scholarly journals Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255335
Author(s):  
Melanie Ricke-Hoch ◽  
Elisabeth Stelling ◽  
Lisa Lasswitz ◽  
Antonia P. Gunesch ◽  
Martina Kasten ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
B Cell ◽  
Life Style ◽  
Severe Disease ◽  
Serum Levels ◽  
Regular Exercise ◽  
Sedentary Life ◽  
Male Sex ◽  
Cox 2 ◽  
Sedentary Life Style

The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.

Epidemiological and Biochemical Factors (Serum Ferritin and Vitamin D) Associated with Premature Graying Of Hair

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Nawres taher Alrgig ◽  
Nermeen Samy Abdel Fattah ◽  
Rania Mahmoud Elhusseiny
Keyword(s):  
Vitamin D ◽  
Serum Ferritin ◽  
Life Style ◽  
Serum Levels ◽  
Stressful Events ◽  
Stress Perception ◽  
Significant Difference ◽  
Sedentary Life ◽  
Sex Assessment ◽  
Sedentary Life Style

Abstract Background Premature graying of hair (PHG) is defined as graying of hair before the age of 20 years in Caucasians and before 30 years in Blacks. Several factors contribute to development of hair graying as genetics, environmental factors, life style and stressful events. Also, many biological markers were associated with development of hair graying as vitamin D, ferritin, vitamin B12 and many other electrolytes as calcium and magnesium. Aim of the study assess various epidemiological factors and biochemical variables (serum ferritin and vitamin D) associated with premature graying of hair. Patients and methods The current study included 75 premature hair graying patients, and 75 apparently healthy controls of matched age and sex. Assessment of epidemiological, clinical characteristics, estimation of serum levels of vitamin D and ferritin was done for included subjects. Results We detected positive correlation of sedentary life style, stress perception and family history with PHG development. No significant difference of vitamin D between the two groups, while low serum ferritin was significantly associated with PHG patients.

scholarly journals Assessing the Primary Causes of Hypertension in Khyber Pakhtunkhwa, Pakistan

2015 ◽  
Vol 6 (2) ◽  
pp. 24 ◽  
Author(s):  
Zafar Khan ◽  
Mushtaq Ahmad ◽  
Ghufran Dr ◽  
Ghulam Nabi ◽  
Asma Hameed
Keyword(s):  
Blood Pressure ◽  
Life Style ◽  
Dietary Habits ◽  
Salt Intake ◽  
Kidney Diseases ◽  
Regular Exercise ◽  
Hypertensive Patients ◽  
Khyber Pakhtunkhwa ◽  
Sedentary Life ◽  
Sedentary Life Style

Hypertension also called a silent killer is a serious problem. The numbers of hypertensive patients are increasing day by day. The present study aim to assess the primary causes of hypertension in Khyber Pakhtunkhwa. Data for the study were collected from 298 hypertensive patients who were admitted or visited to Hayatabad Medical Complex Peshawar as patients. Simple random sampling method was used for selection of the sampled respondents. The results indicate a significant association between hypertension and the level of education (P=.000). Educated people were found not only having more information about hypertension but also found more conscious about the disease (P=.000), while no or low level of educated patients were reported not only caring (P.000) the hypertension but also were not consulting doctors (P=.000). Sampled hypertensive patients were also agreed that regular use of antihypertensive medicines (P=.000), easy supply of medicines (P=.001), regular exercise (P=.000) and regular check-up of blood pressure (P.000) can help maintain blood pressure in normal range while irregularity in taking of medicines (P=.000) and sedentary life style (P=.000) contributed to high blood pressure. Dietary habits (P=.005) such as junk food (P=.000) and spicy diet (P.000) reported affected the blood pressure. Regarding precautions significant association was found with life style modification (P=.000), regular check-up of blood pressure (P=.000), regular exercise (P=.036), weight reduction (P=.001), avoid alcohol consumption (P=.000), stopped smoking (P=.000) and avoid stress (P=.002) along with more use of vegetables and fruits (P=.001). On the other hand hypertension was also associated significantly with the people who have obesity (P=.004), lake of exercise P=.000), old people (P=.034), low socio-economic status (P=.000), kidney diseases (P=.000), endocrine diseases (P=.000), excessive salt intake (P=.008), low potassium intake (P=.010) and family history (P=.001). Individually and psychologically the hypertension can also be due to alcohol intake (P=.000), cigarette smoking (P=.000), sedentary life style (P=.000), lake of exercise (P=.000), lake of knowledge about the signs, symptoms of hypertension (P=.000), its causes (P=.000), and precautions (P=.000). Study recommends that in order to control hypertension, a special attention is needed to follow the precautions about hypertension, diet plan, regular check-up of blood pressure, awareness about the disease and avoid stress.

scholarly journals SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution

2020 ◽  
Author(s):  
Melanie Ricke-Hoch ◽  
Elisabeth Stelling ◽  
Lisa Lasswitz ◽  
Antonia-Patricia Gunesch ◽  
Martina Kasten ◽  
...  
Keyword(s):  
Air Pollution ◽  
B Cells ◽  
Prostaglandin E2 ◽  
Severe Disease ◽  
Lung Epithelial Cells ◽  
Pge2 Production ◽  
Blood Levels ◽  
B Cell Survival ◽  
Male Sex ◽  
Cox 2

Abstract The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds prostaglandin E2 (PGE2) blood levels elevated in COVID-19 patients with positive correlation with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human-lung-precision-slices infected with SARS-CoV-2 display upregulated COX-2. PGE2 in serum of COVID-19 patients lowers the expression of Paired-Box-Protein-Pax-5 (PAX5), a master regulator of B-cell survival, proliferation and differentiation, in both human and mouse pre-B-cells, while the PGE2 inhibitor taxifolin directly reduces SARS-CoV-2-induced PGE2 production and attenuates viral replication. Risk-factors for severe disease courses, i.e. older age, male sex and air pollution are associated with higher PGE2 production and lower PAX5 expression in pre-B-cells. Since PGE2 acts broadly immunosuppressive its elevation might reduce the early anti-viral defense and its inhibition may therefore reduce severe disease courses.

Role of Panchakarma in the management of Hypothyroidism

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Dr.Suraj Kumbar ◽  
Dr.Lohith BA ◽  
Dr.Ashvinikumar M ◽  
Dr. Amritha R ◽  
Dr. Shameem Banu
Keyword(s):  
Metabolic Rate ◽  
Pituitary Gland ◽  
Life Style ◽  
The Body ◽  
Management Guidelines ◽  
Quality Of Food ◽  
Sedentary Life ◽  
Sedentary Life Style

We are in technical era where there is more of sedentary life style and stress along with this urbanization is affecting our quality of food and health. This is leading to many lifestyle disorders and hormonal imbalances in our body. Hypothyroidism one among the endocrinal disorder. Thyroid is an endocrinal gland secrets T3 and T4 hormones regulated by TSH which is secreted by Pituitary gland. These hormones have two major effects on the body, 1) To increase the overall metabolic rate in the body 2) To stimulate growth in children. Hypothyroidism is common health issue in India. The highest prevalence of hypothyroidism (13.1%) is noted in people aged 46-54yrs old. With people aged 18-35 yrs being less affected (7.5%). To prevent these hazards Panchakarma is beneficiary to maintain metabolic rate. Here an attempt is made to diagnose hypothyroidism in the light of Ayurveda and management guidelines through Panchakarma.

scholarly journals A Comparison of Lipid Profile Between Sedentary and Non Sedentary Workers

1970 ◽  
Vol 22 (1) ◽  
pp. 10-14
Author(s):  
Iftekhar Mahmood ◽  
MM Rahman Khan ◽  
M Khalilur Rahman ◽  
MM Hoque Chowdhury
Keyword(s):  
Cardiovascular Disease ◽  
Life Style ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Epidemiological Studies ◽  
Control Group ◽  
Age Group ◽  
Sedentary Life ◽  
Bank Employees ◽  
Sedentary Life Style

In different epidemiological studies, an association between sedentary life style and incidence of cardiovascular diseases has been demonstrated. Dyslipidaemia is one of the important risk factors of cardiovascular disease. An association of dyslipidaemia with sedentary life style has been considered. This study was carried out among 50 sedentary workers (teachers, office staffs, bank employees) at Pabna District and 50 individuals with non-sedentary jobs matched for age group and sex for the control group to see the association. Body mass index (BMI), blood pressure (BP), plasma level of glucose, total cholesterol, low density lipoprotein (LDL), and triglycerides (Tgs) were found to be significantly higher whereas high density lipoprotein (HDL) was found to be significantly lower among the sedentary workers as compared with the control subjects. From the study, it appears that dyslipidaemia is more common in sedentary workers and the relative risk for cardiovascular disease is increased among them due to the sedentary nature of their jobs. DOI: 10.3329/taj.v22i1.5014 TAJ 2009; 22(1): 10-14

Prevalence of Hypertension and Associated Factors among Bank Workers in Harar Town, Eastern Ethiopia 2018

2020 ◽  
Vol 2 (3) ◽  
pp. 1-6
Author(s):  
Gosaye Teklehaymanot Zewde ◽  
Keyword(s):  
Risk Factor ◽  
Heart Disease ◽  
Life Style ◽  
Associated Factors ◽  
Study Participant ◽  
P Value ◽  
Eastern Ethiopia ◽  
Sedentary Life ◽  
Sedentary Life Style

Background: Hypertension clinically defined as a blood pressure of 140/90 mmHg or more on at least two readings on separated time. It is one of the most prevalent non communicable diseases and the most important preventable risk factor for premature death worldwide, due to heart disease and stroke. It is the most important modifiable risk factor for coronary heart disease, stroke, congestive heart failure, end stage renal disease and peripheral vascular diseases. Objective: To assess the prevalence of hypertension and its associated factors among bank workers in Harar town, Eastern Ethiopia 2018. Methods and material: Institutions based cross sectional study was conducted on 149 Bank workers in 6 governmental and 19 private banks which were found in Harar Town. Sample was allocated proportionately and study participant was selected by simple random sampling. Collected and checked data were entered in to Epi Data software version 3.02 and exported and analyzed using SPSS version 21. Descriptive statistics were used to determine prevalence such as frequency, percentage, mean and ratio. Both Bivariate and multiple logistic regressions were used to observe the association between the outcome variable and associated factors. P value less than 0.2 in Bivariate analysis was transferred to multivariate analysis and P value less than or equal to 0.05 was considered as level of statistically significance. Result: The prevalence of hypertension on this study was 27.5 %. Among study participant 6(4%) had diagnosed with hypertension and only 3 (2%) had on treatment and follow- up. 26(17.4%) bank workers BMI Was obsessed. In multivariable logistic regression analysis Age, Sedentary life style and BMI of bank workers had significant association with hypertension. Conclusion and recommendation: The prevalence of Hypertension in the study was 27.5% Age, Sedentary life style and BMI (Obesity) in this study was positively associated with higher odds of having hypertension. Regular blood monitoring, conducting physical exercise and reduction of Alcohol consumption and street Treatment care and follow-up strategy need to be maintained.

Review of concept of vihara with special reference to viharaja hetu of amlapitta.

2020 ◽  
Vol 8 (02) ◽  
Author(s):  
Ranibala Nemade
Keyword(s):  
Special Reference ◽  
Present Article ◽  
Life Style ◽  
Food Culture ◽  
Modern World ◽  
Great Contribution ◽  
Common Diseases ◽  
Equal Importance ◽  
Sedentary Life ◽  
Sedentary Life Style

The modern world is currently facing an epidemic of life style related diseases as a result of improper diet,sedentary life style and stress.Ayurveda has great contribution in prevention of the diseases as well as treatment of diseases.Ayurveda has given equal importance to Ahara and Vihara.All types of activities are included in Vihara.Vihara is a very broad concept.It has a key role in Swasthavrutta,Nidana and Chikitsa.The present article mainly focuses on the Nidana (Hetu-reason) aspect of Vihara as the Nidana Parivarjana is the prime treatment of any disease. Modern era’s changing lifestyle along with changing food culture has given birth to various diseases.Amlapitta is one of the most common diseases seen in the society.The disease Amlapitta is not directly mentioned in Bruhatrayi.Acharya Kashaypa was the first to describe Amlapitta as a disease.Viharaja  Hetu play important role in the pathogenesis of Amlapitta.

scholarly journals Risk factors for hepatitis C disease in Tando Allahyar, Pakistan: a case-control study

1970 ◽  
Vol 10 (3) ◽  
pp. 163-169 ◽  
Author(s):  
NA Channa ◽  
H Khan
Keyword(s):  
Risk Factors ◽  
Hepatitis C ◽  
Family History ◽  
Blood Transfusion ◽  
Life Style ◽  
Psychological Problems ◽  
Multiple Pregnancies ◽  
Key Words Hepatitis C ◽  
Sedentary Life ◽  
Sedentary Life Style

Objective: Present study was undertaken to explore the epidemiological and dietary risk factors for hepatitis C disease in Tando Allahyar during June to December 2007. Materials and methods: 140 Hepatitis C patients and 149 controls (age, sex and locality matched with no personal or family history of hepatitis C) were randomly selected from the Tando Allahyar population during June 2007 to December 2007. A standard questionnaire specially developed for that purpose, was distributed among patients and controls. Accurate rapid card test was performed to confirm Hepatitis C virus (HCV) positive or negative patients and controls. O.R with 95% confidence interval was computed and p values were calculated by chi square test. Results: Over all findings showed that among 140 HCV patients 64% were females and 36% males (mean age range was 20-48 years). Our results showed strong positive association of sedentary life style (OR=4, 95% CI, 1.48-10.6, p=0.005), marital status, +ve family history, B+ve blood group, piercing, syringe use (70%), multiple pregnancies (OR=4.72, 95% CI, 1.47-15.15, p=0.008), blood transfusion (OR=4.4, 95% CI, 1.2-14.95, p=0.017), take out food debris by office pins (NS), shave at barber’s shop (NS), dental procedures (NS), medicines used in past (OR=3.08, 95% CI, 1.2-7.71, P=0.016), G.I.T diseases (OR =8.66, 95% CI, 1.28-55.58, p=0.023), stones of kidney or gallbladder, jaundice, Tuberculosis and psychological problems (OR =2.5, 95% CI, 1.04-6.13, P=0.04) with hepatitis C disease. We did not find any association of surgery, BMI, ENT, diseases, meat consumption and smoking with the disease. Vegetables OR =0.842, 95% CI, 0.361-1.964, P=0.694), pulses, tomatoes (OR =0.31, 95% CI, 0.041-2.53, P=0.31), and tea (OR =0.598, 95% CI, 0.251-1.431, P=0.25) were found to be the protective factors for Hepatitis C disease. Conclusion: Sedentary life style, multiple pregnancies, blood transfusion, medicines used in past, G.I.T diseases, and psychological problems are significantly positively associated with Hepatitis C disease. Key words: Hepatitis C disease, HCV infection, epidemiological risk factors, Diet, blood transfusion, G.I.T diseases, and psychological problems. DOI: http://dx.doi.org/ 10.3329/bjms.v10i3.8359 BJMS 2011; 10(3): 163-169

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