Prevalence of work-related musculoskeletal disorders among Egyptian printing workers evidenced by using serum biomarkers of inflammation, oxidative stress, muscle injury, and collagen type I turnover

2020 ◽  
pp. 074823372097739
Author(s):  
Basma Hussein Mourad
Keyword(s):  
Musculoskeletal Disorders ◽  
Serum Biomarkers ◽  
High Rate ◽  
Musculoskeletal Symptoms ◽  
Individual Risk ◽  
Control Group ◽  
Type I ◽  
Work Related ◽  
Tnf Α ◽  
Tissue Changes

Objective: Printing workers experience a high rate of musculoskeletal disorders (MSDs). This study aims to determine the prevalence of MSDs, estimate serum biomarkers denoting musculoskeletal tissue changes, and determine some individual risk factors for MSDs among Egyptian printing workers. Methods: Eighty-five male printing workers and 90 male administrative employees (control group) were recruited from a printing press in Giza. A validated version of the standardized Nordic questionnaire was used. Serum biomarkers of inflammation (interleukin (IL)-1α, IL-1β, IL-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP)), cell stress or injury (malondialdehyde (MDA) and creatine kinase skeletal muscle (CK-MM)), and collagen metabolism (collagen-I carboxy-terminal propeptide (PICP) and type-I collagen cross-linked C-telopeptide (CTx)) were measured for all participants. Results: This study showed a significant ( p < 0.001) prevalence of the musculoskeletal symptoms (76.5%) and significant ( p < 0.001) elevation in the levels of all measured biomarkers among the printing workers (means ± SD: IL-1α = 1.55 ± 0.9, IL-1β = 1.53 ± 0.87, IL-6 = 1.55 ± 0.85, TNF-α = 4.9 ± 2.25, CRP = 6.78 ± 3.07, MDA = 3.41 ± 1.29, CK-MM = 132.47 ± 69.01, PICP = 103.48 ± 36.44, and CTx = 0.47 ± 0.16) when compared with their controls (prevalence: 34.4%; means ± SD: IL-1α = 0.88 ± 0.61, IL-1β = 0.96 ± 0.72, IL-6 = 1.03 ± 0.75, TNF-α = 2.56 ± 1.99, CRP = 2.36 ± 1.1, MDA = 0.85 ± 0.21, CK-MM = 53.48 ± 33.05, PICP = 56.49 ± 9.05, and CTx = 0.31 ± 0.06). Also, significant ( p < 0.001) positive strong associations were observed between age, body mass index (BMI), and the duration of employment with all measured biomarkers, where all correlation coefficients were >0.7. Conclusion: Printing workers suffer a high prevalence of work-related MSDs that might be related to some individual factors (age, BMI, and duration of employment). Consequently, preventive ergonomic interventions should be applied. Further studies should be done to elucidate the link between tissue changes and detected biomarkers to follow the initiation and progression of MSDs and study the effectiveness of curative interventions.

scholarly journals MicroRNA-513b-5p targets COL1A1 and COL1A2 associated with the formation and rupture of intracranial aneurysm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zheng Zheng ◽  
Yan Chen ◽  
Yinzhou Wang ◽  
Yongkun Li ◽  
Qiong Cheng
Keyword(s):  
Cell Death ◽  
Intracranial Aneurysm ◽  
Luciferase Reporter Assay ◽  
Luciferase Reporter ◽  
Control Group ◽  
Type I ◽  
Mrna Levels ◽  
Reporter Assay ◽  
Over Expression ◽  
Tnf Α

AbstractCollagen-type I alpha 1 chain (COL1A1) and COL1A2 are abnormally expressed in intracranial aneurysm (IA), but their mechanism of action remains unclear. This study was performed to investigate the mechanism of COL1A1 and COL1A2 affecting the occurrence and rupture of IA. Quantitative real-time polymerase chain reaction was used to measure the expression of hsa-miR-513b-5p, COL1A1, COL1A2, TNF-α, IL-6, MMP2, MMP3, MMP9 and TIMP4 in patients with ruptured IA (RA) (n = 100), patients with un-ruptured IA (UA) (n = 100), and controls (n = 100). Then, human vascular smooth muscle cells (HASMCs) were cultured, and dual luciferase reporter assay was performed to analyse the targeting relationship between miR-513b-5p and COL1A1 or COL1A2. The effects of the miR-513b-5p mimic and inhibitor on the proliferation, apoptosis, and death of HASMC and the RIP1-RIP3-MLKL and matrix metalloproteinase pathways were also explored. The effect of silencing and over-expression of COL1A1 and COL1A2 on the role of miR-513b-5p were also evaluated. Finally, the effects of TNF-α on miR-513b-5p targeting COL1A1 and COL1A2 were tested. Compared with those in the control group, the serum mRNA levels of miR-513b-5p, IL-6 and TIMP4 were significantly decreased in the RA and UA groups, but COL1A1, COL1A2, TNF-α, IL-1β, MMP2, MMP3 and MMP9 were significantly increased (p < 0.05). Compared with those in the UA group, the expression of COL1A1, COL1A2, TNF-α, IL-1β and MMP9 was significantly up-regulated in the RA group (p < 0.05). Results from the luciferase reporter assay showed that COL1A1 and COL1A were the direct targets of miR-513b-5p. Further studies demonstrated that miR-513b-5p targeted COL1A1/2 to regulate the RIP1-RIP3-MLKL and MMP pathways, thereby enhancing cell death and apoptosis. Over-expression of COL1A1 or COL1A2, rather than silencing COL1A1/2, could improve the inhibitory effect of miR-513b-5p on cell activity by regulating the RIP1-RIP3-MLKL and MMP pathways. Furthermore, over-expression of miR-513b-5p and/or silencing COL1A1/2 inhibited the TNF-α-induced cell proliferation and enhanced the TNF-α-induced cell death and apoptosis. The mechanism may be related to the inhibition of collagen I and TIMP4 expression and promotion of the expression of RIP1, p-RIP1, p-RIP3, p-MLKL, MMP2 and MMP9. MiR-513b-5p targeted the inhibition of COL1A1/2 expression and affected HASMC viability and extracellular mechanism remodelling by regulating the RIP1-RIP3-MLKL and MMP pathways. This process might be involved in the formation and rupture of IA.

The epidemiology of work-related musculoskeletal disorders in beauty therapists working within the hotel spa industry in the eThekwini municipality

2017 ◽  
Author(s):  
◽  
Jolene Jacquire
Keyword(s):  
Musculoskeletal Disorders ◽  
Musculoskeletal Pain ◽  
Well Being ◽  
High Rate ◽  
Ability To Work ◽  
Cross Sectional ◽  
Work Related ◽  
Validated Questionnaire ◽  
Co Morbidity ◽  
Work Related Musculoskeletal Disorders

Background The growing popularity and competitive nature of the beauty industry has resulted in beauty therapists performing an extensive range of treatments to meet the demand, often at the jeopardy of their own well-being. Treatments include massage, waxing, pedicures and facials. These techniques involve vigorous and repetitive movements that may lead to overuse and strain on the musculoskeletal system, resulting in injury. Work-related activities together with factors such as socio-demographic, psychosocial, environmental and anthropometric can influence the prevalence of work-related musculoskeletal disorders (WRMDs). There has been little investigation into the WRMDs of beauty therapists both locally and internationally. Aim The aim of this study was to determine the prevalence, selected risk factors and impact of self-reported work related musculoskeletal disorders (WRMDs) in beauty therapists working within the hotel spa industry in the eThekwini municipality. Method A cross sectional epidemiological design was used to survey 254 beauty therapists working in the hotel spa industry in the eThekwini municipality of Durban. A pre-validated questionnaire was hand delivered to beauty therapists working at all hotel spas that agreed to participate. Informed consent was obtained. The survey contained questions related to musculoskeletal pain, socio-demographic, psycho-social, lifestyle and occupational factors. Results A response rate of 70% was obtained (n=178). The majority of the respondents were female (94.3%; n=165), the mean age of the respondents was 27.74 (SD±4.83) years. The respondents had been working as beauty therapists for an average of 5.91 (SD±4.19; n=176) years and performed on average 27.89 (SD±13.33; n=170) treatments per week, working 47.38 (SD±13.36; n=175) hours per week. Those working overtime worked on average 5.43 (SD±2.94; n=59) hours of overtime per week. There was a high rate of reported WRMDs with the lifetime, current and 12 month period prevalence being 86% (n=153), 85% (n=151) and 83% (n=148), respectively. The area most affected were the low back followed by the neck, the hand and wrist. Ninety percent of the respondents indicated that their pain was mild to moderate in nature, with half expressing an inability to cope with the pain, and 78% reporting that it interfered with their ability to work. Mental exhaustion (p=0.032), suffering from a concomitant co-morbidity (p=0.031), years worked as a beauty therapist (p˂0.001) and treating clients after hours (p=0.007) were significantly associated with the presence of musculoskeletal pain. Performing manual massage (p=0.043) and reporting feelings of exhaustion whilst performing specialised massage techniques (p=0.014) and applying makeup/eyelashes (p=0.022) were associated with the presence of WRMDs. Those who reported having co-worker (p=0.006) and managerial support (p˂0.001) were less likely to experience musculoskeletal pain. In contrast, feeling frustrated by work (p=0.007), being under pressure (p=0.005) and over worked (p=0.009) increased the chances of experiencing WRMDs. Working with the back in an awkward position (p˂0.001), standing for prolonged periods (p˂0.001), lifting heavy loads (p=0.019) and working in a hot and humid environment (p<0.001) increased the risk of WRMDs. Conclusion WRMDs have a significant impact on beauty therapists’ ability to work. Effective strategies to prevent and manage WRMDs in hotel spa beauty therapists is required, along with governmental regulation.

Work-related musculoskeletal symptoms in otorhinolaryngology and their relationship with physical activity. A nationwide survey

2019 ◽  
Vol 133 (8) ◽  
pp. 713-718 ◽  
Author(s):  
D Lobo ◽  
M A Gandarillas ◽  
S Sánchez-Gómez ◽  
R Megía
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Musculoskeletal Disorders ◽  
Nationwide Survey ◽  
Physical Symptoms ◽  
Musculoskeletal Symptoms ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Work Related ◽  
Significant Difference

AbstractObjectiveThe main objective of this study was to determine the prevalence of work-related musculoskeletal symptoms in otolaryngology and head and neck surgery specialists and trainees in Spain, and to measure the effect that physical exercise could have on muscular discomfort.MethodA cross-sectional survey was administered between September and December 2017 to practising otolaryngologists.ResultsFour hundred and three ENT surgeons responded, with a median age of 44.9 years, and 89.8 per cent reported discomfort or physical symptoms that they attributed to surgical practice. More female surgeons reported musculoskeletal symptoms (92.8 per cent vs 87.1 per cent; p = 0.04). When the level of physical activity was compared with the frequency of physical discomfort, no significant difference was found.ConclusionThis study has shown a high prevalence of musculoskeletal disorders among ENT surgeons in Spain but has failed to demonstrate an important role of physical exercise in the prevention of musculoskeletal disorders.

scholarly journals Is Repetitive Workload a Risk Factor for Upper Extremity Musculoskeletal Disorders in Surgical Device Mechanics? A Cross-Sectional Analysis

2020 ◽  
Vol 17 (4) ◽  
pp. 1383 ◽  
Author(s):  
Oliver Lotter ◽  
Tobias Lieb ◽  
Viktor Breul ◽  
Jochen Molsner
Keyword(s):  
Upper Extremity ◽  
Musculoskeletal Disorders ◽  
Control Group ◽  
Dash Score ◽  
Personal Factors ◽  
Cross Sectional ◽  
Work Related ◽  
Surgical Device ◽  
Study Participants ◽  
And Control

To assess the prevalence of upper extremity work-related musculoskeletal disorders (WMSDs) among surgical device mechanics compared to a control group, a total of 70 employees were included and assigned to three occupational groups (grinders, packers, and control). Personal factors, work exposure, manual skill, and complaints were assessed by two self-administered questionnaires and an industry test. WMSDs were diagnosed in a standardised clinical examination. The two-one-sided t-tests (TOST) procedure was used to test the clinical equivalence of the respective grinding and packaging groups vs. the control group in terms of the Disabilities of the Arm, Shoulder and Hand (DASH) score. Thirty-nine study participants (56%) experienced at least one WMSD at the elbow, forearm, and/or wrist, mainly with signs of epicondylitis and nerve entrapment at the medial elbow. The risk of grinders developing upper extremity WMSD was about 2.5-times higher and packers had an 8.6-fold higher risk of a clinically relevant DASH > 29 compared to the control group. However, these differences were not statistically significant. The groups were also proven to be clinically equivalent in terms of DASH score. Surgical device mechanics do not seem to have worse DASH values or be at higher risk of upper limb WMSDs compared to a control group. This is the first study to analyse and compare different workplaces in this industry that are also common in other industries.

Work related musculoskeletal disorders among adolescent girls and young women employees of textile industries in Tamil Nadu, India – a comparative study

2017 ◽  
Vol 30 (6) ◽  
Author(s):  
Gnanaselvam Nancy Angeline ◽  
Joseph Bobby
Keyword(s):  
Musculoskeletal Disorders ◽  
Musculoskeletal Pain ◽  
Adolescent Girls ◽  
Young Women ◽  
Textile Industry ◽  
Musculoskeletal Symptoms ◽  
Work Related ◽  
Women Employees ◽  
Work Related Musculoskeletal Disorders ◽  
Textile Industries

Abstract Musculoskeletal disorders are common in those employed in the textile industry. The aim of the study is to assess musculoskeletal disorders among adolescent girls who are current employees of textile industries in comparison with the adolescent girls and young women who are past employees of textile industries and adolescent girls who have never been employed in the textile industry. Methodology This is a cross-sectional study. A total of 321 subjects, 107 in each study group were sampled. Standardized nordic questionnaires (SNQ) was used to assess musculoskeletal symptoms. Results More than half of the current employees (67.28%) and past employees (67.28%) reported musculoskeletal pain. Among the never been employed, 18.69% reported musculoskeletal pain. Neck and shoulder were the most common sites of musculoskeletal pain among the current employees (49.5% and 50.5%, respectively) and the past employees (45.8% and 49.5%, respectively). In the regression model, having ever been diagnosed for anemia (AOR 6.57, 95% CI 1.4 to 30.76), working for more than 48 h in a week (AOR 3.37, 95% CI 1.53 to 7.41) and the presence of depression (AOR 6.6, 95% CI 1.48 to 29.36) were significantly associated with the presence of musculoskeletal pain in the study participants. Conclusion Musculoskeletal disorders are a major occupational health problem among the adolescent and young women employees of textile industries. Working hours should be fixed at 48 h per week and anemia and depression should be treated to avert the work related musculoskeletal disorders in the study population.

scholarly journals Comprehensive assessment of vascular lesions in predicting cardiovascular events in atherosclerosis and carbohydrate metabolism disorders

2019 ◽  
Vol 2 (21) ◽  
pp. 22-27
Author(s):  
A. A. Tarasov ◽  
M. A. Gordeeva ◽  
S. I. Davydov ◽  
E. A. Reznikova ◽  
A. R. Babaeva
Keyword(s):  
Diabetes Mellitus ◽  
Adverse Events ◽  
Cardiovascular Events ◽  
Cardiovascular Complications ◽  
High Rate ◽  
Vascular Lesions ◽  
Type I ◽  
Tnf Α ◽  
Circulating Markers ◽  
Artery Disease

The article presents the results of a cluster analysis of the contribution of immune inflammationmarkers and endothelial dysfunction (ED) to the cardiovascular complicationsfrequency and severity in cohorts of patients with asymptomatic atherosclerosis (AAS), coronary artery disease (CAD), tyepe 2 diabetes mellitus (T2DM) and metabolic syndrome (MS) during 3 years of prospective observation. A comparative analysis of the spectrum of the examined markers was performed depending on the stage of the development of the disease, the presence of T2DM and the MS. It was revealed that the greatest contribution to the cardiovascular complications development in AAS is provided by such circulating markers of ED and immune inflammation as ET-1, IL-1β, TNF-α, total autoantibodies to type I and III collagen (a-Coll) and to Chondroitine-sulfate (a-ChS). With IHD, the greatest contribution is provided by ET-1, eNOs, antibodies a-Coll and also IL-6 and vWf.In T2DM patients without CAD, a profile of markers associated with the high rate of adverse events includes ET-1, eNOs, IL-6, a-Coll and antibodies against hyaluronic acid (a-HA). In a cohort of patients with chronic CAD in the setting of T2DM, a profile of markers associated with the development of adverse events includes vWf, TNF-α, as well as the level of eNOs, IL-6, a-Coll, a-HA and CRP. In the cases of AAS without concomitant MS, the greatest contribution is due to the increase in the level of ET-1, vWf, a-Coll and a-ChS content; in the presence of MS — IL-1β, TNF-α, a-Coll, anti-ChS, anti-HA and CRP. In CAD without MS profile of markers associated with the development of adverse events, includes ET-1, eNOs and a-HA, the presence of the MS — a-Coll, ET-1 and IL-6 levels.

scholarly journals Work-related musculoskeletal disorders among health care professionals

2017 ◽  
Vol 7 (1) ◽  
pp. 4-9
Author(s):  
Mokhlesur Rahman ◽  
Abhijit Chowdhury ◽  
Mohammad Shiblee Zaman ◽  
Nihar Sultana ◽  
Mariam Binte Amin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Musculoskeletal Disorders ◽  
Musculoskeletal Pain ◽  
Health Care Professionals ◽  
Musculoskeletal Symptoms ◽  
P Value ◽  
Care Hospital ◽  
Work Related ◽  
Work Related Musculoskeletal Disorders

Musculoskeletal disorders (MSDs) represent a significant occupational problem among health care professionals; however, data on prevalence of work-related musculoskeletal disorders (WMSDs) are limited in our country for referencing. A descriptive cross sectional study was conducted during January to December 2016 among 160 health care professionals (doctors, nurses) working in a tertiary care hospital in Dhaka city. The aim of the study was to determine the prevalence, distribution and to find out the multiple risk factors that contribute to the development of WMSDs among the sample population. Data were collected with semi structured questionnaire based on a validated research instrument Standardized Nordic Questionnaire (SNQ) which records the prevalence of MSDs in terms of musculoskeletal symptoms (ache, pain, discomfort) in the preceding 12 months. The statistical analysis was done by using the SPSS software 21 version. The study result revealed that out of 160 (100.0%) health care professionals 109 (68.1%) had musculoskeletal pain or discomfort in the last 12 months and 51 (31.9%) had not, and it was also found that 57 (61.3%) doctors and 52 (77.6%) nurses had musculoskeletal pain or discomfort in the last 12 months and the prevalence of work-related musculoskeletal disorders in different body region in the last 12 months, where more than 1 site involvement 46 (42.2%) followed by neck 19 (17.4%), shoulder 15 (13.8%), lower back 13 (11.9%), hips 8 (7.3%), hand/fingers 5 (4.6%). About the self reported risk factors among the health care professionals for WMSDs were found working the same position for long periods 48 (29.8%),followed by treating excessive number of patients in a day 47 (29.1%), inadequate training on injury prevention 25 (15.9%), working awkward or cramped position18(11.6%).There were no statistically significant association found in age and years of experience of the health care professionals with the WMSDs (p value .281, .083 respectively), but significant association found in sex and occupation of the health care professionals with WMSDs (p value .045, .031 respectively). As because a high proportion of health care professionals had WMSDs and they are on the risk for development of WMSDs, it can be recommended that education programmes on prevention and coping strategies for musculoskeletal disorders be made mandatory for health care professionals in order to reduce the rate of WMSDs among them and to promote efficiency in patient care.Update Dent. Coll. j: 2017; 7 (1): 04-09

Impact of the Groningen Exercise Therapy for Symphony Orchestra Musicians Program on Perceived Physical Competence and Playing-Related Musculoskeletal Disorders of Professional Musicians

2003 ◽  
Vol 18 (4) ◽  
pp. 156-160
Author(s):  
Mathieu de Greef ◽  
Ruud van Wijck ◽  
Koop Reynders ◽  
Joost Toussaint ◽  
Rike Hesseling
Keyword(s):  
Musculoskeletal Disorders ◽  
Exercise Therapy ◽  
Symphony Orchestra ◽  
High Rate ◽  
Physical Workload ◽  
Control Group ◽  
Physical Competence ◽  
Professional Musicians ◽  
Repetitive Motion ◽  
Lower Back

The goal of the Groningen Exercise Therapy for Symphony Orchestra Musicians (GETSOM) program is to change the limited repetitive motion and playing habits of musicians and stimulate their motion repertoire to reduce the effects of physical overload. The research was motivated directly by the high rate of absences due to illness in a regional symphony orchestra resulting from playing-related musculoskeletal disorders (PRMDs). The secondary preventive effects of the GETSOM program on perceived physical competence and PRMDs were studied in a clinical trial in which 45 professional musicians of a symphony orchestra were included and randomized to an experimental (n = 17) and a control group (n = 28). To decrease PRMDs, the GETSOM program focuses on enhancing the perceived physical competence of musicians. The program pays special attention to relaxation, postural exercises for the shoulder, neck, and lower back; and exercises to enhance physical workload and deal with mental stress. Participation in the 15-week GETSOM program has shown a statistically significant (p < 0.05) and clinically relevant (d > 0.20) increase in perceived physical competence and a decrease in PRMDs in the experimental group compared with the control group. According to a multiple regression analysis, 45% of the decrease in PRMDs was explained by an increase in physical competence. There is evidence that the GETSOM program is efficacious in promoting changes in perceived physical competence and a decrease in PRMDs.

scholarly journals PREVALENCE OF MUSCULOSKELETAL SYMPTOMS RELATED TO WORK IN DENTAL SURGEONS: A WIDE REVIEW OF CURRENT MEDICAL LITERATURE

2019 ◽  
Vol 7 (11) ◽  
pp. 80-92
Author(s):  
Alan Mesquita Santos ◽  
Flavia Martão Flório ◽  
Eber Coelho Paraguassu ◽  
José Pedro Gomes Moura ◽  
Thamilly Joaquina Picanço da Silva ◽  
...  
Keyword(s):  
Musculoskeletal Disorders ◽  
Laboratory Tests ◽  
Public Health Problem ◽  
Musculoskeletal Symptoms ◽  
Permanent Disability ◽  
Work Related ◽  
High Prevalence ◽  
Work Related Musculoskeletal Disorders ◽  
Repetitive Strain ◽  
The Relationship

Introduction: Repetitive Strain Injury (RSI) and Work-Related Musculoskeletal Disorders (WMSD) are considered a public health problem because of their high prevalence in various professions, including dental professionals. Because of poor posture and organization at work, for example, dental surgeons occupy the top spot on sick leave due to temporary or permanent disability, accounting for approximately 30% of the causes of premature abandonment between medical activities.Objectives: To identify the prevalence of musculoskeletal symptoms and their relationship with dentist activity and to evaluate the relationship between symptomatology and laboratory test results.Methodology: A scan was performed, but Scopus, Web of Sciences and Google Scholar indexing databases were used to unite musculoskeletal disorders, dental surgeons, prevalence, laboratory tests. We found 15,000 articles, of which 56 were selected based on the best h index score or Qualis rating on the Sucupira platform.Conclusion: The relationship between musculoskeletal pain and dentist activity is strong and in some cases, these disorders can be detected on laboratory tests.

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