scholarly journals Effect of Halita mouthwash on oral halitosis treatment: A randomized triple-blind clinical trial

2019 ◽  
Vol 13 (1) ◽  
pp. 31-35
Author(s):  
Zahra Jamali ◽  
Mahdieh Alipour ◽  
Syamand Ebrahimi ◽  
Marzie Aghazadeh
Keyword(s):  
Clinical Trial ◽  
Statistical Analysis ◽  
Side Effects ◽  
Oral Cavity ◽  
Oral Malodor ◽  
Group I ◽  
Significant Difference ◽  
The World ◽  
Chi Squared ◽  
Organoleptic Score

Background. Halitosis (oral malodor) is a common problem all over the world and its prevalence has been estimated at 23‒ 50%. Halitosis originates from oral cavity in 85% of patients. This clinical trial was conducted to evaluate the efficacy of the Halita mouthwash in oral halitosis treatment. Methods. Fifty subjects with an organoleptic score of >2 at baseline participated in this triple-blinded clinical trial. Subjects were divided into 2 groups. Group I subjects (N=25) were instructed to rinse with 0.2% chlorhexidine (CHX) mouthwash twice a day for 1 week. Group II subjects (N=25) used Halita mouthwash with the same instruction. Halitosis was evaluated at baseline and one week after using the mouthwashes by organoleptic method. Data were analyzed with chi-squared and Mann-Whitney U tests (P<0.05). Results. In the Halita group subjects exhibited 2.04±0.65 reduction in OLS. OLS reduction in the chlorhexidine group was 1.95±0.74. Statistical analysis showed no significant difference between the two groups (P>0.05). Conclusion. Based on the results, Halita mouthwash has the same effect on oral halitosis as routine 0.2% CHX mouthwash. Halita mouthwash has fewer side effects because of lower concentration of chlorhexidine. Therefore 0.2% CHX mouthwash could be replaced by Halita mouthwash for the treatment of halitosis.

scholarly journals EFFICACY OF ORAL REFRESHER STRIP CONTAINING FIVE TYPES OF ESSENTIAL OILS ON ORAL MALODOR

2017 ◽  
Vol 10 (17) ◽  
pp. 38
Author(s):  
Fiestaellyzha Eka Hendraputri ◽  
Anton Rahardjo ◽  
Sry Angky Soekanto
Keyword(s):  
Clinical Trial ◽  
Essential Oil ◽  
Oral Cavity ◽  
Essential Oils ◽  
Trial Design ◽  
Controlled Trial ◽  
Tongue Coating ◽  
Oral Malodor ◽  
Double Blind ◽  
Organoleptic Score

Objective: The aim of this study was to determine the efficacy of an oral freshener strip containing five types of essential oils on oral malodor.Methods: This study was a clinical trial using cross-over, randomized-double-blind, and placebo-controlled trial design with 15 male participants. The measured parameters were tongue coating, organoleptic score, and volatile sulfur compounds (VSCs) score.Results: After the essential oil strip dissolved in the oral cavity, there was no significant reduction in tongue coating, but there was significant reduction (p<0.05) in the organoleptic score until 60 minutes after dissolved and VSCs until 30 minutes after dissolved.Conclusion: Essential oil strips are more effective than placebo strips in reducing oral malodor.

scholarly journals Comparing the efficacy and side-effects of PDLASTA® (Pegfilgrastim) with PDGRASTIM® (Filgrastim) in breast cancer patients: a non-inferiority randomized clinical trial

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Safa Najafi ◽  
Maryam Ansari ◽  
Vahid Kaveh ◽  
Shahpar Haghighat
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Single Dose ◽  
Side Effects ◽  
Randomized Clinical Trial ◽  
Cancer Patients ◽  
Injection Site Reaction ◽  
Study Groups ◽  
Breast Cancer Patients ◽  
Significant Difference

Abstract Background The objective of this study was to compare the efficacy and side effects of a single dose (Pegfilgrastim or PDL) or repeated six daily injections (Filgrastim or PDG) during chemotherapy courses in breast cancer patients in a non-inferiority clinical trial. Methods In this randomized clinical trial, 80 patients were recruited and allocated randomly to two equal arms. In one group, a single subcutaneous dose of PDL was injected the day after receiving the chemotherapy regimen in each cycle. The second arm received a subcutaneous injection of PDG for six consecutive days in each cycle of treatment. The side effects of GCF treatment and its effect on blood parameters were compared in each cycle and during eight cycles of chemotherapy. Results Hematologic parameters showed no significant differences in any of the treatment courses between the two study groups. The comparison of WBC (p = 0.527), Hgb (p = 0.075), Platelet (p = 0.819), Neutrophil (p = 0.575), Lymphocyte (p = 705) and ANC (p = 0.675) changes during the eight courses of treatment also revealed no statistically significant difference between the two study groups. Side effects including headache, injection site reaction and muscle pain had a lower frequency in patients receiving PDL drugs. Conclusion It seems that PDL is non-inferior in efficacy and also less toxic than PDG. Since PDL can be administered in a single dose and is also less costly, it can be regarded as a cost-effective drug for the treatment of chemotherapy-induced neutropenia. Trial registration IRCT20190504043465N1, May 2019.

scholarly journals Results of modern tuboperitoneal infertility treatment

2009 ◽  
Vol 66 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Drenka Turjacanin-Pantelic ◽  
Dragana Bojovic-Jovic ◽  
Biljana Arsic ◽  
Eliana Garalejic
Keyword(s):  
Statistical Analysis ◽  
Surgical Treatment ◽  
Infertility Treatment ◽  
P Value ◽  
Modern Approach ◽  
Vitro Fertilization ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background/Aim. A modern approach to surgical treatment of tuboperitoneal infertility is based on laporascopic techniques. The aim of this study was to compare results of tuboperitoneal infertility treatment by the use of laparoscopy and classical laparotomy. Methods. A retrospectiveprospective study on 66 women treated operatively form tuboperitoneal infertility was performed. Data from patient's anamnesis and those related to the surgical treatment results, obtained by the use of an inquiry, were used in retrospective and prospective analysis, respectively. Chi-square test was used in statistical analysis. P value < 0.05 was considered significant. Results. Classical laparotomy was used on 34 women in a period from 1996 to 1997, while 32 women were operated laparoscopically in a period from 1999 to 2000. The results were as follows: a total number of conceived women was 16 (24%), seven in the group I (20.6%) and nine in the group II (28.1%); 13 women were with one pregnancy, six in the group I (17.6%) and seven in the group II (22%). Twice pregnant were three women, one in the group I (2.9%) and two in the group II (6.2%). The resulting pregnancies were: five women with abortion spontaneous, two in the group I (5.9%) and three in the group II (9.4%); two women with extrauterine pregnancy in the group I (5.9%); three with pretemporal birth, one in the group I (2.9%) and two in the group II (6.2%), while six women were with the temporal birth, two in the group I (5.9%) and four in the group II (12.5%). Statistical analysis showed that there was no significant difference in the results between these two groups. Conclusion. Surgical treatment of tubeperitoneal infertility, regardless of the used methods (classical laparotomy or laparoscopy) was successful in a great number of women. These methods have a great advantage over in vitro fertilization, and they should not be ignored.

scholarly journals Determination of Platelets Parameters among People Vaccinated with Oxford-AstraZeneca Vaccine - COVID Vaccine at Khartoum State -Sudan

2021 ◽  
pp. 529-535
Author(s):  
Wafa Salah Eldein Ibrahim Mohamed ◽  
Elharam Ibrahim Abdallah ◽  
Alaa Eltayeb Omer ◽  
Lienda Bashier Eltayeb
Keyword(s):  
Statistical Analysis ◽  
Side Effects ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Muscle Pain ◽  
Healthcare Providers ◽  
Vein Thrombosis ◽  
Significant Difference ◽  
And Gender

Background: The global SARS-CoV-2 vaccination program has been hampered by the rare-and initially inexplicable emergence of vaccine-associated thrombosis, particularly venous territory strokes or other venous obstructions, including portal vein thrombosis, which has been dubbed Vaccine-Induced Thrombotic Thrombocytopenia (VITT). So, this study was conducted to determine platelets parameters among people vaccinated with the AstraZeneca vaccine at Khartoum state. Materials & Methods: A total of 50 AstraZeneca vaccinated participants (22 male and 26 female) were utilized as a case and 50 healthy non-vaccinated participants (21 male and 29 female) were used as control. The age of both groups ranged between (20-62) years with a mean of 34.6 ± 11.9. Platelets parameters were assayed for all patients using Sysmex KX-21. Results: The statistical analysis was performed by using SPSS. The results of the study showed that there was no significant difference in platelets count and platelets indices when compared according to vaccine intake and gender. Also, the most frequent symptoms among vaccinated people were: muscle pain at the site of puncture (56%), fatigue (54%), fever (34%), headache (22%), nausea (16%), and diarrhea (6%) respectively and developed no symptoms (30%). Conclusions: The study concludes that the side effects of the COVID-19 AstraZeneca vaccine in Khartoum state, Sudan was consistent with the manufacturers’ data.  Healthcare providers and recipients of vaccines can be more confident about the safety of Oxford-AstraZeneca COVID-19 vaccines.

scholarly journals Effectiveness of a custom-made natural tooth powder on oral hygiene status of children: A randomized controlled trial

2020 ◽  
Vol 5 (4) ◽  
pp. 125-129
Author(s):  
Sharath Asokan ◽  
◽  
Geetha Priya PR ◽  
Sudhandra Viswanath ◽  
B Kesavaraj ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Streptococcus Mutans ◽  
Oral Hygiene ◽  
Antioxidant Properties ◽  
Diffusion Method ◽  
Group I ◽  
Custom Made ◽  
Significant Difference ◽  
Group Ii ◽  
Natural Tooth

Aim: To evaluate antibacterial, antifungal, antioxidant properties of custom-made natural tooth powder and the effectiveness of custom-made natural tooth powder on the oral hygiene status of children. Methodology: Antibacterial and antifungal properties were determined by agar diffusion method against Streptococcus mutans, Candida albicans and antioxidant properties were determined by DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay. Clinical trial included 60 children aged 8 to 11 years. Oral prophylaxis was done and after a washout period of 10 days, baseline Simplified Oral Hygiene index (OHI-S) scores, plaque scores and Streptococcus mutans colony counts were recorded. Children were randomly divided into two groups: Group I children brushed with custom-made natural tooth powder and Group II children used commercially available natural tooth powder twice daily. At the end of 30 days, post intervention data was collected and statistically analyzed. Results: In-vitro trial showed that the custom-made natural tooth powder exhibited both antimicrobial and antioxidant properties. Intragroup assessment of clinical trial showed significant reduction in the OHI-S [Group I (p=0.03), Group II (p=0.01)] plaque scores [Group I (p=0.05), Group II (p=0.006)] and Streptococcus colony counts [Group I (p=0.000), Group II (p=0.000)] in both the groups. But there was no statistically significant difference between the two groups. Conclusion: The newer custom-made natural tooth powder is effective in oral hygiene maintenance and can be a possible alternative to the commercially available natural tooth powder.

scholarly journals A comparison of airway maintenance by cuffed Oropharyngeal airway (COPA) and laryngeal mask airway (LMA) in spontaneously breathing adult patients

2016 ◽  
Vol 11 (3) ◽  
Author(s):  
Ashraf Zia ◽  
Tahir Chaudhry ◽  
Riaz Hussain ◽  
Tafoorul Islam Ghalani
Keyword(s):  
Statistical Analysis ◽  
Laryngeal Mask Airway ◽  
Head Tilt ◽  
Adult Patients ◽  
Laryngeal Mask ◽  
Oropharyngeal Airway ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Spontaneously Breathing

In this study total hundred patients wee included. Fifty (group I) were subjected to COPA device for airway maintenance and in other fifty (group II) LMA was used. In this study first attempt successful insertion rate in group I was 90% while in group II it was 94%. However statistical analysis showed no significant different in both groups. Regarding maneuvers needed to maintain smooth breathing in group I head tilt was used in 2 %. It is significantly high in group I than in group II. Laboured breathing was seen in 6% in group I while 2% in group II. There was no significant difference in both groups. According to this study LMA is better in all respect as it is easier to insert and better fit in.

scholarly journals Voice changes associated with inhaled steroids 1n obstructive lung disease patients

2020 ◽  
Vol 12 (1) ◽  
pp. 1-7
Author(s):  
Baraka M ◽  
Hossam ElDessouky ◽  
Ahmed Amer Khamees ◽  
Ayman Ali Abd ElFattah ◽  
Eman Ezzat ◽  
...  
Keyword(s):  
Side Effects ◽  
Lung Disease ◽  
Bronchial Asthma ◽  
Obstructive Lung Disease ◽  
Inhaled Corticosteroids ◽  
Group I ◽  
Voice Changes ◽  
Significant Difference ◽  
Local Side ◽  
Laryngeal Examination

Background/Aims: The widespread use of inhaled corticosteroids (ICS) for the treatment of obstructive lung disease may be associated with both systemic and local side effects. These local side effects; including voice problems, oropharyngeal candidiasis, throat clearing, sense of fullness, pharyngitis, and cough, are generally viewed as minor complications of therapy in what is called steroid inhaler laryngitis (SIL). Few studies have been performed to specifically evaluate local side effects of ICS. However, they can be clinically significant, affect patient's quality of life, hinder compliance with therapy, and mask symptoms of more serious disease. The aim of this study is to examine the effect of ICS on the larynx and subsequent voice changes, and highlighting if these voice problems related to the type of inhaled corticosteroids in order to determine the importance of regular laryngeal examination in those patients. Methods: 40patients with bronchial asthma and 40 patients with COPD admitted to Chest department in Menoufia and Zagazig University Hospitals during the period from March 2017 to March 2019 were included in the study. They were divided according to the type of cortisone used into four groups; group (I): beclomethasone dipropionate (BDP) users, group (II): budesonide (BUD) users, group (III): Ciclesonide users and group (IV): fluticasone propionate (FP) users. They were evaluated as regards videolaryngoscopic examination and acoustic analysis Results: The age of the patients with bronchial asthma ranged from 29 to 42years and the age of the patients with COPD ranged from 31 to 43years. There was a statistically significant difference among the four groups of cortisone inhalation regarding laryngoscopic findings; as presence of congestion (diffuse and local), mucus spills on VF and glottis gap were all higher in frequency among the group of patients used fluticasone FP, while least signs found among ciclesonide users. Also, average pitch, Jitter, H/N ratio and MPT were more worsen in fluticasone group when compared with Ciclesonide group. Conclusion: obstructive lung disease patients may suffer from voice problems related to the type of inhaled corticosteroids that could be fade when therapy is stopped. So, regular laryngeal examination in those patients is important.

scholarly journals Efektivitas Vaksinasi Crude dan Soluble Protein Spora Myxobolus Koi terhadap Tingkat Kerusakan Usus Ikan Koi (Cyprinus carpio Koi) [ The Effectivety Crude and Soluble Protein of Myxobolus Koi Spore againts Intestine Different Degrees in Koi (Cyprinus carpio Koi)]

2019 ◽  
Vol 7 (1) ◽  
pp. 55
Author(s):  
Rachma Woro Anggarani ◽  
Gunanti Mahasri ◽  
Lucia Tri Suwanti
Keyword(s):  
Molecular Weight ◽  
Statistical Analysis ◽  
Cyprinus Carpio ◽  
Soluble Protein ◽  
Crude Protein ◽  
Soluble Proteins ◽  
Test Results ◽  
Group I ◽  
Significant Difference ◽  
Cyprinus Carpio Koi

Abstract Myxobolus koi is one species of Myxobolus sp that can cause parasitic diseases in fish called Myxobolusis. Based on the Decree of the Minister of Marine and Fisheries No: KEP.03/MEN/2010 that Myxobolus koi in the list of Fish Quarantine Pests group I. Myxosporean diseases are most numerous in the water can cause Proliferative Kidney Disease (PKD) and Whirling Disease (WD). The aim of this research is to finding, analyzing and determining the protein of spores Myxobolus koi that can effectively reduce the level of damage to the intestinal organs as well as for the prevention myxobolusis on Koi’s. Then for finding, analyzing and determining the protein of spores Myxobolus koi do isolation of spore proteins. The study consisted of three phases examination to preparation and identification of spores, isolation and analyze of crude and soluble protein spores for obtain dose and molecular weight each protein and histopathological test. This research uses descriptive method. The data presented may be narratives, images, tables or charts for each group. Intestinal histopathology test results of research carried scoring Koi’s were analyzed using the Kruskal-Wallis. The results showed a profile crude protein and soluble proteins from spores Myxobolus koi showed that the molecular weight of crude protein Myxobolus koi in this study was 150 kDa and 72 kDa and for soluble protein was 73 kDa. Results scoring the degree of infection caused by exposure to Myxobolus koi then statistically processed with an average yield of scoring in a sequence of 0; 1.6; 0.64 and 0.32. Statistical analysis showed no significant difference in the treatment of K + with crude protein, and K + with soluble proteins. Statistical analysis showed that there were significant differences in treatment with K+ and K-, K- with soluble protein and crude protein and soluble protein. Histopathological changes in the intestine in the form of inflammatory cell infiltration, necrosis and haemorage

scholarly journals Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial

2017 ◽  
Vol 18 (12) ◽  
pp. 1112-1116
Author(s):  
A Nishad ◽  
NS Sreesan ◽  
Joseph Joy ◽  
Lakshmi Lakshmanan ◽  
Joyce Thomas ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Antibacterial Activity ◽  
Randomized Clinical Trial ◽  
Control Group ◽  
Orthodontic Appliances ◽  
Group I ◽  
Fixed Orthodontic Appliances ◽  
Significant Difference ◽  
The Impact ◽  
Experimental Group

ABSTRACT Aim The study aimed to assess the impact of mouthwashes on antibacterial activity of individuals with fixed orthodontic appliances. Materials and methods A total of 60 individuals were considered in the study. Sixty (20 each group) nonextraction class I individuals were randomly divided into experimental and control groups. Group I: Experimental group [chlorhexidine (CHX) mouthwash], group II: Experimental group (neem mouthwash), group III: Control group (distilled water). All the clinical examinations were done at baseline and 30th day respectively, after the start of orthodontic treatment. The mean differences between the different experimental groups were calculated using one-way analysis of variance (ANOVA) test. Results There was no statistical significance at baseline mean plaque index (PI), gingival index (GI) scores, and Streptococcus mutans (SM) colony count between groups. The PI and GI scores among CHX and neem mouthwash groups (p = 0.002, p = 0.032 respectively) were significantly reduced after intervention and also the SM colonies count was reduced in CHX and neem mouthwash groups and there was significant difference between the groups. Conclusion As both mouthwashes showed significant effectiveness on antibacterial activity in individuals with fixed orthodontic appliances, neem mouthwash can be used as an alternative to CHX. Clinical significance It is better to have a sound knowledge regarding the use of mouthwash in long term as fixed orthodontics are associated with accumulation of SM, enamel demineralization, and an increased number of carious lesions, predominantly in sites adjacent to bracket. How to cite this article Nishad A, Sreesan NS, Joy J, Lakshmanan L, Thomas J, Anjali VA. Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial. J Contemp Dent Pract 2017;18(12):1112-1116.

scholarly journals The effectiveness of online metacognitive versus face-to-face counseling on anxiety and metaworry in women with a history of spontaneous miscarriage: A Randomized clinical trial

2020 ◽  
Author(s):  
Mina Ghiasi shaham Abadi ◽  
Tahmineh Farajkhoda ◽  
Hassan Zareei Mahmoodabadi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Secondary Outcome ◽  
Base Line ◽  
Satisfaction Scale ◽  
Face To Face ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Online Group

Abstract BackgroundOnline and face-to-face counseling interventions can be performed on women with a history of miscarriage, which causes their anxiety and metaworry.The aim of this study was to compare effectiveness of metacognitive counseling methods, online and face-to-face, on anxiety and metaworry of women with miscarriage.MethodsIn this parallel randomized clinical trial, 40 women with a history of miscarriage, anxiety and metaworry were randomly assigned to two groups (n = 20/each): group I receiving metacognitive counseling via online network and software, and group II (control) receiving face-to-face metacognitive counseling with same content and time, 90-minute sessions. Data were collected demographic form, Beck Anxiety Inventory, Wellz metaworry questionnaire and satisfaction scale. Primary outcomes included changes in the scores of anxiety, metaworry were measured in both groups in three times including at the base line, and at the end of week eight and twelve of the intervention initiation. Satisfaction with counseling method was assessed as secondary outcome at the end of week eight and twelve of the intervention beginning in both groups.ResultsIn both groups, mean score of anxiety in 12th week was significantly different from before the intervention; difference was more significant in online group (p = 0.04). In both groups, the mean score of metaworry in 12th week had a statistically significant difference compared to the beginning of the study, and the decrease was again more significant in the online group (p = 0.03). Satisfaction with the counseling method had statistically significant difference between the two groups in week eight and twelve (respectively p ≈ 0.00).ConclusionsMetacognitive counseling both online and face-to-face improves anxiety and metaworry in women with miscarriage. Online counseling was more effective, satisfying, and longer compared with face-to-face counseling method, especially in corona virus19 outbreak.Trial registration: ISRCTN, IRCT20181120041707N1, Prospectively registered, Registered 23 May 2019, https://en.irct.ir/trial/35643/ IRCT20181120041707N1

Sign in / Sign up

Export Citation Format

Share Document