scholarly journals Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259047
Author(s):  
Ya-Wen Lin ◽  
Jong-Yi Wang ◽  
Ming-Hung Lin
Keyword(s):  
Health Insurance ◽  
Young Women ◽  
Quantitative Research ◽  
Population Based ◽  
Study Data ◽  
Research Approach ◽  
Distribution Analysis ◽  
Stroke Incidence ◽  
Comparative Risk ◽  
History Of

Objective Dysmenorrhea is among the most common type of gynecological problem, affecting young women across the globe. This study assessed the comparative risk of stroke associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and non-NSAIDs in women with dysmenorrhea while taking into account the following factors such as age, history of pregnancy, NSAIDs uses and its duration of use, and selected comorbidities. Methodology We used a quantitative research approach based on a comparative case-control study design. The study data was selected from the Longitudinal Health Insurance Database (LHID) 2000, of the Taiwan National Health Research Institutes. Among the estimated 23.4 million insured Taiwanese, who were covered by the Taiwan health insurance system, in the 2000 registry of beneficiaries, one million individuals were randomly selected from the database. A total of 24,955 females suffering from dysmenorrhea were selected for the study. Out of those 3238 (13%) participated in the study group and 21,717 (87%) were randomly distributed into the controls group. Women in the age range, 15–49 years, who did not have any history of stroke, hysterectomy, and/or ovariectomy, were included in the study. A comparative proportional distribution analysis was used for data analysis. Results Age and use of NSAIDs and its duration of usage were factors associated with an increased incidence of stroke. The stroke incidence rate was 12.77 per 10,000 person-years, and 1.83-fold higher in NSAIDs use cohort than in comparisons with adjusted hazard ratio (aHR) of 1.47 (95% CI = 0.93–2.32). Among women with dysmenorrhea use of NSAIDs, the stroke incidence increased to 2.29-fold (aHR 95% CI = 1.36–3.84) in those use for ≧24 days per month and to 0.51-fold (aHR 95% CI = 0.13–2.10) in those use for 6–12 days per month. Conclusions Women with dysmenorrhea who use NSAIDs have a higher risk of stroke. Especially young women, the risk of stroke is further increased, and the longer the medication, the higher the risk of stroke. Every woman with symptoms of dysmenorrhea deserves specialized outpatient treatment and care.

The deleterious association between proton pump inhibitors and prostate cancer specific death.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 309-309
Author(s):  
Hanan Goldberg ◽  
Faizan Moshin ◽  
Refik Saskin ◽  
Girish S. Kulkarni ◽  
Alejandro Berlin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Cox Regression ◽  
Population Based ◽  
Study Data ◽  
History Of ◽  
Time Dependent Covariates

309 Background: Proton pump inhibitors (PPIs) are a commonly prescribed class of medications. Although in-vitro and in-vivo data have shown PPIs to have anti-tumor effects, more recent studies suggest an increased cancer risk in several solid organs. Pantoprazole, a commonly prescribed PPI, has been shown to harbor a protective effect in human prostate cancer (PCa) cells. We aimed to investigate the effect of pantoprazole and other PPIs on PCa-specific death and additional PCa outcomes. Methods: In this retrospective, population-based cohort study, data were incorporated from the Institute for Clinical and Evaluative Sciences to identify all men aged 66 and above with a history of a single negative prostate biopsy between 1994 and 2016. We used multivariable Cox regression models with time-dependent covariates, to assess the effect of PPIs on PCa diagnosis, androgen deprivation therapy (ADT) use, and PCa-specific death. All models included other medications with a putative effect on PCa. All models were adjusted for age, rurality, comorbidity, and year of patient study inclusion. Results: Overall, 21,512 men were included, with a mean follow-up time of 8.06 years (SD 5.44 years). A total of 10,999 patients (51.1%) used a PPI. A total of 5,187 patients (24.1%) were diagnosed with PCa, 2,043 patients (9.5%) were treated with ADT, and 805 patients (3.7%) died from PCa. Pantoprazole was associated with a 3.0% (95% CI 0.3%-6,0%) increased rate of being treated with ADT for every six months of cumulative use, while any use of all other PPIs was associated with a 39.0% (95% CI 18.0%-64.0%) increased PCa-specific mortality. No significant association was found with PCa diagnosis. Conclusions: Upon validation of the potentially negative association of PPIs with PCa outcomes, the expansive use of PPIs may need to be reassessed, especially in PCa patients.

scholarly journals Motivasi Kepesertaan Mandiri BPJS di Era Universal Health Coverage Jaminan Kesehatan Nasional

2019 ◽  
Vol 1 (1) ◽  
pp. 11-18
Author(s):  
Anita Dahliana
Keyword(s):  
Health Insurance ◽  
Universal Health Coverage ◽  
Random Sampling ◽  
Quantitative Research ◽  
Research Approach ◽  
Health Coverage ◽  
Motivational Theory ◽  
Universal Health

Abstract. This research was conducted to determine the motivation of BPJS Health participants as independent participants. In this study, researchers used a motivational theory developed by Clayton Alderfer with three indicators namely Existence, Relatedness and Growth with a descriptive quantitative research approach with non-random sampling using a purposive method using conditions in selecting respondents ie respondents were outpatients in Specialist Poly Wiyung Hospital, Surabaya. The selected respondents were 43 people.The results of this study were the discovery of community motivation as independent health insurance participants. Abstrak. Penelitian ini dilakukan untuk mengetahui motivasi peserta BPJS Kesehatan sebagai peserta mandiri. Pada penelitian ini, peneliti menggunakan teori motivasi yang dikembangkan oleh Clayton Alderfer dengan tiga indikator yaitu Existence, Relatedness dan Growth dengan pendekatan penelitian kuantitatif deskriptif. Teknik pengambilan sampel non-random menggunakan cara purposive, yakni pemilihan responden menggunakan syarat tertentu (responden adalah pasien rawat jalan di Poli Spesialis RS Wiyung Surabaya). Responden yang dipilih berjumlah 43 orang. Hasil penelitian ini menunjukkan adanya motivasi masyarakat yang menjadi peserta mandiri jaminan kesehatan.

scholarly journals Travellers’ Satisfaction on the Applications of Artificial Intelligence in Malaysia’s Tourism and Hospitality Industry.

2021 ◽  
Vol 8 (1) ◽  
pp. 38-42
Author(s):  
Tung Soon Theam ◽  
Puvaneswari Veloo ◽  
Nor Haliza Binti Che Hussain ◽  
Yap Kim Luu
Keyword(s):  
Artificial Intelligence ◽  
Quantitative Research ◽  
Hospitality Industry ◽  
Study Data ◽  
Research Approach ◽  
Policy Makers ◽  
Travel Experience ◽  
Visa Application ◽  
Tourism And Hospitality Industry ◽  
Tourism And Hospitality

Artificial intelligence (AI) is perceived as being able to transform tourism and hospitality industry’s operations into a greater efficiency and cost-effectiveness while offering travellers unique experiences. This study examines travellers’ satisfaction of AI applications, specifically through e-Hailing, e-Wallet, e-Gate and e-Visa in the tourism and hospitality industry in Malaysia. Quantitative research approach was adopted in the current study. Data was gathered from 200 respondents using self-administrative questionnaires. Local and foreign travellers of age 18 and above who had past travel experience were chosen as samples. The findings indicated that e-Hailing, e-Gate and e-Wallet significantly influence travellers’ satisfaction. However, the outcome shows that e-Visa application has no relationship with travellers’ satisfaction. This study helps to strengthen the tourism ministry’s current initiatives in boosting the tourism and hospitality industry in Malaysia. The outcome of the study might be of interest to the policy makers and regulators to improve on the applications of AI in tourism and hospitality in Malaysia.

scholarly journals Placement International Textile Companies Santa Catarina State, Brazil: A Qualitative Analysis

2013 ◽  
Vol 12 (2) ◽  
pp. 42-68
Author(s):  
Renata Granemann Bertoldi Platchek ◽  
Dinorá Eliete Floriani
Keyword(s):  
International Market ◽  
Study Data ◽  
Point Of View ◽  
Research Approach ◽  
Risk Minimization ◽  
Business Growth ◽  
Santa Catarina ◽  
International Environment ◽  
History Of ◽  
Depth Interviews

Since the early '90s, interest in the internationalization has been growing not only among businessmen and investors, but also among academics researchers like Goulart (1996) point out that the internationalization not only the firm interacts in some way with the international environment, but also considers the effects reflected by the external environment in national companies. Thus this paper aims to present the profile os Santa Catarina textile companies internationalized under the light of internationalization behavioral approaches, which aim to explain the process of internationalization by the influence of the perceptions of executives and entrepreneurs, which would take its decisions in a context of rationality limited search and risk minimization (CARNEIRO, 2007) the research approach is qualitative and is considered from the point of view, a descriptive exploratory study. Data collection consisted of in-depth interviews with six entrepreneurs from four textile companies that have operations in the international market. The interviews were carried out from August to October 2010. By the perception that it had the history of business growth and their involvement in the international market, especially in the last decade, we see that the environment offered more threats than opportunities. It seems that companies are not increasing their involvement with the international market for exports and imports but compared to the initial movement of engagement with the international market occurred in the 70 and 80.

scholarly journals Stopping when knowing: use of snus and nicotine during pregnancy in Scandinavia

2019 ◽  
Vol 5 (2) ◽  
pp. 00197-2018 ◽  
Author(s):  
Ina Kreyberg ◽  
Karen E.S. Bains ◽  
Kai-H. Carlsen ◽  
Berit Granum ◽  
Hrefna K. Gudmundsdóttir ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Young Women ◽  
Regression Models ◽  
Population Based ◽  
Maternal History ◽  
Urban Living ◽  
Logistic Regression Models ◽  
History Of ◽  
Electronic Questionnaires ◽  
In Pregnancy

In young women, the use of snus increases in parallel with decreasing smoking rates but the  use in pregnancy is unclear. Our aims were to determine the prevalence of snus use, smoking and other nicotine-containing product use during pregnancy, and to identify predictors for snus use in pregnancy.Prevalence was determined for 2528 women in Norway and Sweden based on the Preventing Atopic Dermatitis and ALLergies (PreventADALL) study, a population-based, mother–child birth cohort. Electronic questionnaires were completed in pregnancy week 18 and/or week 34, and potential predictors of snus use were analysed using logistic regression models.Ever use of any snus, tobacco or nicotine-containing products was reported by 35.7% of women, with similar rates of snus use (22.5%) and smoking (22.6%). Overall, 11.3% of women reported any use of nicotine-containing products in pregnancy up to 34 weeks, most often snus alone (6.5%). Most women (87.2%) stopped using snus by week 6 of pregnancy.Snus use in pregnancy was inversely associated with age and positively associated with urban living and personal or maternal history of smoking. While 11.3% of women used snus or other nicotine-containing products at some time, most stopped when recognising their pregnancy. Younger, urban living, previously smoking women were more likely to use snus in pregnancy.

The association of acne and menstrual symptoms among young women (18–25 years) in Egypt: a population-based cross-sectional study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ahmed Arafa ◽  
Alshimaa Mostafa ◽  
Yasser Khamis
Keyword(s):  
Young Women ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Multi Stage ◽  
Menstrual Symptoms ◽  
History Of ◽  
The Relationship ◽  
Age Of Menarche

AbstractBackgroundAcne and menstrual symptoms are highly prevalent among young women. Since both acne and menstrual symptoms have similar hormonal pathogenesis, it is highly suggested that the two conditions are associated. Herein, we conducted this study to assess the relationship between acne and menstrual symptoms among young women.Subjects and methodsIn this population-based cross-sectional study, a multi-stage random sampling approach was used to include 3065 young women (18–25 years) from Egypt. Women were interviewed for their socio-demographic characteristics, gynecological history, premenstrual and menstrual symptoms, and history of acne and perimenstrual acne flare during the past 6 months.ResultsThe mean age of women was 21.5 ± 2.2 and their age of menarche was 13.1 ± 1.5 years. During the previous 6 months, 44.8% of participants had acne. After adjusting for socio-demographic and gynecological characteristics, acne was associated with most menstrual symptoms with odds ratios (ORs) and 95% confidence intervals (CIs) as follows: [premenstrual symptoms: 1.23 (1.05–1.44) for irritation or nervousness, 1.45 (1.24–1.68) for fatigue, 1.37 (1.15–1.62) for breast tenderness, 1.48 (1.21–1.80) for abdominal bloating, and 1.36 (1.11–1.66) for nausea or vomiting], [menstrual symptoms: 1.63 (1.19–2.23) for dysmenorrhea and 1.24 (1.06–1.45) for dysmenorrhea requiring drugs], and [symptoms severity: 1.44 (1.24–1.68) for missing events and 1.38 (1.16–1.64) for medical consultation]. Of acne patients, 56.7% reported perimenstrual acne flare: 58.5% before menses, 35% during menses, and 6.5% after menses.ConclusionThis study supports the concept that acne is associated with menstrual symptoms. Physicians should consider screening for menstrual symptoms among young women with acne.

scholarly journals TATHAWWUR MU’TAQADĀT AL-THULLĀB HAULA TA’ALLUM AL-LUGHAH FI BARNĀMAJ DAURAH AL-LUGHAH AL-ARABIYYAH AL-MUKATSTSAFAH ‘ABR AL-JINSI WA AL-KHALFIYĀTI AL-TARBAWIYYAH: DIRĀSAH MAQTA’IYYAH WA THŪLIYYAH

2021 ◽  
Vol 4 (1) ◽  
pp. 85
Author(s):  
Nurul Wahdah
Keyword(s):  
Language Learning ◽  
Quantitative Research ◽  
Longitudinal Research ◽  
Study Data ◽  
Research Approach ◽  
Cross Sectional ◽  
Educational Backgrounds ◽  
Significant Difference ◽  
New Students ◽  
Development Of Students

This study aims to investigate the development of students’ beliefs about learning Arabic in Intensive Arabic Course program at IAIN Palangka Raya across the educational backgrounds and gender. This study used a quantitative research approach by combining cross sectional and longitudinal research types. There are 214 (two hundred and fourteen) new students in Academic Year 2019 at IAIN Palangka Raya as participants of the study. Data were analyzed by using mean, independent sample test and ANOVA. The results showed that 1) the new students studying in the intensive Arabic course program had a strong belief about Arabic learning 2) there was no statistically significant difference between the students belief about Arabic learning across gender and the educational backgrounds at the beginning of the Intensive Arabic Course meeting, 3) there was no statistically significant difference between the students’ beliefs about Arabic learning across the educational backgrounds and the gender after the end of the Intensive Arabic course program, 4) there was no statistically significant difference in development of students' belief about learning Arabic between the beginning and the end of the Intensive Arabic Course program. Keywords: Arabic, beliefs about language learning, course, development

scholarly journals Assessment of Knowledge regarding Polycystic Ovary Syndrome (PCOS) among Nursing Students

2021 ◽  
Vol 07 (03) ◽  
pp. 42-45
Author(s):  
Saliqua Sehar ◽  
Keyword(s):  
Nursing Students ◽  
Polycystic Ovary Syndrome ◽  
Quantitative Research ◽  
Polycystic Ovary ◽  
Communicable Disease ◽  
Study Data ◽  
Research Approach ◽  
Ovary Syndrome ◽  
Online Mode ◽  
Health Complications

Introduction:PCOS is most common non-communicable disease in females after hypertension and diabetes mellitus in India. Females with PCOS have a higher risk of developing health complications like infertility, HTN, abortion, insulin resistance etc. Lack of knowledge and poor lifestyle choices are considered to be the major factor leading to this syndrome. Nurses are in unique position to create awareness regarding this syndrome. Informed choices and lifestyle management like weight loss ,stress management are key factors in management of this disease. Objectives:The objective of the study was to assess the knowledge regarding PCOS (Polycystic Ovary Syndrome) among Nursing Students. Methodology: The present study has used Quantitative Research Approach and Descriptive Research Design. A total 60 nursing students who were studying in DGNM 3rd year and B.Sc. Hons Nursing 4th year participated in the study. Data was gathered using demographic sheet and structured questionnaire which was administered through online mode after formal permission. Descriptive statistics such as frequency, percentage, means and median and standard deviation were used to describe the demographic profile and level of knowledge regarding PCOS. Result:The study found that majority of Nursing Students (60%) have average knowledge, 38.33% have Good knowledge and 1.66% have poor knowledge regarding Polycystic Ovary Syndrome. Conclusion:The finding of the study indicates that the majority of the Nursing students had average knowledge regarding Polycystic Ovary Syndrome (PCOS).

scholarly journals Incidence of stroke in the diabetic and non-diabetic population in Upper Austria (2008-2012) and

2015 ◽  
Vol 44 (3) ◽  
pp. 69-83
Author(s):  
Karl Schableger ◽  
Lisa Inreiter
Keyword(s):  
Relative Risk ◽  
Confidence Interval ◽  
Population Attributable Risk ◽  
Population Based ◽  
Incidence Rates ◽  
Study Data ◽  
Attributable Risk ◽  
Stroke Incidence ◽  
Upper Austria ◽  
Diabetic Population

Abstract: Background and Purpose: Although it is generally known that diabetes has a negative effect on the stroke incidence, only a limited number of long-term population-based studies focus on the comparison of incidence rates of stroke in diabetics and non-diabetics. Hence, the aim of this study was to estimate the risk of stroke in the diabetic and the non-diabetic population with the help of incidence rates and effect measures. Methods: For this study, data from the Upper Austrian stroke register and the statutory Upper Austrian health insurance (1.3 million members) was used to analyse all first strokes from 2008-2012. This was done by assessing stroke incidence for the total, the diabetic and the non-diabetic population. The analysis was mainly conducted on an age/sex-specific basis. Moreover, age/sex-standardized incidence rates were calculated as well. In addition, effect measures like the relative risk, the attributable risk among exposed and the population attributable risk were computed. Results: Out of the total cohort of 1,319,761 subjects, 17,663 had a first stroke (mean age (Sd.): 71.6 (±14.3) years; 46.0 per cent male). Among these, 19.5 per cent were classified as diabetics. Concerning the stroke standardized incidence rates of the Upper Austrian population (per 100,000 person years), the following results were obtained for the diabetic and the non-diabetic population respectively: men: 571.9 (95%-confidence interval: 530.1-613.6), 319.3 (95%-confidence interval: 311.3-327.2); women: 600.9 (95%-confidence interval: 559.3-642.5), 343.5 (95%-confidence interval: 335.7-351.3). The age-standardised relative risk was found to be 1.79 (95%-confidence interval: 1.66-1.93) for men and 1.75 (95%-confidence interval: 1.63-1.88) for women. Attributable risks among exposed are as follows: men: 0.44 (95%-confidence interval: 0.40-0.48); women: 0.43 (95%-confidence interval: 0.39-0.47). For the population attributable risks 0.08 (95%-confidence interval: 0.04-0.11) was obtained for men and 0.07 (95%-confidence interval: 0.04-0.09) for women. Conclusion: This investigation showed that the stroke risk in the diabetic population is significantly higher compared to the non-diabetic population.

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