Dynamics of Cognitive Disorders in Different Periods of Traumatic Brain Disease Depending on the Treatment

2015 ◽  
Vol 22 (3) ◽  
pp. 49-52
Author(s):  
Вышлова ◽  
I. Vyshlova ◽  
Карпов ◽  
Sergey Karpov ◽  
Апагуни ◽  
...  
Keyword(s):  
Neuropsychological Tests ◽  
Young Patients ◽  
Cognitive Disorders ◽  
Cognitive Disorder ◽  
Control Group ◽  
Symptomatic Therapy ◽  
Early Assessment ◽  
Progressive Type ◽  
Attention Memory ◽  
The Brain

The development of the syndrome of cognitive disorders and its dynamics in young patients after concussion in the acute, intermediate and remote periods of traumatic disease of the brain depending on the method of treatment was studied. To define traumatic encephalopathy, it is necessary an early assessment of cognitive functions: attention, memory, speech, rapid reactions. The cognitive disorders were divided on mild, moderate and severe. The most informative in the diagnosis of syndrome of cognitive disorders were neuropsychological tests. The use of the Phenotro-pil increases the percentage of mild forms in combination with the reduction of moderate and severe symptoms in structure of the syndrome of cognitive disorder, thus regressive type of this syndrome was noted. In the control group, mild cognitive disorders with increasing moderate and severe forms of this syndrome decreases at the symptomatic therapy. This indicates about progressive type of this syndrome in a remote period of traumatic disease. The authors prove the effectiveness of the Phenotropil in prevention of the development of persistent effects of trauma, including the progression of the cognitive disorders syndrome.

Cognitive Disorders in Hospitalized Adolescent Anorectic and Bulimic Patients

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
I. Namyslowska ◽  
B. Remberk ◽  
A. Krempa-Kowalewska
Keyword(s):  
Eating Disorders ◽  
Adolescent Girls ◽  
Cognitive Functions ◽  
Digit Span ◽  
Young Patients ◽  
Cognitive Disorders ◽  
Control Group ◽  
Research Results ◽  
Digit Span Test ◽  
Span Test

Objective:The problem of cognitive dysfunction in eating disorders remains controversial and the research results are not univocal. Because of that, research was undertaken on a homogenous group of young patients suffering from eating disorders, hospitalized in the adolescent unit.Method:The cognitive functions were assessed by Wisconsin Card Sorting Test (WCST) and Digit Span Test in the group of 60 adolescent girls (30 anorectic, 30 bulimic) of the same age and compared with the control group of 39 healthy adolescent girls. Also the relation of cognitive disorders with some clinical features of the illness such as the degree of weight loss, BMI at the admission and discharge and the results of EDI test were assessed.Results:Research results did not show statistically significant differences in the performance in the WCST between anorectic and bulimic patients and the control group. However, the group of anorectic patients show the tendency to perform worse in some parameters of WCST (TA, TE, PE, %PE, %CLR) than the control group, althought the results do not reach statistical significance. The results of the bulimic patients were better (p=0.04) than the control group in the Digit Span Test.No correlation was found between clinical data and results in WCST in eating disorder groups of patients while the correlation was found between results of Digit Span Test and BMI at admission in both clinical groups.Conclusions:The research does not fully confirms that patients suffering from eating disorders show deficits in cognitive functions.

scholarly journals Cognitive Skills Questionnaire: Comparative Results in Elderly Population without Cognitive Deficit, Mild Cognitive Impairment and Alzheimer's Disease

2020 ◽  
pp. 1-8
Author(s):  
Edith Labos ◽  
Edith Labos ◽  
Sofia Trojanowski ◽  
Karina Zabala ◽  
Miriam Del Rio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Skills ◽  
Cognitive Disorders ◽  
Cognitive Disorder ◽  
Screening Tools ◽  
Control Group ◽  
Cognitive Complaint

The increase in consultations for changes and/or cognitive complaints in the elderly, together with the current interest in epidemiological research in this context creates the need for screening tools for cognitive assessment to enable the detection of early deficits. Evidence shows its predictive value in the development of dementia disease. This study aims at displaying the results of a Cognitive Skills Questionnaire (CSQ) in a patient population with mild cognitive impairment (MCI) and Alzheimer’s disease (AD), both compared with a control group (CG) with no cognitive disorder and verifying its sensitivity and specificity in order to identify risk patients with cognitive disorder. Participants and Methods: A total of 208 participants were evaluated, out of which 60 had MCI, 46 had AD and a remaining group of 102 subjects who had no cognitive disorder. All participants were administrated the CSQ and a battery of neuropsychological proofs. We analysed the statistical data using ANOVA, Student’s t-test, Tuckey test, ROC curve and principal components analysis. A multiple regression analysis was carried out so as to single out those questions which better differentiated the studied groups. Results: The CSQ showed significant differences between the CG and both groups of patients (AD p> 0.01 and MCI p> 0.05). It was established a cut-off point of 17.5 in the CSQ total score with a sensitivity of 93% and a specificity of 91.3%. Conclusion: The CSQ could eventually allow us to identify patients with cognitive disorders and those others with a cognitive complaint greater than expected. Thus, this questionnaire could be a useful testing and counselling tool in health primary attention.

scholarly journals Features of the use of choline alfoscerate in the complex correction of cognitive disorders in patients with alcohol dependence with encephalopathy

2020 ◽  
Keyword(s):  
Alcohol Dependence ◽  
Execution Time ◽  
Cognitive Disorders ◽  
Performance Standards ◽  
Control Group ◽  
Treatment Standards ◽  
Paroxysmal Activity ◽  
Test Execution ◽  
Group I ◽  
The Brain

The results of studying the dynamics of clinical and psychopathological manifestations, cognitive disorders, brain electrogenesis in patients with alcohol dependence under the influence of therapy according to the treatment standards (I group) and using the drug "Cereglia" in complex correction (II group) are shown in the work. As a result of treatment revealed positive dynamics of psychopathological symptoms relief in both groups was revealed; in patients II group improving electrogenesis brain manifested a decrease of irritatie, regress polymorphic paroxysmal activity, the representation of slow-wave complexes, normalization of the ratio of alpha- and beta-rhythms, the emergence of regional differences and the reactions of absorption on the functional load clinically manifested by increase of functional activity of the brain and improving cognitive function (improving ability to work and steadfastness of focus, logic of judgments, the correctness and validity of generalizations, processes of semantic memorization, the ability to highlight the main meaning of the perceived material, the ability to analyze, understand and put into words the information received), before the performance standards, the test execution time was significantly shorter in group II patients than in group I patients (p<0.05) and was closer to the test execution time in the control group. It was found that the dynamics of cognitive functions under the influence of treatment is a marker of the degree of manifestations of encephalopathy and evaluation of the effectiveness of therapy with the use of the drug "Cereglia".

Paraoxonase 1 activity in different types of multiple sclerosis

2009 ◽  
Vol 15 (3) ◽  
pp. 399-402 ◽  
Author(s):  
A Jamroz-Wisniewska ◽  
J Beltowski ◽  
Z Stelmasiak ◽  
H Bartosik-Psujek
Keyword(s):  
Paraoxonase 1 ◽  
High Density Lipoproteins ◽  
Pon1 Activity ◽  
Phenyl Acetate ◽  
Control Group ◽  
Progressive Type ◽  
Relapsing Remitting ◽  
Different Types ◽  
Plasma High Density ◽  
The Brain

Background Paraoxonase 1 (PON1) is an antioxidant enzyme bound to plasma high-density lipoproteins and is also present in the brain. Objective The aim of this study was to estimate the activity of PON1 in patients with different types of MS. Methods The PON1 activity toward paraoxon and phenyl acetate and lipid profile was examined in 40 relapsing-remitting (RR) patients in relapse, in 42 RR patients in remission, in 55 progressive MS patients and in 40 healthy individuals. Results PON1 activity did not differ in MS patients compared to control group. PON1 activity in relapse was significantly lower in comparison to the other MS groups. Hypercholesterolemia was observed in MS patients. Conclusion PON1 activity does not change in the course of stable and progressive type of MS and is decreased by the relapse of MS.

scholarly journals RISK FACTORS OF DEVELOPMENT OF HALLUCINATORY-PARANOIDAL DISORDERS IN PATIENTS WITH DEMENTIA OF A MIXED GENESIS

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
K. Shevchenko-Bitensky
Keyword(s):  
Risk Factors ◽  
Late Onset ◽  
Cognitive Disorders ◽  
Female Gender ◽  
Control Group ◽  
Financial Conditions ◽  
The Family ◽  
Paranoid Symptoms ◽  
Low Levels ◽  
The Brain

Abstract Seventy-two patients with Alzheimer's disease (AD) with late onset and vascular brain disease, dementia with hallucinatory-paranoid symptoms (the main group) were examined. The control group included 61 patients with AD with late onset and vascular disease of the brain without hallucinatory-paranoid symptoms. The risk factors for the development of hallucinatory-paranoid disorders in patients with mixed dementia were determined. These factors included: female gender; age of 78.6 ± 7.3 years old; hereditary burden of personality disorders; genetic predisposition for cognitive disorders; the presence of a neuropathic constitution in childhood; a retardation of a psychophysical development in childhood; low levels of academic performance; absence of family; secondary and secondary speciaized education; a physical type of a job; acute psychogenic factors associated with the worsening of financial conditions, conflicts in the family, and divorce.

scholarly journals Neurosteroids in Cognitive Disorder - From Well-Known Pharmacological Aspects to a Source of Controversy

2020 ◽  
Vol 25 (1) ◽  
pp. 23-27
Author(s):  
Mădălina-Georgiana Bătrînu ◽  
Amelia Tero-Vescan
Keyword(s):  
Brain Function ◽  
De Novo ◽  
Neurological Diseases ◽  
Cognitive Disorders ◽  
Cognitive Disorder ◽  
Target Organ ◽  
Considerable Part ◽  
Endogenous Modulator ◽  
Synthetic Steroids ◽  
The Brain

AbstractThe nervous system is not just a target organ for synthetic steroids. It is also controlled in a certain manner by steroids synthesized de novo in the brain, at the level of both neurones and glial cells. The impressive recent number of literature studies, clearly demonstrates the presence of enzymes necessary for syntheses of central neurosteroids and also the mechanism by which they act. Neurosteroids play a considerable part as an endogenous modulator of brain function and behaviour processes, and the decrease of their concentration can be associated with the pathophysiology of different neurological diseases accompanied by cognitive disorders such as depression, anxiety, schizophrenia, Alzheimer disease.

Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats

2020 ◽  
pp. 1-8
Author(s):  
Zafer Sahin ◽  
Alpaslan Ozkurkculer ◽  
Omer Faruk Kalkan ◽  
Ahmet Ozkaya ◽  
Aynur Koc ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Central Area ◽  
Essential Elements ◽  
Male Rats ◽  
Control Group ◽  
Male Wistar Rats ◽  
Swimming Test ◽  
The Brain ◽  
Center Area ◽  
Chronic Immobilization Stress

Abstract. Alterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals. Adult male Wistar rats were divided into 3 groups as follows ( n = 10/group): control, immobilization stress-1 (45 minutes daily for 7-day) and immobilization stress-2 (45 minutes twice a day for 7-day). Stress-related behaviors were evaluated by open field test and forced swimming test. In the immobilization stress-1 and immobilization stress-2 groups, percentage of time spent in the central area (6.38 ± 0.41% and 6.28 ± 1.03% respectively, p < 0.05) and rearing frequency (2.75 ± 0.41 and 3.85 ± 0.46, p < 0.01 and p < 0.05, respectively) were lower, latency to center area (49.11 ± 5.87 s and 44.92 ± 8.04 s, p < 0.01 and p < 0.01, respectively), were higher than the control group (8.65 ± 0.49%, 5.37 ± 0.44 and 15.3 ± 3.32 s, respectively). In the immobilization stress-1 group, zinc (12.65 ± 0.1 ppm, p < 0.001), magnesium (170.4 ± 1.7 ppm, p < 0.005) and phosphate (2.76 ± 0.1 ppm, p < 0.05) levels were lower than the control group (13.87 ± 0.16 ppm, 179.31 ± 1.87 ppm and 3.11 ± 0.06 ppm, respectively). In the immobilization stress-2 group, magnesium (171.56 ± 1.87 ppm, p < 0.05), phosphate (2.44 ± 0.07 ppm, p < 0.001) levels were lower, and manganese (373.68 ± 5.76 ppb, p < 0.001) and copper (2.79 ± 0.15 ppm, p < 0.05) levels were higher than the control group (179.31 ± 1.87 ppm, 3.11 ± 0.06 ppm, 327.25 ± 8.35 ppb and 2.45 ± 0.05 ppm, respectively). Our results indicated that 7-day chronic immobilization stress increased anxiety-related behaviors in both stress groups. Zinc, magnesium, phosphate, copper and manganese levels were affected in the brain.

Risk of Depression in Adolescents and Young Adults with Rheumatic Diseases

2020 ◽  
Vol 62 (1) ◽  
pp. 38-42
Author(s):  
Anna Kostiukow ◽  
Wojciech Strzelecki ◽  
Mateusz W. Romanowski ◽  
Marta Rosołek ◽  
Ewa Mojs ◽  
...  
Keyword(s):  
Young Adults ◽  
Young People ◽  
Rheumatic Diseases ◽  
Disease Risk ◽  
Statistical Significance ◽  
Energy Levels ◽  
Young Patients ◽  
Depression Scale ◽  
Adolescents And Young Adults ◽  
Control Group

Introduction: The study is aimed at drawing the attention of the medical environment to the mental health aspects of young patients as a factor that significantly influences the efficiency of their rheumatic disease treatment. Aim: This paper is to check the risk of depression among a group of adolescents and young adults with rheumatic diseases. Material and Methods: The study was conducted among a group of 68 late adolescents and young adults (18-22 years old) with rheumatic diseases. The control group consisted of 102 young people (18-22 years old) without a diagnosed chronic disease. Risk of depression was measured using a screening tool – the Kutcher Adolescent Depression Scale (KADS). Results: The analysis showed that the probability of depression in the study group was 35.3%. In the control group, this rate was 19.6%. The results were statistical significance (p=0.028). Conclusions: The results of this study prove that the risk of depression among adolescents and young adults with rheumatic diseases is significantly higher than in healthy young people. The highest risk of depression is related to feeling tired, fatigue, low energy levels and lack of motivation as well as feeling worried, nervous, panicky, tense, keyed-up and anxious.

Dendrobium officinalis Flower Improves Learning and Reduces Memory Impairment by Mediating Antioxidant Effect and Balancing the Release of Neurotransmitters in Senescent Rats

2020 ◽  
Vol 23 (5) ◽  
pp. 402-410 ◽  
Author(s):  
Lin-Zi Li ◽  
Shan-Shan Lei ◽  
Bo Li ◽  
Fu-Chen Zhou ◽  
Ye-Hui Chen ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Brain Aging ◽  
Morris Water Maze Test ◽  
Control Group ◽  
Histopathological Analysis ◽  
Hippocampal Damage ◽  
Common Belief ◽  
Mao B ◽  
Positive Effects ◽  
The Brain

Aim and Objective: The Dendrobium officinalis flower (DOF) is popular in China due to common belief in its anti-aging properties and positive effects on “nourish yin”. However, there have been relatively few confirmatory pharmacological experiments conducted to date. The aim of this work was to evaluate whether DOF has beneficial effects on learning and memory in senescent rats, and, if so, to determine its potential mechanism of effect. Materials and Methods: SD rats were administrated orally DOF at a dose of 1.38, or 0.46 g/kg once a day for 8 weeks. Two other groups included a healthy untreated control group and a senescent control group. During the 7th week, a Morris water maze test was performed to assess learning and memory. At the end of the experiment, serum and brain samples were collected to measure concentrations of antioxidant enzymes, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH-Px) in serum, and the neurotransmitters, including γ-aminobutyric acid (γ-GABA), Glutamic (Glu), and monoamine oxidase B (MAO-B) in the brain. Histopathology of the hippocampus was assessed using hematoxylin-eosin (H&E) staining. Results: The results suggested that treatment with DOF improved learning as measured by escape latency, total distance, and target quadrant time, and also increased levels of γ-GABA in the brain. In addition, DOF decreased the levels of MDA, Glu, and MAO-B, and improved SOD and GSHPx. Histopathological analysis showed that DOF also significantly reduced structural lesions and neurodegeneration in the hippocampus relative to untreated senescent rats. Conclusion: DOF alleviated brain aging and improved the spatial learning abilities in senescent rats, potentially by attenuating oxidative stress and thus reducing hippocampal damage and balancing the release of neurotransmitters.

scholarly journals Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 143
Author(s):  
Ganchimeg Davaa ◽  
Jin Young Hong ◽  
Tae Uk Kim ◽  
Seong Jae Lee ◽  
Seo Young Kim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Cortex ◽  
Functional Recovery ◽  
Treadmill Exercise ◽  
Exercise Group ◽  
Control Group ◽  
Epigenetic Changes ◽  
Cord Injury ◽  
The Brain

Exercise training is a traditional method to maximize remaining function in patients with spinal cord injury (SCI), but the exact mechanism by which exercise promotes recovery after SCI has not been identified; whether exercise truly has a beneficial effect on SCI also remains unclear. Previously, we showed that epigenetic changes in the brain motor cortex occur after SCI and that a treatment leading to epigenetic modulation effectively promotes functional recovery after SCI. We aimed to determine how exercise induces functional improvement in rats subjected to SCI and whether epigenetic changes are engaged in the effects of exercise. A spinal cord contusion model was established in rats, which were then subjected to treadmill exercise for 12 weeks. We found that the size of the lesion cavity and the number of macrophages were decreased more in the exercise group than in the control group after 12 weeks of injury. Immunofluorescence and DNA dot blot analysis revealed that levels of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in the brain motor cortex were increased after exercise. Accordingly, the expression of ten-eleven translocation (Tet) family members (Tet1, Tet2, and Tet3) in the brain motor cortex also elevated. However, no macrophage polarization was induced by exercise. Locomotor function, including Basso, Beattie, and Bresnahan (BBB) and ladder scores, also improved in the exercise group compared to the control group. We concluded that treadmill exercise facilitates functional recovery in rats with SCI, and mechanistically epigenetic changes in the brain motor cortex may contribute to exercise-induced improvements.

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