Modified Magnetic Metal-Carbon Mesoscopic Composites with Bioactive Substances

A large number of biologically active substances, organic acids, tannins, and pectin substances were detected during the study of fruits, leaves, and pulp of the fruits of mountain Ash. The content of these substances in leaves and pulp will significantly expand the arsenal of medicinal plant raw materials used. Given the wide distribution of mountain Ash in the territory of the Russian Federation, harvesting leaves from the same plants after harvesting the fruit and using pulp will make it possible to obtain new phytopreparations.

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PERAN AIR REBUSAN DAUN SALAM (SYZGIUM POLYANTHUM) DALAM MENURUNKAN KADAR ASAM URAT

Media Ilmu Kesehatan ◽

10.30989/mik.v5i2.55 ◽

2016 ◽

Vol 5 (2) ◽

pp. 83-91

Author(s):

Miftafu Darussalam ◽

Dwi Kartika Rukmi

Keyword(s):

Uric Acid ◽

Vascular Inflammation ◽

Vascular Lesion ◽

Wilcoxon Test ◽

Test Time ◽

Control Group ◽

Target Area ◽

Bioactive Substances ◽

Control Group Design ◽

Boiled Water

Background: Uric acid is a final product or a waste that is resulted from the metabolism of purines. A high level of uric acid (hyperuricemia) will cause several health problems, such as vascular inflammation, smooth muscle proliferation, and vascular lesion in kidneys. The syzygium polyanthum leaves contain bioactive substances that may affect the level of uric acid in blood. Objective: This study aimed to determine the influence of boiled water of syzygium polyanthum leaves to the changes of uric acid levels in the target area of Puskesmas Pandak 1 Bantul. Methods: This study employed pre- and post-test without control group design. The population consisted of all patients with hyperuricemia in the target area of Puskesmas Pandak 1 Bantul. Sample was selected with a concecutive sampling, gaining a total number of 24 respondents. Data were analyzed with the Wilcoxon test. The dose of boiled water of syzygium polyanthum leaves intake was 0.36g/ KgBW, once a day for 14 days. Result: This research showed that the boiled water of syzygium polyanthum leaves decreased hyperuricemia (uric acid levels), along with the significancy value of 0.009 (p <0.05). At the pre-test time, the average level of uric acid reached 7.279 mg/dl, and after the treatment, it decreased to 6.76 mg/dl. Conclusion: This study has established evidence that the boiled water of syzygium polyanthum leaves is able to decrease hyperuricemia (uric acid level in blood). Keywords: syzygium polyanthum, boiled water of syzygium polyanthum leaves, hyperuricemia

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ANTI-CANCER COMPOUNDS ISOLATED FROM SOFT CORAL SINULARIA CRUCIATA - ALCYONIIDAE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2012.1.11 ◽

2012 ◽

pp. 84-89

Author(s):

Quoc Hung Vo ◽

Nguyen Phuong Nhi Doan ◽

Dinh Quynh Phu Nguyen ◽

Thi Dieu Tram Ho ◽

Thi Hoai Nguyen

Keyword(s):

Mass Spectrometry ◽

Soft Coral ◽

Normal Phase ◽

Ionization Mass ◽

Medical Field ◽

Bioactive Substances ◽

Anti Cancer ◽

The World ◽

Pure Compounds ◽

Layer Chromatography

Objectives: Nowadays, bioactive substances isolated from marine organisms which are abundant and varied in Vietnamese sea attracted more and more the attention of scientists in the world and Vietnam as well. We have studied on soft coral Sinularia cruciata – Alcyoniidae, which has never been studied in Vietnam before, to find substances which are useful in medical field, especially in anti-cancer therapy. Materials and method: Specimens of soft coral Sinularia cruciata were collected from Con Co, Quang Tri province in May 2011. Pure compounds were isolated by using Thin Layer Chromatography; Column Chromatography normal phase and inverse phase; Shephadex LH 20. Structures of them were determined by spectral data of Nuclear Magnetic Resonance (NMR), Electrospray Ionization Mass Spectrometry (ESI-MS). Results & Conclusion: Structures of 4 compounds were identified: (1) 5.8-epidioxycholest-6-en-3-ol (2) Cholesterol (3) 1-O-hexadecyl-glycerol (Chimyl alcohol) (4) Glycerol 1-O-octadecyl ether (Batyl alcohol). The substance (1) was demonstrated to have strong anti-cancer effects in previous study. Key words Sinularia cruciata, Alcyoniidae, 5,8-epidioxycholest-6-en-3-ol, soft coral, cancer.

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Wastewater Treatment Using Marine Algae Biomass as Pollutants Removal

Revista de Chimie ◽

10.37358/rc.18.5.6267 ◽

2018 ◽

Vol 69 (5) ◽

pp. 1089-1098

Author(s):

Elena Suzana Biris Dorhoi ◽

Maria Tofana ◽

Simona Maria Chis ◽

Carmen Elena Lupu ◽

Ticuta Negreanu Pirjol

Keyword(s):

Wastewater Treatment ◽

Green Algae ◽

Marine Algae ◽

Tap Water ◽

Ulva Lactuca ◽

Raw Material ◽

Bioactive Substances ◽

Algae Biomass ◽

Marine Biomass ◽

Pollutants Removal

The valorification of the marine biomass is an important resource for many industries like pharmaceutical, supplying raw material for the extraction of bioactive substances (vitamins, sterols and collagen), cosmetics, biofertilizers and wastewater treatment. In the last years a special attention has been given to the use of macroalgae. The aim of this study was to emphasize the capacity of two representative green algae species frequent presents on the Romanian shore, Ulva lactuca (L.) and Cladophora vagabunda (L.) Hoek, to remove two usual detergents from wastewater. The green algae washed, dried at room temperature, macerated to powder were introduced into different filter paper for comparison, then immersed in waste water treated with different concentrations of detergents. Tap water was used for the experiment. The results show that Ulva lactuca (L.) species is suitable than Cladophora vagabunda (L.) Hoek species, for wastewater treatment.

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The Epitome of Novel Techniques and Targeting Approaches in Drug Delivery for Treating Lymphatic Filariasis

Current Drug Targets ◽

10.2174/1389450121666200630111250 ◽

2020 ◽

Vol 21 (12) ◽

pp. 1250-1263

Author(s):

Saurabh Shrivastava ◽

Anshita Gupta ◽

Chanchal Deep Kaur

Keyword(s):

Lymphatic Filariasis ◽

Neglected Tropical Diseases ◽

Therapeutic Interventions ◽

Tropical Diseases ◽

Human Beings ◽

Therapeutic Approaches ◽

Preventive Chemotherapy ◽

Bioactive Substances ◽

Lymphatic Diseases ◽

Life Threatening

Background: Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the geographical outbreak of infection, and lack of preventive chemotherapy have brought this epidemic to the edge of Neglected Tropical Diseases. Many medications and natural bioactive substances have seen to promote filaricidal activity against the target parasitic species. However, the majority of failures have occurred in pharmaceutical and pharmacokinetic issues. Objective: The purpose of the study is to focus on the challenges and therapeutic issues in the treatment of filariasis. The review brings novel techniques and therapeutic approaches for combating lymphatic filariasis. It also offers significant developments and opportunities for such therapeutic interventions. Conclusion: Through this review, an attempt has made to critically evaluate the avenues of innovative pharmaceuticals and molecular targeting approaches to bring an integrated solution to combat lymphatic filariasis.

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Preventive Effect of Liupao Tea Polyphenols on HCl/Ethanol-Induced Gastric Injury in Mice

Journal of Food Quality ◽

10.1155/2020/5462836 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Kai Zhu ◽

Peng Peng ◽

Ning Wu ◽

Xianrong Zhou ◽

Jianfei Mu ◽

...

Keyword(s):

Gastric Juice ◽

Tea Polyphenols ◽

Gastric Injury ◽

Mouse Serum ◽

Gastric Tissue ◽

Preventive Effect ◽

High Concentration ◽

Sod Activity ◽

Bioactive Substances ◽

Gastric Mucosal Lesions

Liupao tea is a traditional Chinese tea drink. The preventive effect of crude polyphenols in Liupao tea on HCl/ethanol-induced gastric injury was investigated in this study. After a model of gastric injury in mice was established, mouse serum and tissues were analyzed by biochemical and molecular biological methods. The results showed that Liupao tea polyphenols (LTPs) could effectively reduce the area of gastric mucosal lesions, decrease the volume of gastric juice, and increase the pH of gastric juice in mice with gastric injury. Observations of the pathology revealed that LTPs could alleviate cell necrosis and gastric mucosal injury in mice with gastric injury. The SOD activity and GSH level were decreased in mice after gastric injury, while the level of MDA was increased. LTPs could inhibit the changes caused by gastric injury and make the SOD activity, GSH, and MDA levels close to the normal levels. In addition, LTPs could upregulate the mRNA expression of Cu/Zn-SOD, Mn-SOD, CAT, nNOS, and eNOS and downregulate the expression of iNOS in the gastric tissue of mice with gastric injury. Therefore, LTPs can effectively prevent HCl/ethanol-induced gastric injury. HPLC analysis showed that LTP contains six bioactive substances of gallic acid, catechin, caffeine, epicatechin, epigallocatechin gallate, and epicatechin gallate, so the effect of LTP might mainly come from these six components. The effect of a high concentration of LTP is similar to that of ranitidine. LTPs represent a kind of active substance with a protective effect on gastric tissue.

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Design and synthesis of a new magnetic metal organic framework as a versatile platform for immobilization of acidic catalysts and CO2 fixation reaction

New Journal of Chemistry ◽

10.1039/d1nj02140k ◽

2021 ◽

Author(s):

Faezeh Taghavi ◽

Amir Khojastehnezhad ◽

Reza Khalifeh ◽

Maryam Rajabzadeh ◽

Fahimeh Rezaei ◽

...

Keyword(s):

Co2 Fixation ◽

Metal Organic Framework ◽

Environmentally Friendly ◽

Chemical Fixation ◽

Design And Synthesis ◽

Acidic Catalysts ◽

Magnetic Metal ◽

Metal Organic ◽

Fixation Reaction ◽

Organic Framework

The first report of the use of an acidic magnetic metal organic framework for the chemical fixation of CO2 as an environmentally friendly reaction.

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Enhancement of Thermostability of Aspergillus flavus Urate Oxidase by Immobilization on the Ni-Based Magnetic Metal–Organic Framework

Nanomaterials ◽

10.3390/nano11071759 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1759

Author(s):

Neda Motamedi ◽

Mahmood Barani ◽

Azadeh Lohrasbi-Nejad ◽

Mojtaba Mortazavi ◽

Ali Riahi-Medvar ◽

...

Keyword(s):

Aspergillus Flavus ◽

Metal Organic Framework ◽

Urate Oxidase ◽

Significant Activity ◽

Original Activity ◽

Long Term Stability ◽

Magnetic Metal ◽

Metal Organic ◽

Almost All ◽

Organic Framework

The improvement in the enzyme activity of Aspergillus flavus urate oxidase (Uox) was attained by immobilizing it on the surface of a Ni-based magnetic metal–organic framework (NimMOF) nanomaterial; physicochemical properties of NimMOF and its application as an enzyme stabilizing support were evaluated, which revealed a significant improvement in its stability upon immobilization on NimMOF (Uox@NimMOF). It was affirmed that while the free Uox enzyme lost almost all of its activity at ~40–45 °C, the immobilized Uox@NimMOF retained around 60% of its original activity, even retaining significant activity at 70 °C. The activation energy (Ea) of the enzyme was calculated to be ~58.81 kJ mol−1 after stabilization, which is approximately half of the naked Uox enzyme. Furthermore, the external spectroscopy showed that the MOF nanomaterials can be coated by hydrophobic areas of the Uox enzyme, and the immobilized enzyme was active over a broad range of pH and temperatures, which bodes well for the thermal and long-term stability of the immobilized Uox on NimMOF.

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