Erectile Impotence from Veno-Occlusive Dysfunction: Our Experience and Present Diagnostic-Therapeutic Indications

1993 ◽  
Vol 60 (3) ◽  
pp. 283-287
Author(s):  
A. Meazza ◽  
V. Nebulone ◽  
L Musso ◽  
F. Pachera ◽  
G. Reali ◽  
...  
Keyword(s):  
Dynamic Testing ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Functional Evaluation ◽  
Therapeutic Approaches ◽  
Radiographic Images ◽  
Non Invasive ◽  
Appropriate Treatment ◽  
Erectile Impotence

The authors evaluate erectile impotence from veno-occlusive dysfunction, concentrating on diagnostic techniques, both invasive and non-invasive, and appropriate treatment. In particular dynamic testing is reviewed, where a vasoactive drug, Papaverine or more recently PGE1, is injected into one of the corpora cavernosa. Measurement of blood flow velocity with Doppler ultrasonography allows a functional evaluation, while radiographic images during cavernosography give an anatomical view of the erectile abnormality. A review of case histories and partial follow-up of patients has confirmed the actual precision of the diagnostic methods and various therapeutic approaches.

scholarly journals Urinary incontinence: Clinical observation on 30 patients undergoing treatment with F.R.E.M.S (Frequency Rhythmic Electrical Modulation System)

2015 ◽  
Vol 87 (3) ◽  
pp. 243
Author(s):  
Massimo Massari ◽  
Patrizia Desideri ◽  
Paolo Menchinelli ◽  
Lucia Cerrito ◽  
Luciano De Giovanni
Keyword(s):  
Electric Fields ◽  
Clinical Observation ◽  
Clinical Results ◽  
Diagnostic Techniques ◽  
Pharmacological Therapy ◽  
Non Invasive ◽  
Impulse Duration ◽  
Electrical Modulation ◽  
Immunohistochemical Studies

Aim of the study: Urge incontinence is considered to be a dysfunctional pathology of social interest due to the psychological and relational implications of such disability, the elevated number of affected patients and the consequent treatment costs. We propose an innovative non-pharmacological and non-invasive care methodology: Frequency rhythmic electrical modulation system (F.R.E.M.S.) therapy (FT), based on the administration of electric fields of monophasic pulsed, negative, asymmetric current, generated by a neurostimulator with the characteristics of low variable frequency, high voltage and very low impulse duration. Material and Methods: 30 patients were studied with urodynamic evaluation and radiological diagnostic techniques, and underwent 2 cycles of 15 days therapy, with a 12 months follow-up. Results: In 93% of cases, we obtained a positive result, with either disappearance or improvement of symptoms. Conclusion: Although the Authors believe that clinical results deserve further neurohistological and immunohistochemical studies, in order to define the anathomophysiological and biochemical changes induced by FT, they propose it as a possible alternative to traditional pharmacological therapy and electrical stimulation.

scholarly journals Application of electrochemical aptasensors in detection of cancer biomarkers

2019 ◽  
Vol 6 (7) ◽  
pp. 3315-3324 ◽  
Author(s):  
Masoud Negahdary ◽  
Ali Moradi ◽  
Hossein Heli
Keyword(s):  
Cancer Therapy ◽  
Cost Saving ◽  
High Selectivity ◽  
Cancer Biomarkers ◽  
Diagnostic Techniques ◽  
Late Diagnosis ◽  
Diagnostic Methods ◽  
Related Factors ◽  
Cancer Markers

Today, the late diagnosis of cancers is a big challenge, and using novel diagnostic techniques will provide essential, faster and more accurate treatments. Unfortunately, existing common and traditional diagnostic methods have not been helpful completely and most cancers are diagnosed too late. Recently, researchers have found new diagnostic methods against cancers by aptasensors; these sensory systems can detect involved biomarkers in various cancers so that the research in this field is continued strictly. Aptasensors can detect cancer markers in small quantities and high selectivity; moreover, other advantages of cancer aptasensors such as optimized time and cost saving can be considered. In addition, the aptasensors have been used in the diagnosis of the effective and related factors in cancer therapy follow-up. Here, the most researches about cancer aptasensors and other involved markers were collected, reviewed and described.  

Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? – case report and literature review

2020 ◽  
Vol 33 (2) ◽  
pp. 319-322
Author(s):  
Krzysztof Jeziorny ◽  
Arleta Waszczykowska ◽  
Dobromiła Barańska ◽  
Agnieszka Szadkowska ◽  
Wojciech Młynarski ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cerebral Edema ◽  
Diagnostic Methods ◽  
Newly Diagnosed ◽  
Cns Disorders ◽  
Case Presentation ◽  
Non Invasive ◽  
Appropriate Treatment ◽  
Life Threatening

AbstractBackgroundCerebral edema (CE) is one of the most serious complications of diabetic ketoacidosis (DKA) and can result in central nervous system (CNS) disorders and even lead to death of the patient.Case presentationWe present the case of a 11-year-old boy with severe DKA in the course of newly diagnosed type 1 diabetes (T1D). The delay in the diagnosis of DKA and some therapeutic problems contributed to the development of CE and direct life-threatening conditions. Early diagnosis of CE development in the course of DKA using non-invasive methods such as pachymetry or transorbital ultrasound seems to be a very important prognostic factor.ConclusionsThis case highlights the importance of appropriate treatment according to the newest recommendations and presents the usefulness of new diagnostic methods to assess the risk of CE in children with newly diagnosed T1D.

scholarly journals Antenal hydronephrosis

2018 ◽  
Vol 97 (3) ◽  
pp. 287-294
Author(s):  
Amilcar Martins Giron
Keyword(s):  
Urinary Tract ◽  
Good Condition ◽  
Voiding Cystourethrography ◽  
Functional Evaluation ◽  
Pediatric Nephrologist ◽  
Non Invasive ◽  
Technical Advances ◽  
Genitourinary Anomalies ◽  
To Receive

Genitourinary anomalies can be detected in the antenatal period with incidence of 0.5 a 1% in gestational population; 20 a 30% of these anomalies involve the urinary tract. Hydronephrosis is the most frequent urinary tract anomaly followed by cystic anomalies. Currently, technical advances of high-resolution ultrasound identify, in a non-invasive way, the gestational anatomy. The evaluation of the urinary tract, by means of complementary examinations: precocious abdominal and pelvic ultrasound (US), laboratory analysis, functional evaluation (DTPA99 -glomerular function; DMSA99 -tubular function and MAG99 -MAG-3), voiding cystourethrography and others if necessary. Conclusion - Every pregnant woman should undergo at least one morphological ultrasound examination carried out in satisfactory conditions and by qualified professional during the prenatal follow-up to identify possible malformations of the fetus. Following a pre-established roadmap of complementary examinations, it is possible to treat the pathology safely, allowing the newborn to receive hospital discharge in good condition, with a mandatory multidisciplinary outpatient follow-up with pediatric, nephrologist and pediatric urologist’s consultations.

scholarly journals Bladder Cancer Diagnosis and Follow-Up: The Current Status and Possible Role of Extracellular Vesicles

2019 ◽  
Vol 20 (4) ◽  
pp. 821 ◽  
Author(s):  
Eline Oeyen ◽  
Lucien Hoekx ◽  
Stefan De Wachter ◽  
Marcella Baldewijns ◽  
Filip Ameye ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Clinical Practice ◽  
Extracellular Vesicles ◽  
Urine Cytology ◽  
Diagnostic Methods ◽  
Urinary Biomarkers ◽  
Non Invasive ◽  
Low Sensitivity

Diagnostic methods currently used for bladder cancer are cystoscopy and urine cytology. Cystoscopy is an invasive tool and has low sensitivity for carcinoma in situ. Urine cytology is non-invasive, is a low-cost method, and has a high specificity but low sensitivity for low-grade urothelial tumors. Despite the search for urinary biomarkers for the early and non-invasive detection of bladder cancer, no biomarkers are used at the present in daily clinical practice. Extracellular vesicles (EVs) have been recently studied as a promising source of biomarkers because of their role in intercellular communication and tumor progression. In this review, we give an overview of Food and Drug Administration (FDA)-approved urine tests to detect bladder cancer and why their use is not widespread in clinical practice. We also include non-FDA approved urinary biomarkers in this review. We describe the role of EVs in bladder cancer and their possible role as biomarkers for the diagnosis and follow-up of bladder cancer patients. We review recently discovered EV-derived biomarkers for the diagnosis of bladder cancer.

COVID-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods

2021 ◽  
Vol 21 ◽  
Author(s):  
Faroogh Marofi ◽  
Ramyar Azizi ◽  
Roza Motavalli ◽  
Ghasem Vahedi ◽  
Maryam Nasimi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Skin Color ◽  
Color Change ◽  
Clinical Symptoms ◽  
Current Knowledge ◽  
Clinical Manifestations ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
World Health ◽  
Therapeutic Approaches

: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) firstly emerged in Wuhan, China at the end of 2019. After going through the experimental process, the virus was named the novel coronavirus (2019-nCoV) by the World Health Organization (WHO) in February 2020 which has created a global pandemic. The coronavirus disease 2019 (COVID-19) infection is challenging the people who are especially suffering from chronic health problems such as asthma, diabetes, and heart disease or immune system deteriorating disorders, including cancers, Alzheimer's, etc. Other predisposing/risk factors consist of smoking and age (elderly people are at higher risk). The 2019-nCoV attacks epithelial cells in all organs, particularly epithelial cells in the lungs, resulting in viral pneumonia. The 2019-nCoV starts its invasion with the attachment and entry into the respiratory tract epithelial cells via angiotensin-converting enzyme 2 (ACE2) receptors on the epithelial cells. The critical problem with 2019-nCoV is its ability in human to the human asymptomatic transmission which causes the rapid and hidden spread of the virus among the population. Also, there are several reports of highly variable and tightly case-dependent clinical manifestations caused by SARS-CoV2, which made the virus more enigmatic. The clinical symptoms are varied from common manifestations which occurred in flu and cold, such as cough, fever, body-ache, trembling, and runny nose to severe conditions, like the acute respiratory distress syndrome (ARDS) or even uncommon/unusual symptoms such as anosmia, skin color change, and stroke. In fact, besides serious injuries in the respiratory system, COVID-19 invades and damages various organs, including the kidney, liver, gastrointestinal, and nervous system. Accordingly, to cut the transmission chain of disease and control the infection spread. One of the major solutions seems to be early detection of the carriers, particularly the asymptomatic people with the help of sensitive and accurate diagnostic techniques. Moreover, developing novel and appropriate therapeutic approaches will contribute to the suitable management of the pandemic. Therefore, there is an urgent necessity to make comprehensive investigations and study reviews about COVID-19, offering the latest findings of novel therapies, drugs, epidemiology, and routes of virus transmission and pathogenesis. In this review, we discuss new therapeutic outcomes and cover and the most significant aspects of COVID-19, including the epidemiology, biological features, organs failure, and diagnostic techniques.

scholarly journals Pyogenic brain abscess

2008 ◽  
Vol 24 (6) ◽  
pp. E2 ◽  
Author(s):  
Ersin Erdoğan ◽  
Tufan Cansever
Keyword(s):  
Treatment Options ◽  
Neurological Status ◽  
Diagnostic Techniques ◽  
Diagnosis And Treatment ◽  
Appropriate Treatment ◽  
Significant Difference ◽  
Immunodeficiency Virus ◽  
Brain Abscesses ◽  
Lower Morbidity

✓ Brain abscesses have been one of the most challenging lesions, both for surgeons and internists. From the beginning of the computed tomography (CT) era, the diagnosis and treatment of these entities have become easier and less invasive. The outcomes have become better with the improvement of diagnostic techniques, neurosurgery, and broad-spectrum antibiotics. Atypical bacterial abscesses are more often due to chemotherapy usage in oncology, long life expectancy in patients with human immunodeficiency virus (HIV) infection, and immunosuppression in conjunction with organ transplantation. Surgical treatment options showed no significant difference with respect to mortality levels, but lower morbidity rates were achieved with stereotactically guided aspiration. Decompression with stereotactically guided aspiration, antibiotic therapy based on results of pus culture, and repeated aspirations if indicated from results of periodic CT follow-up scans seem to be the most appropriate treatment modality for brain abscesses. Immunosuppression and comorbidities, initial neurological status, and intraventricular rupture were significant factors influencing the outcomes of patients. The pitfalls and evolution in the diagnosis and treatment of brain abscesses are discussed in this study.

LUNG CANCER DIAGNOSIS: NON-INVASIVE AND INVASIVE METHODS

2020 ◽  
Vol 66 (1) ◽  
pp. 42-49
Author(s):  
Andrey Arsenev ◽  
Sergey Novikov ◽  
Aleksey Barchuk ◽  
Sergey Kanaev ◽  
Anton Barchuk ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Minimally Invasive ◽  
Cancer Diagnosis ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Lung Cancer Diagnosis ◽  
Wide Range ◽  
Sensitivity Specificity

This article reviews the literature and summarizes single institution experience of applying different diagnostic algorithms for lung cancer. All diagnostic methods can be divided into three groups: non-invasive; minimally invasive and invasive. The non-invasive methods include clinical examination; imaging methods for anatomical, functional and multimodal visualization; sputum cytological, analysis of the exhaled breath, detection of various blood and sputum markers. Minimally invasive methods include endoscopy, percutaneous fine-needle and core-needle biopsy. Invasive methods include diagnostic thoracoscopy and laparoscopy, mediastinoscopy, parasternal mediastinotomy and diagnostic thoracotomy. While creating an individual diagnostic plan for each patient it is necessary to carefully analyze the effectiveness, safety, sensitivity, specificity and of different methods available among wide range of modern diagnostic techniques. Optimization of lung cancer diagnosis methods, which includes early cancer detection, is one of priority areas of modern oncology. Many aspects of this problem remain unresolved and require further research

TMOD-12. COMPARING TUMOR CELL INVASION AND MYELOID CELL COMPOSITION IN GENETICALLY IDENTICAL PRIMARY AND RELAPSING GLIOBLASTOMA

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi218-vi218
Author(s):  
Roland Kälin ◽  
Dongxu Zhao ◽  
Huabin Zhang ◽  
Ramazan Uyar ◽  
Jörg-Christian Tonn ◽  
...  
Keyword(s):  
Immune Cell ◽  
Myeloid Cell ◽  
Genetically Engineered ◽  
Specific Cell ◽  
Therapeutic Approaches ◽  
Cell Composition ◽  
Non Invasive ◽  
Human Gbm ◽  
Simplex Virus

Abstract Glioblastoma (GBM) recurrence after treatment is almost inevitable, but addressing this issue with adequate preclinical models has remained challenging. Here, we introduce a GBM mouse model allowing non-invasive and scalable de-bulking of a tumor mass located deeply in the brain, which can be combined with conventional therapeutic approaches. Towards this aim we genetically engineered mouse GBM cells to stably express the herpes simplex virus thymidine kinase. Strong reduction of the GBM volume is achieved after pharmacologically inducing a tumor-specific cell death mechanism by the prodrug ganciclovir. This is followed by GBM re-growth over a predictable timeframe. Pharmacological de-bulking followed by tumor relapse was accomplished with an orthotopic mouse glioma model. Relapsing experimental tumors recapitulated pathological features often observed in recurrent human GBM, like increased invasiveness or altered immune cell composition. Orthotopic implantation of GBM cells originating from biopsies of one patient at initial or follow-up treatment reproduced these findings. Interestingly, relapsing GBM of both models contained a much higher ratio of monocyte-derived macrophages (MDMs) versus microglia than primary GBM. This was not altered when combining pharmacological de-bulking with invasive surgery. We interpret that factors released from viable primary GBM cells preferentially attract microglia whereas relapsing tumors preponderantly release chemoattractants for MDMs. All in all, this relapse model has the capacity to provide novel insights into clinically highly relevant aspects of GBM treatment.

scholarly journals Successful conservative management in cervical Ectopic Pregnancy

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Khurram Ahmad ◽  
Tahira Bashir Solehria
Keyword(s):  
Ectopic Pregnancy ◽  
Assisted Reproduction ◽  
Conservative Management ◽  
Individual Case ◽  
Diagnostic Techniques ◽  
Appropriate Treatment ◽  
Ectopic Pregnancies ◽  
Tubal Pathology ◽  
Cervical Ectopic Pregnancy

Incidence of cervical ectopic pregnancy is 6% of all the ectopic pregnancies. And this percentage is rising since last decade with increased incidence of ectopic pregnancies in general. Assisted reproduction, tubal pathology due to pelvic inflammatory disease or/and adhesions due to surgery are leading causes for increased incidence of ectopic pregnancy. Modern diagnostic techniques and regular follow up in assisted reproduction cases, pick up ectopic pregnancy at an earlier gestation. Previously hysterectomy was the only resort in majority if not all the cases of cervical ectopic pregnancies But now in selective cases like saving fertility in a patient a promising management has emerged It is however emphasized that appropriate treatment option - medical or surgical should be considered according to individual case. This case of ectopic cervical pregnancy at 6 weeks of gestation is managed successfully by conservative management.

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