scholarly journals Levels of proteins and immunoglobulins in rabbit blood during Рassalurosis

2019 ◽  
pp. 91-95
Author(s):  
Yu. V. Duda ◽  
M. P. Prus
Keyword(s):  
Uric Acid ◽  
Total Protein ◽  
Acid Output ◽  
Immune Defense ◽  
Control Group ◽  
Total Protein Content ◽  
Protein Ratio ◽  
Γ Globulins ◽  
Group A ◽  
High Level

The purpose of our work was to determine the influence of Passalurus ambiguus on proteinogram and the level of immunoglobulins in the blood of rabbits. Analog groups of male rabbits of 3–5 months of age were selected for the experiments. Intensity of invasion was determined by the method of the MacMaster. By spectrophotometric method in the blood of animals there was determined: the content of total protein, albumin, globulin fractions, the level of IgA, IgG, IgM — discrete deposition method according to M. Kostina. Rabbits with pasalurosis have different levels of invasion intensity (II): low (II = 276.47 ± 43.33 eggs/g of feces), high (II = 2,446.67 ± 422.11 eggs/g of feces) — II and medium (II = 1,293.75 ± 275.80 eggs/g of feces) — III research groups. We did not find eggs in the control group. The total protein content was significantly (p < 0.001) higher — from 1.38 times to 1.66 times compared with healthy ones, due to an increase in the content of globulins from 2.08 times (p < 0.001) to 2.26 times (p < 0.001), which led to a decrease in the protein ratio from 2.16 times (p < 0.001) to 3.29 times (p < 0.001) in sick animals with different II. We recorded a high content of γ-globulins almost 1.4 times in these animals compared to healthy ones. We observed a high content of β-globulins and α2-globulins by 6.70% and 7.05% (p < 0.01) and 5.15% and 3.99% (p < 0.05) in animals II and III experimental groups in comparison with control group. A decreased level of uric acid from 4.77 times (p < 0.001) to 6.19 times (p < 0.001) in rabbits with passalurosis is probably due to a violation of the process of its formation in the liver against the background of an increase in acid output through the intestines and kidneys. The creatinine level in experimental rabbits was significantly higher in groups I, II, III by 42.64% (p < 0.001), 46.49% (p < 0.001) and 44.42% (p < 0.001), respectively, compared with the control. IgA and IgG levels were high (p < 0.001) in comparison to healthy rabbits: 2.22 and 2.16 times (in animals with low II), 1.51 and 1.85 times (in animals with high II). We observed a significant (p < 0.001) high level of IgM against the control 1.58 times, 1.82 times and 1.70 times, respectively, in groups I, II, III of infected rabbits. The content of total protein, globulins, γ-globulins, IgA, IgG, IgM and creatinine were significantly higher (p < 0.001) in the blood of sick rabbits than healthy ones. We observed significant changes in the proteinogram of rabbits with high levels of II. These changes indicate an increase in the body’s immune defense under the influence of Passalurus ambiguus. We found a decreased level of uric acid and a protein coefficient due to the low percentage of albumin in sick rabbits. This is possibly due to a violation of the process of their formation in the liver against the background of increased output

scholarly journals Dynamics of individual indicators of protein metabolism in the body of broiler chickens on the background of combined stress when included in the diet “Reasil Humic Vet” + “Laktin” and “Reasil Humic Health”

2020 ◽  
Vol 3 (2) ◽  
pp. 42-46
Author(s):  
V. G. Stoyanovskyy ◽  
M. O. Shevchuk ◽  
I. A. Kolomiiets ◽  
V. A. Kolotnytskyy
Keyword(s):  
Total Protein ◽  
Protein Metabolism ◽  
Broiler Chickens ◽  
Stress Factor ◽  
The Body ◽  
Control Group ◽  
Total Protein Content ◽  
Combined Stress ◽  
Stages Of Development ◽  
Γ Globulins

The body of  broiler chickens is characterized by a high metabolism, which promotes rapid growth and development, but their performance indicators are largely related to housing conditions, which are known to include a number of technological stressors. With the development of stress in the body of poultry changes the course of metabolic processes, which causes changes in all types of metabolism, including protein. The aim of the study was to determine the changes in individual indicators of protein metabolism in the body of broiler chickens against the background of combined stress when included in the diet “Reasil Humic Vet” + “Laktin” and “Reasil Humic Health”. At 13th day of life, all clinically healthy poultry were exposed to combined stress – revaccination (intranasal Newcastle disease) plus cold stress (for 60 minutes by air conditioning and 5 °C in the vivarium). Material for research was selected for 3 days after the action of the stress factor (stage of anxiety), 13, 20 and 26 days after the action of the stress factor (the resistance stage). The material for the study was blood plasma, which determined the concentration of total protein, as well as the content of albumin, globulin fraction (α1, α2, β, γ). It was found that 3 days after the action of stress in chickens of Control group the development of adaptive reactions is manifested by the stability of the total protein content and redistribution of the fractional composition of plasma globulins in the form of increased albumin and α2-globulins. At different stages of development of the stage of resistance in birds of Control group, the content of total protein decreases by an average of 14.6 % due to the content of albumin by 6.9 % and α2-globulins – by 15.9 %, against the background of increasing α1- and γ-globulins by 23.1 and 33.5 % with the stabilization of individual studied indicators at the final stages of development of the resistance stage. The use in the diet of broilers feed “Reasil Humic Vet”, probiotic feed supplement “Laktin”, feed “Reasil Humic Health” under the influence of complex stress helps to increase the intensity of protein metabolism in poultry with the development of adaptation syndrome, as evidenced by the growth of total protein on average by 37.8 % (P < 0.05) and albumin – by 17.0 % (P < 0.05), which indicates an increase in the intensity of protein-synthesizing properties of the organism. In different periods of stress in the blood of broiler chickens Research groups there is an increase in the ratio of individual protein fractions, especially the content of γ-globulins - an average of 21.3 % (P < 0.05), which indicates an increase in the immune status of their body with a predominance of numerical values in the Research 1 group of poultry.

Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Akinleye Stephen Akinrinde ◽  
Halimot Olawalarami Hameed
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Therapeutic Index ◽  
Control Treatment ◽  
Control Group ◽  
Protective Effects ◽  
Serum Total Protein ◽  
Significant Amelioration ◽  
Group A ◽  
Group B

Abstract Objectives This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats. Methods Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out. Results DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar. Conclusions The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.

The effect of ethanol on some hematological parameters of the australian red claw crayfish (Cherax quadricarinatus)

2022 ◽  
pp. 85-91
Author(s):  
D. Skafar ◽  
D. Shumeyko
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Hematological Parameters ◽  
Group Versus ◽  
Control Group ◽  
Total Protein Content ◽  
Cherax Quadricarinatus ◽  
Total Hemocyte Count ◽  
Red Claw Crayfish ◽  
Experimental Group

Purpose: to study the effect of ethanol on the parameters of THC, the percentage of granulocytes and total protein in the hemolymph of the Red claw crayfish (Cherax quadricarinatus).Materials and methods. The object of this experiment was 26 males of the Australian red-clawed crayfish (Cherax quadricarinatus) weighing from 23 to 83 g. The individuals were evenly divided into two experimental groups - with an injection of ethanol and a control group without an injection of 13 crayfish for each group. The injection dose was 2515 mg per 100 g of body weight. A day after the introduction of ethanol, hemolymph was taken with a syringe from the ventral sinus, the syringe was pre-washed with a 4% EDTA-Na2 solution. Three parameters were determined: the total hemocyte count (THC), percent granulocytes and percent total protein content. Counting of hemocytes and determination of granulocytes were performed in a Goryaev chamber under a light microscope. The total protein was determined by the refractometric method.Results. Differences in THC and total protein between the groups were statistically unreliable (p>0,05). THC in the experimental group is 36% more than in the control group. The total protein after the introduction of ethanol actually increased by 0,7%, and relatively by 14%. There were statistically different indicators of the proportion of granulocytes (p<0,05) - the average value of 33,1% in the experimental group versus 24,5% in the control group. A reliable (p<0,05) strong feedback was revealed between the total protein and the mass of individuals in both experimental groups, while in the experimental group there is a visible shift in the values of dependent hemolymph indicators towards an increase in smaller individuals.Conclusion. A single injection of ethyl alcohol with a dosage of 2515 mg per 100 g of body weight into the hemolymph of C. quadricarinatus does not cause significant changes in the THC and total protein after 24 hours. At the same time, the proportion of granulocytes actually increases by 9%, relative to 37%. This may indicate that granulocytes are involved in the formation of cancer defense mechanisms when exposed to toxic substances. The effect of different dosages of ethanol injections and the duration of its effect on hematological parameters requires additional consideration. It is necessary to investigate its effect on other indicators, such as the pH and buffer capacity of the hemolymph, the concentration of hemocyanin, glucose, lactates and calcium.

Homologous and heterologous resistance in Echinostoma revolutum infections in mice

Parasitology ◽  
1980 ◽  
Vol 80 (3) ◽  
pp. 479-486 ◽  
Author(s):  
S. B. Sirag ◽  
N. Ø. Christensen ◽  
F. Frandsen ◽  
J. Monrad ◽  
P. Nansen
Keyword(s):  
Primary Infection ◽  
Worm Burden ◽  
Challenge Infection ◽  
Control Group ◽  
Echinostoma Revolutum ◽  
Heterologous Challenge ◽  
Challenge Control ◽  
Complete Resistance ◽  
Group A ◽  
High Level

SummaryHomologous and heterologous resistance in Echinostoma revolutum infections was studied in mice. A high level of homologous resistance was demonstrated in mice harbouring a 13-day-old primary E. revolutum infection with 9–10 and 11–15 worms, corresponding to a 70·0 and 66·7% reduction in the size of the established worm burden as compared with that of the challenge control group. A 14- and 20-day-old primary infection with 3–4 worms induced a level of resistance of 61·7 and 81·8% respectively, while higher worm levels of 9–10 and 11–15 induced almost complete resistance corresponding to a 95·1–100% reduction in the size of the established worm burden. Complete resistance was also demonstrated in mice challenged 8 days after elimination of a 20-day-old primary infection with 11–15 worms by anthelmintic treatment. A primary 43-day-old Schistosoma mansoni infection induced a 73·1% reduction in the size of the established E. revolutum challenge infection while infections of an age of 79 and 99 days conferred complete resistance to heterologous challenge with E. revolutum. Primary pre-patent S. mansoni infections and a patent S. bovis infection of an age of 56 days did not induce any resistance to challenge with E. revolutum. A primary 14- and 21-day-old infection of E. revolutum did not stimulate any significant level of resistance to heterologous challenge with S. mansoni.

scholarly journals Some Biochemical parameters Of People With Atopic Eczema And There Comparison With Normal People

2019 ◽  
Vol 23 (10) ◽  
pp. 1
Author(s):  
Azeez Khalid Hameed ◽  
Buraq Hikmat Alwan
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Atopic Eczema ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Blood Analysis ◽  
Total Serum ◽  
Control Group ◽  
Healthy Control ◽  
And Control

The present study aimed to identify the biochemical changes in sera of patients with Atopic Eczema, which included some blood analysis included serum urea, uric acid, creatinine, cholesterol, blood glucose, albumin, total protein, calcium, GPT, ALP, total serum bilirubin. Samples were collected from 19 August to 19 December in Salahelddin Hospital in tikrit city, the study included 94 sample, 65 from patients with Atopic Eczema, and 29 healthy people as a control group, the results were compared between the Atopic Eczema patients group and the healthy control group, and there was elevation in blood urea, uric acid, ceatinine, total protein, GPT, ALP, TSB,( 34.9+22.10), (5.49 + 4.38), (0.788+ 0.669), (7.34 +6.41), (13.38 +6.96), (13.63+ 8.52), (0.831+0.190),  respectively. And there was no elevation in,  total albumin, cholesterol, calcium, blood glucose, (4.595+4.321), (161.5+ 148.1), (8.96 + 9.13), (109.3+ 105.3), respectively when compared between patients group and control group.   http://dx.doi.org/10.25130/tjps.23.2018.161

scholarly journals Comparison of the effect of two anti-adhesion materials on the formation of postoperative adhesions after myomectomy – an experimental study on rabbit does

2021 ◽  
Vol 90 (4) ◽  
pp. 407-414
Author(s):  
Soňa Pánková ◽  
Andrea Nečasová ◽  
Jana Lorenzová ◽  
Vladimír Jekl ◽  
Alois Nečas ◽  
...  
Keyword(s):  
Experimental Study ◽  
Statistical Evaluation ◽  
Scoring Systems ◽  
Control Group ◽  
Routine Practice ◽  
Postoperative Adhesions ◽  
Group A ◽  
Level Of Significance ◽  
Group B ◽  
High Level

This study compares the effect of Hyalobarrier Gel and 4DryField® PH on the formation of postoperative adhesions after myomectomy in an experimental study on rabbit does. Thirty experimental animals were divided into three groups: group A – control, group B – use of 4DryField® PH, and group C – use of the Hyalobarrier Gel. A simulated myomectomy was performed in each group. The animals were euthanised 14 days after the procedure and the antiadhesive effect of the above-mentioned preparations was evaluated according to the criteria. Statistical evaluation clearly showed differences in the antiadhesive effect in the scoring systems for groups B and C compared to control group A at a high level of significance. We demonstrated an obvious, statistically confirmed antiadhesive effect of the Hyalobarrier Gel and 4DryField® PH in an experimental model of the rabbit uterus. Comparing both preparations, the Hyalobarrier Gel shows a higher level of effectiveness. Based on the results of the experiment, both preparations can be unambiguously recommended for routine practice.

scholarly journals Effect of fundectomy, antrectomy and gastrectomy on pancreatic and brush border enzyme activity in rats

2018 ◽  
Vol 74 (1) ◽  
pp. 6031-2018
Author(s):  
MAŁGORZATA KAPICA ◽  
IWONA PUZIO
Keyword(s):  
Enzyme Activity ◽  
Protein Content ◽  
Brush Border ◽  
Total Protein ◽  
Control Group ◽  
Total Protein Content ◽  
Surgical Removal ◽  
Hormonal Changes ◽  
Serum Samples ◽  
Distal Jejunum

The aim of our study was to investigate the possible effects of the removal of different parts of the stomach (fundectomy, antrectomy, gastrectomy) on the total protein content and enzyme activity in the pancreas and the brush border of the intestinal mucosa. Twenty-four 2.5-month-old male Wistar rats were divided into four groups: sham-operated animals (SHO) and those subjected to gastrectomy (Gx), fundectomy (Fx), and antrectomy (ANT). After a six-week experiment, the rats were sacrificed, and blood was collected for further gastrin analysis in serum. Samples of the pancreas, duodenum, and jejunum (proximal part in 25% of length, middle part in 50% of length, and distal part in 75% of length) were collected to determine the total protein content and enzyme activity. The rats subjected to fundectomy, antrectomy and gastrectomy showed an increased total protein content and enzyme activity (amylase, trypsin) in pancreatic tissue. They exhibited an increase in the total protein content in the homogenates of the mucosa of the proximal, middle and distal jejunum, compared to the control, and a statistical increase in maltase activity. Compared with the control group, the rats subjected to Fx and ANT showed a decreased sucrase activity in the homogenates of the mucosa of the duodenum and of the proximal, middle and distal jejunum. In the gastrectomized rats, there was a statistically significant increase in the total protein content in the homogenates of the mucosa of the jejunum, compared to the control, while the activities of lactase and sucrase were decreased. There was a statistically significant increase in the gastrin level in all experimental groups (Fx, ANT, Gx). We suggest that surgical removal of a part of the stomach radically changes the level of hormones that determine many functions of the organism. Hormonal changes may have an impact on the pancreas and the activity of brush border enzymes. .

scholarly journals Effect of pollution with lead, cupper, cadmium on gene expression pattern of liver GST and serum lysozymes in Nile tilapia (Oreochromis. niloticus)

2020 ◽  
Vol 21 (3) ◽  
pp. 53-60
Author(s):  
Enas Hassan ◽  
Gehad El-Sayed ◽  
Azza Hassan ◽  
Shaimaa Abd Elsalam
Keyword(s):  
Gene Expression ◽  
Uric Acid ◽  
Expression Pattern ◽  
Total Protein ◽  
Oreochromis Niloticus ◽  
Nile Tilapia ◽  
Gene Expression Pattern ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Nile Tilapia Oreochromis Niloticus

Objective: This study was conducted to evaluate the influence of pollution with lead, copper, cadmium on the gene expression pattern of liver Glutathione-S-transferase and serum lysozyme in Nile tilapia (Oreochromis. niloticus). Design: Descriptive study. Fish: A Total of 120 Nile tilapia fish (Oreochromis niloticus) samples were collected from Lake Manzala, and drainage water at different localities. Procedures: Cd, Cu, and Pb concentrations residues within mid-dorsal muscle tissue, within gills, liver, and kidney were determined. Erythrocyte count, hemoglobin concentration, Packed Cell volume and other blood indices, as well as, total leukocyte count were measured. Biochemically, Alanine transaminase, Aspartate transaminase activities, total protein, creatinine, uric acid, lysozymes activity were estimated. GST gene expression was determined in the liver. Results: The results showed that Pb, Cu and Cd were bio accumulated at a higher level in the liver, kidney and gills of Nile tilapia fish (Oreochromis niloticus) from all sampling sites. The levels of the ALT and AST were increased, total protein and Albumin concentrations were decreased. Creatinine and uric acid were significantly (P≤ 0.05) increased in all groups (compared to the control group. Hematological parameters and lysozyme activity were decreased. Up regulation of the hepatic GST expression levels in Nile tilapia exposed to the heavy metals in comparison to the control value. Conclusion and clinical relevance: This study shows that lead, copper and cadmium were bio accumulated at higher concentration in liver, kidney, gills and muscles of Nile tilapia due to large industrial activities near locations of the sampling sites. Additionally, GST gene expression represents sensitive biomarker of aquatic pollution.

scholarly journals Impact of Pinch Strength Training along with Postural Education on Upper Extremity Functional Performance among Dentist

2021 ◽  
Vol 11 (5) ◽  
pp. 241-247
Author(s):  
Simulia Dhinju B ◽  
Paulraj M ◽  
Manjula Devi K
Keyword(s):  
Strength Training ◽  
Functional Performance ◽  
Pinch Strength ◽  
Control Group ◽  
Study Materials ◽  
Active Range Of Motion ◽  
Post Test ◽  
Group A ◽  
High Level ◽  
And Control

Background: Dentists are required to maintain a high level of precision during manual scaling, polishing and Flossing. As a result of sustained griping activity finger and wrist pain are more common among Dentists. Therefore the excess pinch force, leads to musculoskeletal disorders which in turn affects the functional ability. Study design: An Experimental study. Materials & Methods: The sum of 30 Dental professionals were selected under inclusion criteria into this study, ages between 20 to 35 years with decrease in pinch strength and functional abilities. Selected subjects were randomly allocated into two groups such as experimental group (Pinch strength training and conventional exercise) and control group (Conventional Exercises - Postural corrective exercises, active range of motion exercises, shoulder bracing and shoulder shrugging exercise, Ergonomics advices) were given. The outcome tools used are Modified Sphygmomanometer test and Disabilities of the Arm, Shoulder and Hand Questionnaires (DASH). The Statistical analysis of pre &post test values were analyzed using paired & unpaired ‘t’ test. Result: The result of this study shows that Group A using Pinch strength along with Postural Education were found to be effective over the control group, where only the postural education were done (p <0.0001). Conclusion: Therefore this study concludes that Pinch strength training along with Postural education were proven to be significant in improving Pinch strength and Functional performance among Dentist. Key words: DASH Questionnaires, Functional disabilities, Modified Sphygmomanometer test and Pinch strength training.

P–564 Analysis of efficiency and outcomes of assisted reproductive technology (ART) programs after embryo transfer with a low-level of mosaicism

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
M Shishimorova ◽  
S Tevkin ◽  
T Jussubaliyeva
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Live Birth Rate ◽  
Control Group ◽  
Art Programs ◽  
Low Level ◽  
Mosaic Embryo ◽  
Group A ◽  
Group B ◽  
High Level

Abstract Study question How does embryo transfer with a low-level of mosaicism affect the success of ART programs, pregnancy, and live birth in comparison with euploid embryo transfer? Summary answer The transfer of mosaic embryos results in the delivery of a healthy baby however significantly decreases the outcome of ART programs and live birth rate. What is known already Present methods of preimplantation genetic testing of aneuploidy (PGT-A) allow detecting a mixture of euploid and aneuploid cells at the blastocyst stage with high accuracy. Such embryos are classified as mosaics with varying levels according to the guidelines of the International Society for Preimplantation Genetic Diagnosis (PGDIS). Numerous sources describe that number of mosaic embryos can vary from 4 to 22%. Several publications report that mosaic embryos can lead to successful pregnancies and healthy childbirth, but with a lower frequency and higher rates of pregnancy loss compared to euploid embryos. Nevertheless, the effect of mosaicism on ART outcomes remains controversial. Study design, size, duration It has been analyzed 2506 embryos from 648 patients undergoing the ART program with PGT-A at the Institute of Reproductive Medicine for 2018 - 2019. Embryos after PGT-A were classified as euploid, aneuploid, and having mosaicism of less than 40% as low level and more than 40% as high level following PGDIS guidelines. Patients of (group A) were transferred 467 single euploid embryos, and 43 patients (group B) underwent single low-level mosaic embryo transfer. Participants/materials, setting, methods The embryos on day 5 or 6 were graded by Gardner Scoring System. Approximately 5–10 TE cells were biopsied from good quality blastocysts and subsequently vitrified. PGT-A was performed utilizing an array comparative genomic hybridization (aCGH) (Agilent). The transfer of mosaic embryos was performed in the absence of an alternative, only after medical genetic counseling with a risk explanation and the subsequent signing of an informed agreement. Statistical tests processed by Pearson’s chi-squared test. Main results and the role of chance Of all analyzed embryos, the proportion of euploid embryos was 48.6% (n = 1002), the total number of mosaics was 18.6% (n = 384) and aneuploid ones were 32.8% (n = 676). Depending on the level of mosaicism, the ratio between embryos with low-level mosaicism (≤40%) / high-level (≥40%) was 38.3% / 61.7%, respectively. According to the study, there was a significant decrease in the indicator of clinical pregnancy rate after embryo transfer with a low-level of mosaicism of 44.1% versus 63.2% transferred euploid embryo (р&lt;0,01), however, despite an increase losses pregnancy in the group B (26.3%) there was no significant difference (p = 0.16) in comparison with the control group (15.4%). The live birth rate (LBR) significantly decreased (p &lt; 0.001) after the transfer of the mosaic embryo by 32.5%, while in the control group the indicator was 53.9%. In all cases, after the transfer of the mosaic embryo, healthy babies were born. There were 2 cases of high-level mosaic embryo transfer as a result of which pregnancy did not occur. According to the survey, about 70% of patients agree to replant mosaic embryos, 20% are ready to go to the new program, and 10% cannot make a decision. Limitations, reasons for caution The number of patients in group B was significantly lower than in group A. Not enough cases of embryo transfer with a high-level of mosaicism. Wider implications of the findings: The current study might help to develop and to select a more appropriate strategy for transfer mosaic embryos. The next series of studies should focus on obstetric and neonatal outcome data from mosaic embryo transfer to gain a better understanding of the chromosomal and physiological health of children. Trial registration number Not applicable

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