Catheter-related venous thrombosis in NICU: A case-control retrospective study

2020 ◽  
pp. 112972982098320
Author(s):  
Karolina Chojnacka ◽  
Zbigniew Krasiński ◽  
Katarzyna Wróblewska-Seniuk ◽  
Jan Mazela
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Venous Thrombosis ◽  
Neonatal Intensive Care ◽  
Neonatal Period ◽  
Clinical Manifestations ◽  
Significant Risk ◽  
Case Control ◽  
Control Group ◽  
Vein Thrombosis

Introduction: Newborns treated in a neonatal intensive care unit (NICU) are susceptible to several complications one of them being vein thrombosis. Aim: The study aims to evaluate risk factors of catheter-related venous thrombosis, clinical manifestations, treatment, and the outcomes of thrombotic events (TE) during the neonatal period. Methods: This work is a case-control retrospective study performed on patients in the tertiary NICU between January 2013 and June 2016. The analysis includes data from infants with CVC diagnosed with thrombosis and infants with CVC, not being diagnosed with thrombosis (control group). Statistica 10 software was used for statistical analysis. Results: Vein thrombosis was diagnosed in 19 NICU infants including 16 cases of catheter-related vein thrombosis (84% of complicated cases). Other statistically significant risk factors were asphyxia, infection, and the duration of CVC use. The incidence of thrombosis in our population increased during the study which may result from a statistically significant increase in the number of inserted CVC (294 vs 435), and more frequent diagnosis of incidental thrombosis (1 vs 9). Conclusion: Vein catheterization, asphyxia, infection, and prolonged CVC use are critical risk factors for thrombosis in the neonatal period. Given the hereinbefore mentioned increased number of central line catheterizations in the NICU, it would be useful to conduct a prospective study with a scheduled routine ultrasound protocol applied not only as a tool to diagnose thrombosis but also to prevent it by determining a proper catheter for a particular vein.

scholarly journals Analysis of the Risk Factors Associated with Hearing Loss of Infants Admitted to a Neonatal Intensive Care Unit: A 13-Year Experience in a University Hospital in Korea

2020 ◽  
Vol 17 (21) ◽  
pp. 8082
Author(s):  
Kyu Young Choi ◽  
Bum Sang Lee ◽  
Hyo Geun Choi ◽  
Su-Kyoung Park
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Hearing Loss ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Significant Risk ◽  
University Hospital ◽  
Control Group ◽  
Brainstem Response

Early detection of hearing loss in neonates is important for normal language development, especially for infants admitted to the neonatal intensive care unit (NICU) because the infants in NICU have a higher incidence of hearing loss than healthy infants. However, the risk factors of hearing loss in infants admitted to the NICU have not been fully acknowledged, especially in Korea, although they may vary according to the circumstances of each country and hospital. In this study, the risk factors of hearing loss in NICU infants were analyzed by using the newborn hearing screening (NHS) and the diagnostic auditory brainstem response (ABR) test results from a 13-year period. A retrospective chart review was performed using a list of NICU infants who had performed NHS from 2004 to 2017 (n = 2404) in a university hospital in Korea. For the hearing loss group, the hearing threshold was defined as 35 dB nHL or more in the ABR test performed in infants with a ‘refer’ result in the NHS. A four multiple number of infants who had passed the NHS test and matched the age and gender of the hearing loss group were taken as the control group. Various patient factors and treatment factors were taken as hearing loss related variables and were analyzed and compared. From the 2404 infants involved, the prevalence of hearing loss was 1.8% (n = 43). A comparison between the hearing loss group (n = 43) and the control group (n = 172) revealed that history of sepsis, peak total bilirubin, duration of vancomycin use, days of phototherapy, and exposure to loop-inhibiting diuretics were significantly different, and can be verified as significant risk factors for hearing loss in NICU infants.

scholarly journals Predisposing Factors for Deep Venous Thrombosis in Children and Adolescents with Nephrotic Syndrome

2011 ◽  
Vol 2011 ◽  
pp. 1-5
Author(s):  
Gabriela de Toledo Passos Candelaria ◽  
Vera Maria Santoro Belangero
Keyword(s):  
Risk Factors ◽  
Nephrotic Syndrome ◽  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Children And Adolescents ◽  
Odds Ratio ◽  
Significant Risk ◽  
Vein Thrombosis ◽  
Deep Vein

Nephrotic syndrome (NS) is a state of hypercoagulability. In this paper, we sought to determine risk factors for the occurrence of deep vein thrombosis (DVT) in children with NS. The “with DVT” group included patients with decompensated NS and diagnosed with DVT. The “without DVT” group included the same patients, six to eighteen months prior to the episode of DVT, with decompensated NS but without DVT. Different prediction variables were analyzed. The odds ratio for the occurrence of DVT in patients with triglyceride levels ≥300 mg/dL was 3.14 (95% CI 1.14 to 8.64). For hematocrit levels ≥43% and for the presence of infection or a severe systemic event, the odds ratio was 4.37 (95% CI 1.23 to 15.53). The presence of significant risk factors for the occurrence of DVT in children with NS may serve as a warning for the occurrence of venous thrombosis.

Rare thromboses of cerebral, splanchnic and upper-extremity veins

2010 ◽  
Vol 103 (06) ◽  
pp. 1136-1144 ◽  
Author(s):  
Valerio De Stefano ◽  
Ida Martinelli
Keyword(s):  
Risk Factors ◽  
Lower Extremity ◽  
Venous Thrombosis ◽  
Upper Extremity ◽  
Myeloproliferative Neoplasms ◽  
Clinical Manifestations ◽  
First Episode ◽  
Vein Thrombosis ◽  
Local Risk ◽  
Venous Thromboses

SummaryVenous thrombosis typically involves the lower extremity circulation. Rarely, it can occur in the cerebral or splanchnic veins and these are the most frightening manifestations because of their high mortality rate. A third site of rare venous thrombosis is the deep system of the upper extremities that, as for the lower extremity, can be complicated by pulmonary embolism and post-thrombotic syndrome. The authors conducted a narrative review focused on clinical manifestations, risk factors, and treatment of rare venous thromboses. Local risk factors such as infections or cancer are frequent in thrombosis of cerebral or portal veins. Upper extremity deep-vein thrombosis is mostly due to local risk factors (catheter- or effort-related). Common systemic risk factors for rare venous thromboses are inherited thrombophilia and oral contraceptive use; chronic myeloproliferative neoplasms are closely associated with splanchnic vein thrombosis. In the acute phase rare venous thromboses should be treated conventionally with low-molecular-weight heparin. Use of local or systemic fibrinolysis should be considered in the case of clinical deterioration in spite of adequate anticoagulation. Anticoagulation with vitamin K-antagonists is recommended for 3–6 months after a first episode of rare venous thrombosis. Indefinite anticoagulation is recommended for Budd-Chiari syndrome, recurrent thrombosis or unprovoked thrombosis and permanent risk factors. In conclusion, the progresses made in the last couple of decades in diagnostic imaging and the broadened knowledge of thrombophilic abnormalities improved the recognition of rare venous thromboses and the understanding of pathogenic mechanisms. However, the recommendations for treatment mainly derive from observational studies.

scholarly journals Incidence, risk factors and management of post cesarean section surgical site infection (SSI) in a tertiary hospital in Egypt: a five year retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Khaled Gomaa ◽  
Ahmed R. Abdelraheim ◽  
Saad El Gelany ◽  
Eissa M. Khalifa ◽  
Ayman M. Yousef ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Mortality Rate ◽  
Cesarean Section ◽  
Surgical Site Infection ◽  
Significant Risk ◽  
Tertiary Hospital ◽  
Control Group ◽  
Site Infection ◽  
Incidence Risk

Abstract Background Surgical site infection (SSI) is one of the commonest complications following cesarean section (CS) with a reported incidence of 3–20%. SSI causes massive burdens on both the mother and the health care system. Moreover, it is associated with high maternal morbidity and mortality rate of up to 3%. This study aims to determine the incidence, risk factors and management of SSI following CS in a tertiary hospital. Methods This was an observational case control retrospective study which was conducted at Minia maternity university hospital, Egypt during the period from January 2013 to December 2017 (Five years). A total of 15,502 CSs were performed during the studied period, of these, 828 cases developed SSI following CS (SSI group). The control group included 1500 women underwent cesarean section without developing SSI. The medical records of both groups were reviewed regarding the sociodemographic and the clinical characteristics. Results The incidence of SSI post-cesarean section was 5.34%. Significant risk factors for SSI were; chorioamnionitis (adjusted odds ratio (AOR) 4.51; 95% CI =3.12–6.18), premature rupture of membranes (PROM) (AOR 3.99; 95% CI =3.11–4.74), blood loss of > 1000 ml (AOR 2.21; 95% CI =1.62–3.09), emergency CS (AOR 2.16; 95% CI =1.61–2.51), duration of CS of > 1 h (AOR 2.12; 95% CI =1.67–2.79), no antenatal care (ANC) visits (AOR 2.05; 95% CI =1.66–2.37), duration of labor of ≥24 h (AOR 1.45; 95% CI =1.06–2.01), diabetes mellitus (DM) (AOR 1.37; 95% CI =1.02–2.1 3), obesity (AOR 1.34; 95% CI =0.95–1.84), high parity (AOR 1.27; 95% CI = 1.03–1.88), hypertension (AOR 1.19; 95% CI = 0.92–2.11) and gestational age of < 37 wks (AOR 1.12; 95% CI = 0.94–1.66). The mortality rate due to SSI was 1.33%. Conclusions The obtained incidence of SSI post CS in our study is relatively lower than other previous studies from developing countries. The development of SSI is associated with many factors rather than one factor. Management of SSI is maninly medical but surgical approach may be needed in some cases. Registration Local ethical committee (Registration number: MOBGYN0040).

scholarly journals Hipertensi dan Faktor Risikonya di Puskesmas Motolohu Kabupaten Pohuwato

2018 ◽  
Vol 1 (1) ◽  
pp. 032
Author(s):  
Zul Adhayani Arda ◽  
Rifa’i Ali ◽  
Marselina Mustapa
Keyword(s):  
Risk Factors ◽  
Smoking Behavior ◽  
Significant Risk ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Case Group ◽  
The Public ◽  
Factors Associated ◽  
Health Organization

Based on WHO (World Health Organization) in 2011, hypertension was causing 8billion of the world citizen pass away every year in which almost 1.5 billion of them were in south east of Asia. The purpose of study was to determine the risk factors associated with hypertension in Pohuwato District in 2017. The study was an observational analytic with case control design. The sample of study was 202 respondents which divided into 101 case group and 101 control group in the  w orkarea of Puskesmas Motolohu in Pohuwato District. The data were analyzed by using odds ratio (OR) test. The study result showed that occupation (OR=2.71;95% CI; 1.45-5.05), gender (OR=2.55; 95% CI; 1.35-4.79), smoking behavior (OR=2.55; 95% CI; 1.35-4.79), hypertension history (OR=6.13; 95% CI; 3.04-12.36), and consumption of coffee (OR=3.20; 95% CI; 1.64-6.25) were significant risk factors for occurance of hypertension. It is recomended to counseled as a means of disseminating information about risk factors and effect of hypertensionto the public.

Risk factors for the Pap test cytological changes in Iran: A multicenter case-control study

2021 ◽  
Vol 17 ◽  
Author(s):  
Gita Sangestani ◽  
Greco Pantaleo ◽  
Ali Reza Soltanian ◽  
Mahnaz Khatiban
Keyword(s):  
Risk Factors ◽  
Pap Smear ◽  
Case Control Study ◽  
Clinical Manifestations ◽  
Pap Test ◽  
Case Control ◽  
Hormonal Contraceptives ◽  
Control Group ◽  
Cytological Changes ◽  
Control Study

Background: Pap tests can detect changes inside the cells of the cervix before cancer develops. Objective: To compare the risk factors and determinants for abnormal cytological changes in Pap test results among the women with and without atypical cytological findings in their Pap test, and to determine the clinical manifestations associated with those changes. Methods: A multicenter case-control study was conducted in four clinics of gynecology and oncology in Iran. Of a total of 201 women with a result of Pap smear, 51 were cases (atypical cytological findings) and 150 women were control (benign/reactive changes). The data was collected by a researcher-designed tool through the interview, observing medical records and clinical examinations. Results: According to the logistic regression, the women’s age (OR= 1.08), age at the menarche (OR= 0.75), number of deliveries (OR= 1.44), and BMI (OR= 2.60) are the determinants of the Pap test cytological changes in Iran. Taking hormonal contraceptives, using IUD, sexual activity, and having a family history of cancer are not determinants (p>.05). The clinical manifestations as having an unhealthy cervix, painful sex, low abdominal pain, pelvic pain, and low back pain were significantly higher (P< .001) in the case group than those of the control group. Conclusion: The Pap test cytological changes in Iranian women are associated with age, age at the menarche, number of deliveries, and BMI. This information can help healthcare providers to predict their patients' health situation in order to have a suitable and quick action.

A retrospective study of risk factors for calf venous thrombosis in patients with cerebral hemorrhage

2020 ◽  
Author(s):  
Xiaogang Gao ◽  
Yi Li ◽  
Dongzhe Hou
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Retrospective Study ◽  
Muscle Strength ◽  
Venous Thrombosis ◽  
Cerebral Hemorrhage ◽  
Clinical Manifestations ◽  
Affected Side ◽  
Gcs Score ◽  
D Dimer

Abstract Purpose：To investigate the risk factors for calf venous thrombosis in patients with cerebral hemorrhage, so as to provide a reference for customized clinical decision.Methods：396 intracerebral hemorrhage (ICH) patients were enrolled in this retrospective study from January 2017 to December 2019. Risk factors and predictors of occurrence for Muscle calf venous thrombosis (MCVT) were summarized and analyzed by Chi-square test and logistic regression analysis.Results: 128 ICH patients with MCVT and 268 without ones were included. Demographic features comparison showed that ICH with MCVT patients showed older average age than those without ones (p=0.039). Co-morbid diseases analysis showed that patients with MCVT tend to complicate with Diabetes Mellitus (DM) (p=0.040). The comparison of laboratory examinations showed serum level of glucose (p=0.011), Fibrinogen (p=0.046) and D-Dimer (p=0.007) was significantly different. For clinical manifestations, the coma degree (GCS score) and muscle strength level were related to occurring of MCVT. Multivariate logistic regression identified higher age (OR=1.036, 95%CI =1.009-1.064, P= 0.008), higher D-Dimer level (OR=2.379, 95%CI =1.338-4.231, P= 0.003), low GCS (OR=0.932, 95%CI =0.868-0.998, P= 0.044) and lower affected side muscle strength (0-3 grade) (OR=1.624, 95%CI =1.009-2.614, P= 0.046) will predict higher incidence of MCVT in ICH patients.Conclusion: According to our study, higher age, higher D-Dimer level, lower GCS score and lower affected side muscle strength were associated with higher incidence of MCVT in ICH patients. Clinical doctors should pay more attention to prevent MCVT in ICH patients which coincide with those risk factors.

scholarly journals Risk factors for the failure to achieve normal albumin serum levels after albumin transfusion in neonates

2016 ◽  
Vol 56 (3) ◽  
pp. 129
Author(s):  
Nadya Arafuri ◽  
Pudjo Hagung Widjajanto ◽  
Ekawaty L. Haksari
Keyword(s):  
Risk Factors ◽  
Critical Illness ◽  
Very Low Birth Weight ◽  
Significant Risk ◽  
Albumin Level ◽  
Control Group ◽  
Case Group ◽  
Severe Bleeding ◽  
Normal Albumin ◽  
Neonatal Ward

Background Albumin transfusion for the treatment of neonatal hypoalbuminemia may reduce morbidity. In conditions with disrupted endothelial integrity (e.g., sepsis and critical illness), the administered albumin may leak into the interstitial space, hence, serum albumin levels may fall below expected levels after transfusion. To date, few studies have been done to evaluate the risk factors for failure to achieve normal neonatal albumin levels after transfusion.Objectives To determine the risk factors for failure to achieve normal neonatal albumin levels after transfusion.Methods We performed a case-control study in the Neonatal Ward of Dr. Sardjito Hospital from 2007 to 2012. Normal albumin level was defined as above 3 g/dL. The case group included neonates with post-transfusion albumin levels <3 g/dL and the control group included those with post-transfusion albumin ≥3 g/dL. Subjects received intravenous transfusions of 25% or 20% albumin according to the clinical standard of the Neonatal Ward of Dr. Sardjito Hospital. Neonates with very low birth weight, severe birth trauma, burn injuries, severe bleeding, or incomplete medical records were excluded. The data were analyzed with logistic regression test.Results From January 2007 to December 2012, 124 neonates were enrolled in the study. Multivariate analysis showed that low albumin levels before transfusion (OR 12.27; 95%CI 2.17 to 69.30), presence of critical illness (OR 4.01; 95%CI 1.49 to 10.79), diagnosis of sepsis (OR 3.56; 95%CI 1.36 to 9.32), and the >24-hour interval between albumin examination and transfusion (OR 0.06; 95%CI 0.01 to 0.37) were significant risk factors affecting the failure to achieve normal albumin levels.Conclusions Failure to achieve normal albumin levels after transfusion in neonates was significantly associated with low albumin level prior to transfusion, critical illness, sepsis, and >24-hour interval between transfusion and post-transfusion albumin examination.[Paediatr Indones. 2016;56:129-33.].

scholarly journals Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Arisara Poosari ◽  
Thitima Nutravong ◽  
Prakasit Sa-ngiamwibool ◽  
Wises Namwat ◽  
Supaporn Chatrchaiwiwatana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Oral Hygiene ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
Poor Oral Hygiene ◽  
History Of ◽  
Control Study ◽  
History Of Cancer

Abstract Background Previous studies have shown the association between Campylobacter species infection and that environmental factors, poor oral hygiene in particular, are linked to an increased risk of esophageal cancer (EC). However, no study has reported on these factors in Thailand. Thus, this study’s objective was to evaluate the impact of the relationship between Campylobacter infection and environmental factors on EC incidence in the population of Thailand. Methods Data from a case–control study were collected from 105 newly diagnosed EC cases and 105 controls recruited from 2007 to 2017. Infection with Campylobacter spp. was detected in the formalin-fixed paraffin-embedded (FFPE) tissue of EC taken from gastroesophageal biopsy specimens obtained from the participants, and evaluated using TaqMan® real-time PCR. Multivariable logistic regression was performed to calculate the odds ratios (ORs) and perform data analysis. Results Smoking, alcohol use, a family history of cancer, history of gastroesophageal reflux disease, poor oral hygiene and Campylobacter spp. infection were shown to be significant risk factors for EC (p  <  0.05). The combination of poor oral hygiene and infection with Campylobacter spp. constituted significant risk for EC (p  <  0.001). In addition, the risk of EC in subjects co-infected with C. rectus and C. concisus that practiced poor oral hygiene was even higher and was significant (ORadj  =  4.7; 95% CI 2.41–9.98; p  =  0.003). Conclusions In Thailand, the major risk factors for EC are smoking status, alcohol drinking, family history of cancer, GERD, poor oral hygiene and Campylobacter spp. infection. This study found Campylobacter spp. prevalence to be associated with EC and appears to be enhanced by poor oral hygiene, suggesting that a combination of poor oral hygiene and Campylobacter species infection may together act as an important etiological risk factor for EC.

scholarly journals Designing a bed-side system for predicting length of stay in a neonatal intensive care unit

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Harpreet Singh ◽  
Su Jin Cho ◽  
Shubham Gupta ◽  
Ravneet Kaur ◽  
S. Sunidhi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Length Of Stay ◽  
Neonatal Intensive Care ◽  
Financial Burden ◽  
Significant Risk ◽  
Model Performance ◽  
Significant Risk Factor ◽  
Validation Dataset ◽  
Patient Records

AbstractIncreased length of stay (LOS) in intensive care units is directly associated with the financial burden, anxiety, and increased mortality risks. In the current study, we have incorporated the association of day-to-day nutrition and medication data of the patient during its stay in hospital with its predicted LOS. To demonstrate the same, we developed a model to predict the LOS using risk factors (a) perinatal and antenatal details, (b) deviation of nutrition and medication dosage from guidelines, and (c) clinical diagnoses encountered during NICU stay. Data of 836 patient records (12 months) from two NICU sites were used and validated on 211 patient records (4 months). A bedside user interface integrated with EMR has been designed to display the model performance results on the validation dataset. The study shows that each gestation age group of patients has unique and independent risk factors associated with the LOS. The gestation is a significant risk factor for neonates < 34 weeks, nutrition deviation for < 32 weeks, and clinical diagnosis (sepsis) for ≥ 32 weeks. Patients on medications had considerable extra LOS for ≥ 32 weeks’ gestation. The presented LOS model is tailored for each patient, and deviations from the recommended nutrition and medication guidelines were significantly associated with the predicted LOS.

Sign in / Sign up

Export Citation Format

Share Document