scholarly journals Sentinel surveillance for influenza A viruses in Lahore District Pakistan in flu season 2015–2016

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Saima Hasan ◽  
Richard J. Webby ◽  
Muhammad Iqbal ◽  
Hamad Bin Rashid ◽  
Mansur-ud-Din Ahmad ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza A ◽  
Descriptive Analysis ◽  
Epidemiological Data ◽  
Respiratory Illness ◽  
Risk Groups ◽  
Global Public Health ◽  
Influenza A Viruses ◽  
Temporal And Spatial Distribution ◽  
Middle Income

Abstract Background Influenza A virus (IAV) remains an important global public health threat with limited epidemiological information available from low-and-middle-income countries. The major objective of this study was to describe the proportions, temporal and spatial distribution, and demographic and clinical characteristics of IAV positive patients with influenza like illness (ILI) and severe acute respiratory illness (SARI) in Lahore, Pakistan. Methods Prospective surveillance was established in a sentinel hospital from October 2015 to May 2016. All eligible outpatients and inpatients with ILI or SARI were enrolled in the study. Nasal and/or throat swabs were collected along with clinico-epidemiological data. Samples were tested by real-time RT-PCR (rRT-PCR) to identify IAV and subtype. The descriptive analysis of data was done in R software. Results Out of 311 enrolled patients, 284 (91.3%) were ILI and 27 (8.7%) were SARI cases. A distinct peak of ILI and SARI activity was observed in February. Fifty individuals (16%) were positive for IAV with peak positivity observed in December. Of 50 IAV, 15 were seasonal H3N2, 14 were H1N1pdm09 and 21 were unable to be typed. The majority of IAV positive cases (98%) presented with current or history of fever, 88% reported cough and 82% reported sore throat. The most common comorbidities in IAV positive cases were hepatitis C (4%), obesity (4%) and tuberculosis (6%). The highest incidence of patients reporting to the hospital was seen three days post symptoms onset (66/311) with 14 of these (14/66) positive for IAV. Conclusion Distinct trends of ILI, SARI and IAV positive cases were observed which can be used to inform public health interventions (vaccinations, hand and respiratory hygiene) at appropriate times among high-risk groups. We suggest sampling from both ILI and SARI patients in routine surveillance as recommended by WHO.

scholarly journals Attenuated Bordetella pertussis Protects against Highly Pathogenic Influenza A Viruses by Dampening the Cytokine Storm

2010 ◽  
Vol 84 (14) ◽  
pp. 7105-7113 ◽  
Author(s):  
Rui Li ◽  
Annabelle Lim ◽  
Meng Chee Phoon ◽  
Teluguakula Narasaraju ◽  
Jowin K. W. Ng ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Virus ◽  
Bordetella Pertussis ◽  
Influenza A ◽  
Public Health Problem ◽  
Nasal Administration ◽  
Protective Mechanism ◽  
Global Public Health ◽  
Influenza A Viruses ◽  
Proinflammatory Mediators

ABSTRACT The threat of a pandemic spread of highly virulent influenza A viruses currently represents a top global public health problem. Mass vaccination remains the most effective way to combat influenza virus. However, current vaccination strategies face the challenge to meet the demands in a pandemic situation. In a mouse model of severe influenza virus-induced pneumonitis, we observed that prior nasal administration of an attenuated strain of Bordetella pertussis (BPZE1) provided effective and sustained protection against lethal challenge with two different influenza A virus subtypes. In contrast to most cross-protective effects reported so far, the protective window offered upon nasal treatment with BPZE1 lasted up to at least 12 weeks, suggesting a unique mechanism(s) involved in the protection. No significant differences in viral loads were observed between BPZE1-treated and control mice, indicating that the cross-protective mechanism(s) does not directly target the viral particles and/or infected cells. This was further confirmed by the absence of cross-reactive antibodies and T cells in serum transfer and in vitro restimulation experiments, respectively. Instead, compared to infected control mice, BPZE1-treated animals displayed markedly reduced lung inflammation and tissue damage, decreased neutrophil infiltration, and strong suppression of the production of major proinflammatory mediators in their bronchoalveolar fluids (BALFs). Our findings thus indicate that protection against influenza virus-induced severe pneumonitis can be achieved through attenuation of exaggerated cytokine-mediated inflammation. Furthermore, nasal treatment with live attenuated B. pertussis offers a potential alternative to conventional approaches in the fight against one of the most frightening current global public health threats.

scholarly journals The Effects of Social Distancing Policies on non-SARS-CoV-2 Respiratory Pathogens

2021 ◽  
Author(s):  
Jeff Nawrocki ◽  
Katherine Olin ◽  
Martin C Holdrege ◽  
Joel Hartsell ◽  
Lindsay Meyers ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza A ◽  
Detection Rate ◽  
Respiratory Illness ◽  
Respiratory Pathogens ◽  
Public Health Response ◽  
Mixed Effect ◽  
Detection Rates ◽  
Social Distancing ◽  
The Impact

Abstract Background The initial focus of the US public health response to COVID-19 was the implementation of numerous social distancing policies. While COVID-19 was the impetus for imposing these policies, it is not the only respiratory disease affected by their implementation. This study aimed to assess the impact of social distancing policies on non-SARS-CoV-2 respiratory pathogens typically circulating across multiple US states. Methods Linear mixed-effect models were implemented to explore the effects of five social distancing policies on non-SARS-CoV-2 respiratory pathogens across nine states from January 1 through May 1, 2020. The observed 2020 pathogen detection rates were compared week-by-week to historical rates to determine when the detection rates were different. Results Model results indicate that several social distancing policies were associated with a reduction in total detection rate, by nearly 15%. Policies were associated with decreases in pathogen circulation of human rhinovirus/enterovirus and human metapneumovirus, as well as influenza A, which typically decrease after winter. Parainfluenza viruses failed to circulate at historical levels during the spring. Total detection rate in April 2020 was 35% less than historical average. Many of the pathogens driving this difference fell below historical detection rate ranges within two weeks of initial policy implementation. Conclusion This analysis investigated the effect of multiple social distancing policies implemented to reduce transmission of SARS-CoV-2 on non-SARS-CoV-2 respiratory pathogens. These findings suggest that social distancing policies may be used as an impactful public health tool to reduce communicable respiratory illness.

scholarly journals Decompressive craniotomy: an international survey of practice

2021 ◽  
Author(s):  
Midhun Mohan ◽  
◽  
Hugo Layard Horsfall ◽  
Davi Jorge Fontoura Solla ◽  
Faith C. Robertson ◽  
...  
Keyword(s):  
Public Health ◽  
Randomized Trial ◽  
Bone Flap ◽  
Acute Subdural Hematoma ◽  
International Survey ◽  
Global Public Health ◽  
Health Issues ◽  
Middle Income ◽  
Middle Income Countries ◽  
Decompressive Craniotomy

Abstract Background Traumatic brain injury (TBI) and stroke have devastating consequences and are major global public health issues. For patients that require a cerebral decompression after suffering a TBI or stroke, a decompressive craniectomy (DC) is the most commonly performed operation. However, retrospective non-randomized studies suggest that a decompressive craniotomy (DCO; also known as hinge or floating craniotomy), where a bone flap is replaced but not rigidly fixed, has comparable outcomes to DC. The primary aim of this project was to understand the current extent of usage of DC and DCO for TBI and stroke worldwide. Method A questionnaire was designed and disseminated globally via emailing lists and social media to practicing neurosurgeons between June and November 2019. Results We received 208 responses from 60 countries [40 low- and middle-income countries (LMICs)]. DC is used more frequently than DCO, however, about one-quarter of respondents are using a DCO in more than 25% of their patients. The three top indications for a DCO were an acute subdural hematoma (ASDH) and a GCS of 9-12, ASDH with contusions and a GCS of 3-8, and ASDH with contusions and a GCS of 9-12. There were 8 DCO techniques used with the majority (60/125) loosely tying sutures to the bone flap. The majority (82%) stated that they were interested in collaborating on a randomized trial of DCO vs. DC. Conclusion Our results show that DCO is a procedure carried out for TBI and stroke, especially in LMICs, and most commonly for an ASDH. The majority of the respondents were interested in collaborating on a is a future randomized trial.

scholarly journals Emphasizing the Role of Neurosurgery Within Global Health and National Health Systems: A Call to Action

2021 ◽  
Vol 8 ◽  
Author(s):  
Jean Wilguens Lartigue ◽  
Olaoluwa Ezekiel Dada ◽  
Makinah Haq ◽  
Sarah Rapaport ◽  
Lorraine Arabang Sebopelo ◽  
...  
Keyword(s):  
Public Health ◽  
Global Health ◽  
Health Systems ◽  
Global Burden ◽  
Global Public Health ◽  
Middle Income ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Development Goals ◽  
Global Burden Of Diseases

Background: Worldwide, neurological disorders are the leading cause of disability-adjusted life years lost and the second leading cause of death. Despite global health capacity-building efforts, each year, 22.6 million individuals worldwide require neurosurgeon's care due to diseases such as traumatic brain injury and hydrocephalus, and 13.8 million of these individuals require surgery. It is clear that neurosurgical care is indispensable in both national and international public health discussions. This study highlights the role neurosurgeons can play in supporting the global health agenda, national surgical plans, and health strengthening systems (HSS) interventions.Methods: Guided by a literature review, the authors discuss key topics such as the global burden of neurosurgical diseases, the current state of neurosurgical care around the world and the inherent benefits of strong neurosurgical capability for health systems.Results: Neurosurgical diseases make up an important part of the global burden of diseases. Many neurosurgeons possess the sustained passion, resilience, and leadership needed to advocate for improved neurosurgical care worldwide. Neurosurgical care has been linked to 14 of the 17 Sustainable Development Goals (SDGs), thus highlighting the tremendous impact neurosurgeons can have upon HSS initiatives.Conclusion: We recommend policymakers and global health actors to: (i) increase the involvement of neurosurgeons within the global health dialogue; (ii) involve neurosurgeons in the national surgical system strengthening process; (iii) integrate neurosurgical care within the global surgery movement; and (iv) promote the training and education of neurosurgeons, especially those residing in Low-and middle-income countries, in the field of global public health.

scholarly journals Public health implications of influenza B outbreaks in closed settings in the United Kingdom in the 2007/08 influenza season

2008 ◽  
Vol 13 (38) ◽  
Author(s):  
P Mook ◽  
J Ellis ◽  
J M Watson ◽  
CI Thompson ◽  
M Zambon ◽  
...  
Keyword(s):  
Public Health ◽  
United Kingdom ◽  
Burden Of Disease ◽  
Influenza A ◽  
Health Management ◽  
Influenza Season ◽  
Influenza B ◽  
Influenza A Viruses ◽  
School Aged Children ◽  
The United Kingdom

Several influenza B outbreaks occurred in closed settings late in the 2007/08 influenza season (October to mid-May) in the United Kingdom (UK), with implications for public health management. Influenza B viruses usually circulate late in the season and cause a milder disease than influenza A viruses [1]. Epidemics of influenza B usually occur every two to three years with the burden of disease falling predominantly on school-aged children [2].

scholarly journals Epidemiological Characteristics and Spatiotemporal Analysis of Mumps from 2004 to 2018 in Chongqing, China

2019 ◽  
Vol 16 (17) ◽  
pp. 3052 ◽  
Author(s):  
Zhu ◽  
Zhao ◽  
Ou ◽  
Xiang ◽  
Hu ◽  
...  
Keyword(s):  
Public Health ◽  
Spatial Autocorrelation ◽  
Descriptive Analysis ◽  
Health Resources ◽  
Public Health Problem ◽  
Risk Groups ◽  
Scan Statistics ◽  
Time Space ◽  
High Incidence ◽  
Epidemiological Characteristics

Mumps vaccines have been widely used in recent years, but frequent mumps outbreaks and re-emergence around the world have not stopped. Mumps still remains a serious public health problem with a high incidence in China. The status of mumps epidemics in Chongqing, the largest city in China, is still unclear. This study aimed to investigate the epidemiological and spatiotemporal characteristics of mumps and to provide a scientific basis for formulating effective strategies for its prevention and control. Surveillance data of mumps in Chongqing from January 2004 to December 2018 were collected from the National Notifiable Diseases Reporting Information System. A descriptive analysis was conducted to understand the epidemiological characteristics. Hot spots and spatiotemporal patterns were identified by performing a spatial autocorrelation analysis, a purely spatial scan, and a spatiotemporal scan at the county level based on geographic information systems. A total of 895,429 mumps cases were reported in Chongqing, with an annual average incidence of 36.34 per 100,000. The yearly incidence of mumps decreased markedly from 2004 to 2007, increased sharply from 2007 to 2011, and then tapered with a two-year cyclical peak after 2011. The onset of mumps showed an obvious bimodal seasonal distribution, with a higher peak of mumps observed from April to July of each year. Children aged 5–9 years old, males, and students were the prime high-risk groups. The spatial distribution of mumps did not exhibit significant global autocorrelation in most years, but local indicators of spatial autocorrelation and scan statistics detected high-incidence clusters which were mainly located in the midwestern, western, northeastern, and southwestern parts of Chongqing. The aggregation time frame detected by the purely temporal scan was between March 2009 and July 2013. The incidence of mumps in Chongqing from 2004 to 2018 featured significant spatial heterogeneity and spatiotemporal clustering. The findings of this study might assist public health agencies to develop real-time space monitoring, especially in the clustering regions and at peak periods; to improve immunization strategies for long-term prevention; and to deploy health resources reasonably.

scholarly journals Respiratory Illness in a Piggery Associated with the First Identified Outbreak of Swine Influenza in Australia: Assessing the Risk to Human Health and Zoonotic Potential

2019 ◽  
Vol 4 (2) ◽  
pp. 96 ◽  
Author(s):  
David W. Smith ◽  
Ian G. Barr ◽  
Richmond Loh ◽  
Avram Levy ◽  
Simone Tempone ◽  
...  
Keyword(s):  
Influenza A ◽  
Haemagglutination Inhibition ◽  
Swine Influenza ◽  
Respiratory Illness ◽  
Influenza Viruses ◽  
Influenza A Viruses ◽  
Strict Adherence ◽  
Zoonotic Infections ◽  
Zoonotic Risk ◽  
Biosecurity Practices

Australia was previously believed to be free of enzootic swine influenza viruses due strict quarantine practices and use of biosecure breeding facilities. The first proven Australian outbreak of swine influenza occurred in Western Australian in 2012, revealing an unrecognized zoonotic risk, and a potential future pandemic threat. A public health investigation was undertaken to determine whether zoonotic infections had occurred and to reduce the risk of further transmission between humans and swine. A program of monitoring, testing, treatment, and vaccination was commenced, and a serosurvey of workers was also undertaken. No acute infections with the swine influenza viruses were detected. Serosurvey results were difficult to interpret due to previous influenza infections and past and current vaccinations. However, several workers had elevated haemagglutination inhibition (HI) antibody levels to the swine influenza viruses that could not be attributed to vaccination or infection with contemporaneous seasonal influenza A viruses. However, we lacked a suitable control population, so this was inconclusive. The experience was valuable in developing better protocols for managing outbreaks at the human–animal interface. Strict adherence to biosecurity practices, and ongoing monitoring of swine and their human contacts is important to mitigate pandemic risk. Strain specific serological assays would greatly assist in identifying zoonotic transmission.

scholarly journals Reassortant between Human-Like H3N2 and Avian H5 Subtype Influenza A Viruses in Pigs: A Potential Public Health Risk

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12591 ◽  
Author(s):  
Yanlong Cong ◽  
Guangmei Wang ◽  
Zhenhong Guan ◽  
Shuang Chang ◽  
Quanpeng Zhang ◽  
...  
Keyword(s):  
Public Health ◽  
Health Risk ◽  
Influenza A ◽  
Influenza A Viruses ◽  
Public Health Risk ◽  
H5 Subtype ◽  
Potential Public Health

Concurrent Summer Influenza and Pertussis Outbreaks in a Nursing Home in Sydney, Australia

2004 ◽  
Vol 25 (11) ◽  
pp. 962-966 ◽  
Author(s):  
Mark J. Ferson ◽  
Keira Morgan ◽  
Peter W. Robertson ◽  
Alan W. Hampson ◽  
Ian Carter ◽  
...  
Keyword(s):  
Public Health ◽  
Nursing Home ◽  
Influenza A ◽  
Respiratory Illness ◽  
Case Definition ◽  
Acute Respiratory Illness ◽  
Public Health Response ◽  
Pertussis Infection ◽  
Eastern Australia ◽  
Sydney Australia

AbstractObjective:To report on the investigation of a summer outbreak of acute respiratory illness among residents of a Sydney nursing home.Design:An epidemiologic and microbiological investigation of the resident cohort at the time of the outbreak and medical record review 5 months later.Setting:A nursing home located in Sydney, Australia, during February to July 1999.Patients:The cohort of residents present in the nursing home at the time of the outbreak.Interventions:Public health interventions included recommendations regarding hygiene, cohorting of residents and staff, closure to further admissions, and prompt reporting of illness; and virologic and serologic studies of residents.Results:Of the 69 residents (mean age, 85.1 years), 35 fulfilled the case definition of acute respiratory illness. Influenza A infection was confirmed in 19 residents, and phylogenetic analysis of the resulting isolate, designated H3N2 A/Sydney/203/99, showed that it differed from strains isolated in eastern Australia during the same period. Serologic evidence ofBordetellainfection was also found in 10 residents; however, stratified epidemiologic analysis pointed to influenza A as the cause of illness.Conclusions:The investigation revealed an unusual summer outbreak of influenza A concurrent with subclinical pertussis infection. Surveillance of acute respiratory illness in nursing homes throughout the year, rather than solely during epidemic periods, in combination with appropriate public health laboratory support, would allow initiation of a timely public health response to outbreaks of acute respiratory illness in this setting.

Contribution of innate immune cells to pathogenesis of severe influenza virus infection

2017 ◽  
Vol 131 (4) ◽  
pp. 269-283 ◽  
Author(s):  
Suzanne L. Cole ◽  
Ling-Pei Ho
Keyword(s):  
Immune Response ◽  
Influenza A ◽  
Influenza Virus Infection ◽  
Respiratory Illness ◽  
Airway Epithelial Cells ◽  
Innate Immune ◽  
Airway Epithelial ◽  
Cell Type ◽  
Influenza A Viruses ◽  
Effector Cells

Influenza A viruses (IAVs) cause respiratory illness of varying severity based on the virus strains, host predisposition and pre-existing immunity. Ultimately, outcome and recovery from infection rely on an effective immune response comprising both innate and adaptive components. The innate immune response provides the first line of defence and is crucial to the outcome of infection. Airway epithelial cells are the first cell type to encounter the virus in the lungs, providing antiviral and chemotactic molecules that shape the ensuing immune response by rapidly recruiting innate effector cells such as NK cells, monocytes and neutrophils. Each cell type has unique mechanisms to combat virus-infected cells and limit viral replication, however their actions may also lead to pathology. This review focuses how innate cells contribute to protection and pathology, and provides evidence for their involvement in immune pathology in IAV infections.

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