropod Stylocheilus striatus, with this being the first description of biotransformed laxaphycins. The structure of these new compounds was elucidated, together with the absolute configuration of acyclolaxaphycins B and B3. The bioactivities of the six peptides were determined in SH-SY5Y human neuroblastoma cells. Laxaphycins B and B3 were cytotoxic (IC50: 1.8 and 0.8 µM, respectively) through the induction of apoptosis. In comparison, acyclic laxaphycins did not show cytotoxicity but affected mitochondrial functioning, so their effect on autophagy-related protein expression was analyzed, finding that acyclic peptides affected this process by increasing AMPK phosphorylation and inhibiting mTOR. This work confirms the pro-apoptotic properties of cyclic laxaphycins B and is the first report indicating the effects on autophagy of their acyclic analogs. Moreover, gastropod-derived compounds presented ring opening and amino-acids deletion, a biotransformation that had not been previously described.

scholarly journals Artemisia annua, a Traditional Plant Brought to Light

2020 ◽  
Vol 21 (14) ◽  
pp. 4986 ◽  
Author(s):  
Axelle Septembre-Malaterre ◽  
Mahary Lalarizo Rakoto ◽  
Claude Marodon ◽  
Yosra Bedoui ◽  
Jessica Nakab ◽  
...  
Keyword(s):  
Developing Countries ◽  
Phenolic Compounds ◽  
Artemisia Annua ◽  
State Of The Art ◽  
Biological Activities ◽  
Biological Properties ◽  
Chemical Components ◽  
Traditional Remedies ◽  
Prevention And Treatment ◽  
Immunomodulatory Properties

Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties. Artemisia annua is very rich in secondary metabolites such as monoterpenes, sesquiterpenes and phenolic compounds, of which the biological properties have been extensively studied. The purpose of this review is to gather and describe the data concerning the main chemical components produced by Artemisia annua and to describe the state of the art about the biological activities reported for this plant and its compounds beyond malaria.

scholarly journals Qualitative and Quantitative Analysis of Phenolic Compounds in Spray-Dried Olive Mill Wastewater

2022 ◽  
Vol 8 ◽  
Author(s):  
Cinzia Benincasa ◽  
Massimiliano Pellegrino ◽  
Elvira Romano ◽  
Salvatore Claps ◽  
Carmelo Fallara ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Pharmaceutical Preparations ◽  
Dry Weight ◽  
Mediterranean Area ◽  
Extraction Process ◽  
Biological Properties ◽  
Olive Mill Wastewater ◽  
Bioactive Substances ◽  
Qualitative And Quantitative ◽  
Olive Mill

The processing of olives for oil production generates the most abundant agro-industrial by-products in the Mediterranean area. The three-phase olive oil extraction process requires the addition of a large amount of water to the system, which is difficult to dispose of for its load of toxic pollutants. On the other hand, olive mill wastewater is a rich source of bioactive substances with various biological properties that can be used as ingredients in the food industry for obtaining functional and nutraceutical foods as well as in the pharmaceutical industry. In this study, we present the results relative to the phenolic compounds detected in dried olive mill wastewaters obtained using a spray dryer. Qualitative and quantitative analyses were obtained by high-pressure liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). In particular, the compounds here discussed are: apigenin (9.55 mg/kg dry weight), caffeic acid (2.89 mg/kg dry weight), catecol (6.12 mg/kg dry weight), p-cumaric acid (5.01 mg/kg dry weight), diosmetin (3.58 mg/kg dry weight), hydroxytyrosol (1.481 mg/kg dry weight), hydroxytyrosyl oleate (564 mg/kg dry weight), luteolin (62.38 mg/kg dry weight), luteolin-7-O-glucoside (88.55 mg/kg dry weight), luteolin-4-O-glucoside (11.48 mg/kg dry weight), oleuropein (103 mg/kg dry weight), rutin (48.52 mg/kg dry weight), tyrosol (2043 mg/kg dry weight), vanillin (27.70 mg/kg dry weight), and verbascoside (700 mg/kg dry weight). The results obtained highlighted that the use of dehumidified air as a drying medium, with the addition of maltodextrin, appears to be an effective way to produce a phenol-rich powder to be included in food formulations as well as in pharmaceutical preparations having different biological properties.

Chemistry of phenolic compounds of licorice (Glycyrrhiza species) and their estrogenic and cytotoxic activities

2002 ◽  
Vol 74 (7) ◽  
pp. 1199-1206 ◽  
Author(s):  
Taro Nomura ◽  
Toshio Fukai ◽  
Toshiyuki Akiyama
Keyword(s):  
Estrogen Receptor ◽  
Phenolic Compounds ◽  
Biological Activities ◽  
Sweet Taste ◽  
The Other ◽  
Cytotoxic Activities ◽  
Binding Affinities ◽  
Tumor Cell Lines ◽  
Substituted Phenols ◽  
Oral Tumor

The genus Glycyrrhiza consists of about 30 species in which G. glabra, G. uralensis, G. inflata, G. aspera, G. korshinskyi, and G. eurycarpa are generally recognized as licorice because of their sweet taste. Except G. korshinskyi, we examined isoprenoid-substituted phenols of these licorices. Each plant could be characterized by some isoprenoid phenols. We also investigated the biological activities of the Glycyrrhiza phenols. In the course of screening phytoestrogen in medicinal plants, six Glycyrrhiza phenols exhibited the binding affinities for the bovine uterine estrogen receptor. The affinity of a dihydrostilbene with two 3-methyl-2-butenyl (prenyl) groups, gancaonin R, was higher than those of isoflavone phytoestrogens (genistein and daidzein) in dietary foods. The affinities of the other five phenols, a flavanone (liquiritigenin), two prenylflavanones (isobavachin and sigmoidin B), a prenylated coumestan (glycyrol), and a pyranoisoflav-3-ene (glabrene), were similar to that of the dietary isoflavone, genistein or daidzein. Cytotoxic activities of the Glycyrrhiza phenols against human oral tumor cell lines and HIV-infected MT-4 cells were also reviewed.

scholarly journals Phenolic Compounds of Rumex roseus L. Extracts and Their Effect as Antioxidant and Cytotoxic Activities

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Mohamed Marouane Saoudi ◽  
Jalloul Bouajila ◽  
Khaled Alouani
Keyword(s):  
Volatile Compounds ◽  
Biological Activities ◽  
Biological Properties ◽  
Bioactive Molecules ◽  
Chemical Components ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Before And After ◽  
Hydroxybutanoic Acid ◽  
Chemical Groups

Rumex roseus L. (R. roseus) is acknowledged as an aromatic plant. For its excellent biological properties, it was used as a traditional medicine. The aim of the present study is to evaluate the chemical components and their effect as the biological activities of Tunisian extracts of R. roseus. Consecutive extractions by cold maceration of the aerial part with solvents of increasing polarity (cyclohexane (CYH), dichloromethane (DCM), and methanol (MeOH)) were performed, and the different chemical groups (phenolics, flavonoids, tannins, anthocyanins, etc.) were identified. In addition, the volatile compounds of the obtained extracts were identified before and after derivatization. Moreover, their antioxidant and anticancer activities were evaluated. The analysis of HPLC-DAD revealed the identification of 18 components from organic extracts, among them are, for example, chlorogenic acid and shikonin, while GC-MS analysis allowed the detection of 34 volatile compounds. Some of those compounds were identified for the first time in plant extracts such as pyrazolo[3,4-d] pyrimidine-3,4(2H,5H)-dione (1); L-proline (16); 2-amino-3-hydroxybutanoic acid (19); L-(-)-arabitol (23); D-(-)-fructopyranose (25); and D-(+)-talopyranose (27). DPPH tests revealed that the most important antioxidant activity was found in the methanolic extract with 75.2% inhibition at 50 mg/L and that the highest cytotoxic activity against HCT-116 and MCF-7 was recorded in the dichloromethane extract with 62.1 and 80.0% inhibition at 50 mg/L, respectively. The biological activities were fully correlated with the chemical composition of the different extracts. So, we can suggest that R. roseus is a source of bioactive molecules that could be considered potential alternatives for use in dietary supplements for the prevention or treatment of diseases.

scholarly journals Antioxidant and Antibacterial Activity of Roseroot (Rhodiola rosea L.) Dry Extracts

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1767 ◽  
Author(s):  
Olga Kosakowska ◽  
Katarzyna Bączek ◽  
Jarosław L. Przybył ◽  
Ewelina Pióro-Jabrucka ◽  
Weronika Czupa ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Phenolic Compounds ◽  
Biological Activities ◽  
Rhodiola Rosea ◽  
Array Detector ◽  
Chemical Compositions ◽  
Antioxidant Power ◽  
Scavenging Capacity ◽  
Chemical Profiles

Roseroot (Rhodiola rosea L.) belongs to plants revealing adaptogenic properties, which are attributed to the presence of specific phenolic compounds and are reflected mainly as antioxidant activity. The aim of the present study was to determine the antioxidant and antibacterial activity of various products obtained from R. rosea (underground organs as well as their aqueous and ethanolic dry extracts) in relation to the chemical profiles of phenolic and essential oil compounds. The chemical profiles were determined by High-performance Liquid Chromatography with a diode-array detector (HPLC-DAD) and Gas chromatography-mass spectrometry (GC-MS), antioxidant activity by (1,1-Diphenyl-2-picrylhydrazyl) Scavenging Capacity Assay (DPPH), (2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) Scavenging Capacity Assay (ABTS) and Ferric Reducing Antioxidant Power Assay (FRAP) and antimicrobial properties were expressed as minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) values following the broth microdilutions method. The results show that the investigated samples differed in terms of their chemical compositions and biological activities. The extracts were more abundant in phenolic compounds (salidroside, tyrosol, and rosavin derivatives) in comparison to dried underground organs. The content of the determined phenolics in the analyzed extracts was affected by the solvent used for extraction. The ethanolic extract was characterized by the highest content of these substances in comparison to the aqueous one and the dried raw material, especially with regard to rosavin (969.71 mg/100 g). In parallel, this extract showed the strongest antioxidant and antibacterial activity. However, dried R. rosea underground organs also revealed strong antibacterial effects against, for example, Staphylococcus strains.

scholarly journals Variability of Total Polyphenol Contents in Ground Coffee Products and Their Antioxidant Capacities through Different Reaction Mechanisms

2021 ◽  
Vol 12 (4) ◽  
pp. 4857-4870
Keyword(s):  
Phenolic Compounds ◽  
Reaction Mechanisms ◽  
Biological Activities ◽  
Antioxidant Compounds ◽  
Chemical Compositions ◽  
Total Polyphenol ◽  
Maillard Reactions ◽  
Antioxidant Capacities ◽  
Trolox Equivalent ◽  
Ground Coffee

Coffee is one of the most popular non-alcoholic drinks consumed daily by millions of individuals worldwide. It is characterized by varieties and processing, which cause changes in chemical compositions and biological activities. This study aimed to evaluate the effects of roasting degrees during the processing period (light, medium, and dark) on the total polyphenol contents (TPCs) in-ground coffee products of arabica, robusta, and liberica and their trolox equivalent antioxidant capacities (TEACs) through various chemical reaction mechanisms (DPPH, ABTS, FRAP, and CUPRAC). The analytical methods were conducted based on spectrophotometric principle after the microwave-assisted liquid extraction. The results of the TPCs followed the descending order of robusta (34.3-48.23 mg GAE g–1) > liberica (31.5-34.37 mg GAE g–1) > arabica (27.1-44.11 mg GAE g–1). Moreover, robusta coffee generally performed greater TEACs than liberica and arabica. Besides, the TPCs and TEACs varied regarding different roasting degrees, in which the medium roasting mostly exhibited the highest values due to the balance between the degradation of phenolic compounds and the generation of new antioxidant compounds mainly from the Maillard reactions. Strong correlations between TPCs and antioxidant capacities (R2 > 0.6), indicating rich phenolic compounds played key roles in TEACs of coffee.

scholarly journals Emerging source of bioactive compounds from Arecaceae family: a systematic review

2021 ◽  
Vol 10 (10) ◽  
pp. e426101018994
Author(s):  
Ricardo Sérgio da Silva ◽  
Paulo Henrique Oliveira de Miranda ◽  
Luciclaudio Cassimiro de Amorim ◽  
Paulo Henrique Eloi Fernandes ◽  
Elias Vinícius Ferreira do Amaral ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Phenolic Compounds ◽  
Human Health ◽  
Traditional Knowledge ◽  
Lauric Acid ◽  
Biological Activities ◽  
Biological Properties ◽  
The Family ◽  
Comprehensive Search

The use of plants for medicinal purposes is performed empirically by traditional knowledge with the use of preparations that seek to extract their active principles, and are considered to be fundamental to human health. In this context, the aim of the present study was to of this study was to carry out a systematic review of the biological activities of the Arecaceae family distributed throughout Brazil. This research was carried out through a comprehensive search using the following databases, Scopus, Portal Periódicos Capes, PubMed, Google Scholar and Science Direct, using the following descriptors: “Arecaceae” and “Biological properties of the family Arecaeae”, checked at <www.theplantlist.org/> to check synonyms. It was possible to identify numerous biological activities in the arecaceae family, among the most recurring ones, the antioxidant, antimicrobial and anti-inflammatory activity. These activities are justified by the presence of fatty acids, phenolic compounds, alkaloids and terpenes. Studies routinely report lauric acid as a major in the plants of this family, which makes it a potential compound to cure or assist in the treatment of various diseases.

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