scholarly journals Investigating the marital satisfaction in terms of gender: A meta-analysis studyEvlilik doyumunun cinsiyet açısından incelenmesi: Bir meta-analiz çalışması

2017 ◽  
Vol 14 (4) ◽  
pp. 3328
Author(s):  
Rüstem Göktürk Haylı ◽  
Emine Durmuş ◽  
Ali Kış
Keyword(s):  
Marital Satisfaction ◽  
Effect Size ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Fixed Effects Model ◽  
Random Effects Models ◽  
Marriage Satisfaction ◽  
Relevant Field ◽  
Trim And Fill ◽  
Fail Safe

The purpose of this research is to apply a meta-analysis to determine whether there is a difference in marital satisfaction according to gender. For this purpose, 64 thesis about the subject of marriage satisfaction was reached from the databases of National Thesis Center of the Council of Higher Education. Theses included 27 theses with gender variables and data that correspond to the coding protocol. The sample of the study consisted of a total of 6,755 people including 3418 female (50,6%) and 3337 male (49,4%). The effect size of marriage satisfaction by sex was determined by using the Standardized Mean Difference (SMD) analysis method known as Cohen’s d in the literature. As a result of Egger's Regression Test, Orwin's Fail-Safe N, Duval and Tweedie's Trim and Fill method and funnel graph, it was determined that there was no publication bias in the research. In the study, a negligible effect size in favour of male was found both the fixed effects model and random effects models (Fixed: d = -0.12 Random: d = -0.08) and the study was heterogeneous (Q = 94.83, p = 0.00, I2 = 72, 58). The findings of the research were discussed in the context of the relevant field and some suggestions were presented.Extended English abstract is in the end of PDF (TURKISH) file.ÖzetBu araştırmanın amacı, evlilik doyumunda cinsiyete göre fark olup olmadığını belirlemek için bir meta-analiz uygulamaktır. Bu amaçla Yükseköğretim Kurulu Başkanlığı Ulusal Tez Merkezi Veri Tabanından evlilik doyumunu konu alan 64 teze ulaşılmıştır. Bu tezlerden cinsiyet değişkenine yer verilen ve kodlama protokolüne uyan veriler içeren 27 tez, araştırmaya dahil edilmiştir. Araştırmanın örneklemini 3418’i kadın (%50,6), 3337’si erkek (%49,4) olmak üzere toplam 6755 kişi oluşturmaktadır. Evlilik doyumunun cinsiyete göre etki büyüklüğü, alan yazında Cohen d olarak bilinen Standardize Ortalamalar Farkı (SOF) analiz yöntemi kullanılarak belirlenmiştir. Yayın yanlılığını belirlemek amacıyla uygulanan Egger’in Regresyon Testi, Orwin’in Güvenli N Sayısı, Duval ve Tweedie’nin Kırp ve Doldur yöntemi ve huni grafiği sonucunda araştırmada yayın yanlılığı olmadığı saptanmıştır. Araştırmada hem sabit etkiler hem de rastgele etkiler modeline göre erkekler lehine önemsiz düzeyde (SEM: d=-0.12 REM: d=-0.08) bir etki büyüklüğü saptanmış ve araştırmanın heterojen (Q=94.83, p=0,00; I2= 72,58) olduğu belirlenmiştir. Araştırmanın bulguları ilgili alan yazın çerçevesinde tartışılmış ve birtakım öneriler sunulmuştur.

scholarly journals The efficacy of n-3 fatty acids DHA and EPA (fish oil) for perinatal depression

2010 ◽  
Vol 104 (11) ◽  
pp. 1577-1585 ◽  
Author(s):  
Linda A. W. Jans ◽  
Erik J. Giltay ◽  
A. J. Willem Van der Does
Keyword(s):  
Effect Size ◽  
Fixed Effects ◽  
Perinatal Depression ◽  
Post Partum ◽  
Meta Analysis ◽  
Placebo Treatment ◽  
Small Sample ◽  
Future Research ◽  
Fixed Effects Model ◽  
Beneficial Effects

Depressive symptoms are common during pregnancy and the post-partum period. Although essential n-3 PUFA may have beneficial effects on depression, it remains unclear whether they are also effective for perinatal depression. The purpose of the present study was to assess the efficacy of n-3 supplementation for perinatal depression, by performing a meta-analysis on currently available data. After a thorough literature search, we included seven randomised controlled trials in the meta-analysis, all with EPA and/or DHA supplementation. Most studies were judged to be of low-to-moderate quality, mainly due to small sample sizes and failure to adhere to Consolidated Standards of Reporting Trials guidelines. Some studies were not primarily designed to address perinatal depression. A total of 309 women on n-3 fatty acid supplementation were compared with 303 women on placebo treatment. n-3 Supplementation was not found to be significantly more effective than placebo at post-treatment with a pooled effect size (Hedges's g) of − 0·03 (95 % CI − 0·18, 0·13; P = 0·76) using a fixed-effects model. Heterogeneity was low-to-moderate (I2 = 30 %). In a subgroup analysis of three small studies of pregnant women with major depression, there was some indication of effectiveness (effect size 0·17; 95 % CI − 0·21, 0·55). In conclusion, the question of whether EPA and DHA administration is effective in the prevention or treatment of perinatal depression cannot be answered yet. Future research should focus on women who are clinically depressed (or at risk). The quality of research in this area needs to improve.

scholarly journals Methylation of Ecadherin gene is correlated with increased risk of nasopharyngeal carcinoma: A meta-analysis

2020 ◽  
Vol 9 (1) ◽  
pp. 28-40
Author(s):  
Truong Kim Phuong ◽  
Lao Duc Thuan ◽  
Nguyen Thi Hoang Trinh ◽  
Nguyen Thi Phuong Dieu ◽  
Nguyen Thi Le
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Promoter Methylation ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Nasopharyngeal Cancer ◽  
Clinical Samples ◽  
Fixed Effects Model ◽  
Random Effects Models ◽  
Increased Risk ◽  
Data Heterogeneity

Background: The objective of this study was to estimate the correlation between the Ecadherin (CDH1) promoter methylation and the risk of nasopharyngeal cancer. Methods: Based on previous online articles for the evaluation the hypermethylated status of CDH1 gene at the promoter region with nasopharyngeal carcinoma, two independent reviewers selected studies through databases on PubMed, Google Scholar from 2001 to 2014. The software MedCalc® version 18.11 was applied for calculating pooled odd ratios (OR) with levels of data heterogeneity by the fixed and random effects models. Results: Of a total of 99 articles, 12 studies with 508 clinical samples of nasopharyngeal carcinoma patients and 282 normal samples were selected in the systematic review for meta-analysis. Overall, the results demonstrated the highly significant association between CDH1 promoter methylation with nasopharyngeal carcinoma under the fixed effects model (OR = 16.155, 95% CI: 8.533 - 30.585, p

scholarly journals Examination of nutritional knowledge levels of physical education and sports stakeholders in gender variable: A systematic review and meta-analysis

2021 ◽  
Vol 25 (5) ◽  
pp. 299-306
Author(s):  
Şakir Tüfekçi ◽  
Hulusi Böke ◽  
Oğuzhan Altungül
Keyword(s):  
Physical Education ◽  
Effect Size ◽  
Fixed Effects ◽  
Dietary Habits ◽  
Meta Analysis ◽  
Nutrition Knowledge ◽  
Fixed Effects Model ◽  
Nutritional Knowledge ◽  
Knowledge Levels ◽  
The Impact

Background and Study Aim. Nutrition knowledge is related to dietary behavior in athletes. Therefore, it may also have an impact on performance. Athletes with better nutrition knowledge have more healthy dietary habits. This meta-analysis study focused on the impact of gender on the nutrition knowledge levels of physical education and sports stakeholders. Material and Methods. This study adopted a meta-analysis research design, which is used to analyze, synthesize, and interpret quantitative findings from an array of studies through advanced statistical techniques. A meta-analysis involves combining the findings of studies carried out in different places and at different times on the same topic and obtaining a quantitatively accurate result based on a large sample. This study employed the Comprehensive Meta-Analysis (CMA, v. 2.0) to determine effect sizes and the variance of each study and to compare groups. Cohen’s kappa intercoder reliability and outlier tests were performed using the Statistical Package for Social Sciences (SPSS). Results. We focused on 31 studies with a total sample size of 4575. We calculated the effect size of each study. We found a statistically significant effect size in favor of female stakeholders (d = 0.15; 95% CI -0.22 -0.09) in the fixed effects model, which was a weak result according to Cohen’s classification. We determined a statistically significant effect size in favor of female stakeholders (d = 0.15; 95% CI -0.29-0.01) in the random-effects model. These results suggest a slight difference in nutrition knowledge levels between male and female physical education and sports stakeholders. This result can pave the way for further research. Conclusions. It is understood from the physical education and sports stakeholders that there is a weak difference in the nutritional knowledge levels of women compared to men. It is thought that people who study on sports nutrition and nutrition programs will benefit from the present finding. In addition, it is estimated that the researches to be carried out on the relevant subject will take the current study as a reference.

Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis

2011 ◽  
Vol 36 (6) ◽  
pp. 892-903 ◽  
Author(s):  
Elliott M. McMillan ◽  
Ian J. Newhouse
Keyword(s):  
Effect Size ◽  
Fixed Effects ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Fixed Effects Model ◽  
Control Groups ◽  
Exercise Interventions ◽  
Cancer Related Fatigue ◽  
Effective Treatment Modality ◽  
Underlying Mechanisms

The use of exercise interventions to manage cancer-related fatigue (CRF) is a rapidly developing field of study. However, results are inconsistent and difficult to interpret across the literature, making it difficult to draw accurate conclusions regarding the true effectiveness of exercise interventions for CRF management. The aims of this study were to apply a meta-analysis to quantitatively assess the effects of exercise intervention strategies on CRF, and to elucidate appropriate exercise prescription guidelines. A systematic search of electronic databases and relevant journals and articles was conducted. Studies were eligible if subjects were over the age of 18 years, if they had been given a diagnosis of or had been treated for cancer, if exercise was used to treat CRF as a primary or secondary endpoint, and if the effects of the intervention were evaluated quantitatively and presented adequate statistical data for analysis. A total of 16 studies, representing 1426 participants (exercise, 759; control, 667) were included in a meta-analysis using a fixed-effects model. The standardized mean difference effect size (SMD) was used to test the effect of exercise on CRF between experimental and control groups. The results indicate a small but significant effect size in favour of the use of exercise interventions for reducing CRF (SMD 0.26, p < 0.001). Furthermore, aerobic exercise programs caused a significant reduction in CRF (SMD 0.21, p < 0.001) and overall, exercise was able to significantly improve aerobic and musculoskeletal fitness compared with control groups (p < 0.01). Further investigation is still required to determine the effects of exercise on potential underlying mechanisms related to the pathophysiology of CRF.

Publication and Related Biases

2013 ◽  
Author(s):  
Michael D. Jennions ◽  
Christopher J. Lortie ◽  
Michael S. Rosenberg ◽  
Hannah R. Rothstein
Keyword(s):  
Model Selection ◽  
Publication Bias ◽  
Effect Size ◽  
Statistical Tests ◽  
Meta Analysis ◽  
Narrow Sense ◽  
Funnel Plots ◽  
Trim And Fill ◽  
Fail Safe ◽  
Nonparametric Correlation

This chapter discusses the increased occurrence of publication bias in the scientific literature. Publication bias is associated with the inaccurate representation of the merit of a hypothesis or idea. A strict definition is that it occurs when the published literature reports results that systematically differ from those of all studies and statistical tests conducted; the result is that false conclusions are drawn. The chapter presents five main approaches used to either detect potential narrow sense publication bias or assess how sensitive the results of a meta-analysis are to the possible exclusion. These include funnel plots, tests for relationships between effect size and sample size using nonparametric correlation or regression, trim and fill method, fail-safe numbers, and model selection.

scholarly journals An Estimate of Global Anthrax Prevalence in Livestock: A Meta-analysis

2021 ◽  
pp. 1263-1271
Author(s):  
Bylaiah Sushma ◽  
Seema Shedole ◽  
Kuralayanapalya Puttahonnappa Suresh ◽  
Gowda Leena ◽  
Sharanagouda S. Patil ◽  
...  
Keyword(s):  
High Risk ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Economic Loss ◽  
Control Measures ◽  
Fixed Effects Model ◽  
Random Effects Models ◽  
Online Databases ◽  
Pooled Prevalence

Background and Aim: Anthrax, caused by the soil-borne spore-forming bacteria called Bacillus anthracis, is a zoonotic disease that persists worldwide in livestock and wildlife and infects humans. It is a great hazard to livestock; henceforth, evaluating the global concerns about the disease occurrence in livestock is essential. This study was conducted to estimate the global prevalence of anthrax and predict high-risk regions, which could be an input to veterinarians to take necessary steps to control and avoid the disease. Materials and Methods: A literature review was performed using online databases, namely, PubMed, Google Scholar, Scopus, Biomed Central, and Science Direct, to extract relevant publications worldwide between 1992 and 2020. Initially, 174 articles were selected, and after scrutinizing, 24 articles reporting the prevalence of anthrax were found to be adequate for the final meta-analysis. The statistical study was accompanied by employing fixed effects and random effects models using R. Results: The pooled prevalence of anthrax globally was 28% (95% confidence interval, 26-30%) from 2452 samples through the fixed effects model. Continent-wise subgroup analysis through the random effects model revealed that the pooled prevalence of anthrax was highest in Africa (29%) and least in North America (21%). Conclusion: In these publications, anthrax causes economic loss to farmers and, thus, to the world. Hence, controlling anthrax infections in high-risk regions are essential by implementing appropriate control measures to decrease the effect of the disease, thereby reducing economic loss.

scholarly journals Effects of dutasteride on prostate cancer incidence: A systematic review and meta-analysis

2020 ◽  
Vol 11 (4) ◽  
pp. 7266-7270
Author(s):  
Gyeong-Eun Min ◽  
Haesoo Kim ◽  
Da Eun Lee ◽  
Kisok Kim
Keyword(s):  
Prostate Cancer ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Adult Males ◽  
Fixed Effects Model ◽  
Random Effects Models ◽  
Benign Prostate Hypertrophy ◽  
Fixed And Random Effects ◽  
Meta Analyses

5-Alpha-reductase inhibitors (5-ARIs) are used in the treatment of benign prostate hypertrophy (BPH). 5-ARIs, such as finasteride and dutasteride, suppress the biosynthesis of dihydrotestosterone (DHT), a precursor of androgen, which is closely related to the incidence of prostate cancer (PCa). A previous meta-analysis demonstrated a relationship between finasteride use and the incidence of PCA. However, there have been no meta-analyses on the relationship between PCa and dutasteride alone. This meta-analysis was performed to examine the prevalence of PCa in adult males taking dutasteride. We searched PubMed for reports regarding PCa risk and dutasteride use. The study was conducted according to the PRISMA guidelines for systematic reviews and meta-analyses. The analytic hierarchy process (AHP) method was used to weight the studies. Odds ratios (ORs), 95% confidence intervals (CIs), and P-values were calculated using fixed- and random-effects models. A total of eight articles were included in the meta-analysis. The overall OR for both the fixed- and random-effects models was 0.669 and the 95% CI for the random-effects model (0.526–0.851; P = 0.006) was wider than that for the fixed effects model (0.548–0.817; P < 0.001). This study confirmed that the incidence of PCa was significantly reduced by taking dutasteride.

A Systematic Review and Meta-Analysis about the Effect of Bisphosphonates on the Risk of Skeletal-Related Event in Men with Prostate Cancer

2020 ◽  
Vol 20 (13) ◽  
pp. 1604-1612
Author(s):  
Congcong Wu ◽  
Hua Jiang ◽  
Jianghua Chen
Keyword(s):  
Prostate Cancer ◽  
Fixed Effects ◽  
Data Extraction ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Control Group ◽  
Fixed Effects Model ◽  
Related Event ◽  
Mineral Density ◽  
Skeletal Related Event

Background: Although the adjuvant therapy of bisphosphonates in prostate cancer is effective in improving bone mineral density, it is still uncertain whether bisphosphonates could decrease the risk of Skeletal- Related Event (SRE) in patients with prostate cancer. We reviewed and analyzed the effect of different types of bisphosphonates on the risk of SRE, defined as pathological fracture, spinal cord compression, radiation therapy to the bone, surgery to bone, hypercalcemia, bone pain, or death as a result of prostate cancer. Methods: A systemic literature search was conducted on PubMed and related bibliographies. The emphasis during data extraction was laid on the Hazard Ratio (HR) and the corresponding 95% Confidence Interval (CI) from every eligible Randomized Controlled Trial (RCT). HR was pooled with the fixed effects model, and preplanned subgroup analyses were performed. Results: 5 RCTs (n = 4651) were included and analyzed finally after screening 51 articles. The meta-analysis of all participants showed no significant decrease in the risk of SRE when adding bisphosphonates to control group (HR = 0.968, 95% CI = 0.874 - 1.072, p = 0.536) with low heterogeneity (I2 = 0.0% (d.f. = 4) p = 0.679). There was no significant improvement on SRE neither in the subgroups with Metastases (M1) or Castration-Sensitive Prostate Cancer (CSPC) (respectively HR = 0.968, 95% CI = 0.874 - 1.072, p = 0.536, I2 = 0.0% (d.f. = 4) p = 0.679; HR = 0.954, 95% CI = 0.837 - 1.088, p = 0.484, I2 = 0.0% (d.f. = 3) p = 0.534). Conclusion: Our study demonstrated that bisphosphonates could not statistically significantly reduce the risk of SRE in patients with prostate cancer, neither in the subgroups with M1 or CSPC.

scholarly journals Dyslipidaemia and mortality in COVID-19 patients - a meta-analysis

QJM ◽  
2021 ◽  
Author(s):  
Marco Zuin ◽  
Gianluca Rigatelli ◽  
Claudio Bilato ◽  
Carlo Cervellati ◽  
Giovanni Zuliani ◽  
...  
Keyword(s):  
Random Effects ◽  
Mortality Risk ◽  
Meta Analysis ◽  
Random Effect ◽  
Final Analysis ◽  
Short Term ◽  
Random Effects Models ◽  
Pooled Prevalence ◽  
Statistical Heterogeneity ◽  
Trim And Fill

Abstract Objective The prevalence and prognostic implications of pre-existing dyslipidaemia in patients infected by the SARS-CoV-2 remain unclear. To perform a systematic review and meta-analysis of prevalence and mortality risk in COVID-19 patients with pre-existing dyslipidaemia. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE and Scopus to locate all the articles published up to January 31, 2021, reporting data on dyslipidaemia among COVID-19 survivors and non-survivors. The pooled prevalence of dyslipidaemia was calculated using a random effects model and presenting the related 95% confidence interval (CI), while the mortality risk was estimated using the Mantel-Haenszel random effects models with odds ratio (OR) and related 95% CI. Statistical heterogeneity was measured using the Higgins I2 statistic. Results Eighteen studies, enrolling 74.132 COVID-19 patients [mean age 70.6 years], met the inclusion criteria and were included in the final analysis. The pooled prevalence of dyslipidaemia was 17.5% of cases (95% CI: 12.3-24.3%, p &lt; 0.0001), with high heterogeneity (I2=98.7%). Pre-existing dyslipidaemia was significantly associated with higher risk of short-term death (OR: 1.69, 95% CI: 1.19-2.41, p = 0.003), with high heterogeneity (I2=88.7%). Due to publication bias, according to the Trim-and-Fill method, the corrected random-effect ORs resulted 1.61, 95% CI 1.13-2.28, p &lt; 0.0001 (one studies trimmed). Conclusions Dyslipidaemia represents a major comorbidity in about 18% of COVID-19 patients but it is associated with a 60% increase of short-term mortality risk.

scholarly journals Statin use and clinical outcomes in patients with COVID-19: An updated systematic review and meta-analysis

2021 ◽  
pp. postgradmedj-2020-139172
Author(s):  
Rimesh Pal ◽  
Mainak Banerjee ◽  
Urmila Yadav ◽  
Sukrita Bhattacharjee
Keyword(s):  
Clinical Outcomes ◽  
Observational Studies ◽  
Fixed Effects ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Adverse Outcomes ◽  
Fixed Effects Model ◽  
Adjusted Risk ◽  
Risk Estimates ◽  
Statin Use

PurposeObservations studies have shown that prior use of statins is associated with a reduced risk of adverse clinical outcomes in patients with COVID-19. However, the available data are limited, inconsistent and conflicting. Besides, no randomised controlled trial exists in this regard. Hence, the present meta-analysis was conducted to provide an updated summary and collate the effect of statin use on clinical outcomes in COVID-19 using unadjusted and adjusted risk estimates.MethodsPubMed, Scopus and Web of Science databases were systematically searched using appropriate keywords till December 18 2020, to identify observational studies reporting clinical outcomes in COVID-19 patients using statins versus those not using statins. Prior and in-hospital use of statins were considered. Study quality was assessed using the Newcastle-Ottawa Scale. Unadjusted and adjusted pooled odds ratio (OR) with 95% CIs were calculated.ResultsWe included 14 observational studies pooling data retrieved from 19 988 patients with COVID-19. All the studies were of high/moderate quality. Pooled analysis of unadjusted data showed that statin use was not associated with improved clinical outcomes (OR 1.02; 95% CI 0.69 to 1.50, p=0.94, I2=94%, random-effects model). However, on pooling adjusted risk estimates, the use of statin was found to significantly reduce the risk of adverse outcomes (OR 0.51; 95% CI 0.41 to 0.63, p<0.0005, I2=0%, fixed-effects model).ConclusionsStatin use is associated with improved clinical outcomes in patients with COVID-19. Individuals with multiple comorbidities on statin therapy should be encouraged to continue the drug amid the ongoing pandemic.

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