scholarly journals A review of the most effective medicinal plants for dermatophytosis in traditional medicine

2018 ◽  
Vol 5 (6) ◽  
pp. 2378-2388 ◽  
Author(s):  
Asghar Sepahvand ◽  
Hossein Eliasy ◽  
Mehdi Mohammadi ◽  
Ali Safarzadeh ◽  
Kimia Azarbaijani ◽  
...  

Fungi can evade the immune system via different processes, including recombination, mitosis, and expression of genes involved in oxidative stress responses. These processes can lead to chronic fungal diseases. Despite the growth of health care facilities, the incidence rate of fungal infections is still considerably high. Dermatophytes represent the main cause of cutaneous diseases. Dermatophytes attack keratinized tissues, such as nail, hair, and stratum corneum, due of their gravitation towards keratin, which leads to dermatophytosis. Medicinal plants have long been used to treat different diseases, and in the recent years, use of plant-based products to fight fungal, bacterial, and parasitic infections have attracted extensive attention. This is because the use of medicinal plants has many advantages, such as decreased costs and fewer side effects. This review article was conducted to report medicinal plants with anti-dermatophytosis properties. Seventy-six articles were retrieved from databases Google Scholar, PubMed, ScienceDirect, and Scopus. After exclusion of duplicate and irrelevant articles, 54 articles were selected. Of the remaining articles, 23 articles were screened and included in this study. According to the findings, Azadirachta indica, Capparis spinosa, Anagallisarvensis, Juglans regia, Inula viscosa, Phagnalon rupestre, Plumbago europaea, Ruscus aculeatus, Ruta chalepensis, Salvia fruticosa, Artemisia judaica, Ballota undulate, Cleome amblyocarpa, Peganum harmala, Teucrium polium, Aegle marmelos, Artemisia sieberi, Cuminum cyminum, Foeniculum vulgare, Heracleum persicum, Mentha spicata, Nigella sativa, and Rosmarinus officinalis are the most effective plants against dermatophytes which have been identified to date.

2021 ◽  
Vol 42 ◽  
pp. e71465
Author(s):  
Asma Djahafi ◽  
Khaled Taibi ◽  
Leila Ait Abderrahim

Herbal medicine is gaining an increasing importance in the management of various ailments, but little is known about traditional practices in Algeria. This ethnopharmacological study aims to document medicinal and aromatic plants used in traditional medicine in the region of Tiaret (northwest of Algeria) in order to contribute to safeguard the local pharmacopoeia as cultural heritage, and to provide a scientific basis for developing novel strategies for such practices which can help for drugs discovery. Semi-structured interviews with 64 traditional healers and herbalists were realized in the region of Tiaret (Algeria) throughout field studies achieved from December 2018 to May 2020. Interviews covered sociodemographic information, popular and vernacular names of the medicinal plants, mode of use and toxicity among other data. Results reveal the use of 107 plant species belonging to 45 families and 97 genera for the treatment of various ailments. Lamiaceae, Apiaceae and Asteraceae were the most represented families. The most frequently cited species were Senna alexandrina Mill. (FC=27), Atriplex halimus L. and Bunium incrassatum Amo (FC=23 each), Foeniculum vulgare Mill. (FC=22), and Matricaria chamomilla L. (FC=21). However, the higher use values were reported for Nigella sativa L. (UV=1.5), Trigonella foenum-graecum L. (UV=1.38), Thymus serpyllum L. (UV=1.2), Ziziphus lotus (L.) Lam. (UV=1.14), Urtica dioica L. (1.13), and Senna alexandrina Mill. (UV=0.52) respectively. Interestingly, Bunium incrassatum Amo, Echinops spinosissimus Turra, Cucurbita moschata Duchesne, Pennisetum glaucum (L.) R.Br and Malus domestica Borkh. were reported for the first time as medicinal plants in the north Africa and Algeria. Moreover, 246 new therapeutic uses were described. It should be noted that Pistacia atlantica Desf., Tetraclinis articulata (Vahl) Mast., Oudneya africana R. Br., Euphorbia guyoniana Boiss. & Reut, Teucrium polium L. and Marrubium deserti (Noë) Coss. are endemic to North Africa-Algeria, Northern and Central Sahara. Furthermore, Artemisia herba-alba Asso, Anacyclus pyrethrum (L.) Lag., Cuminum cyminum L., Saussurea costus (Falc.) Lipsch., Boswellia sacra Flueck. and Pistacia atlantica Desf. are considered threatened, rare or endangered species. Our findings are relevant not only for the future studies and experiments in the search for novel compounds, but also for the safeguard of traditional knowledge and biodiversity.


2014 ◽  
Vol 4 (9) ◽  
pp. 381 ◽  
Author(s):  
Mohammed Saleem Ali-Shtayeh ◽  
Rana Majed Jamous ◽  
Salam Yousef Abu Zaitoun ◽  
Iman Basem Qasem

Background: Cholinesterase inhibitory therapy serves as a strategy for the treatment of Alzheimer’s disease (AD). Several acetylcholinesterase inhibitors (AChEIs) are used for the symptomatic treatment of AD. These compounds have been reported to have adverse effects, including gastrointestinal disturbances. This study was therefore partly aimed at investigating in vitro possible AChEIs in herbal medicines traditionally used in Palestine to treat cognitive disorders, and to point out the role of these plants as potential sources for development of newly potent and safe natural therapeutic agents of AD. Assay of AChE activity plays an important role in vitro characterization of drugs including potential treatments for AD. The most widely used method, is based on Ellman’s method. The reactant used in this method shows chemical reactivity with oxime antidots and thiol leading to false positive reactions. A new alternative assay could be of high interest.Methods: The effect on AChE activity of 92 extracts of 47 medicinal plants were evaluated using a new micro-well plate AChE activity (NA-FB) and Ellman’s assays. In addition, antioxidant activity using DPPH was determined.Results: The main advantages of the new method (NA-FB) is that the colorimetric change is better observable visually allowing spectrophotometric as well as colorimetric assay, and does not show any chemical reactivity with thiol. 67.4% and 37% of extracts inhibited AChE by >50% using the NA-FB and Ellman’s assays, respectively. Using NA-FB assay, 84 extracts interacted reversibly with the enzyme, of which Mentha spicata (94.8%), Foeniculum vulgare (89.81), and Oxalis pes-caprae (89.21) were most potent, and 8 showed irreversible inhibition of  which leaves of Lupinus pilosus (92.02%) were most active. Antioxidant activity was demonstrated by 73 extracts Majorana syriaca (IC50 0.21mg/ml), and Rosmarinus officinalis (0.38) were the most active.Conclusions: NA-FB assay has shown to be simple, accurate, sensitive, spectrophotometric and colorimetric, and superior to Ellman’s, and therefore can be used efficiently for qualitative and quantitative studies of AChEI activities of extracts. Palestinian flora have shown to be a rich source for, new and promising agents (AChEIs) for the treatment of AD Further studies are needed to isolate and identify the active compounds responsible for AChEI activities.Keywords: Alzheimer's disease, ACh, medicinal plants, β-naphthyl acetate, micro-well plate AChE activity Assay (NA-FB)


2021 ◽  
Author(s):  
M. Eddouks ◽  
N. Lahrach ◽  
M. Ajebli ◽  
M. Hebi

Darâa-Tafilalet is considered as one of the charming Moroccan areas concerning the knowledge connected to the traditional use of plants for a therapeutic purpose. This work aims to collect, analyze and evaluate the ethnobotanical knowledge about medicinal plants used in the management of diverse forms of cancer in the Darâa-Tafilalet region. The total number of informants interviewed in this study was 1026 (944 were ordinary local inhabitants and 82 were herbalists). Information was obtained by means of structured and semi-structured interviews with local people. Then, data obtained from interviewees were analyzed by calculating some relative cultural importance (RCI) indices (UV, FUV, ROP and FL). Principal component analysis (PCA) was also involved in this study for comparing some characteristics of species. 101 plants used in folk medicine and belonging to 47 families were identified in this study. The highest UV was attributed to Suaeda vermiculata (0.06897); while, the optimal FUV has been given to Ranunculaceae (0.05956). Concerning the FL values, Nigella sativa, Allium sativum, Allium cepa, Calotropis procera, Foeniculum vulgare and Olea europaea were classified in first with a value cited 100% all for general cancer; whereas Nigella sativa had the highest ROP value (86%). The present enquiry highlighted interesting botanical and cultural findings related to the anticancer ethnomedical knowledge adapted by the local population of Darâa-Tafilalet. However, several experimental and fieldwork studies are needed to give more validity and reliability to such investigation.


2017 ◽  
Vol 23 (2) ◽  
Author(s):  
JAMIL AHMED KHAN ◽  
RAJINDER PAUL

Poonch district of Jammu and Kashmir is a reservoir of enormous natural resources including the wealth of medicinal plants. The present paper deals with 12 medicinal plant species belonging to 8 genera of angiosperms used on pneumonia in cattle such as cows, sheep, goats and buffaloes in different areas of Poonch district. Due to poverty and nonavailability of modern health care facilities, the indigenous people of the area partially or fully depend on surrounding medicinal plants to cure the different ailments of their cattles. Further research on modern scientific line is necessary to improve their efficacy, safety and validation of the traditional knowledge.


Author(s):  
Azadeh Foroughi ◽  
Pouya Pournaghi ◽  
Fariba Najafi ◽  
Akram Zangeneh ◽  
Mohammad Mahdi Zangeneh ◽  
...  

Medicinal plants are considered modern resources for producing agents that could act as alternatives to antibiotics in demeanor of antibiotic-resistant bacteria. The aim of the study was to evaluate the chemical composition and antibacterial activities of essential oil of Foeniculum vulgare (FV) against Pseudomonas aeruginosa and Bacillus subtilis. Gas chromatography mass spectrometry was done to specify chemical composion. As a screen test to detect antibacterial properties of the essential oil, agar disk and agar well diffusion methods were employed. Macrobroth tube test was performed to determinate MIC. The results indicated that the most substance found in FV essential oil was Trans-anethole (47.41 %), also the essential oil of FV with 0.007 g/ml concentration has prevented P. aeruginosa and with 0.002 g/ml concentration has prevented B. subtilis from the growth. Thus, the research represents the antibacterial effects of the medical herb on test P. aeruginosa and B. subtilis. We believe that the article provide support to the antibacterial properties of the essential oil. The results indicate the fact that the essential oil from the plant can be useful as medicinal or preservatives composition.


2017 ◽  
Vol 61 (4) ◽  
pp. 611-621 ◽  
Author(s):  
G. Y. Yang ◽  
W. H. Zhang ◽  
Y. D. Sun ◽  
T. T. Zhang ◽  
D. Hu ◽  
...  

2021 ◽  
Vol 25 ◽  
Author(s):  
Mohamad Hesam Shahrajabian

: One of the principal causes of different disorders is an uncontrolled inflammatory response. Alkaloids, flavonoids, polyphenolic, proanthocyanidin, terpenoid, and steroid compounds are the main reasons for the anti-inflammatory activities of medicinal herbs and plants. The current manuscript introduces a series of potential anti-inflammatory plants, particularly those which are routines in Iranian and Chinese traditional herbal medicine, and simplifies the function and mechanisms of natural constituents for the prevention and treatment of inflammatory disorders. PubMed, Science Direct, Google Scholar, Wiley Online Library, Springer, Taylor, Francis, etc., have been used to search for collecting of scientific publications for a full evaluation of current documentation in the literature showing the importance of medicinal plants with anti-inflammatory characteristics and natural medicines. The most notable medicinal plants with anti-inflammatory activities are Baccharis dracunculifolia, Aconitum bulleyanum, Crateya adansonii, Alliums spp., Centella asiatica, Flos lonicerae, Corydalis dubia, Syringae folium, Coptis chinensis, Casearia decandra, Nigella sativa, Cannabis sativa, Tamarindus indica L., Glycyrrhiza glabra, Panax ginseng, Panax notoginseng, Pistacia vera, Smilax china, Scutellaria baicalensis, Rosemarinus officinalis, Moringa olifera, Pulsatilla radix, Pistacia atlantica, Rullia tuberose, Canarium album, Dodonaea polyandra, Forsythia suspense, Polygala tenuifolia, Radiz Isatidis, Hypericum sampsonii, Geranium koreanum, Typha capensis, Isatidis folium, Ginkgo biloba, Houttuynia cordata, snow lotus, etc. Herbal medicine mainly uses numerous parts of plants or combinations of them to prevent and remedy diseases and promote health. More investigations and clinical experiments are needed to provide more information on the importance of medicinal plants as well as their roles in the treatment and prevention of inflammatory diseases.


Author(s):  
Sonali S Gadge

The COVID-19 has spread all over the world and there is no single drug or medicine for the prevention and the treatment of this deadly disease. One can get prevention from this disease by boosting the immune system. Persons with weak immune system e.g. children, elder patients or patients with preexisting diseases affect rapidly due to coronavirus. This novel coronavirus attacks mainly on the person immunity. For the centuries the herbal medicinal plants have many beneficial effects against deadly viruses. Herbal medicines provide a rich resource for new antiviral drug development. These natural agents interact with the life cycle of virus such as virus entry, replication, assembly and release. In this review, the importance, immunomodulator, antiviral and pharmacological activities of some medicinal plants, namely, Allium Sativum, Zingiber Officinalis, Cinnamomum zeylanicum, Curcuma longa, Ocimum sanctum, Glycyrrhiza glabra, Ginseng, Black pepper, Emblica officinalis, Withania somnifera, Tinospora cordifolia, Echinacea purpurea, Azadirachta indica, Piper betel, Eugenia caryophyllata, Cinchona calisaya, Nigella sativa, Cuminum cyminum are highlighted. These medicinal plants have many phytoconstituents like alkaloids, glycosides, terpenoids, flavonoids, lactones, polysaccharides, volatile oils, tannins, resins, etc which are helpful for boosting immunity and will help in the prevention and in the management of COVID-19. Several types of research attempted to use herbal medicines against COVID-19.


2021 ◽  
Vol 18 (4) ◽  
pp. 87-94
Author(s):  
Amer Abed ◽  
Orooba Ibrahim

The principal objective of the study is to investigate the use of Mentha spicata, Thymus vulgaris and Ocimum basilicum as a good alternative option to Antiprotoscolices in-vitro. Hydatid disease, a zoonotic parasitic infection caused by Echinococcus granulosus, an important economic and human public health problem with a wide geographical distribution. Fertile hydatid cysts were collected from livestock and the viability of the protoscolices was confirmed. Protoscolices were subjected to four different concentrations of organic extracts (12.5, 25, 50 and 75 mg/ml) for 10, 20 and 30 min. Each extract was investigated and viability of the protoscolices was tested using 0.1% eosin staining. The highest efficacy was by T. vulgaris, M. spicata (100%), and O. basilicum (98.8%) respectively, after exposure of 20 minutes at 75 mg/ml, that lead to the significant reduction in the viability of protoscolices. The extract had time-dependent effect. Phytochemical were identified qualitatively and weighted quantitatively, that help in the identification of bioactive compounds involved in selective action on the protoscolices tegument layer. In conclusion, all the selected medicinal plants could be a promising source of potent antiprotoscolices effect. The mechanism by which plant extracts killed protoscolices and also their safety for living cells are unclear and need to be investigated further.


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