The combined intravenous laser light of blood in complex treatment of patients with atopic dermatitis

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0 ◽  
Author(s):  
Шнайдер ◽  
D. Shnayder ◽  
Утц ◽  
S. Utts ◽  
Москвин ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Laser Therapy ◽  
Laser Light ◽  
Severe Disease ◽  
Wave Length ◽  
Combined Treatment ◽  
Research Centre ◽  
Complete Regression ◽  
Treatment Technique ◽  
Therapeutic Measures

One of the known methods of treatment of patients with atopic dermatitis is laser therapy, however, the task of improving the efficiency of this method is still relevant. The objective of this study was the evaluation of the effectiveness of treatment technique of patients with atopic dermatitis, including alternation in a day the intravenous laser light of blood by low-intensity laser radiation with a wave length of 365 nm and 525 nm (green spectrum). 37 patients with atopic dermatitis (10 women and 27 men) aged 18 to 56 years (the average age 36,2), having a disease duration of 17 to 54 years, were observed. In the complex of therapeutic measures of the main group the laser therapy was included. It is the original technique by means of laser therapeutic apparatus "Lasmik- VLOK" (Registration certificate № RZN 2014/1410 from 06.02.2014) with the laser emitting heads KLVLOK- 365-2 (for LUFOK®) and KL-VLOK-525-2 for intravenous laser light of blood. For this technique the disposable sterile lights KIVL -01 on TU 9444-005-72085060-2008 made in Research centre "Matrix" (Russia, Moscow) were used. It is shown that the combined intravenous laser light of blood with a wavelength of 365 nm (VLOK-365 or LUFOK®) and radiation with a wavelength of 525 nm (green spectrum, VLOK-525) in a day, 10 sessions in combined treatment of patients with atopic dermatitis – allows to achieve complete regression of all acute inflammatory symptoms of disease - erythema, papules, desquamation, excoriations in 87,5% of patients with moderate-severe disease (the average SCORAD index – 57,5±4,0) and to lower at 3,4 times the average SCORAD index (to 21,3±4,0) in patients with severe disease (initial value – 72,8±3,0) with an overall positive dynamics.

The Combined Laser Therapy in Patients with Psoriasis

2015 ◽  
Vol 22 (4) ◽  
pp. 99-103
Author(s):  
Утц ◽  
S. Utts ◽  
Москвин ◽  
S. Moskvin ◽  
Шнайдер ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Pulse Repetition Frequency ◽  
Local Effect ◽  
Research Centre ◽  
Treatment Technique ◽  
External Impact ◽  
Therapeutic Measures ◽  
Inflammatory Changes ◽  
Methods Of Treatment ◽  
Made In

One of the known methods of treatment of patients with psoriasis is laser therapy, however, the task of improving the efficiency of this method is still relevant. The objective of this study was the evaluation of the effectiveness of treatment technique of patients with psoriasis, including the intravenous laser light of blood and the local effect of pulse infrared laser radiation. 42 patients with widespread forms of psoriasis in the stage of progression (12 women and 30 men) aged 35 to 60 years (the average age 47), having a disease duration of 5 to 20 years, were observed. In the complex of therapeutic measures of the main group the laser therapy was included. It is the original technique by means of laser therapeutic apparatus ʺLasmik‐VLOKʺ (Registration certificate № RZN 2014/1410 from 06.02.2014) with the laser emitting heads KL‐VLOK‐525‐20 for intravenous laser light of blood and ML‐635‐ 40 for external impact. For this technique the disposable sterile lights KIVL ‐01 on TU 9444‐005‐72085060‐ 2008 made in Research centre ʺMatrixʺ (Russia, Moscow) were used.It is shown that the combined laser therapy of patients with moderate form of psoriasis (PASI index 40‐ 50), including local effects on psoriatic lesions by pulsed radiation of the red spectrum (635 nm) of 40 watts with the change of the pulse repetition frequency to 10000 Hz and VLOK‐525, allows effectively to stop the inflammatory changes, to decrease of erythema, infiltration and desquamation. The rapid decrease in the area affected of the skin is observed.

scholarly journals Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers

2021 ◽  
Vol 13 (3) ◽  
pp. 347-356
Author(s):  
Aoife Naughton ◽  
Ariel Yuhan Ong ◽  
Goran Darius Hildebrand
Keyword(s):  
Effective Treatment ◽  
Beta Blockers ◽  
Combined Treatment ◽  
Infantile Hemangioma ◽  
Intracranial Extension ◽  
Vascular Tumors ◽  
Complete Regression ◽  
Pharmacological Management ◽  
Excellent Outcome ◽  
The Right

Infantile hemangiomas are common benign vascular tumors but are rarely found in an intracranial location. Our literature review identified 41 reported cases. There is no general consensus on management of these rare lesions and until recently, treatment was limited to surgery or pharmacological management with steroids or interferon. Although beta-blockers have been widely prescribed in the treatment of cutaneous infantile hemangiomas since 2008, their use in the treatment of intracranial infantile hemangiomas has been minimal. We present a case of infantile hemangioma affecting the right orbit, associated with intracranial extension, causing intermittent right facial nerve palsy. The patient achieved an excellent outcome following combined treatment with oral propranolol and topical timolol maleate 0.5%, with complete regression of the lesion by 4 months. We conclude that beta-blockers are a safe and effective treatment of intracranial infantile hemangiomas and can be employed as first-line management of these lesions.

scholarly journals Synergistic Effect of Combined Application of a New Fungicide Fluopimomide with a Biocontrol Agent Bacillus methylotrophicus TA-1 for Management of Gray Mold in Tomato

Plant Disease ◽  
2019 ◽  
Vol 103 (8) ◽  
pp. 1991-1997 ◽  
Author(s):  
Xiaoxue Ji ◽  
Jingjing Li ◽  
Zhen Meng ◽  
Shouan Zhang ◽  
Bei Dong ◽  
...  
Keyword(s):  
Field Experiments ◽  
Biocontrol Agent ◽  
Severe Disease ◽  
Combined Treatment ◽  
Field Trials ◽  
Antimicrobial Activities ◽  
Gray Mold ◽  
Control Efficacy ◽  
Bacillus Methylotrophicus

Gray mold caused by Botrytis cinerea can be a severe disease of tomato infecting leaves and fruits of tomato plants. Chemical control is currently the most effective and reliable method; however, application of fungicides has many drawbacks. The combination of biological control agents with newly developed fungicides may be a practicable method to control B. cinerea. Fluopimomide is a newly developed fungicide with a novel mode of action. Bacillus methylotrophicus TA-1, isolated from rhizosphere soil of tomato, is a bacterial strain with a broad spectrum of antimicrobial activities. Little information is currently available about the effect of fluopimomide and its integrated effect on B. cinerea. Therefore, laboratory, pot, and field experiments were carried out to determine the effects of fluopimomide alone and in combination with B. methylotrophicus TA-1 against gray mold on tomato. The in vitro growth of B. methylotrophicus TA-1 was unaffected by 100 mg liter−1 fluopimomide. Inhibition of B. cinerea mycelial growth was significantly increased under combined treatment of fluopimomide and B. methylotrophicus TA-1. In greenhouse experiments, efficacy against gray mold was significantly greater by an integration of fluopimomide and B. methylotrophicus TA-1 than by either alone; control efficacy of fluopimomide at 50 and 100 g ha−1 in combination with B. methylotrophicus TA-1 at 108 colony-forming units (cfu) ml−1 reached 70.16 and 69.32%, respectively, compared with the untreated control. In both field trials during 2017 and 2018, control efficacy was significantly higher for the combination of fluopimomide at 50 and 100 g ha−1 in combination with B. methylotrophicus TA-1 than for either treatment alone. The results from this study indicated that integration of the new fungicide fluopimomide with the biocontrol agent B. methylotrophicus TA-1 synergistically increased control efficacy of the fungicide against gray mold of tomato.

Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis

2018 ◽  
Vol 32 (6) ◽  
pp. 502-517 ◽  
Author(s):  
Nuray Bayar Muluk ◽  
Fazilet Altın ◽  
Cemal Cingi
Keyword(s):  
T Cells ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Inflammatory Response ◽  
Chronic Rhinosinusitis ◽  
Inflammatory Responses ◽  
Immunoglobulin E ◽  
Severe Disease ◽  
Allergic Inflammation ◽  
Allergic Dermatitis

Objectives Our intention was to review all material published to date regarding superantigens (SAgs) and allergy from an otorhinolaryngological viewpoint to understand this association more clearly. Methods We identified all materials published mentioning both SAg and allergic rhinitis (AR), chronic sinusitis, asthma, and atopic dermatitis (AD) that are indexed on PubMed, Google, or the ProQuest Central databases. Results Staphylococcus aureus is a significant bacterial pathogen in humans and has the ability to produce enterotoxins with superantigenic features. The inflammatory response in allergy seen in both B cell and T cell may be attributed to SAgs. Sufferers of both allergic asthma with rhinitis and AR alone produce serological evidence of immunoglobulin E formation to SAgs produced by S. aureus. Perennial AR sufferers carry S. aureus more frequently and the presence of the organism within the nasal cavity may exacerbate perennial AR. SAg produced by S. aureus potentially worsens the asthmatic inflammatory response within the airway and may lead to the airways becoming hyperresponsive, as well as possibly activating T cells if asthmatic control is poor. Staphylococcal SAgs potentially increase the risk of developing chronic rhinosinusitis with nasal polyposis, additionally being a marker for more severe disease. If SAgs bring about chronic inflammatory responses in the nose and sinuses, then T cells excreting interferon-gamma may be a crucial mediator. In allergic dermatitis, S. aureus could be a key player in exacerbation of the condition. Even in younger pediatric patients with allergic dermatitis, allergic hypersensitivity to SAgs is frequent and may be a factor explaining how severe the condition becomes. Conclusion Just as SAgs are known to feature in many allergic conditions, they play their part in AR, chronic rhinosinusitis, asthma, and AD. Further research is required before the relationship between SAgs and allergy can be adequately explained.

scholarly journals The use of laser biostimulation in human and animal physiotherapy – a review

2017 ◽  
Vol 86 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Paulina Zielińska ◽  
Maria Soroko ◽  
Anna Zwyrzykowska ◽  
Zdzisław Kiełbowicz
Keyword(s):  
Veterinary Medicine ◽  
Laser Beam ◽  
Laser Treatment ◽  
Laser Therapy ◽  
Laser Light ◽  
Regenerative Processes ◽  
Physical Methods ◽  
Animal Organism ◽  
Positive Effect ◽  
Class Iv

Laser biostimulation involves applying a laser beam to the tissue to facilitate healing and regenerative processes. Laser therapy is one of the most important physical methods used in human physiotherapy. In veterinary medicine, laser therapy is a new and so far poorly examined method. The results of studies conducted so far are very promising, yet the positive effect of laser light, especially that of class IV, has yet to be confirmed. This article presents an overview of the available literature on the effect of laser treatment on the human and animal organism.

Combined treatment of coxarthrosis

1993 ◽  
Vol 74 (2) ◽  
pp. 100-104
Author(s):  
Yu. A. Plakseichuk
Keyword(s):  
Laser Therapy ◽  
Combined Treatment ◽  
Intertrochanteric Osteotomy ◽  
Combined Method ◽  
Contracture Formation ◽  
Positive Results

Based on the examinations perfomed in 80 patients with coxarthrosis complicated by contractures, it is concluded that the pain is one of the most important pathogenetic factors of the contracture formation. A combined method of the treatment of coxarthrosis is developed, including laser therapy, acupuncture and intertrochanteric osteotomy using Ilizarovs apparatus. As many as 186 patients are operated. Positive results are obtained in 92% of the cases.

Laser therapy in traumatology and orthopedics

1986 ◽  
Vol 67 (3) ◽  
pp. 182-184
Author(s):  
U. Ya. Bogdanovich
Keyword(s):  
Laser Therapy ◽  
Laser Light ◽  
Years Of Experience ◽  
Healthy Skin ◽  
Regenerative Stage

At our institute, laser therapy of wounds is usually performed in the regenerative stage, after clearing of pus-necrotic masses and granulation, since many years of experience have shown that laser therapy is ineffective in the exudative and destructive phases of the wound process. Before exposure to laser, the skin around the wound must be degreased. The defocused beam of laser light is directed directly to the wound or ulcerous surface and adjacent healthy skin areas. For extensive wounds and ulcers, the laser is irradiated in the margins.

P3513Sex-related differences in the outcome of congestive heart failure: study on rats treated with ACEi alone or combined with soluble epoxide hydrolase inhibitor

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
P Kala ◽  
L Cervenka ◽  
M Taborsky ◽  
J Sadowski ◽  
P Skaroupkova ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Survival Rate ◽  
Epoxide Hydrolase ◽  
Combined Treatment ◽  
Heart Association ◽  
Soluble Epoxide Hydrolase ◽  
Sham Operation ◽  
Male And Female ◽  
Therapeutic Measures

Abstract Introduction In search for new therapeutic measures of congestive heart failure (CHF) attention focused on the role of epoxyeicosatrienoic acids (EETs), cytochrome P450-dependent epoxygenase pathway metabolites of arachidonic acid, with antihypertensive and organ-protective actions. The EETs are rapidly broken-down by soluble epoxide hydrolase (sEH). Blocking sEH and increasing tissue EETs bioavailability had antihypertensive and cardio- and renoprotective effects. The studies of the biological mechanisms underlying the sex-related differences in the CHF and in the responses to new pharmacological measures are missing. The rat model in which CHF is induced by volume overload by creation of the aorto-caval fistula (ACF) is recommended for preclinical studies by American Heart Association. It has been noticed that the hypertensive rat transgenic for the mouse Ren-2 renin gene (TGR) presents a unique angiotensin II-dependent model of hypertension. We found that male ACF TGR displayed tissue deficiency of EETs, and increasing intrarenal EETs levels by pharmacological blockade of sEH attenuated the progression of CHF in male ACF TGR. However, we did not examine if this effect occurs also in female ACF TGR. Purpose The aim was to establish if sex-related differences, if present, are demonstrable with standard treatment with ACEi alone and with the combined treatment with ACEi and sEHi. Methods Male and female TGR rats were randomly assigned either to ACF procedure or to sham-operation. One week after the procedure rats were divided into the 8 experimental groups (sham-operated male TGR + placebo, ACF male TGR + placebo, ACF male TGR + ACEi, ACF male TGR + ACEi + sEHi, sham-operated female TGR + placebo, ACF female TGR + placebo, ACF female TGR + ACEi, ACF female TGR + ACEi + sEHi). C-AUCB was used as an sEHi and trandolapril as ACEi, both in drinking water in doses previously tested. The follow-up period was 50 weeks and the primary end-point was death from any cause. Results All sham-operated male and female TGR survived until the end of experiment. All untreated male ACF TGR animals died by week 20. In contrast, untreated female ACF survived in the rate of 32%. The treatment with ACEi improved survival rate similary in male as well as female ACF TGR (74% and 65%). The combined treatment with ACEi and sEHi worsened the survival in male ACF TGR as compared with ACF TGR + ACEi (38%). In contrast, the combined treatment with ACEi and sEHi in female ACF TGR significantly improved the course and the final survival rate (84%) as compared with female ACF TGR + ACEi alone. Picture 1 Conclusions The study suggests that in CHF individuals in whom hypertension and increased RAS activity run in parallel, the patients' sex is the co-determinant of CHF progression. In particular it can influence the effectiveness of the therapeutic measures applied to slow it down. Therefore, in pre- and clinical studies the sex-related differences should be seriously considered. Acknowledgement/Funding Ministry of Health of the Czech Republic grant no. 17- 28220A; Grant Agency of Charles University, project number 32218

scholarly journals Prevalence of atopic dermatitis, asthma and rhinitis from infancy through adulthood in rural Bangladesh: a population-based, cross-sectional survey

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e042380
Author(s):  
Courtney J Pedersen ◽  
Mohammad J Uddin ◽  
Samir K Saha ◽  
Gary L Darmstadt
Keyword(s):  
Atopic Dermatitis ◽  
Medical Diagnosis ◽  
Severe Disease ◽  
Age Groups ◽  
Working Party ◽  
Atopic Disease ◽  
Secondary Outcome ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
History Of

ObjectiveDescribe the pattern of atopic disease prevalence from infancy to adulthood.DesignCross-sectional household survey.SettingCommunity-based demographic surveillance site, Mirzapur, Bangladesh.Participants7275 individuals in randomly selected clusters within 156 villages.Primary and secondary outcome measuresThe 12-month prevalence of atopic dermatitis (by UK Working Party Criteria (UK criteria) and International Study of Asthma and Allergies in Childhood (ISAAC)), asthma and rhinitis (by ISAAC); disease severity (by ISAAC); history of ever receiving a medical diagnosis.ResultsChildren aged 2 years had the highest prevalence of atopic dermatitis—18.8% (95% CI 15.2% to 22.4%) by UK criteria and 14.9% (95% CI 11.6% to 18.1%) by ISAAC— and asthma (20.1%, 95% CI 16.4% to 23.8%). Prevalence of rhinitis was highest among 25–29 year olds (6.0%, (95% CI% 4.5 to 7.4%). History of a medical diagnosis was lowest for atopic dermatitis (4.0%) and highest for rhinitis (27.3%) and was significantly associated with severe disease compared with those without severe disease for all three conditions (atopic dermatitis: 30.0% vs 11.7%, p=0.015; asthma; 85.0% vs 60.4%, p<0.001; rhinitis: 34.2% vs 7.3%, p<0.001) and having a higher asset-based wealth score for asthma (29.7% (highest quintile) vs 7.5% (lowest quintile), p<0.001) and rhinitis (39.8% vs 12.5%, p=0.003). Prevalence of having >1 condition was highest (36.2%) at 2 years and decreased with age. Having atopic dermatitis (ISAAC) was associated with significantly increased odds ratios (OR) for comorbid asthma (OR 5.56 (95% CI 4.26 to 7.26)] and rhinitis (3.68 (95% CI 2.73 to 4.96)). Asthma and rhinitis were also strongly associated with each other (OR 8.39 (95% CI 6.48 to 10.86)).ConclusionsAtopic disease burden was high in this rural Bangladeshi population. Having one atopic condition was significantly associated with the presence of another. Low incidence of ever obtaining a medical diagnosis highlights an important opportunity to increase availability of affordable diagnosis and treatment options for all age groups.

scholarly journals Right Ventricle Remodeling and Function in Scleroderma Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Roxana Cucuruzac ◽  
Iolanda Muntean ◽  
Imre Benedek ◽  
Andras Mester ◽  
Nora Rat ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Severe Disease ◽  
Mortality Rates ◽  
Pulmonary Artery Hypertension ◽  
Organ Manifestations ◽  
Therapeutic Measures ◽  
The One ◽  
And Function ◽  
Adaptive Pattern ◽  
Functional Alteration

Scleroderma, known also as systemic sclerosis (SSc), is a severe disease associated with high mortality rates, and right ventricular (RV) remodeling and dysfunction, along with pulmonary artery hypertension (PAH), are among the most important internal organ manifestations of this disease. PAH has a higher prevalence in patients with SSc compared to the general population and represents a significant predictor of mortality in SSc. In patients with SSc, the morphological remodeling and alteration of RV function begin even before the setting of PAH and lead to development of a specific adaptive pattern of the RV which is different from the one recorded in patients with IAPH. These alterations cause worse outcomes and increased mortality rates in SSc patients. Early detection of RV dysfunction and remodeling is possible using modern imaging tools currently available and can indicate the initiation of specific therapeutic measures before installation of PAH. The aim of this review is to summarize the current knowledge related to mechanisms involved in the remodeling and functional alteration of the RV in SSc patients.

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