scholarly journals Metabolomics analysis of blood identifies potential biomarkers and possible treatment targets for nocturia

2019 ◽  
Vol 11 ◽  
pp. 175628721985008 ◽  
Author(s):  
Satoru Kira ◽  
Takahiko Mitsui ◽  
Tatsuya Miyamoto ◽  
Tatsuya Ihara ◽  
Hiroshi Nakagomi ◽  
...  
Keyword(s):  
Serum Levels ◽  
Plasma Metabolites ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Night Time ◽  
Flight Mass Spectrometry ◽  
Urine Production ◽  
Metabolite Profiles ◽  
Micturition Frequency

Background: Our aim was to investigate the association between serum metabolites and nocturia. Methods: A total of 66 males aged 65–80 years were enrolled in this study and stratified according to micturition behavior, which was characterized in terms of the 24 h frequency volume chart (FVC) for 3 consecutive days, the International Prostate Symptom Score (IPSS), and quality-of-life score. The nocturia group included participants with any total IPSS and ⩾1.5 micturitions/night as the mean of 3 nights, while the control group included participants with total IPSS < 8 and <1.5 micturitions/night. We conducted a comprehensive capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) study of plasma metabolites. Between-group comparisons of metabolite levels employed the Welch t test. The relationship between nocturia and metabolite profiles was determined using multivariable logistic regression analysis. Results: Of 66 participants, 45 were included in the nocturia group and 21 in the control group. There were no differences in background factors between the two groups. FVC analysis revealed that urine production during night-time, as well as micturition frequency during daytime and night-time were significantly higher in the nocturia group. CE-TOFMS identified eight metabolites whose plasma levels differed between the two groups. Multivariate analysis indicated that increased levels of lauric acid and imidazolelactic acid, as well as decreased levels of thiaproline and glycerol, contribute to the etiology of nocturia in aged men. Conclusions: Our findings suggest that abnormal serum levels of metabolites in several pathways play a role in the pathogenesis of nocturia in aged men.

scholarly journals Effect of Root Canal Therapy Combined with Full Crown Restoration on the Level of Inflammatory Factors and Chewing Function in Patients with Cracked Teeth and Chronic Pulpitis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Ying Lu ◽  
Ning Wu ◽  
Bin Ma ◽  
Feng Qin
Keyword(s):  
Quality Of Life ◽  
Research Group ◽  
Root Canal ◽  
Serum Levels ◽  
Effective Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Root Canal Therapy ◽  
Total Incidence

Objective. To explore the clinical effect of root canal therapy combined with full crown restoration in patients with cracked teeth and chronic pulpitis. Methods. From May 2018 to June 2020, 87 patients with cracked teeth and chronic pulpitis in our hospital were selected; the patients were randomly divided into the control group and the research group by random number method. The control group only used root canal therapy; the research group used root canal therapy combined with full crown restoration. The therapeutic effect, levels of inflammatory factors, chewing function, periodontal index, complications, and quality of life were compared between the two groups. Results. The total effective rate of the research group (97.78%) was better than the total effective rate of the control group (85.71%) ( P < 0.05 ). Compared with before treatment, the serum levels of interleukin-1β (IL-1β), IL-6, and C-reactive protein (CRP) of the two groups of patients decreased after treatment. After treatment, compared with the control group, the serum levels of IL-1β, IL-6, and CRP in the research group decreased ( P < 0.05 ). Compared with before treatment, the bite force of teeth and chewing efficiency of the two groups of patients increased after treatment. After treatment, compared with the control group, the bite force of teeth and chewing efficiency of the research group increased ( P < 0.05 ). Compared with before treatment, the plaque index (PLI), probing depth (PD), gingival sulcus bleeding index (BI), and gingival index (GI) of the two groups of patients decreased after treatment. After treatment, compared with the control group, the PLI, PD, BI, and GI of the research group decreased ( P < 0.05 ). The total incidence of complications in the research group was (11.11%), and the total incidence of complications in the control group was (16.67%); there was no significant difference between the two groups ( P > 0.05 ). After treatment, compared with the control group, the quality of life scores of the patients in the research group were reduced ( P < 0.05 ). Conclusion. Root canal therapy and full crown restoration have a definite curative effect in patients with cracked teeth and chronic pulpitis, which can improve the inflammatory response, restore chewing function, maintain periodontal health, improve the quality of life, and do not increase the incidence of complications, so it has good application value.

scholarly journals A Review of the Effects of Psychological Interventions on the Quality of Life for Children with Atopic Dermatitis

2010 ◽  
Vol 1 (1) ◽  
pp. 23
Author(s):  
Maria A Czerniakow
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Disease Severity ◽  
Intervention Group ◽  
Control Group ◽  
Education Intervention ◽  
Night Time ◽  
Pubmed Database ◽  
Video Education

Atopic Dermatitis (AD) is a psychologically debilitating disease due to its embarrassing skin lesions and pruritic nature which disturb the quality of life (QOL) of the patients. Even though children are primarily affected, caregivers can also be affected due to being the first line of care for others who are inflicted. This review focuses on randomized control trials which investigated the use of non-chemical forms of treatment to improve QOL and disease severity in children. A search of the PubMed database identified six studies that met the inclusion criteria. The studies were ranked from most rigorous trial to least. Various forms of education as an intervention were used. Conversely, the viewing of a humorous film was tested to examine if it had an impact on QOL. Education intervention versus no education at all showed that the intervention group had a larger decrease in disease severity than the control group. The form of education as a single consult with an AD educated nurse showed no difference between the control and the intervention group. Comparison of nurse-led clinics with the dermatologist-led clinics indicated that the nurse-led clinics were more successful. Viewing humorous films before bedtime was demonstrated as a successful means of reducing night-time awakenings. Also specific AD education versus routine education and consultations showed improvement in both groups. Finally, AD video education versus direct parental teaching concluded that the video-education was more effective. Although the studies show that any form of education intervention is better than none, the methodological assessment of the studies showed that four of the studies were not rigorous enough or were not described at all. Further studies must be conducted in a more methodologically sound manner for the results to be considered replicable and valid. 

Potential Targets for Overactive Bladder in Older Men Based on Urinary Analysis of Metabolomics

2021 ◽  
pp. 1-7
Author(s):  
Satoru Kira ◽  
Tatsuya Miyamoto ◽  
Sachiko Tsuchiya ◽  
Hiroshi Nakagomi ◽  
Tatsuya Ihara ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Urine Volume ◽  
Prostaglandin F2α ◽  
Urinary Metabolites ◽  
Older Men ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Metabolomic Analysis ◽  
Micturition Frequency ◽  
Urgency Score

<b><i>Objective:</i></b> We investigated the association between overactive bladder (OAB) and urinary metabolites in men. <b><i>Methods:</i></b> This prospective observational study included 42 men aged 65–80 years. The 3-day frequency volume chart (FVC), International Prostate Symptom Score (IPSS), and quality of life score were adapted to assess the micturition behavior. Participants with IPSS urgency score ≥2 were included in the OAB group, and those with IPSS urgency score &#x3c;2 were included in the control group. We performed a comprehensive metabolomic analysis using urine samples. Metabolites were compared between the groups using an unpaired <i>t</i> test and Fisher’s exact test in a nonadjusted analysis. Multivariable logistic regression analysis was performed to investigate the association between OAB and the metabolites. <b><i>Results:</i></b> Overall, 23 men were included in the OAB group and 19 in the control group. There were no differences in the background factors except age between the groups. FVC analysis demonstrated that nocturnal urine volume, 24-h micturition frequency, and nocturnal micturition frequency were significantly higher, and the maximum voided volume was significantly lower in the OAB group than in the controls. Metabolomic analysis revealed 14 metabolites that were differentially expressed between the groups. Multivariate analysis indicated that an increase in the levels of 5-iso prostaglandin F2α-VI (5-iPF2a-VI) and 5-methoxyindoleacetic acid was associated with OAB. <b><i>Conclusion:</i></b> Abnormal urinary metabolites, including metabolites in the tryptophan (5-methoxyindoleacetic acid, 3-indoleacetonitrile, and 3-hydroxyanthranilic acid) and arachidonic acid (5-iPF2a-VI) pathways, play a role in the pathogenesis of OAB in older men.

Effect of Poria polysaccharide oral liquid on cancer-related fatigue in postoperative patients with colorectal cancer

2021 ◽  
Vol 7 (6) ◽  
pp. 6519-6528
Author(s):  
Wei Tan ◽  
Weidong Zhou ◽  
Youya Zhao ◽  
Tingting Fu ◽  
Xuhui Huang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Tumor Resection ◽  
Serum Levels ◽  
Control Group ◽  
Observation Group ◽  
Cancer Related Fatigue ◽  
Tnf Α ◽  
Oral Liquid

Objective: We aimed to explore the effect of Poria polysaccharide oral liquid (PPOL) on cancer-related fatigue (CRF) in postoperative patients with colorectal cancer. Methods: Fifty patients with colorectal cancer who were diagnosed in our hospital from March 2015 to March 2019 were included in this retrospective study. They were all underwent tumor resection. They were randomly divided into control group (n = 25) and observation group (n = 25). Patients in the control group were treated according to the F0LF0X4 chemotherapy regimen, and those in the observation group were treated with F0LF0X4 chemotherapy plus PPOL (10 ml/time, 3 times/day) for 6 weeks. The quality of life index (QL-index) and brief fatigue scale (BFI) were used to investigate the quality of life and fatigue, respectively. The serum levels of inflammatory factors, IL-6 and TNF-a, were measured. Results: Compared with the control group, the QL-index score in the observation group was significantly better (P< 0.05). Moreover, the BFI in the observation group was significantly lower than that in the control group (P < 0.05). Furthermore, the serum levels of IL-6 and TNF-α in the observation group were notably decreased in comparison with the control group (P < 0.05). Conclusion: PPOL can effectively improve the fatigue state of postoperative patients with colorectal cancer by reducing the levels of IL-6 and TNF- α and improving the quality of life.

scholarly journals Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats

2007 ◽  
Vol 21 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Carlos Augusto Nassar ◽  
Patricia Oehlmeyer Nassar ◽  
Denise Carleto Andia ◽  
Morgana Rodrigues Guimarães ◽  
Maria Teresa Pepato ◽  
...  
Keyword(s):  
Serum Levels ◽  
Cardiovascular Complications ◽  
Term Therapy ◽  
Control Group ◽  
Post Transplantation ◽  
Tacrolimus Therapy ◽  
Biochemical Evaluation ◽  
Long Term Therapy

One of the more serious complications following transplantation is the development of post-transplantation diabetes mellitus (PTDM), which has a major impact on the quality of life, with effects ranging from the control of glycemia times to increased susceptibility to infections and cardiovascular complications. It has been suggested that immunosuppressive therapy, mainly tacrolimus therapy, may be an important factor in the development of PTDM. There is a lack of studies that explore the effects of long-term tacrolimus on PTDM in animal protocols. The objective of this study was therefore to evaluate the effects of long-term therapy with tacrolimus in rats. One group was treated with tacrolimus, injected subcutaneously, in a daily dose of 1 mg/kg of body weight. The chosen dose was sufficient to achieve therapeutic tacrolimus serum levels. The experimental periods were 60, 120, 180 and 240 days. One group was used as control and received daily subcutaneous injections of saline solution during all periods. A tendency towards increased glycemia levels during the initial periods (60 and 120 days) was observed. However, at 180 and 240 days, the glycemia levels were not statistically different from that of the control group of the same period. It may thus be concluded that the deleterious effects of tacrolimus therapy on glycemia may be a time-related side effect.

scholarly journals The Impact of Movement, Physical Activity and Position on Urine Production: A Pilot Study

2021 ◽  
Author(s):  
Mutlu Deger ◽  
Vansh Kapila ◽  
Marie Astrid Denys ◽  
Ibrahim Aridogan ◽  
Karel Everaert ◽  
...  
Keyword(s):  
Physical Activity ◽  
New Technology ◽  
Body Movement ◽  
University Hospital ◽  
Night Time ◽  
Internal Factors ◽  
Production Methods ◽  
Urine Production ◽  
The Impact

Background: Many different internal factors have been proven to influence urine production such as age, weight, and quality of sleep. External factors such as consumption of caffeine and fluid consumption have been shown to have an impact on urine production. Aim: To investigate the impact of movement, physical activity, and position on urine production. Methods: This prospective observational study was executed at Ghent University Hospital, Belgium. Study participation was open for anyone visiting the hospital. Participants collected 1 basic and 2 extended 24-hour urine collections and filled in questionnaires concerning their general health and physical activity. Urinary levels of osmolality, sodium, and creatinine were determined. Data on movement, physical activity and position was described. Results: An increase in body movement leads to a significant increase in diuresis during daytime, night-time, and 24 hours (p=0,002, p= <0,001, and p=<0,001, respectively). An increase in body movement leads to a significant decrease in osmolality during night-time and 24 hours (p=0,009, and p=0,004, respectively). However, no significant influence of movement on osmolality was found during daytime (p=0,12). An increase in body movement leads to a significant decrease in creatinine during daytime, night-time, and 24 hours (p=0,001, <0,001, and p=<0,001, respectively). An increase in body movement leads to a significant increase in sodium during daytime (p=0,046) but this was statistically significant during night-time and 24 hours (p=0,32, and p=0,84 respectively). Conclusion: Our study demonstrates a statistically significant association of movement, physical activity, and position with urine production. It would therefore be interesting to explore this association further with the use of new technology to have more accurate data. Here lays a potential role for conservative measurements and lifestyle adaptations in the management of patients with bothersome LUTS and more precisely nocturia.

scholarly journals GC/MS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated by Opuntia humifusa

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Seung-Ho Seo ◽  
Eun-Ju Kim ◽  
Seong-Eun Park ◽  
Sung-Hoon Byun ◽  
Soon-Young Lee ◽  
...  
Keyword(s):  
Murine Model ◽  
Arachidic Acid ◽  
Principal Component ◽  
Serum Levels ◽  
Control Group ◽  
Dexamethasone Treatment ◽  
Multivariate Statistical ◽  
Score Plot ◽  
Opuntia Humifusa ◽  
Metabolite Profiles

GC/MS coupled with multivariate statistical analysis was performed to identify marker metabolites in serum of mice after healing ovalbumin- (OVA-) induced asthma using Opuntia humifusa. Principal component analysis (PCA) score plot showed separation among groups, with metabolite profiles of serum showing differences according to various treatments for the asthma murine model. Levels of stearic acid and arachidic acid were significantly lower in the serum from OVA-induced group than those from the control group. Dexamethasone treatment group was characterized by higher serum levels of urea, myristic acid, and palmitic acid along with lower levels of aspartic acid compared to OVA-induced group. O. humifusa treatment mice groups showed dose-proportional higher levels of urea and glycerol than OVA-induced group. These results highlight that GC/MS-based metabolomics is a powerful technique for identifying molecular markers of asthma.

scholarly journals The role of serum and local IgE concentration in quality of life in allergic rhinosinusits patients

2019 ◽  
Vol 17 (3) ◽  
pp. 212-214
Author(s):  
A. Vlaykov ◽  
D. Mihaylov ◽  
V. Stoyanov ◽  
M. Platikanova
Keyword(s):  
Quality Of Life ◽  
Serum Levels ◽  
Nasal Lavage ◽  
Control Group ◽  
Subjective Feeling ◽  
Life Questionnaire ◽  
Potential Health ◽  
Ige Antibodies ◽  
Snot 22

Purpose: The task we set was to determine the concentrations of IgE molecules in serum and nasal lavage in patients with intermittent and persistentallergic rhinitis (AR) and to compare them with a control group of healthy volunteers, comparing the results with a quality of life questionnaire about their subjective feeling of potential health damage. Material and methods:: A comparison was performed between serum and nasal lavage IgE concentration in 50 participants - 40 cases and 10 controls. Results: Serum level of IgE-total in the patients with intermittent (AR) was 284,19 IU/ml while in persistent (AR) patients - 215,29 IU/ml, but not significantly higher than in the controls -160,87 IU/ml. IgE antibodies in nasal lavage in IAR patients was 1,39 IU/ml, while in PAR was 1,65 IU/ml and 1,05 IU/ml in controls.Total score of SNOT-22 in IAR (2,16) and PAR (2,03) was significantly higher than in the controls (0,85). Conclusions:In our study, although the different serum levels of IgE among groups, we did not find significant correlation between the concentration of IgE antibodies in blood serum or nasal lavage and the degree of impairment of the quality of life in patients with IAR and PAR assessed by SNOT-22 quality of life test.

Epistemic and relational conflicts in sharing identical vs. complementary information during cooperative learning

2002 ◽  
Vol 61 (3) ◽  
pp. 139-151 ◽  
Author(s):  
Céline Darnon ◽  
Céline Buchs ◽  
Fabrizio Butera
Keyword(s):  
Cooperative Learning ◽  
Social Comparison ◽  
Positive Relationship ◽  
Learning Task ◽  
Control Group ◽  
Complementary Information ◽  
Relational Conflict ◽  
The Social ◽  
The University

When interacting on a learning task, which is typical of several academic situations, individuals may experience two different motives: Understanding the problem, or showing their competences. When a conflict (confrontation of divergent propositions) emerges from this interaction, it can be solved either in an epistemic way (focused on the task) or in a relational way (focused on the social comparison of competences). The latter is believed to be detrimental for learning. Moreover, research on cooperative learning shows that when they share identical information, partners are led to compare to each other, and are less encouraged to cooperate than when they share complementary information. An epistemic vs. relational conflict vs. no conflict was provoked in dyads composed by a participant and a confederate, working either on identical or on complementary information (N = 122). Results showed that, if relational and epistemic conflicts both entailed more perceived interactions and divergence than the control group, only relational conflict entailed more perceived comparison activities and a less positive relationship than the control group. Epistemic conflict resulted in a more positive perceived relationship than the control group. As far as performance is concerned, relational conflict led to a worse learning than epistemic conflict, and - after a delay - than the control group. An interaction between the two variables on delayed performance showed that epistemic and relational conflicts were different only when working with complementary information. This study shows the importance of the quality of relationship when sharing information during cooperative learning, a crucial factor to be taken into account when planning educational settings at the university.

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