The alarming rise in gastric and colorectal cancers in young adult patients: Analysis of large databases.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 805-805
Author(s):  
Amir Ali Khan ◽  
Philip HG Ituarte ◽  
Isaac Benjamin Paz ◽  
Ajay Goel ◽  
Lily L. Lai ◽  
...  

805 Background: The alarming rise in the incidence of gastric (GC) and colorectal (CRC) adenocarcinomas in young adults (YA) over the past three decades is not well understood. How YA populations differ from older patients with the same gastrointestinal malignancies warrants further investigation. Methods: We retrospectively analyzed the California Cancer Registry and the Office of Statewide Health Planning and Development data for all GC and CRC cases from 2000 to 2012. Pearson’s Chi-square analysis was used to analyze differences in demographic, clinical and histopathologic features and log-rank test to compare survival between young (≤ 40 years old) and older adults (40-90 years old) with GC or CRC. Results: Of the GC (n = 19,368) and CRC (n = 117,415) patients included in the study, YA accounted for 4.5% (n = 883) of GC and 3.2% (n = 3723) of CRC. Hispanic ethnicity was more common in YA for both cancers compared to older patients (50.9% vs 26.8% GC, 29.6% vs. 15.7% CRC, p < 0.0001). YA were more likely to have poorly differentiated (74.6% vs. 59.8% GC, 22.5% vs 17.5% CRC, p < 0.0001), higher grade (77.0% vs 61.6% GC, 23.9% vs 18.6 CRC, p < 0.0001), and signet ring features (44.6% vs 21.0% GC, 3.2% vs 1.1% CRC, p < 0.0001) compared to older patients. Synchronous peritoneal metastases were more common in YA compared to older patients (32.1% vs. 14.1% GC, 8.8% vs 5.4% CRC, p < 0.0001). YA with GC or CRC had a greater 5-year survival compared with older patients with the same stage of malignancy. Subgroup analysis of Stage I GC demonstrated lower survival in YA compared with adults aged 41-49 and 50-64 years (65.1% vs. 70.7% and 69.1%, 95% CI 49.7-76.9%, 62.5-77.3%, 65.2-72.7% respectively). Conclusions: GC and CRC in young adults have distinctly worse clinical and histopathologic features compared to older patients with the same malignancy. Ethnic disparity exists in the YA patients. This study contributes to improving the understanding of younger versus older GI cancer patients.

2019 ◽  
Vol 11 (2) ◽  
pp. 80
Author(s):  
Ribka Wowor

Abstract: Prehypertension is a warning sign, early in age which denotes the risk of hypertension later on in life. Clinical and academic challenges of medical students may have adverse effect on their lifestyle, predisposing vulnerable subjects to elevated blood pressure. This study was aimed to determine the association between dietary habits and prehypertension among Indonesian young adults in Manado. This was an analytical study with a cross-sectional study. Subjects were 111 medical students (undergraduate and postgraduate) aged between 20-30 years, of either sex. A pre-tested questionnaire was used to elicit the details on physical activity, family history of hypertension, tobacco use, and dietary habits. According to JNC-7 guidelines, a systolic blood pressure (SBP) of 120 to 139 mmHg and/or diastolic blood pressure (DBP) of 80 to 89 mmHg is considered as prehypertension. Of the 111 subjects, 22.5% showed blood pressure levels within the range of prehypertension. Chi-square analysis revealed that junk food consumption (OR=3,152; 95% CI=1,253-7,925; P=0,023), and soft drink consumption (OR=4,747; 95% CI=1,797-12,539; P=0,002) were the risk factors of prehypertension. Conclusion: Dietary habits were associated with the prehypertension among young adults in Manado.Keywords: dietary habits, prehypertension, young adultsAbstrak: Prehipertensi merupakan tanda peringatan dini akan resiko terjadinya hipertensi di kemudian hari. Mahasiswa kedokteran memiliki kesibukan studi terutama pada masa kepaniteraan klinik di Rumah Sakit. Tuntutan dalam pendidikan dan pelayanan sekaligus di RS berdampak terhadap pola aktivitas mereka sehari-hari sehingga dapat memengaruhi tekanan darah. Penelitian ini bertujuan untuk mengetahui hubungan antara diet (konsumsi makanan dan minuman) dengan kejadian prehipertensi pada mahasiswa kedokteran Univrsitas Sam Ratulangi. Jenis penelitian ialah analitik dengan desain potong lintang. Hasil penelitian mendapatkan 111 mahasiswa kedokteran peserta P3D dan PPDS (calon spesialis) berusia antara 20-30 tahun sebagai subyek penelitian. Dilakukan pemeriksaan tekanan darah dan berat badan. Penentuan kebiasaan makan ditetapkan berdasarkan hasil pengisian kuesioner. Definisi prehipertensi berdasarkan kriteria JNC 7 yaitu tekanan darah sistolik lebih dari 120 mmHg tapi kurang dari 140 mmHg, dan atau tekanan darah diastolik lebih dari 80 mmHg tapi kurang dari 90 mmHg. Uji Chi-square dilakukan untuk melihat hubungan antara konsumsi junk food dan soft drink dengan kejadian prehipertensi dan didapatkan adanya hubungan antara konsumsi junk food (OR=3,152; 95% CI=1,253-7,925; P=0,023), dan soft drink (OR=4,747; 95% CI=1,797-12,539; P=0,002) dengan kejadian prehipertensi pada subyek dewasa muda. Simpulan: Diet (konsumsi junk food dan soft drink) berhubungan dengan kejadian prehipertensi pada subyek dewasa muda di Manado.Kata kunci: diet, prehipertensi, dewasa muda


2020 ◽  
Vol 25 (Supplement_2) ◽  
pp. e36-e36
Author(s):  
Sebastian James Kilcommons ◽  
Simonne Horwitz ◽  
Seong Eon Ha ◽  
Kirsten Ebbert ◽  
Lea Restivo ◽  
...  

Abstract Background Electronic cigarette use (“vaping”) is associated with negative health outcomes. Vaping among youth has recently risen to the highest levels recorded. Between 2017 and 2018, Canadians 16 to 19 years old who reported vaping over the past 30 days increased by 74%. This directly coincides with the Tobacco and Vaping Products Act (the “Act”) enactment, which lifted the ban on e-cigarette importation and sales without pre-approval while attempting to restrict youth access to e-cigarettes, and the entry of JUUL e-cigarette products into the Canadian market. Objectives The purpose of the study was to evaluate the Act’s effectiveness in protecting the health of youth by preventing their access to vaping products, using a secret shopper interventional design. Design/Methods Study subjects were vaping and convenience store employees and deliverers of vaping products ordered online. Confederate researchers (minors aged 15-16 and young adults aged 19-21) entered retail stores to buy JUUL Starter Kits. Three improper scenarios were used: (1) a minor(s); (2) a young adult with no or invalid identification; and (3) a young adult with valid identification clearly purchasing on behalf of an accompanying minor. The main outcome measured was vendor willingness to sell, recorded upon exit from stores. Five minors also ordered JUUL Starter Kits online from their homes. Frequencies were calculated for each variable and tests of association were completed using chi square analysis. Results In total, 42.5% of vendors (51/120) were willing to sell JUUL Starter Kits to the young adults and minors. Most vendors requested identification in all scenarios (97/120, 80.8%) but, of these, 28 vendors were willing to sell even though no or false identification was provided (28.9% of those who requested identification). Of those vendors who did not request identification (23/130, 19.2%), all were willing to sell. Where a young adult was clearly buying vaping products for a minor, vendors were willing to sell 63.2% of the time (24/38, p=0.016). In five online purchase attempts, 60% of deliverers did not meet the Act’s verification requirements. Conclusion Given that almost half of the vendors were willing to sell JUUL Starter Kits in improper circumstances, the Act does not adequately achieve its goal of protecting the health of youth. To prevent youth access to vaping products, the Act needs stricter enforcement and amendment to impose positive obligations on vendors to request identification, to prohibit sales to adults buying for minors, and to require manufacturers to disclose the product contained in delivered parcels.


2010 ◽  
Vol 04 (02) ◽  
pp. 171-174 ◽  
Author(s):  
Selma Elekdag-Turk ◽  
Nurhat Ozkalayci ◽  
Devrim Isci ◽  
Tamer Turk

Objectives: To determine the color preferences for elastic ligatures among patients receiving fixed-appliance orthodontic therapy.Methods: Five hundred patients with metal brackets (336 female patients and 164 male patients) were included, and their color preferences for elastic ligatures were recorded using a color scale. Chi-square analysis was performed to evaluate the color preferences and to determine the influence of age and gender on color preferences (P<.05).Results: Two hundred and seventy-six patients (55.2%) preferred strikingly colorful elastic ligatures, while 224 patients (44.8%) preferred less noticeable elastic ligatures. No significant difference was observed between the color preferences of female and male patients (P>.05). However, significant differences were observed between the color preferences of adolescents and older patients (P<.001).Conclusions: Female patients preferred red–purple-colored tones, while male patients preferred blue–black-colored tones. Adolescents preferred colorful elastic ligatures, while older patients preferred ligatures with less-noticeable colors. A stock of 10–12 colorful and less-noticeable elastic ligatures seems to be adequate to ensure patient satisfaction. (Eur J Dent 2010;4:171-174)


2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Emma Cunningham ◽  
Nicola Gallagher ◽  
Paul Hamilton ◽  
Leeann Bryce ◽  
David Beverland

Abstract Background Hyponatraemia, defined as a serum sodium [Na] concentration below 135 mmol/L, is common following surgery. As inpatient peri-operative stays shorten, there is a need to recognise pre-operative risk factors for post-operative hyponatraemia and complications associated with a peri-operative drop in Na. This audit aimed to investigate the prevalence of, risk factors for, and complications associated with hyponatraemia following elective primary hip and knee arthroplasty. Methods Data were collected within a retrospective audit of inpatient complications and unplanned reattendance or readmission at hospital in consecutive elective primary hip and knee arthroplasty patients in a single high throughput elective primary joint unit. The hospital’s electronic database identified 1000 patients who were admitted electively between February 2012 and June 2013 under the care of a single consultant orthopaedic surgeon for either total hip arthroplasty, total knee arthroplasty, or uni-compartmental knee arthroplasty. Groups were compared using appropriate tests, including chi-square analysis (or Fisher’s exact test), Mann-Whitney U test, Kruskal-Wallis test, and Wilcoxin signed-rank test. Logistic regression analysis was used to determine factors associated with hyponatraemia. Results Of the total 1000 patients, 217 (21.7%) developed post-operative hyponatraemia. Of these, 177 (81.6%) had mild (Na 130–134 mmol/L), 37 (17.1%) had moderate (Na 125–129 mmol/L), and 3 (1.4%) had severe (Na < 125 mmol/L) hyponatraemia. In multivariate analysis, age, pre-operative Na, and fasting glucose on day 1 remained significantly associated with having hyponatraemia post-operatively. There were no significant differences in reattendance at emergency departments and/or readmission within 90 days between those who had post-operative hyponatraemia whilst in hospital (39/217 = 18.0%) and those who did not (103/783 = 13.2%), or between those who were discharged with hyponatraemia (18/108 = 16.7%) and those discharged with normal Na (124/880 = 14.1%). Conclusion Approximately one fifth of elective joint arthroplasty patients had post-operative hyponatraemia. In these patients, older age, lower pre-operative Na and higher fasting glucose predicted post-operative hyponatraemia. We found no evidence that those discharged with hyponatraemia had more reattendance at emergency departments or readmission to hospital. We suggest that otherwise well patients with mild hyponatraemia can safely be discharged and followed up in the community.


2021 ◽  
Author(s):  
Marika Huffer ◽  
Anita Cservenka

While cannabis is the most commonly used illicit substance, few studies have focused on the relationship between sociodemographic factors and primary method or form of cannabis use. The primary aims of this study were to understand the effects of age and sex on primary form (marijuana, concentrates, edibles) and method (joints, blunts, hand pipe, bong, hookah, vaporizer, edibles) of cannabis use. Participants (n=852; n=536 male) completed an online survey that included the ‘Daily Sessions, Frequency, Age of Onset, and Quantity of Cannabis Use Inventory’ used to collect information on the primary method and form of cannabis use in male and female participants divided into young adults ages 18 to 25 (Y) and adults 26 and older (O). Chi square analysis showed a significant effect of sex for primary method (χ2 (1)=122.4, p<.001) and primary form (χ2 (1)=24.6, p<.001) of cannabis use. Post hoc comparisons using Bonferroni corrections (adjusted p=0.002) showed that males were significantly more likely to report blunts (M=35%; F=10%), while females were significantly more likely to report joints (F=16%; M=8%) and edibles (F=15%; M=4%) as their primary method of cannabis use. Males were also significantly more likely to report marijuana (M=66%; F=55%), while females were significantly more likely to endorse edibles (F=17%; M=10%) as their primary form of cannabis use. Chi square analysis showed a significant effect of age for primary method (χ2 (1)=139.9, p<.001) of cannabis use. Young adults were significantly more likely to report using bongs (Y=19%; O=11%), vaporizers (Y=26%; O=9%), and edibles (Y=12%; O=5%), while participants 26 or older were significantly more likely to report using blunts (O=39%; Y=10%) as their primary method of cannabis use. There were no significant differences between age groups for the primary form of cannabis use. Findings from this study suggest there are significant effects of age and sex on primary method and form of cannabis use. Future studies should examine how other sociodemographic factors may affect cannabis use and how method and form of cannabis use affect long-term health outcomes.


2007 ◽  
Vol 107 (6) ◽  
pp. 946-953 ◽  
Author(s):  
Christian Breschan ◽  
Manuela Platzer ◽  
Robert Jost ◽  
Florian Schaumberger ◽  
Haro Stettner ◽  
...  

Background The primary aim of this study was to compare catheter-associated infections and tip contaminations between percutaneously placed central venous catheters in the internal jugular and subclavian veins in surgical neonates undergoing major noncardiac surgery. Methods The prospectively computerized protocols of 295 procedures were analyzed retrospectively. Results One hundred twenty-nine internal jugular venous (group I) and 107 subclavian venous catheters (group S) were included. The median postconceptual age was 37 weeks in group I and 38 in group S. The weight ranged from 580 g to 4.5 kg in group I and from 820 g to 4.5 kg in group S at the time of insertion. Significantly more catheter-associated infections were observed in group I (15.5 vs. 4.7%; chi-square analysis: P &lt; 0.01). The internal jugular venous catheters were also associated with a significantly increased probability of an earlier onset of a catheter-associated infection compared with the subclavian venous catheters (log rank test: P &lt; 0.01; Cox model: P &lt; 0.01). This probability was only slightly increased by a lower weight (Cox model: P = 0.075), and it was not increased by a lower age (Cox model: P = 0.93). Significantly more catheter tips were contaminated by pathogens in group I (55.8 vs. 33.6%; chi-square analysis: P &lt; 0.01). Conclusion The internal jugular venous catheters were associated with a higher infection rate as well as earlier onset of catheter-associated infection compared with the subclavian venous catheters.


2017 ◽  
Vol 13 (2) ◽  
pp. 241-245
Author(s):  
Ashish Shrestha ◽  
Sushmita Shrestha ◽  
Vinay Marla ◽  
Navin Agrawal

Background & Objectives: The current study was conducted to identify and determine the association between gender and characteristics of palatal rugae in Nepalese population.  Materials & Methods: Characteristics of palatal rugae including number, length, shape, direction and unification were analyzed in 100 maxillary dental plaster casts.  Association between palatal rugae and gender were tested using chi square analysis and statistical descriptors were identified using SPSS 10.0 keeping the level of statistical significance at p<0.05. Results: A total of 997 rugae were traced. Females were found to have more rugae than males though statistically not significant. In the present study significant difference in secondary (p=0.012), fragmentary (p=0.005), straight (p=0.001) and perpendicular directed (p<0.0001) palatal rugae were observed, which were higher among females. Forward directed followed by backward were predominantly observed and more among females. Wavy followed by curved, straight and circular rugae was the most prevalent shape.Conclusion: No two individual had similar rugae pattern. They can be used to identify people and differentiate between males and females in addition to other tools of identification and has great application in forensic science.


2016 ◽  
Vol 14 (2) ◽  
Author(s):  
Gian Hendra ◽  
Amiruddin Saleh ◽  
Retno Sri Hartati Mulyandari

Breeding beef cattle is one of the agriculture sector which is very important in Indonesia. In fact the household consumption of beef can’t be fulfilled by the production in the country. The attention to the human resources which arecattle ranchers have a vital role in the form of increasing knowledges and skills to advance the production of beef cattle. Television is one of a mass media that has potential to increase farmers’ knowledges like cultivation knowledgeand marketing knowledge in Ngantru Village, Bojonegoro District, East Java Province. The purpose of this research are 1) to analyze the characteristics, motives and patterns of breeder cattle in watching television, 2) to analyze therelation between the motifs and patterns of breeder cattle watching television with the information needs of breeding beef cattle, 3) to analyze the relation between farmers beef cattle in watching the television with the fulfillment ofinformation needs of beef cattle breeding, and 4) to analyze the relation between the information needs of farmers skills in beef breeding. This study was designed as a survey research, with a quantitative approach supported by qualitative data with the number of respondents which are 50 people selected randomly. Analyzed using descriptive statistics and inferential statistical with Chi-Square analysis test and Spearman Rank test. The results of this research is there is a real connection between the level’s of ownership of livestock with a duration of watching television. The entertainment motif has related with beef cattle farmers’ pattern in watching television, like the frequency and duration. The frequency of beef cattle farmers in watching television also related with entertainment needs.Keywords: cattle breeding, information needs, motif, scheme, television


2019 ◽  
Vol 12 (1) ◽  
pp. 42-51
Author(s):  
Dwi Indah Sulistiani ◽  
Ujang Maman ◽  
Junaidi J

Objective of this research; 1) determine the perception of ranchers against the properties and behavior of the leadership of the companion in the Society of Al-Awwaliyah 2) analyze the relationship between productivity breeder with productivity of livestock in the Society of Al-Awwaliyah 3) identify the relationship perceptions of ranchers against the leadership companion with productivity of livestock in the Society of Al-Awwaliyah , The data used in this study are primary and secondary data. Primary data were obtained from questionnaires which stem from ranchers while secondary data sourced from literature in the form of books and articles. Data processing was performed using Chi-square analysis using SPSS software version 21. One of the factors relating to the productivity of ranchers is the perception of ranchers against the leadership of their companion. Leadership companion views of the nature and behavior of which is owned by a companion. Productivity ranchers indirectly related to the productivity of the cattle business. Characteristics breeder visits of age, years of education, experience ranchers, and businesses in addition to ranchers. The results of data analysis showed that there is a significant relationship between business other than ranchers with ranchers productivity. The relationship between the perception of the nature of the companion breeder with productivity ranchers produce Pearson Chi-Square value is 9.751 and Asymp. Sig. (2-sided) of 0.002. This is due to interest ranchers against leadership qualities possessed by a companion who produce prolific ranchers. Ranchers consider that a companion of his leadership qualities are ideal as a companion.


2018 ◽  
Vol 34 (1) ◽  
Author(s):  
Dewi Rosiana ◽  
Achmad Djunaidi ◽  
Indun Lestari Setyono ◽  
Wilis Srisayekti

This study aims to describe the effect of sanctions (individual sanctions, collective sanctions, and absence of sanctions) on cooperative behavior of individuals with medium trust in the context of corruption. Both collective sanctions and individual sanctions, are systemic, which means sanctioning behavior is exercised not by each individual but by the system. Cooperative behavior in this context means choosing to obey rules, to reject acts of corruption and to prioritize public interests rather than the personal interests. Conversely, corruption is an uncooperative behavior to the rules, and ignores the public interest and prioritizes personal interests. Research subjects were 62 students. The Chi-Square Analysis was used to see the association between the variables and the logistic regression model was applied to describe the structure of this association. Individual sanction is recommended as punishment to medium trust individuals to promote cooperative behavior in the context of corruption. The results showed that individuals with medium trust had more cooperative behavior.


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