scholarly journals Етіологія та клініко-біохімічні показники крові за аліментарної остеодистрофії корів

2017 ◽  
Vol 19 (73) ◽  
pp. 79-83
Author(s):  
L. Slivinska ◽  
S. Demydjuk ◽  
А. Shcherbatyy ◽  
V. Fedorovich ◽  
I. Tyndyk
Keyword(s):  
Clinical Study ◽  
Body Temperature ◽  
Total Protein ◽  
Control Group ◽  
Total Protein Content ◽  
Total Calcium ◽  
Carotene Content ◽  
Excess Calcium ◽  
Caudal Vertebrae ◽  
Mucous Membranes

Established etiological factors of nutritional osteodystrophy cows LLC Danylo Galician Yavoriv district, Lviv region. A clinical study on nutritional osteodystrophy cows. A decrease in productivity, alotriophagy, strained course, lameness, thickening and tenderness of the joints, softening of the caudal vertebrae, in severe cases – the formation of animals have been established. The fatness of most animals was below average, hypotension and atony of the predniegens were observed, body temperature was within the norm. In 50% of cows pallor of the mucous membranes was noted, in 10 cows – tachypnea (47.0 ± 0.45) and tachycardia (110.0 ± 3.65). In 10% of the cows, the thorax was pulled up, and the vertebral trunk – curved upwards. In 5 cows, fluctuations of the teeth were noted. Analyzing the diet of feeding cows, a shortage of phosphorus (10–15 g), cobalt (4–5 mg), zinc (27–110 mg), iodine (5–6 mg), sugar (120–180 g), copper (24–26 mg), carotene content (20–30 mg), excess calcium (14–28 g), iron (1400–2200 mg), manganese (210–360 mg). In the blood of experimental cows, the level of hemoglobin was reduced (by 10.6%), the number of erythrocytes (18.8%) in comparison with the animals in the control group. Leukoformula in cows was characterized by a decrease in the number of basophils (9%), eosinophils (47.6%), stabnoid (82.3%) and segmented (4%) neutrophils, monocytes (13.3%) and an increase in lymphocyte count (11% ). In the blood serum of the experienced, a decrease in the total protein content (7.2%), total calcium (26.3%), carotene (22.8%) and cobalt (58.8%) was established.

scholarly journals State of protein and mineral exchange in broiler-chickens for the use of Zinc and Mangane chelates

2019 ◽  
pp. 85-94
Author(s):  
V. Sakara ◽  
A. Melnyk ◽  
F. Markhenkov
Keyword(s):  
Total Protein ◽  
Broiler Chickens ◽  
Zinc Content ◽  
Calcium Content ◽  
Inorganic Phosphorus ◽  
The Body ◽  
Control Group ◽  
Total Protein Content ◽  
Total Calcium ◽  
Experimental Group

The results of the application of a complex of Zinc and Manganese chelates to protein, macro- and micro-mineral exchanges in the body of broiler chickens of the Cobb 500 cross-breed are presented. The administration of Zn and Mn chelates in a dose of 0,2 ml/l for chicken broilers of 23 days of age (1st experimental group) during 14 days influenced the increase in the total protein content to 35,3±0,8 g/l, which is 8 % higher compared with the control – 32,5±0,7 g/l (p<0,01 ) The concentration of total Calcium in serum of broiler chickens 37-day-old (end of trial) was higher in the first experimental group by 7,3 % (2,05±0,06 mmol/l) compared to control – 1,9±0,03 mmol/l. In the second group, where chelates were administered in a dose of 0,4 ml/l of water, the Calcium content was 2,0±0,02 mmol/l, which is 5 % more than the control group. The two-week application of Zn and Mn chelates also led to an increase in the level of inorganic Phosphorus in the serum of the first group to 2,6±0,12 mmol/l (+ 11,5 %) compared with the control group. After administration of chelates Zn and Mn at doses of 0,2 ml/l water, the Zinc content was higher by 4,3% (23,5±0,2 μmol/l) compared to control – 22,5±0,34 μmol/l (p<0,01). In the second group, where the dose of chelates was 0,4 ml/l, the concentration of Zinc was 23,6±0,16 μmol/l, which is more than 4,6 % for control (p<0,01). At the end of the study, the content of Manganese in serum of broiler chickens in the first group was 1,9±0,07 μmol/l (p<0,05), which is 10,4% higher compared with the control – 1,7±0,06 μmol/l (3rd sampling). The level of this element in the second group was 2,0±0,08 μmol/l (p<0,01), which is higher by 16,7 % relative to the control. At the end of the experiment, the coupon concentration in the first and second experimental groups was 12,6 and 9,3 % higher, compared with control, 7,0±0,37 μmol/l. In turn, the serum Ferrum content of the first group was greater by 9,3 % (19,3±0,69 μmol/l), and the second by 6,7 % (18,8±0,47 μmol/l) compared to the bird of the control group. Key words: chicken broilers, chelates, Zinc, Manganese, Cuprom, Ferrum, metabolism.

scholarly journals Біохімічні показники крові свиноматок за профілактики порушень обміну мінеральних речовин

2017 ◽  
Vol 19 (82) ◽  
pp. 71-76 ◽  
Author(s):  
N.G. Grushanska ◽  
V.М. Kostenko
Keyword(s):  
Blood Serum ◽  
Protein Content ◽  
Total Protein ◽  
Calcium Concentration ◽  
Emission Spectrometry ◽  
Control Group ◽  
Total Protein Content ◽  
Total Calcium ◽  
Pig Production ◽  
Experimental Group

Of all domestic animals, pigs suffer the most from deficiency of minerals. This is due to the specificity of pig production, feeding technology, retention and anatomical – physiological characteristics of pigs. In order to obtain the best qualities of pig production, it is necessary to make correction the ration for swines of various technological groups using mineral feed additives that take into consideration not only the physiological needs for minerals of the corresponding age groups and classes of swines but also the biogeochemical zone or the province where the farm is located. Also, conditions that accompany the emergence of a mineral deficit are taken into account. The development of new, eco-friendly, non-toxic means of preventing disorders of metabolism of minerals in pigs is a promising direction of veterinary medicine.The research was carried out ont the farm of the Kyiv region (northeastern biogeochemical zone). Biochemical parameters of blood were studied using biochemical analyzer «Labline-010» with standard sets of reagents. The content of chemical elements in water was investigated by the method of atomic emission spectrometry on the Optima 210 DV device.The paper presents the authors’ own research on determining the biochemical status of an organism of lactating sows in the northeastern biogeochemical zone of Ukraine at the prevention of microelementosis using new experimental eco-friendly means.The content of total protein, albumin, glucose, total calcium, inorganic phosphorus, cholesterol, bilirubin, activity of ALT, AST, AF in the blood serum of sows of the northern-eastern biogeochemical zone of Ukraine before and after the application of experimental drugs was investigated. The positive influence of prophylactic agents on the parameters of metabolism of proteins and calcium was defined.In the blood serum of the sows of the first experimental group, 28 days later, the total protein content on 5.3% lower and the total calcium concentration on 16.5% higher than the control group  of animals were found.In the blood serum of sows in the second experimental group,  28 days later, the total protein content on 8.3%  lower and the total calcium concentration on 19.9% higher than the control group of animals were found.

The effect of ethanol on some hematological parameters of the australian red claw crayfish (Cherax quadricarinatus)

2022 ◽  
pp. 85-91
Author(s):  
D. Skafar ◽  
D. Shumeyko
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Hematological Parameters ◽  
Group Versus ◽  
Control Group ◽  
Total Protein Content ◽  
Cherax Quadricarinatus ◽  
Total Hemocyte Count ◽  
Red Claw Crayfish ◽  
Experimental Group

Purpose: to study the effect of ethanol on the parameters of THC, the percentage of granulocytes and total protein in the hemolymph of the Red claw crayfish (Cherax quadricarinatus).Materials and methods. The object of this experiment was 26 males of the Australian red-clawed crayfish (Cherax quadricarinatus) weighing from 23 to 83 g. The individuals were evenly divided into two experimental groups - with an injection of ethanol and a control group without an injection of 13 crayfish for each group. The injection dose was 2515 mg per 100 g of body weight. A day after the introduction of ethanol, hemolymph was taken with a syringe from the ventral sinus, the syringe was pre-washed with a 4% EDTA-Na2 solution. Three parameters were determined: the total hemocyte count (THC), percent granulocytes and percent total protein content. Counting of hemocytes and determination of granulocytes were performed in a Goryaev chamber under a light microscope. The total protein was determined by the refractometric method.Results. Differences in THC and total protein between the groups were statistically unreliable (p>0,05). THC in the experimental group is 36% more than in the control group. The total protein after the introduction of ethanol actually increased by 0,7%, and relatively by 14%. There were statistically different indicators of the proportion of granulocytes (p<0,05) - the average value of 33,1% in the experimental group versus 24,5% in the control group. A reliable (p<0,05) strong feedback was revealed between the total protein and the mass of individuals in both experimental groups, while in the experimental group there is a visible shift in the values of dependent hemolymph indicators towards an increase in smaller individuals.Conclusion. A single injection of ethyl alcohol with a dosage of 2515 mg per 100 g of body weight into the hemolymph of C. quadricarinatus does not cause significant changes in the THC and total protein after 24 hours. At the same time, the proportion of granulocytes actually increases by 9%, relative to 37%. This may indicate that granulocytes are involved in the formation of cancer defense mechanisms when exposed to toxic substances. The effect of different dosages of ethanol injections and the duration of its effect on hematological parameters requires additional consideration. It is necessary to investigate its effect on other indicators, such as the pH and buffer capacity of the hemolymph, the concentration of hemocyanin, glucose, lactates and calcium.

scholarly journals Dynamics of individual indicators of protein metabolism in the body of broiler chickens on the background of combined stress when included in the diet “Reasil Humic Vet” + “Laktin” and “Reasil Humic Health”

2020 ◽  
Vol 3 (2) ◽  
pp. 42-46
Author(s):  
V. G. Stoyanovskyy ◽  
M. O. Shevchuk ◽  
I. A. Kolomiiets ◽  
V. A. Kolotnytskyy
Keyword(s):  
Total Protein ◽  
Protein Metabolism ◽  
Broiler Chickens ◽  
Stress Factor ◽  
The Body ◽  
Control Group ◽  
Total Protein Content ◽  
Combined Stress ◽  
Stages Of Development ◽  
Γ Globulins

The body of  broiler chickens is characterized by a high metabolism, which promotes rapid growth and development, but their performance indicators are largely related to housing conditions, which are known to include a number of technological stressors. With the development of stress in the body of poultry changes the course of metabolic processes, which causes changes in all types of metabolism, including protein. The aim of the study was to determine the changes in individual indicators of protein metabolism in the body of broiler chickens against the background of combined stress when included in the diet “Reasil Humic Vet” + “Laktin” and “Reasil Humic Health”. At 13th day of life, all clinically healthy poultry were exposed to combined stress – revaccination (intranasal Newcastle disease) plus cold stress (for 60 minutes by air conditioning and 5 °C in the vivarium). Material for research was selected for 3 days after the action of the stress factor (stage of anxiety), 13, 20 and 26 days after the action of the stress factor (the resistance stage). The material for the study was blood plasma, which determined the concentration of total protein, as well as the content of albumin, globulin fraction (α1, α2, β, γ). It was found that 3 days after the action of stress in chickens of Control group the development of adaptive reactions is manifested by the stability of the total protein content and redistribution of the fractional composition of plasma globulins in the form of increased albumin and α2-globulins. At different stages of development of the stage of resistance in birds of Control group, the content of total protein decreases by an average of 14.6 % due to the content of albumin by 6.9 % and α2-globulins – by 15.9 %, against the background of increasing α1- and γ-globulins by 23.1 and 33.5 % with the stabilization of individual studied indicators at the final stages of development of the resistance stage. The use in the diet of broilers feed “Reasil Humic Vet”, probiotic feed supplement “Laktin”, feed “Reasil Humic Health” under the influence of complex stress helps to increase the intensity of protein metabolism in poultry with the development of adaptation syndrome, as evidenced by the growth of total protein on average by 37.8 % (P < 0.05) and albumin – by 17.0 % (P < 0.05), which indicates an increase in the intensity of protein-synthesizing properties of the organism. In different periods of stress in the blood of broiler chickens Research groups there is an increase in the ratio of individual protein fractions, especially the content of γ-globulins - an average of 21.3 % (P < 0.05), which indicates an increase in the immune status of their body with a predominance of numerical values in the Research 1 group of poultry.

scholarly journals Effect of fundectomy, antrectomy and gastrectomy on pancreatic and brush border enzyme activity in rats

2018 ◽  
Vol 74 (1) ◽  
pp. 6031-2018
Author(s):  
MAŁGORZATA KAPICA ◽  
IWONA PUZIO
Keyword(s):  
Enzyme Activity ◽  
Protein Content ◽  
Brush Border ◽  
Total Protein ◽  
Control Group ◽  
Total Protein Content ◽  
Surgical Removal ◽  
Hormonal Changes ◽  
Serum Samples ◽  
Distal Jejunum

The aim of our study was to investigate the possible effects of the removal of different parts of the stomach (fundectomy, antrectomy, gastrectomy) on the total protein content and enzyme activity in the pancreas and the brush border of the intestinal mucosa. Twenty-four 2.5-month-old male Wistar rats were divided into four groups: sham-operated animals (SHO) and those subjected to gastrectomy (Gx), fundectomy (Fx), and antrectomy (ANT). After a six-week experiment, the rats were sacrificed, and blood was collected for further gastrin analysis in serum. Samples of the pancreas, duodenum, and jejunum (proximal part in 25% of length, middle part in 50% of length, and distal part in 75% of length) were collected to determine the total protein content and enzyme activity. The rats subjected to fundectomy, antrectomy and gastrectomy showed an increased total protein content and enzyme activity (amylase, trypsin) in pancreatic tissue. They exhibited an increase in the total protein content in the homogenates of the mucosa of the proximal, middle and distal jejunum, compared to the control, and a statistical increase in maltase activity. Compared with the control group, the rats subjected to Fx and ANT showed a decreased sucrase activity in the homogenates of the mucosa of the duodenum and of the proximal, middle and distal jejunum. In the gastrectomized rats, there was a statistically significant increase in the total protein content in the homogenates of the mucosa of the jejunum, compared to the control, while the activities of lactase and sucrase were decreased. There was a statistically significant increase in the gastrin level in all experimental groups (Fx, ANT, Gx). We suggest that surgical removal of a part of the stomach radically changes the level of hormones that determine many functions of the organism. Hormonal changes may have an impact on the pancreas and the activity of brush border enzymes. .

scholarly journals The biochemical indicators of a cow organizm at the prevention of microelementosis

2018 ◽  
Vol 20 (83) ◽  
pp. 183-188
Author(s):  
N.G. Grushanska
Keyword(s):  
Total Protein ◽  
Chemical Elements ◽  
Organic Phosphorus ◽  
Zinc Content ◽  
Emission Spectrometry ◽  
Control Group ◽  
Total Calcium ◽  
Creatinine Concentration ◽  
Animal Group ◽  
Mineral Substances

Correction of cattle feed, taking into account the physiological needs of their organism in the mineral substances of the corresponding biogeochemical zone or the province, where the farm is located, as well as the conditions that accompany the emergence of the deficit, promotes the obtaining of quality livestock products. An urgent task of the present is the search for eco-friendly, non-toxic and highly effective, preventive drugs of complex action, which positively affect the metabolism of mineral substances in the animal organism. The research was carried out on the farm of Kyiv region (central biogeochemical zone). We studied the biochemical parameters of blood and saliva using biochemical analyzer «Labline-010» with standard sets of reagents. The content of chemical elements in blood and saliva was investigated by the method of atomic emission spectrometry with inductively coupled plasma using Optima 210 DV device. The paper presents the research on determining the biochemical status of an organism of lactating cows at the prevention of microelementosis using new experimental eco-friendly drug. The content of total protein, albumin, glucose, total calcium, non-organic phosphorus, cholesterol, total bilirubin, aluminium, chrome, copper, zinc, nickel and activity of ALT, AST, ALP, GGT in cow blood and saliva in the first and 28th day for the use of the drug oxyminkor. The diagnostic informativity of saliva content according to the content of mineral substances is determined. In cow blood at the use of the drug oxyminkor for 28th day of the experiment, the content of total protein was determined to be 17% higher, albumin was 19% higher, total calcium was 36 % higher and creatinine concentration was 25% lover, compared with the indicators of the control group. In the cow saliva at the use of the drug oxyminkor on the 28th day of the experiment, the content of zinc was 2.1 times higher, compared with the control animal group. The correlation coefficient for zinc content in cow blood and saliva was 0.80, which points the informativity of this indicator. We defined the positive influence of the prophylactic agent on the metabolism of proteins, minerals and functional state of the cow liver. The introduction of new methods of non-invasive diagnosis and the development of ecological, non-toxic agents for the prevention of mineral disbolism among cows is a promising area of research.

scholarly journals Prediction of birth and postpartum pathology in deep-calving heifers by biochemical parameters of blood

2021 ◽  
Vol 23 (101) ◽  
pp. 21-25
Author(s):  
L. V. Koreyba
Keyword(s):  
Blood Serum ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Mineral Metabolism ◽  
Obstetric Care ◽  
Calcium Content ◽  
Inorganic Phosphorus ◽  
The State ◽  
Total Protein Content ◽  
Carotene Content

The success of the control of obstetric diseases in cattle depends on the timely implementation of preventive measures, and, in cases of pathology, on diagnosis, effective obstetric care and treatment. A prominent place is given to blood tests among the methods that allow to objectively assess the state of health and the course of the pathological process in animals' bodies. The study of biochemical parameters of blood allows for the assessment of the state of metabolic processes in animals, with high accuracy in establishing the body's general condition and predicting complications and adjusting their prevention and therapy. The goal of the work: our work aimed to study the biochemical parameters of the blood of deep-calving heifers for the prediction, correction, and prevention of obstetric pathology during childbirth and puerperium. The research was carried out on deep-calving heifers of Holstein breed selected on the principle of analogues. Biochemical examination of blood serum was performed in the district laboratory of veterinary medicine. Indicators of protein and mineral metabolism were determined in the blood serum of deep- calving heifers: total protein, carotene, reserve alkalinity, inorganic phosphorus, albumin content, class M immunoglobulins. The obtained research results indicate that the total protein content corresponds to the norm in deep-calving heifers of the Holstein black-spotted breed. The protein coefficient exceeds the standard. There are pronounced deviations in the blood's biochemical parameters: low levels of carotene almost two-fold, reserve alkalinity – 1.91-fold, the total calcium content – by 16.08 % and the ratio of calcium to phosphorus by 17.78 %. Since the decrease in carotene content correlates with the predisposition to endometritis, the Holstein black-spotted breed's deep-calving heifers are prone to developing birth and postpartum pathology. For pregnant cows which are predisposed to postpartum obstetric pathology, that occur in weak parturition activity, failure to release the placenta, uterus subinvolution, endometritis and postpartum hypocalcaemia, unfavorable prognostication is the low concentration in blood plasma of general calcium, inorganic phosphorus and carotene.

scholarly journals THE INFLUENCE OF NEW BEDDING MATERIAL ON MORPHOBIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS OF BLOOD OF GOSLINGS OF BROILERS

2021 ◽  
Vol 247 (3) ◽  
pp. 244-248
Author(s):  
V.G. Sofronov ◽  
◽  
R.N. Fayzrakhmanov ◽  
N.I. Danilova ◽  
E.L. Kuznetsova ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Total Protein ◽  
Blood Cells ◽  
Inorganic Phosphorus ◽  
The Body ◽  
Allergic Reactions ◽  
Bedding Material ◽  
Total Calcium ◽  
Immunological Parameters ◽  
Mucous Membranes

The harmlessness of the new hygienic bedding material and the effect of broilers on the body have been studied. During the experiment, it was found that the new hygienic litter material, representing waste from the woodworking industry, treated with thermochemical and biotechnological methods, does not have an irritating effect on the skin, does not irritate the mucous membranes of the eyes and allergic reactions in rabbits, but, on the contrary, improves certain morphobiochemical and immunological parameters of the body’s blood are goslings. Ultimately, this was reflected in an increase in red blood cells by 7.04 %, hemoglobin – 5.20 %, total protein – 6.3 %, total calcium – 5.8 %, inorganic phosphorus – 5.1 %, glucose – 5,4 % compared with the control.

scholarly journals The effect of herbal phytoextract on metabolic parameters of sows and piglets

2021 ◽  
Vol 22 (3) ◽  
pp. 428-435
Author(s):  
A. A. Ivanovsky ◽  
N. A. Latushkina ◽  
E. Yu. Timkina
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Control Group ◽  
Total Protein Content ◽  
Herbal Extracts ◽  
Control Groups ◽  
Normal Range ◽  
Experimental Group ◽  
Experimental Pigs

The purpose of the research was to study the effect of a phytocomplex containing herbal extracts of R. carthamoides, S. coronata, F. ulmaria on blood biochemistry of milking sows, the development and viability of piglets born by the time of weaning. For the experiment, the animals were divided into an experimental (Phytoadditive) and a control (SPK-2 compound feed) groups, 10 animals each. Phytoadditive in dry form was introduced into the diet of pigs of the experimental group during the sucking period (30 days) daily, once per head per day - 10 grams (individually). Before the beginning and at the end of the experiment, the blood of sows was examined for biochemical parameters. The multiplicity, the quality of the piglets born, the weight of the nest and one pig after birth and before weaning, as well as viability were determined. As the result, it was found that the concentration of the investigated extractives in the Phytoadditive was 13.5 g/kg, of which 10.5 g were ecdysteroids and 3.0 g of flavonoid rutin. Significant changes in the total protein content in the blood compared with the beginning of the experiment were noted in experimental pigs from 60.2±0.5 to 67.3±0.2 g/l (P <0.05) and in the control group from 61.0±0.2 to 66.1±0.1 g/l (P <0.05), the "Ca" content from 2.1±0.01 to 2.7±0.02 mmol/l (P <0.05) in the experimental group and from 2.0±0.01 to 2.5±0.02 mmol/l (P <0.05) in the control groups, while being within the normal range. The amount of albumin significantly increased only in the experimental group from 40.8±1.2 to 49.3±2.8 g/l (P <0.05), in the control from 42.2±2.1 to 46.0±1.5 g/l (P> 0.05). The number of piglets with low viability in the experimental group was 2 times less than in the control group. The viability of piglets in the experimental group by the time of weaning was 92.6 %, in the control ‒ 83.2 %.

scholarly journals Levels of proteins and immunoglobulins in rabbit blood during Рassalurosis

2019 ◽  
pp. 91-95
Author(s):  
Yu. V. Duda ◽  
M. P. Prus
Keyword(s):  
Uric Acid ◽  
Total Protein ◽  
Acid Output ◽  
Immune Defense ◽  
Control Group ◽  
Total Protein Content ◽  
Protein Ratio ◽  
Γ Globulins ◽  
Group A ◽  
High Level

The purpose of our work was to determine the influence of Passalurus ambiguus on proteinogram and the level of immunoglobulins in the blood of rabbits. Analog groups of male rabbits of 3–5 months of age were selected for the experiments. Intensity of invasion was determined by the method of the MacMaster. By spectrophotometric method in the blood of animals there was determined: the content of total protein, albumin, globulin fractions, the level of IgA, IgG, IgM — discrete deposition method according to M. Kostina. Rabbits with pasalurosis have different levels of invasion intensity (II): low (II = 276.47 ± 43.33 eggs/g of feces), high (II = 2,446.67 ± 422.11 eggs/g of feces) — II and medium (II = 1,293.75 ± 275.80 eggs/g of feces) — III research groups. We did not find eggs in the control group. The total protein content was significantly (p < 0.001) higher — from 1.38 times to 1.66 times compared with healthy ones, due to an increase in the content of globulins from 2.08 times (p < 0.001) to 2.26 times (p < 0.001), which led to a decrease in the protein ratio from 2.16 times (p < 0.001) to 3.29 times (p < 0.001) in sick animals with different II. We recorded a high content of γ-globulins almost 1.4 times in these animals compared to healthy ones. We observed a high content of β-globulins and α2-globulins by 6.70% and 7.05% (p < 0.01) and 5.15% and 3.99% (p < 0.05) in animals II and III experimental groups in comparison with control group. A decreased level of uric acid from 4.77 times (p < 0.001) to 6.19 times (p < 0.001) in rabbits with passalurosis is probably due to a violation of the process of its formation in the liver against the background of an increase in acid output through the intestines and kidneys. The creatinine level in experimental rabbits was significantly higher in groups I, II, III by 42.64% (p < 0.001), 46.49% (p < 0.001) and 44.42% (p < 0.001), respectively, compared with the control. IgA and IgG levels were high (p < 0.001) in comparison to healthy rabbits: 2.22 and 2.16 times (in animals with low II), 1.51 and 1.85 times (in animals with high II). We observed a significant (p < 0.001) high level of IgM against the control 1.58 times, 1.82 times and 1.70 times, respectively, in groups I, II, III of infected rabbits. The content of total protein, globulins, γ-globulins, IgA, IgG, IgM and creatinine were significantly higher (p < 0.001) in the blood of sick rabbits than healthy ones. We observed significant changes in the proteinogram of rabbits with high levels of II. These changes indicate an increase in the body’s immune defense under the influence of Passalurus ambiguus. We found a decreased level of uric acid and a protein coefficient due to the low percentage of albumin in sick rabbits. This is possibly due to a violation of the process of their formation in the liver against the background of increased output

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