Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis

2011 ◽  
Vol 36 (6) ◽  
pp. 892-903 ◽  
Author(s):  
Elliott M. McMillan ◽  
Ian J. Newhouse
Keyword(s):  
Effect Size ◽  
Fixed Effects ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Fixed Effects Model ◽  
Control Groups ◽  
Exercise Interventions ◽  
Cancer Related Fatigue ◽  
Effective Treatment Modality ◽  
Underlying Mechanisms

The use of exercise interventions to manage cancer-related fatigue (CRF) is a rapidly developing field of study. However, results are inconsistent and difficult to interpret across the literature, making it difficult to draw accurate conclusions regarding the true effectiveness of exercise interventions for CRF management. The aims of this study were to apply a meta-analysis to quantitatively assess the effects of exercise intervention strategies on CRF, and to elucidate appropriate exercise prescription guidelines. A systematic search of electronic databases and relevant journals and articles was conducted. Studies were eligible if subjects were over the age of 18 years, if they had been given a diagnosis of or had been treated for cancer, if exercise was used to treat CRF as a primary or secondary endpoint, and if the effects of the intervention were evaluated quantitatively and presented adequate statistical data for analysis. A total of 16 studies, representing 1426 participants (exercise, 759; control, 667) were included in a meta-analysis using a fixed-effects model. The standardized mean difference effect size (SMD) was used to test the effect of exercise on CRF between experimental and control groups. The results indicate a small but significant effect size in favour of the use of exercise interventions for reducing CRF (SMD 0.26, p < 0.001). Furthermore, aerobic exercise programs caused a significant reduction in CRF (SMD 0.21, p < 0.001) and overall, exercise was able to significantly improve aerobic and musculoskeletal fitness compared with control groups (p < 0.01). Further investigation is still required to determine the effects of exercise on potential underlying mechanisms related to the pathophysiology of CRF.

scholarly journals The efficacy of n-3 fatty acids DHA and EPA (fish oil) for perinatal depression

2010 ◽  
Vol 104 (11) ◽  
pp. 1577-1585 ◽  
Author(s):  
Linda A. W. Jans ◽  
Erik J. Giltay ◽  
A. J. Willem Van der Does
Keyword(s):  
Effect Size ◽  
Fixed Effects ◽  
Perinatal Depression ◽  
Post Partum ◽  
Meta Analysis ◽  
Placebo Treatment ◽  
Small Sample ◽  
Future Research ◽  
Fixed Effects Model ◽  
Beneficial Effects

Depressive symptoms are common during pregnancy and the post-partum period. Although essential n-3 PUFA may have beneficial effects on depression, it remains unclear whether they are also effective for perinatal depression. The purpose of the present study was to assess the efficacy of n-3 supplementation for perinatal depression, by performing a meta-analysis on currently available data. After a thorough literature search, we included seven randomised controlled trials in the meta-analysis, all with EPA and/or DHA supplementation. Most studies were judged to be of low-to-moderate quality, mainly due to small sample sizes and failure to adhere to Consolidated Standards of Reporting Trials guidelines. Some studies were not primarily designed to address perinatal depression. A total of 309 women on n-3 fatty acid supplementation were compared with 303 women on placebo treatment. n-3 Supplementation was not found to be significantly more effective than placebo at post-treatment with a pooled effect size (Hedges's g) of − 0·03 (95 % CI − 0·18, 0·13; P = 0·76) using a fixed-effects model. Heterogeneity was low-to-moderate (I2 = 30 %). In a subgroup analysis of three small studies of pregnant women with major depression, there was some indication of effectiveness (effect size 0·17; 95 % CI − 0·21, 0·55). In conclusion, the question of whether EPA and DHA administration is effective in the prevention or treatment of perinatal depression cannot be answered yet. Future research should focus on women who are clinically depressed (or at risk). The quality of research in this area needs to improve.

scholarly journals Effect of pretreatment with midazolam on etomidate-induced myoclonus: A meta-analysis

2017 ◽  
Vol 45 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Chengmao Zhou ◽  
Yu Zhu ◽  
Zhen Liu ◽  
Lin Ruan
Keyword(s):  
Incidence Rate ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Group Versus ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Fixed Effects Model ◽  
Control Groups ◽  
Randomized Controlled ◽  
Review Manager

Objective To investigate the effect of pretreatment with midazolam on myoclonus induced by etomidate injection. Methods A meta-analysis was performed using Review Manager software, version 5.2. Two researchers independently searched PubMed, Cochrane Library, and Embase® databases for randomized controlled trials involving patients who underwent etomidate induced general anaesthesia with or without midazolam pretreatment, published between 1990 and 2016. Outcome measures comprised overall myoclonus incidence rate and incidence rate classified by degree of myoclonus following etomidate injection. Data were assessed using a fixed effects model. Results Five studies, comprising 302 patients, were included for analysis. Overall incidence rate of etomidate injection-induced myoclonus was significantly lower in the pooled midazolam group versus controls (relative risk [RR] 0.34, 95% confidence interval [CI] 0.26, 0.44); Results subgrouped by degree of myoclonus showed significantly lower incidence in midazolam groups versus control groups for mild myoclonus (RR 0.56, 95% CI 0.39, 0.80); moderate myoclonus (RR 0.20, 95% CI 0.10, 0.41); and severe myoclonus (RR 0.12, 95% CI 0.04, 0.39). Conclusion Midazolam can effectively prevent etomidate-induced myoclonus, and alleviate the degree of etomidate-induced myoclonus.

scholarly journals Examination of nutritional knowledge levels of physical education and sports stakeholders in gender variable: A systematic review and meta-analysis

2021 ◽  
Vol 25 (5) ◽  
pp. 299-306
Author(s):  
Şakir Tüfekçi ◽  
Hulusi Böke ◽  
Oğuzhan Altungül
Keyword(s):  
Physical Education ◽  
Effect Size ◽  
Fixed Effects ◽  
Dietary Habits ◽  
Meta Analysis ◽  
Nutrition Knowledge ◽  
Fixed Effects Model ◽  
Nutritional Knowledge ◽  
Knowledge Levels ◽  
The Impact

Background and Study Aim. Nutrition knowledge is related to dietary behavior in athletes. Therefore, it may also have an impact on performance. Athletes with better nutrition knowledge have more healthy dietary habits. This meta-analysis study focused on the impact of gender on the nutrition knowledge levels of physical education and sports stakeholders. Material and Methods. This study adopted a meta-analysis research design, which is used to analyze, synthesize, and interpret quantitative findings from an array of studies through advanced statistical techniques. A meta-analysis involves combining the findings of studies carried out in different places and at different times on the same topic and obtaining a quantitatively accurate result based on a large sample. This study employed the Comprehensive Meta-Analysis (CMA, v. 2.0) to determine effect sizes and the variance of each study and to compare groups. Cohen’s kappa intercoder reliability and outlier tests were performed using the Statistical Package for Social Sciences (SPSS). Results. We focused on 31 studies with a total sample size of 4575. We calculated the effect size of each study. We found a statistically significant effect size in favor of female stakeholders (d = 0.15; 95% CI -0.22 -0.09) in the fixed effects model, which was a weak result according to Cohen’s classification. We determined a statistically significant effect size in favor of female stakeholders (d = 0.15; 95% CI -0.29-0.01) in the random-effects model. These results suggest a slight difference in nutrition knowledge levels between male and female physical education and sports stakeholders. This result can pave the way for further research. Conclusions. It is understood from the physical education and sports stakeholders that there is a weak difference in the nutritional knowledge levels of women compared to men. It is thought that people who study on sports nutrition and nutrition programs will benefit from the present finding. In addition, it is estimated that the researches to be carried out on the relevant subject will take the current study as a reference.

scholarly journals Effects of exercise on cancer related fatigue in adults: A literature review and meta-analysis of randomized controlled trials

2018 ◽  
Vol 9 (1) ◽  
pp. 6
Author(s):  
Suma Vijayakumar ◽  
Mi-Yeon Kim ◽  
Eric Chan ◽  
Ayman Allam
Keyword(s):  
Literature Review ◽  
Randomized Controlled Trials ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Randomized Controlled ◽  
Cancer Related Fatigue ◽  
Study Heterogeneity ◽  
Cancer Trajectory

Cancer related fatigue (CRF) is one among the common distressing symptoms experienced by cancer patients. Evidence showed that exercise interventions are effective in decreasing CRF. This review is to evaluate the evidence of the effectiveness of exercise interventions on CRF among adults with varied types of cancer in all phases of the cancer trajectory. A literature review with meta-analysis of randomized controlled trials (RCTs) was conducted. The results of RCTs (n = 20) that examined the effects of exercise on CRF were combined using two approaches: meta-analysis (n = 18) and summative analysis (n = 2). A summary effects size of the standardized mean difference (SMD) with 95% confidence intervals was calculated using random effects model and heterogeneity was assessed with the I2 statistic. The results showed overall, a small but significant decrease in the level of CRF (SMD, -0.32; 95% CI, -0.51 to -0.12; p = .002) was observed following exercise intervention. Subgroup analyses showed that both mixed modes (combination of resistance and aerobic exercises) and aerobic exercises were effective in significantly reducing CRF (p = .033; p = .046 respectively). The results indicated substantial heterogeneity between studies (I2 = 79%; p ≤ .0001). Summative analysis also suggested that exercise may be effective in reducing CRF. In conclusion, both resistance and aerobic exercises may be effective in decreasing CRF in adult patients. The result needs to be interpreted with caution due to considerable between-study heterogeneity.

scholarly journals Investigating the marital satisfaction in terms of gender: A meta-analysis studyEvlilik doyumunun cinsiyet açısından incelenmesi: Bir meta-analiz çalışması

2017 ◽  
Vol 14 (4) ◽  
pp. 3328
Author(s):  
Rüstem Göktürk Haylı ◽  
Emine Durmuş ◽  
Ali Kış
Keyword(s):  
Marital Satisfaction ◽  
Effect Size ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Fixed Effects Model ◽  
Random Effects Models ◽  
Marriage Satisfaction ◽  
Relevant Field ◽  
Trim And Fill ◽  
Fail Safe

The purpose of this research is to apply a meta-analysis to determine whether there is a difference in marital satisfaction according to gender. For this purpose, 64 thesis about the subject of marriage satisfaction was reached from the databases of National Thesis Center of the Council of Higher Education. Theses included 27 theses with gender variables and data that correspond to the coding protocol. The sample of the study consisted of a total of 6,755 people including 3418 female (50,6%) and 3337 male (49,4%). The effect size of marriage satisfaction by sex was determined by using the Standardized Mean Difference (SMD) analysis method known as Cohen’s d in the literature. As a result of Egger's Regression Test, Orwin's Fail-Safe N, Duval and Tweedie's Trim and Fill method and funnel graph, it was determined that there was no publication bias in the research. In the study, a negligible effect size in favour of male was found both the fixed effects model and random effects models (Fixed: d = -0.12 Random: d = -0.08) and the study was heterogeneous (Q = 94.83, p = 0.00, I2 = 72, 58). The findings of the research were discussed in the context of the relevant field and some suggestions were presented.Extended English abstract is in the end of PDF (TURKISH) file.ÖzetBu araştırmanın amacı, evlilik doyumunda cinsiyete göre fark olup olmadığını belirlemek için bir meta-analiz uygulamaktır. Bu amaçla Yükseköğretim Kurulu Başkanlığı Ulusal Tez Merkezi Veri Tabanından evlilik doyumunu konu alan 64 teze ulaşılmıştır. Bu tezlerden cinsiyet değişkenine yer verilen ve kodlama protokolüne uyan veriler içeren 27 tez, araştırmaya dahil edilmiştir. Araştırmanın örneklemini 3418’i kadın (%50,6), 3337’si erkek (%49,4) olmak üzere toplam 6755 kişi oluşturmaktadır. Evlilik doyumunun cinsiyete göre etki büyüklüğü, alan yazında Cohen d olarak bilinen Standardize Ortalamalar Farkı (SOF) analiz yöntemi kullanılarak belirlenmiştir. Yayın yanlılığını belirlemek amacıyla uygulanan Egger’in Regresyon Testi, Orwin’in Güvenli N Sayısı, Duval ve Tweedie’nin Kırp ve Doldur yöntemi ve huni grafiği sonucunda araştırmada yayın yanlılığı olmadığı saptanmıştır. Araştırmada hem sabit etkiler hem de rastgele etkiler modeline göre erkekler lehine önemsiz düzeyde (SEM: d=-0.12 REM: d=-0.08) bir etki büyüklüğü saptanmış ve araştırmanın heterojen (Q=94.83, p=0,00; I2= 72,58) olduğu belirlenmiştir. Araştırmanın bulguları ilgili alan yazın çerçevesinde tartışılmış ve birtakım öneriler sunulmuştur.

A Systematic Review and Meta-Analysis about the Effect of Bisphosphonates on the Risk of Skeletal-Related Event in Men with Prostate Cancer

2020 ◽  
Vol 20 (13) ◽  
pp. 1604-1612
Author(s):  
Congcong Wu ◽  
Hua Jiang ◽  
Jianghua Chen
Keyword(s):  
Prostate Cancer ◽  
Fixed Effects ◽  
Data Extraction ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Control Group ◽  
Fixed Effects Model ◽  
Related Event ◽  
Mineral Density ◽  
Skeletal Related Event

Background: Although the adjuvant therapy of bisphosphonates in prostate cancer is effective in improving bone mineral density, it is still uncertain whether bisphosphonates could decrease the risk of Skeletal- Related Event (SRE) in patients with prostate cancer. We reviewed and analyzed the effect of different types of bisphosphonates on the risk of SRE, defined as pathological fracture, spinal cord compression, radiation therapy to the bone, surgery to bone, hypercalcemia, bone pain, or death as a result of prostate cancer. Methods: A systemic literature search was conducted on PubMed and related bibliographies. The emphasis during data extraction was laid on the Hazard Ratio (HR) and the corresponding 95% Confidence Interval (CI) from every eligible Randomized Controlled Trial (RCT). HR was pooled with the fixed effects model, and preplanned subgroup analyses were performed. Results: 5 RCTs (n = 4651) were included and analyzed finally after screening 51 articles. The meta-analysis of all participants showed no significant decrease in the risk of SRE when adding bisphosphonates to control group (HR = 0.968, 95% CI = 0.874 - 1.072, p = 0.536) with low heterogeneity (I2 = 0.0% (d.f. = 4) p = 0.679). There was no significant improvement on SRE neither in the subgroups with Metastases (M1) or Castration-Sensitive Prostate Cancer (CSPC) (respectively HR = 0.968, 95% CI = 0.874 - 1.072, p = 0.536, I2 = 0.0% (d.f. = 4) p = 0.679; HR = 0.954, 95% CI = 0.837 - 1.088, p = 0.484, I2 = 0.0% (d.f. = 3) p = 0.534). Conclusion: Our study demonstrated that bisphosphonates could not statistically significantly reduce the risk of SRE in patients with prostate cancer, neither in the subgroups with M1 or CSPC.

scholarly journals Remote interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Saïd Ibeggazene ◽  
Rebecca Turner ◽  
Derek Rosario ◽  
Liam Bourke
Keyword(s):  
Systematic Review ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Exercise Interventions ◽  
Exercise Behaviour ◽  
Cancer Services ◽  
The Social ◽  
Intervention Adherence ◽  
Randomised Controlled ◽  
Exercise Guidelines

Abstract Background The COVID-19 pandemic has forced many cancer services to consider a transition to a remote format of delivery that is largely untested. Accordingly, we sought to perform a systematic review of the effects of remotely delivered interventions to improve exercise behaviour in sedentary adults living with and beyond cancer. Methods Eligible studies were randomised controlled trials comparing a remotely delivered exercise intervention to a usual care comparison in sedentary people over 18 years old with a primary cancer diagnosis. Nine electronic databases were searched from inception to November 2020. Results The review included three trials, totalling 186 participants. Two of the included trials incorporated prescriptions that meet current aerobic exercise recommendations, one of which also meets the guidelines for resistance exercise. No trials reported an intervention adherence of 75% or more for a set prescription that meets current exercise guidelines. Conclusion There is little evidence suggesting that remote exercise interventions promote exercise behaviours or improve physical function in sedentary adults living with and beyond cancer. The development and evaluation of novel remote exercise interventions is needed to establish their usefulness for clinical practice. Given the social response to the COVID-19 pandemic, further research in this area is urgently needed.

scholarly journals Statin use and clinical outcomes in patients with COVID-19: An updated systematic review and meta-analysis

2021 ◽  
pp. postgradmedj-2020-139172
Author(s):  
Rimesh Pal ◽  
Mainak Banerjee ◽  
Urmila Yadav ◽  
Sukrita Bhattacharjee
Keyword(s):  
Clinical Outcomes ◽  
Observational Studies ◽  
Fixed Effects ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Adverse Outcomes ◽  
Fixed Effects Model ◽  
Adjusted Risk ◽  
Risk Estimates ◽  
Statin Use

PurposeObservations studies have shown that prior use of statins is associated with a reduced risk of adverse clinical outcomes in patients with COVID-19. However, the available data are limited, inconsistent and conflicting. Besides, no randomised controlled trial exists in this regard. Hence, the present meta-analysis was conducted to provide an updated summary and collate the effect of statin use on clinical outcomes in COVID-19 using unadjusted and adjusted risk estimates.MethodsPubMed, Scopus and Web of Science databases were systematically searched using appropriate keywords till December 18 2020, to identify observational studies reporting clinical outcomes in COVID-19 patients using statins versus those not using statins. Prior and in-hospital use of statins were considered. Study quality was assessed using the Newcastle-Ottawa Scale. Unadjusted and adjusted pooled odds ratio (OR) with 95% CIs were calculated.ResultsWe included 14 observational studies pooling data retrieved from 19 988 patients with COVID-19. All the studies were of high/moderate quality. Pooled analysis of unadjusted data showed that statin use was not associated with improved clinical outcomes (OR 1.02; 95% CI 0.69 to 1.50, p=0.94, I2=94%, random-effects model). However, on pooling adjusted risk estimates, the use of statin was found to significantly reduce the risk of adverse outcomes (OR 0.51; 95% CI 0.41 to 0.63, p<0.0005, I2=0%, fixed-effects model).ConclusionsStatin use is associated with improved clinical outcomes in patients with COVID-19. Individuals with multiple comorbidities on statin therapy should be encouraged to continue the drug amid the ongoing pandemic.

scholarly journals Effects of Exercise Interventions on Weight, Body Mass Index, Lean Body Mass and Accumulated Visceral Fat in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 18 (5) ◽  
pp. 2635
Author(s):  
Hyun Suk Lee ◽  
Junga Lee
Keyword(s):  
Body Mass Index ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Visceral Fat ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Randomized Controlled

(1) Background: Exercise interventions for overweight and obese individuals help reduce accumulated visceral fat, which is an indicator of cardiometabolic risk, but the effectiveness of these interventions is controversial. The purpose of this meta-analysis was to investigate the effectiveness of exercise interventions in overweight and obese individuals in order to reduce weight, body mass index (BMI), and accumulated visceral fat, and increase lean body mass. (2) Methods: Databases were used to select eligible studies for this meta-analysis. Randomized controlled trials with control and experimental groups were included. The degrees of effectiveness of the exercise interventions were computed to assess the benefits on reducing weight, BMI, and accumulated visceral fat, and increasing lean body mass. (3) Results: Sixteen studies were included in this meta-analysis. Participation in exercise interventions reduced weight (d = −0.58 (95% confidence interval (CI), −0.84–−0.31; p < 0.001; k = 9)), BMI (d = −0.50 (95% CI, −0.78–−0.21; p < 0.001; k = 7)), and accumulated visceral fat (d = −1.08 (95% CI, −1.60–−0.57; p < 0.001; k = 5)), but did not significantly increase lean body mass (d = 0.26 (95% CI, −0.11–0.63; p = 0.17; k = 6)). The average exercise intervention for overweight and obese individuals was of moderate to vigorous intensity, 4 times per week, 50 min per session, and 22 weeks duration. (4) Conclusions: Participating in exercise interventions has favorable effects on weight, BMI, and accumulated visceral fat. Further studies considering different modalities, intensities, durations, and measurements of fatness need to be conducted.

scholarly journals Association between early bronchiolitis and the development of childhood asthma: a meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e043956
Author(s):  
Guizuo Wang ◽  
Dong Han ◽  
Zhengdong Jiang ◽  
Manxiang Li ◽  
Shumei Yang ◽  
...  
Keyword(s):  
Early Life ◽  
Fixed Effects ◽  
Late Onset ◽  
Meta Analysis ◽  
Later Life ◽  
Analysis Data ◽  
Fixed Effects Model ◽  
Case Control Studies ◽  
Increased Risk ◽  
Registration Number

ObjectiveEarly life bronchiolitis has been hypothesised to be associated with the subsequent risk of persistent wheezing or asthma. However, the link remains controversial. The objective of our study was to evaluate the association between bronchiolitis before 2 years of age and the late-onset wheezing/asthma.DesignSystematic review and meta-analysis.MethodsPubMed, Embase and Web of Science databases were systematically searched for studies published between 1955 and January 2020. Meanwhile, we also checked through the reference lists of relevant articles to see whether these references included reports of other studies that might be eligible for the review. Cohort and case–control studies assessing the association between early-life bronchiolitis and late-onset wheezing/asthma were included in this meta-analysis. Data were extracted by two independent reviewers. Results were pooled using a random-effects model or fixed-effects model according to the heterogeneity among studies.Results32 original articles with 292 844 participants, which met the criteria, were included in this meta-analysis. Bronchiolitis before 2 years of age was associated with an increased risk of subsequent wheezing/asthma (relative risk=2.46, 95% CI 2.14 to 2.82, p<0.001). After categorising studies into different groups based on age at the end of follow-up, geographical region and study quality, the association still remained significant.ConclusionsThe meta-analysis indicates an association between bronchiolitis before 2 years of age and the wheezing/asthma in later life. Well-designed and highly standardised prospective studies that better address bias due to potential confounding factors are needed to validate the risk identified in our meta-analysis.PROSPERO registration numberCRD42018089453.

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