Hydrogen Peroxide: Its Use in an Extensive Acute Wound to Promote Wound Granulation and Infection Control – Is it Better Than Normal Saline?

2021 ◽  
pp. 153473462110325
Author(s):  
Sanjay Rai ◽  
Tej Pratap Gupta ◽  
Omna Shaki ◽  
Amit Kale
Keyword(s):  
Hydrogen Peroxide ◽  
Wound Healing ◽  
Granulation Tissue ◽  
Lower Limb ◽  
Exothermic Reaction ◽  
Saline Group ◽  
Wound Management ◽  
Biological Behavior ◽  
Control Group ◽  
Free Oxygen Radicals

Background: Hydrogen peroxide (H2O2) is used as a topical antiseptic in contaminated wounds caused by road traffic accidents. It kills bacteria by producing oxidation through local, nascent, free oxygen radicals. It also removes dirt from the wound due to its frothing action. H2O2 is synthesized by various cells as an active biochemical agent that affects cell biological behavior through complex chemical reactions. H2O2 has also been used as a wound cleaning agent, removing debris, preventing infection, and causing hemostasis due to its exothermic reaction with blood. Despite its widespread use, there is scanty literature on its use to promote granulation tissue formation. Objective: In the orthopaedics literature, studies on H2O2 use are very limited and its potential is underestimated. In the present study, we would like to report our protocol of use of H2O2 for its tremendous potential for stimulating granulation and early wound healing. Material and Methods: A total of 53 patients with large acute extensive lower limb contaminated wounds reported to the emergency department have been included with and without lower limb fracture. In group A (43 patients) wound management was done using 7% H2O2 and group B (10 patients) was treated by only saline dressing as a control group. Results: In the present study, daily dressing by 7% H2O2 solution and provide solution gives excellent results compared to the Saline group. Granulation tissue appeared much earlier with a mean SD 6.3 ± 6.8 days in the hydrogen peroxide group as compared to the Saline group where granulation tissue appeared in 9.3 ± 8.4 days. Conclusion: Spontaneous wound healing is a controlled balance between destructive and healing processes. It is mandatory to remove damaged tissue to promote healing by secondary intention and minimize infection. The dynamic effect of H2O2 promotes faster healing, stimulates granulation, and minimizes infection by oxidative stress.

scholarly journals The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing

2021 ◽  
Vol 10 (7) ◽  
pp. 1495
Author(s):  
Yu-Chi Wang ◽  
Hsiao-Chen Lee ◽  
Chien-Lin Chen ◽  
Ming-Chun Kuo ◽  
Savitha Ramachandran ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Early Period ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Management ◽  
Control Group ◽  
Diabetic Patients ◽  
High Morbidity

Diabetic foot ulcers (DFUs) are a serious complication in diabetic patients and lead to high morbidity and mortality. Numerous dressings have been developed to facilitate wound healing of DFUs. This study investigated the wound healing efficacy of silver-releasing foam dressings versus silver-containing cream in managing outpatients with DFUs. Sixty patients with Wagner Grade 1 to 2 DFUs were recruited. The treatment group received silver-releasing foam dressing (Biatain® Ag Non-Adhesive Foam dressing; Coloplast, Humlebaek, Denmark). The control group received 1% silver sulfadiazine (SSD) cream. The ulcer area in the silver foam group was significantly reduced compared with that in the SSD group after four weeks of treatment (silver foam group: 76.43 ± 7.41%, SSD group: 27.00 ± 4.95%, p < 0.001). The weekly wound healing rate in the silver foam group was superior to the SSD group during the first three weeks of treatment (p < 0.05). The silver-releasing foam dressing is more effective than SSD in promoting wound healing of DFUs. The effect is more pronounced in the initial three weeks of the treatment. Thus, silver-releasing foam could be an effective wound dressing for DFUs, mainly in the early period of wound management.

Deep dissecting haematoma in patients with dermatoporosis: implications for home nursing

2021 ◽  
Vol 26 (Sup3) ◽  
pp. S6-S13
Author(s):  
Valentina Vanzi ◽  
Elena Toma
Keyword(s):  
Wound Healing ◽  
Emergency Management ◽  
Lower Limb ◽  
Essential Role ◽  
Early Recognition ◽  
Wound Management ◽  
Home Nursing ◽  
High Prevalence ◽  
Clinical Emergency

Dermatoporosis is a chronic cutaneous insufficiency/fragility syndrome with a high prevalence in older adults. Dermatoporotic skin becomes thin and fragile and tends to tear. It may lead to deep dissecting haematomas (DDHs) as a final stage of dermatoporosis, which is a clinical emergency. Management can be challenging, as patients with lower-limb haematomas are frequently older and affected by multiple comorbidities, or are probably on medications that negatively influence wound healing. This article describes the essential role of nurses in prevention, early recognition and wound management of DDHs in patients with dermatoporosis.

scholarly journals Effectivity of topical mangosteen pericarp extract cream on wound healing in Swiss albino mice

2019 ◽  
Vol 92 (2) ◽  
Author(s):  
Hilda Brigitta Sombolayuk ◽  
Khairuddin Djawad ◽  
Siswanto Wahab ◽  
Upik A. Miskad ◽  
Gemini Alam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Inflammatory Cells ◽  
Control Group ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Swiss Albino Mice ◽  
Accelerate Wound Healing ◽  
Acute Wound ◽  
Albino Mice

Wound healing is a complex physiological process consisting of four phases: coagulation, inflammation, proliferation and migration, and remodeling, each with distinct characteristics. Studies have suggested that mangosteen pericarp extract (MPE) may accelerate wound healing. However, the mechanism has not been fully understood. This study aims to evaluate the effect of MPE cream in various concentrations in acute wound healing of albino mice, both histologically and macroscopically. Thirty-two healthy female Swiss albino mice, aged 6-9 weeks, weight 20-30 g, were included in this study. The samples were randomly divided into eight groups each consisting of 4 mice. The first four groups were treated with MPE cream 5%, 10%, and 20%, and no medication (control group), respectively, and were sacrificed after three days. The other four groups received the same application and were sacrificed after 8 days. Wound bed diameter was measured and biopsy from the skin lesion was performed for histopathologic examination. Mann-Whitney test was used to analyze the diameter of the wound bed and histopathological findings of granulation tissue formation, reepithelialization, and inflammation, with P<0.05 considered as significant. MPE cream significantly improved wound healing by increasing granulation tissue formation, and reepithelialization. In addition, MPE cream application was also shown to decrease the number of inflammatory cells, particularly in 5% and 10% concentrations, both in the 3-day and 8-day groups. MPE cream application can accelerate wound healing and thus can be used in acute wound treatment.

scholarly journals The Efficacy of Gelam Honey Dressing towards Excisional Wound Healing

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Mui Koon Tan ◽  
Durriyyah Sharifah Hasan Adli ◽  
Mohd Amzari Tumiran ◽  
Mahmood Ameen Abdulla ◽  
Kamaruddin Mohd Yusoff
Keyword(s):  
Wound Healing ◽  
Saline Group ◽  
Wound Management ◽  
Full Thickness ◽  
Sprague Dawley ◽  
Histological Features ◽  
Positive Effects ◽  
Gelam Honey ◽  
Neck Area ◽  
Excisional Wound

Honey is one of the oldest substances used in wound management. Efficacy of Gelam honey in wound healing was evaluated in this paper.Sprague-Dawleyrats were randomly divided into four groups of 24 rats each (untreated group, saline group, Intrasite Gel group, and Gelam honey group) with 2 cm by 2 cm full thickness, excisional wound created on neck area. Wounds were dressed topically according to groups. Rats were sacrificed on days 1, 5, 10, and 15 of treatments. Wounds were then processed for macroscopic and histological observations. Gelam-honey-dressed wounds healed earlier (day 13) than untreated and saline treated groups, as did wounds treated with Intrasite Gel. Honey-treated wounds exhibited less scab and only thin scar formations. Histological features demonstrated positive effects of Gelam honey on the wounds. This paper showed that Gelam honey dressing on excisional wound accelerated the process of wound healing.

scholarly journals Healing Effects of Human Amniotic Membrane and Burned Wool on the Second-degree Burn in Rats

2020 ◽  
Vol 9 ◽  
pp. 1759
Author(s):  
Nader Tanideh ◽  
Farideh Keshavarzi ◽  
Aida Hemat Zadeh ◽  
Sajad Daneshi ◽  
Omid Koohi-Hosseinabadi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Granulation Tissue ◽  
Male Rats ◽  
Control Group ◽  
Human Amniotic Membrane ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Degree Burn ◽  
Second Degree

ackground: This study aimed to compare sheep burnt wool and human amniotic membrane (AM) on second-degree burn wound healing in rats. Materials and Methods: Seventy-two adult male rats of Sprague Dawley underwent general anesthesia, and a deep second-degree burn was created on their skin by a hot iron plate. Afterward, human AM, silver sulfadiazine ointment (SSD), and sheep burned wool were used on wound area for burn treatment. On days 7, 14, and 21 of the experiment, the rats were sacrificed, and histopathological assessments were done. Results: Human AM, in comparison with other groups, significantly (P<0.05) showed better improvement in all pathologic variables. Burned wool showed significant improvement compared to the control group on day 7 in the angiogenesis, on day 14 in granulation tissue formation and epithelial formation, and on day 21 in new epithelial formation (P<0.05). Burned wool compared with SSD ointment in granulation tissue formation improved significantly (P<0.05) on days 7 and 14. Also, SSD ointment in comparison with the control group significantly improved (P<0.05) granulation tissue formation and macrophage on day 7. Conclusion: Human AM has a significant effect on the treatment of second-degree burn. Burned wool has a better effect on wound healing than SSD ointment and negative control group without treatment in terms of granulation tissue and epithelium formation. [GMJ.2020;9:e1759]

scholarly journals Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model

2014 ◽  
Vol 66 (6) ◽  
pp. 1757-1761 ◽  
Author(s):  
M.T. Tillmann ◽  
A.O.C. Felix ◽  
E.N. Mueller ◽  
S.R. Felix ◽  
G.H. Alves ◽  
...  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Rabbit Model ◽  
Control Group ◽  
Epithelial Tissue ◽  
Strength Evaluation ◽  
Group I ◽  
Scar Quality ◽  
Group Ii ◽  
Tension Strength

While Triticum sp. has been shown to act in wound healing, stimulating collagen synthesis by fibroblasts, the use of this plant extract has yet to be assessed in vivo, in commercially viable presentations. This study used rabbits and assessed, on days seven, 14, and 21, the presence or absence of granulation tissue and epithelialization, histopathological structures, and scar quality through the breaking and tension strength. Treatments, performed for 21 days, were aqueous extract of T. aestivum at a concentration of 2mg/mL (group I) and 10mg/mL (group II) and a nonionic cream (control group). We demonstrate that the formation of granulation tissue was not significantly different between treatments. In the analysis of epithelial tissue, wounds in group II differed from other treatments by day 7. On days 14 and 21 there was no significant clinical difference between groups. In the histopathological evaluation, scar quality and rupture strength did not differ between the groups in the studied period. In the tension strength evaluation, group I differed from the others, presenting a higher tension strength overall. The studied treatments did not differ regarding healing evolution of the skin wounds, but T. aestivum extract, at 2mg/mL, presents better results in the tension strength evaluation.

scholarly journals Application Experience of Moist Wound Healing Theory Combined with Modern New Dressings in the Treatment of Pressure Ulcers

2021 ◽  
Vol 5 (4) ◽  
pp. 119-123
Author(s):  
Na Zhao ◽  
Mingjuan Zhao ◽  
Yulan Zhao
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Pressure Ulcers ◽  
Tissue Growth ◽  
Growth Time ◽  
Control Group ◽  
Reduction Time ◽  
Group 15 ◽  
Diameter Reduction ◽  
Experimental Group

Objective?Research on the effect of moist wound healing theory in a combination with modern new dressingtreatment in patients diagnosed with pressure ulcers. Method: Selected 30 patients with pressure ulcers from our hospital, which is Shandong Tai’an Municipal Hospital, from January 2019 to January 2021 were divided into experimental group (15 cases, treated with moist wound healing theory combined with modern new dressings) and control group (15 cases, applied conventional treatments). The treatment effect, time of wound edema subsidence, wound healing time, number of dressing changes, granulation tissue growth time, and diameter reduction time were compared between the two groups. Results: The total effective rate of the experimental group (93.33%, 14/15) was higher than that of the control group (53.33%, 8/15), P<0.05; the time to subsidence of wound edema in the experimental group was (3.11±0.22), and the time for wound healing was (12.78±0.45), the number of dressing changes (7.13±0.34) times, the growth time of granulation tissue (5.43±2.22), the diameter reduction time (6.25±3.75), compared with the control group, P<0.05. Conclusion?In the clinical treatment of patients diagnosed with pressure ulcers, the effective combination of moist healing theory and modern new dressing therapy has significant effects, whereby it speeds up the healing process of the pressure ulcers, and it is proven to be worthy to be promoted for usage.

Biogenic synthesis of nano-sulfur using Punica granatum fruit peel extract with enhanced antimicrobial activities for accelerating wound healing

Nano Futures ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 045003
Author(s):  
K Samrat ◽  
M N Chandraprabha ◽  
R Hari Krishna ◽  
R Sharath ◽  
B G Harish
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Breaking Strength ◽  
Punica Granatum ◽  
Control Group ◽  
Fruit Peel ◽  
Burn Wound ◽  
Excision Wound ◽  
Tissue Weight ◽  
Peel Extract

Abstract Microbial wound infections leading to secondary complications in wound healing has resulted in high demand for therapeutic drugs with improved efficacy. Despite achieving enhanced bio-activity and higher bioavailability compared to its bulk form, nano-sulfur (SNP) has been explored to a very limited extent for wound healing applications. In this work, we prepare biogenic SNP (SNP-B) via simple biogenic technique using pomegranate (Punica granatum) peel extract and demonstrate its antimicrobial and wound healing activity. The SNP-B was characterized using powder x-ray diffractometer, FESEM, transmission electron microscopy and Raman spectroscopy. Different wound models (excision, incision, dead space and burn) were used to assess the wound healing potential of SNP-B. The 2% (w/w) SNP-B treated group exhibited enhanced wound contraction rate (excision wound, 99.62 ± 0.59%; burn wound, 99.46 ± 0.59%), breaking strength (393.2 ± 10.87 g cm−2), and granulation tissue weight (166.8 ± 9.45 mg) compared to the control group (excision wound, 84.24 ± 2.78%; burn wound, 90.58 ± 3.2%; breaking strength, 241.3 ± 16.11 g cm−2; granulation tissue weight, 91.17 ± 7.28 mg). The efficacy of 2% (w/w) SNP-B was comparable to that of standard (5% w/w povidone-iodine ointment) in all the wound models analyzed. The SNP-B showed enhanced antibacterial activity with a MIC value of 90, 80, 80, and 60 μg ml−1 for Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis and Staphylococcus aureus, respectively. The results obtained prove the potential of SNP-B as a multifunctional therapeutic agent for topical applications.

scholarly journals Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension

Medicina ◽  
2020 ◽  
Vol 56 (7) ◽  
pp. 321 ◽  
Author(s):  
Shiro Jimi ◽  
Satoshi Takagi ◽  
Francesco De Francesco ◽  
Motoyasu Miyazaki ◽  
Arman Saparov
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Smooth Muscle Actin ◽  
Skin Grafting ◽  
Skin Wound ◽  
Control Group ◽  
Distribution Analysis ◽  
Skin Wound Healing ◽  
Tissue Samples ◽  
Tissue Reactions

Background and objectives: Skin grafting is a method usually used in reconstructive surgery to accelerate skin regeneration. This method results frequently in unexpected scar formations. We previously showed that cutaneous wound-healing in normal mice is accelerated by a micrograft (MG) technique. Presently, clinical trials have been performed utilizing this technology; however, the driving mechanisms behind the beneficial effects of this approach remain unclear. In the present study, we focused on five major tissue reactions in wound-healing, namely, regeneration, migration, granulation, neovascularization and contraction. Methods: Morphometrical analysis was performed using tissue samples from the dorsal wounds of mice. Granulation tissue formation, neovascularization and epithelial healing were examined. Results: The wound area correlated well with granulation sizes and neovascularization densities in the granulation tissue. Vascular distribution analysis in the granulation tissue indicated that neovessels extended and reached the subepidermal area in the MG group but was only halfway developed in the control group. Moreover, epithelialization with regeneration and migration was augmented by MG. Myofibroblast is a known machinery for wound contraction that uses α-smooth muscle actin filaments. Their distribution in the granulation tissue was primarily found beneath the regenerated epithelium and was significantly progressed in the MG group. Conclusions: These findings indicated that MG accelerated a series of wound-healing reactions and could be useful for treating intractable wounds in clinical situations.

scholarly journals Topical application of silver-curcumin on wound healing in rabbits

2016 ◽  
Vol 32 (2) ◽  
pp. 55-64
Author(s):  
R Islam ◽  
UK Rima ◽  
MM Haq ◽  
MM Hossain ◽  
MM Rahman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Connective Tissue ◽  
Topical Application ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Wound Management ◽  
Control Group ◽  
Wound Healing Process ◽  
Fibrous Connective Tissue ◽  
Positive Effects

Curcumin, a natural product obtained from the rhizomes of Curcuma longa, is used traditionally in prevention of wound infection. To determine the effects of silver and curcumin combination on surgical wound healing, a study was conducted in rabbits. A total of 32 surgical wounds were created in 16 rabbits in four groups. Information was recorded from Day 0 to Day 42 postoperatively. Swelling area of wound, elevation of suture line from the skin surface, width of sutured area and contraction length were recorded weekly. Treatment with curcumin, 1% silver sulfadiazine (1% SSD) and a mixture of the two resulted in swelling of 11.4 ± 0.1 mm, 11.1 ± 0.4 mm and 11.0 ± 0.1 mm, respectively. Swelling (12.2 ± 0.3mm) and elevation of sutured line was higher (3.4 ± 0.2 mm) in wounds of control group and lower (2.3 ± 0.1 mm) in wounds treated with a mixture of curcumin and 1% SSD. The scores of wound colonization were lowest (0.8) in 1% SSD group followed by mixture of curcumin and 1% SSD (1.0), curcumin (1.3) and tincture of benzoin (1.6) alone. Histopathologically reactive cells decreased markedly in wounds treated with combination of 1% SSD and curcumin at D3 with increased fibrous connective tissue. However, wounds treated with 1% SSD showed fewer reactive cells than curcumin group. Proliferation of fibrous connective tissue was highest in the silver treated wound, which indicates good wound healing process. Overall, wound healing was improved by the topical application of 1% SSD alone. Curcumin had positive effects on wound healing process but less than 1% SSD. These results indicate that 1% silver sulfadiazine is the best topical therapy for wound management in rabbits.Bangl. vet. 2015. Vol. 32, No. 2, 55-64

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