Differences in Mechanisms Between Weight Reduction Sensitive and Insensitive Blood Pressure Reduction in Obese Subjects

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 725-725
Author(s):  
Kazuko Masuo ◽  
Hiroshi Mikami ◽  
Toshio Ogihara ◽  
Michael L Tuck
Keyword(s):  
Weight Loss ◽  
Family History ◽  
Weight Reduction ◽  
Blood Pressure Reduction ◽  
Study Groups ◽  
Plasma Norepinephrine ◽  
Ang Ii ◽  
Major Mechanism ◽  
History Of ◽  
History Of Obesity

P180 This study was conducted to clarify the differences in mechanisms between weight reduction (WR) sensitive and insensitive BP reduction, and to evaluate the contribution of family history of obesity (FH) to WR-induced BP reduction. In 61 obese hypertensive men (HT, 28.1±0.9 kg/m2, 35±3 years, 171±6/106±5 mmHg) and 52 obese normotensive men (NT, 27.9±0.6 kg/m2, 34±4 years, 131±5/83±4 mmHg), BMI, BP, fasting plasma norepinephrine (NE), angiotensin II (Ang II), PRA, leptin, insulin were measured every 2 week for 24 weeks with weight loss program (low caloric diet 1000kcal, 7gNaCl + excercise≥1 hr/day). WR and WR sensitive BP reduction were defined as >10% reduction in BMI or mean BP at week 12. 64% of HT and 63% of NT succeeded in WR, and 59% of HT with WR (sensitive vs insensitive P<.05) and 70% of NT with WR (P<.01) were sensitive in BP reduction. When FH+ was defined as at least one parent was obese (BMI>27.0 kg/m2), prevalence of FH+ was higher in 86% of HT and 95% of NT who failed in WR, and higher in 94% of HT and 80% of NT with WR insensitive BP reduction. Only the subjects who succeeded in WR were analyzed in this study. At entry, BP, NE, Ang II, PRA and insulin were higher in HT than in NT, although BMI and leptin were similar. However, the parameters at entry were similar between WR sensitive and insensitive BP reduction in each NT and HT. The decrements (Δ) in BP, NE, Ang II, leptin,insulin were significantly greater in subjects with WR sensitive BP reduction than subjects with WR insensitive BP reduction regardless of BP status during the study, although ΔBMI was similar. Significant decreases in the parameters were noted in earlier period in subjects with WR sensitive BP reduction than in subjects with insensitive BP reduction, and in NT than in HT. In the 4 study groups regardless of BP status or WR induced BP reduction, the decrease in NE preceded BP decline, and the decreases in Ang II, insulin, leptin & PRA followed BP decline with WR. These results suggest that a family history of obesity appears to contribute closely to resistance in weight loss and also to WR insensitive BP reduction. Suppression on sympathetic overactivity is a major mechanism in WR induced BP reduction.

scholarly journals Major clinical risk factors for seizures in febrile children aged 6 to 60 months.

2020 ◽  
Vol 27 (05) ◽  
pp. 891-894
Author(s):  
Shahid Ishaq ◽  
Ejaz Mazari ◽  
Fazal ur Rehman
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Febrile Seizures ◽  
Study Groups ◽  
Clinical Risk Factors ◽  
P Value ◽  
Chi Square ◽  
Clinical Risk ◽  
Significant Difference ◽  
History Of

Objectives: Febrile seizures (FS) are the most common type of seizures and typically transpire in children with ages from 6 to 60 months. This study was planned to find out major clinical risk factors for seizures in febrile children who were aged 6 to 60 months. A total of 100 febrile children aged 6 to 60. Study Design: Analytical Study. Setting: Department of Neurology, Children’s Hospital and the Institute of Child Health, Multan. Period: From 1st April 2018 to 31st December 2018. Material & Methods: Group A had 40 children with febrile seizures while group B had 60 febrile children but without seizures. Demographic features along with family history of (H/O) epilepsy as well as family history of febrile seizure, types of seizure and infection diseases were noted and analyzed using SPSS version 20. Odds ratio was calculated for various risk factors. Chi square test was applied and P value < 0.05 was considered as significant. Results: Out of a total of 100 children, there were 54 (54.0%) male and 46 (46.0%) female. There was no statistical difference in terms of gender between the two groups (p value = 0.566). Overall, mean age of the children was 26.02 months with standard deviation of 13.4 months. There were 28 (70.0%) children who reported with simple seizures while complex seizures were found in 12 (30.0%) cases. Statistically significant difference (p value = 0.001) was seen in terms of types of infections between the two study groups. When risk of seizures for various risk factors was calculated, family H/O FS, family H/O epilepsy, and upper RTI were as 14, 7 and 3 times respectively and turned out to be the major risk factors for seizures in febrile children. Conclusions: Family H/O FS, family H/O epilepsy and upper RTIs are the major risk factors related with seizures in febrile children. Measures to prevent these risk factors can decrease the burden of FS in our population.

Failure of angiotensin II to suppress plasma renin activity in normotensive subjects with a positive family history of hypertension

2005 ◽  
Vol 109 (3) ◽  
pp. 311-317 ◽  
Author(s):  
Hans Herlitz ◽  
Eva Palmgren ◽  
Bengt Widgren ◽  
Mattias Aurell
Keyword(s):  
Angiotensin Ii ◽  
Family History ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Urinary Sodium ◽  
Renin Activity ◽  
Ang Ii ◽  
History Of ◽  
Family History Of Hypertension ◽  
Normotensive Subjects

The renin–angiotensin system is implicated in the pathophysiology of hypertension. Renin release is regulated by a number of factors, including circulating Ang II (angiotensin II), the so-called short feedback loop. The aim of the present study was to investigate the responsiveness of circulating Ang II on PRA (plasma renin activity) in normotensive subjects with a PFH or NFH (positive or negative family history of hypertension respectively). PRA, renal haemodynamics and urinary sodium excretion were measured during infusion of Ang II without and with pretreatment with the AT1 (Ang II type 1) receptor blocker irbesartan. Normotensive men with a PFH (n=13) and NFH (n=10), with a mean age of 38 years, were given on different occasions intravenous Ang II infusions of 0.1, 0.5 and 1.0 ng·kg−1 of body weight·min−1 before and after pretreatment with 150 mg of irbesartan once a day for 5 consecutive days. RPF (renal plasma flow) and GFR (glomerular filtration rate) were also measured. Before Ang II infusion, the PFH and NFH groups did not differ with respect to BP (blood pressure), body mass index, PRA, RBF (renal blood flow) or urinary sodium. There was no difference in BP or renal haemodynamic response to the highest Ang II dose between the groups. PRA declined with the highest Ang II dose (P<0.01) in subjects with a NFH, but not in subjects with a PFH. After treatment with irbesartan when Ang II had no effect on BP in either group, Ang II also suppressed PRA in subjects with a PFH (P<0.01), and the difference between the groups at baseline was thus eliminated. In conclusion, these findings indicate that subjects with a PFH have a defective Ang II suppression of PRA, which is corrected by AT1 receptor blockade.

scholarly journals The Effect of Ranitidine on Olanzapine-Induced Weight Gain

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Fatemeh Ranjbar ◽  
Alireza Ghanepour ◽  
Homayoun Sadeghi-Bazargani ◽  
Mahbob Asadlo ◽  
Amineh Alizadeh
Keyword(s):  
Weight Gain ◽  
Family History ◽  
Positive Family History ◽  
First Episode ◽  
Long Run ◽  
Combined Use ◽  
History Of ◽  
History Of Obesity ◽  
Baseline Bmi ◽  
First Time

Induced weight gain is a disturbing side effect of Olanzapine that affects the quality of life in psychotic patients. The aim of this study was to assess the efficacy of Ranitidine in attenuating or preventing Olanzapine-induced weight gain. A parallel 2-arm clinical trial was done on 52 patients with schizophrenia, schizoaffective and schizophreniform disorders who received Olanzapine for the first time. All these were first-episode admitted patients. They were randomly allocated to receive either Ranitidine or placebo. The trend of body mass index (BMI) was compared between groups over 16-week course of treatment. Mean weight was 62.3 (SD: 9.6) kg at baseline. Thirty-three subjects (63.5%) had positive family history of obesity. The average BMI increment was 1.1 for Ranitidine group and 2.4 for the placebo group. The multivariate analysis showed this effect to be independent of sex, family history of obesity, and baseline BMI value. The longitudinal modeling after controlling for baseline values failed to show the whole trend slope to be different. Although the slight change in trend’s slope puts forward a hypothesis that combined use of Ranitidine and Olanzapine may attenuate the weight gain long run, this needs to be retested in future larger scale long-term studies. This trial is registered with IRCT.ir201009112181N5.

scholarly journals Body Mass Index and its Relation with Socio-Demographic Factors among Healthcare Workers

BioMedica ◽  
2021 ◽  
Vol 37 (2) ◽  
pp. 93-99
Author(s):  
Mehnaz Munir ◽  
Hamza Nadeem Malik ◽  
Muhammad Jareer Alam ◽  
Ammara Arif ◽  
Fiza Khalid
Keyword(s):  
Body Mass Index ◽  
Family History ◽  
Marital Status ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
History Of ◽  
Socio Demographic Factors ◽  
History Of Obesity

<p><strong>Background and Objective:</strong> Obesity leads to multiple complications that in turn increase mortality worldwide. There is a rapid rise in obesity in the last decade, especially among physicians. The objective of this study was to find out the frequency and relationship of obesity with socio-economic factors among faculty of a local medical college in Lahore, Pakistan.<br /><strong>Methods: </strong>A descriptive cross-sectional study was conducted on 162 medical and paramedical staff of Fatima Memorial College of Medicine and Dentistry, Lahore for a duration of 7 months from February 2019 to August 2019. Data were collected by filling the questionnaires and standard tools were used for height and weight measurement. Overweight/obesity was defined as a body mass index of &ge;25 kg/m2.<br /><strong>Results:</strong> In this study, out of 86 males and 76 females, the majority of the respondents were between the ages of 21 and 35 years. Seventy three (45.1%) and thirty (18.5%) respondents were overweight and obese, respectively. Out of a total 162 subjects, 38 (24%) were hypertensive and 18 (11%) were suffering from diabetes. There was a statistically significant association of obesity with age (p &lt; 0.05), marital status (p &lt; 0.001), family history of obesity (p &lt; 0.001), and smoking (p &lt; 0.05).<br /><strong>Conclusion: </strong>Risk factors like age, marital status, family history of obesity, and smoking have a strong correlation with obesity in faculty members of a medical school.</p>

scholarly journals A Multivariate Multilevel Analysis of the Risk Factors Associated with Anthropometric Indices in Iranian mid-adolescents

2020 ◽  
Author(s):  
Marzieh Alamolhoda ◽  
Seyyed Taghi Heydari ◽  
Seyyed Mohammad Taghi Ayatollahi ◽  
Reza Tabrizi ◽  
Maryam Akbari ◽  
...  
Keyword(s):  
Family History ◽  
Multilevel Analysis ◽  
Body Fat ◽  
Screen Time ◽  
Overweight And Obesity ◽  
Age Group ◽  
Factors Associated ◽  
History Of ◽  
Three Body ◽  
History Of Obesity

Abstract Background: The present study was conducted to jointly assess some specific factors related to body fat measures using a multivariate multilevel analysis in a representative sample of Iranian mid-adolescents. Methods: This study was conducted among 2538 students (1286 boys) aged 14 - 20 years old, who were randomly selected among 16 public high schools by multi-stage random sampling procedure from all education districts of Shiraz, Iran. Data on demographic characteristics, family history of obesity, physical activity, socio-economic (SES) variables and screen time were collected. Height, weight, triceps (TST), abdominal (AST), and subscapular (SST) skinfold thickness were measured and their body mass index (BMI) was calculated. A multivariate multilevel approach was used to analyze the factors associated with obesity measures of the TST, AST, SST at the child and district levels. Results: In this study, the prevalence of overweight and obesity was estimated to be 10.2 and 5.1%, respectively. Overall, the major portion of the total variance in TST (97.1%), AST (97.7%), and SST (97.5%) was found at the child level. The results of multivariate multilevel method revealed that being girls, having a family history of obesity, and SES were significantly associated with increasing of three body fat measures (all the p-values were less than 0.05). There were significant positive associations between moderate to vigorous physical activities with AST and SST (for AST: β =2.54, SE=1.40, p=0.05; for SST: β =2.24, SE=1.20, p=0.05). Compared to children in 14-16 age group, children in age group 16-18 years had less TST (β =-0.67, SE=0.34, p=0.04). Furthermore, other age groups and screen time did not play an important role in three outcome variables. Conclusions: The results showed some factors that contribute to three body fat measures. Therefore, it is necessary to develop effective interventions to prevent the effects of individual and environmental undesirable factors on childhood obesity in both family and community levels.

Pharmacotherapy for Weight Reduction: Bupropion/Naltrexone Drugs for Obesity

2021 ◽  
Vol 15 (9) ◽  
pp. 2293-2295
Author(s):  
Sabeen Arjumand ◽  
Maira Bhatti ◽  
Zubaida Qayyum ◽  
Zarish Ghafoor ◽  
Fouzia Perveen
Keyword(s):  
Weight Loss ◽  
Food Intake ◽  
Combination Therapy ◽  
Weight Reduction ◽  
Eating Behaviors ◽  
Complex Interaction ◽  
Food Craving ◽  
Melanocortin System ◽  
Major Mechanism

Background: There is no valid and accurate documentation on the combination therapy of bupropion along with naltrexone. The experimentations on these actions of combination drugs have resulted in rare success. Methods: A complex interaction occurs in the central and peripheral nervous system for reducing weight loss. It is difficult to find out the major mechanism of action of these drugs on weight reduction. Naltrexone and bupropion is the experimental combination for reducing the weight. For obesity, the combination of naltrexone/bupropion therapy’s mechanism working is still unknown. Results: The attempts for weight loss rarely have a long-term effect. It is an outcome of more likely some complex interaction between various peripheral and Central Nervous systems, and an overwhelming lack of real obesity treatment may be explained. Based on the evidence that obesity involves a change in the hypothalamic melanocortin system in addition to a brain reward system, which causes food craving and mood swings, this investigational combination therapy of NB was developed. Naltrexone and bupropion work in an interesting way. Conclusion: It affects the parts of the brain that influences food craving, food intake, eating behaviors, and loss of body weight. We will have a review on the working of naltrexone, and bupropion separately, and Vivo, current in vitro, and clinical evidence will be provided, describing how NB affects food intake and food craving. Keywords: CNS, obesity, medicine, weight lose, NB, therapy.

scholarly journals Does Family History of Obesity, Cardiovascular, and Metabolic Diseases Influence Onset and Severity of Childhood Obesity?

2018 ◽  
Vol 9 ◽  
Author(s):  
Domenico Corica ◽  
Tommaso Aversa ◽  
Mariella Valenzise ◽  
Maria Francesca Messina ◽  
Angela Alibrandi ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Family History ◽  
Metabolic Diseases ◽  
History Of ◽  
History Of Obesity

scholarly journals Fasting Blood Glucose Profile among Secondary School Adolescents in Ado-Ekiti, Nigeria

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
I. O. Oluwayemi ◽  
S. J. Brink ◽  
E. E. Oyenusi ◽  
O. A. Oduwole ◽  
M. A. Oluwayemi
Keyword(s):  
Blood Glucose ◽  
Family History ◽  
Secondary School ◽  
Fasting Blood Glucose ◽  
Positive Family History ◽  
Cross Sectional ◽  
Female Ratio ◽  
History Of ◽  
History Of Obesity ◽  
The Impact

Background.Over the past two decades there has been an increase in type 2 diabetes mellitus (T2DM) in children. Baseline data is needed to assess the impact of changing lifestyles on Ado-Ekiti, a previously semiurban community in Southwest Nigeria. This study was therefore conducted to assess the fasting blood glucose (FBG) of adolescents in Ado-Ekiti, Nigeria.Methodology.This was a cross-sectional study involving 628 adolescents from three different secondary schools in Ado-Ekiti, Nigeria. With parental consent, volunteers completed a structured questionnaire, and an overnight FBG was measured.Results.There were 346 males and 282 females (male : female ratio = 1.2 : 1). Their ages ranged from 10 to 19 years (mean age:14.2±1.7years). Four hundred and forty-four (70.7%) had normal FBG, while 180 (28.7%) and 4 (0.6%) had FBG in the prediabetic and diabetic range, respectively. Female gender, age group 10–14 years, and family history of obesity were significantly associated with impaired FBG (Pvalue <0.001, <0.001, and 0.045, resp.).Conclusion.Impaired FBG is common among secondary school adolescents and it is more prevalent among younger female adolescents (10–14 years) with positive family history of obesity.

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