scholarly journals Length of Stay Children Hospitalized with Chronic Kidney Disease Based on Etiology and Stage in Dr. Hasan Sadikin Hospital Bandung

2020 ◽  
Vol 8 (1) ◽  
pp. 27-31
Author(s):  
Angelreika Libowo ◽  
Ahmedz Widiasta ◽  
Dedi Rachmadi

Objectives: This study aims to describe the LOS children hospitalized with CKD based on the etiology and stage at Dr. Hasan Sadikin General Hospital, Bandung in 2016–2018. Methods: This was a retrospective study with a cross-sectional design from June–October 2019. The inclusion were all medical records of pediatric inpatient diagnosed with CKD and exclusion criteria were incomplete medical record data and hospital readmission patients. The variables studied were CKD etiology, CKD stage, and length of stay Results: From 103 patients, the etiologies found were steroid-resistant nephrotic syndrome (SRNS) (58.25%), congenital anomalies of kidney and urinary tract (9.71%), urinary tract infection (5.83%), and chronic glomerulonephritis (21.36%). The mean LOS was 19 days. The longest LOS found in CKD stage 5 patients caused by SRNS (141 days). Meanwhile, the shortest LOS was found in CKD stage 2 patients caused by chronic glomerulonephritis and CKD stage 5 patients were caused by SRNS who died (1 day). Conclusion: Pediatric patients with CKD stage 5 with SRNS has the potential to have a longer LOS than other etiologies.

2020 ◽  
Vol 22 ◽  
pp. 02026
Author(s):  
Natalya Zhuravleva ◽  
Vladimir Buryak ◽  
Sergey Horoshev ◽  
Natalya Mineeva

Nephrotic syndrome (NS) is one of the most severe kidney pathologies. NS often relapses and becomes resistant to immunosuppressive therapy. In order to identify factors that prevent NS relapses development and possible increase of therapy effectiveness, we have analyzed the course nature of primary (idiopathic) and secondary frequently relapsing steroid-resistant nephrotic syndrome (FRNS) in 22 children who received immunosuppressive therapy (IS) (cyclosporin (CSA) or mycophenolic acid (MPA)). As a result of the study, the following factors of NS progression in observed children were revealed: hereditary predisposition for diseases of urinary system organs; presence of more than 5 small external abnormalities development, greater disease record, presence of herpetic infection and chronic infection focal points. In children with long disease experience, a reliably higher level of proteinuria was identified. At the time of examination, stage I chronic kidney disease was registered in most children, one in five children had stage II CKD. CKD stage was not dependent on the type of immunosuppressive therapy received (p<0.05). For children who had NS activity persistence at the time of the study, it was recommended to re-perform nephrobiopsy in order to verify morphological changes in the kidneys, correction – including the institution of alternative immunosuppressive therapy.


Author(s):  
Diah Wulandari ◽  
Mohamad Sulchan ◽  
Syarief Thaufik Hidayat

Background: Angiogenic and antiangiogenic imbalances play a major role in the pathogenesis of preeclampsia. Increased production of sFlt-1 by the placenta causes free circulating PIGF and VEGF concentrations to lower because it is bound by sFlt-1. Measuring levels of angiogenic and antiangiogenic proteins as biomarkers indicates placental dysfunction and distinguishes preeclampsia from other disorders. This study aims to analyze the levels of angiogenic and antiangiogenic molecules in pregnant women at risk for preeclampsia.Methods: The study with a cross-sectional design was carried out in 11-15 weeks gestational age whom had a risk of preeclampsia with 30 samples in primary health care starting April-August 2018. Blood serum was measured by molecular levels of VEGF, PlGF, sFlt-1, and sFlt-1/PlGF ratio using the ELISA method. Data analysis used Pearson product moment test.Results: The mean of VEGF levels are 15.5±21.6, PlGF 89.7±55.5, sFlt-1 11519.4±5126.0 and the ratio sFlt-1/PlGF 166.7±102.1. Correlation value of risk factors for preeclampsia with molecular levels of VEGF r= -0.05; p = 0.76, PlGF r= -0.21; p = 0.26, sFlt r= 0.01; p =0.99 and ratio sFlt-1/PlGF r = 0.10; p = 0.58.Conclusions: The higher the total score of preeclampsia risk factor, the lower the molecular level of VEGF and PlGF is. Moreover, the higher the total score of preeclampsia risk factor, the higher the molecular level sFlt-1 and the sFlt-1/PlGF ratio is. There are no significant correlation between total score of preeclampsia risk factor and levels of molecule VEGF, PlGF, sFlt-1 and sFlt-1/PlGF ratio.


Author(s):  
Dang Thi Hong Khanh ◽  
Nguyen Thi Ut ◽  
Nguyen Thi Chien ◽  
Giang Thi Thanh Ha ◽  
Vu Thi Thuy Linh

Objectives: To measure the waiting time for medical visit at the Outpatient Department 2, NationalChildren’s Hospital in 2018.Study method: Cross sectional design combines quantitative study.Result:The study on waiting time for medical visit of2060 patients showed that: the mean follow- up time was 32.5minutes. Average time for 01 technique was 137 minutes. The median time for medical consultation and 2techniques implemented was 162 minutes. The median time for the medical consultation and 03 techniquesimplemented was 208 minutes. Among sub- clinical techniques, blood test took the maximum time (137minutes).Conclusion: The waiting time for medical consultation was standardized according to the Decision 1313 /QĐ-BYT in 2013; Approximately 70 patients per visit / 8 hours.


2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Agnes Asare Bediako ◽  
Rasheed Ofosu-Poku ◽  
Andrews Adjei Druye

Errors in transfusion of blood and blood products can lead to preventable morbidity and mortality. Nurses constitute a significant aspect of the transfusion process as they are the last in the chain of getting blood directly to the patient. They must, therefore, be conversant with the current standard of national and international guidelines on blood transfusion and appropriate management of adverse transfusion events. This study assesses the knowledge and practices of blood transfusion safety among nurses at Komfo Anokye Teaching Hospital. A descriptive cross-sectional design was employed, and structured questionnaire (Routine Blood Transfusion Knowledge Questionnaire) was used to collect data from 279 nurses from seven clinical directorates of the hospital. The data were processed with Stata version 14.0. Variables were analyzed using descriptive statistics, and relationships were drawn using inferential statistics. Over 90% of the respondents had a minimum of a diploma in nursing or midwifery, 63% had performed blood transfusion at least 5 times, and 46% had never received any training on blood transfusion. The mean score obtained in all four categories of blood transfusion knowledge assessed was 29, with 54% of the respondents scoring below the mean. The highest overall score on knowledge was 53%. This indicates that nurses had poor knowledge regarding safe blood transfusion practices as stipulated in the clinical guidelines for blood transfusion by Ghana’s National Blood Service. There was no statistically significant relationship between training/experience and knowledge of safe blood transfusion practices. Regular and continuous update training and audit are needed to safeguard patient safety during blood transfusion.


2021 ◽  
Vol 12 (1) ◽  
pp. 69-76
Author(s):  
Rico Januar Sitorus ◽  
Nyoman Yudi Antara ◽  
Rosyada Elviani ◽  
Zen Ahmad ◽  
Harun Hudari ◽  
...  

World Health Organization (WHO) has declared the novel corona virus (COVID-19) as a pandemic due to its high transmission and the rapid spread of the COVID-19. Along these lines, there is a need for more research about risk factors that can affect the spread of COVID-19 and its fatality. Therefore, this study aims to analyze risk factors in patients who died from COVID-19 at the Mohammad Hoesin Hospital in Palembang, South Sumatra, Indonesia. This study used a cross-sectional approach. The data were collected from all patients who died with suspected, probable, and confirmed status until September 2020  Data on death due to COVID-19 were collected with suspect, probable, and confirmed status. The results showed that comorbidity became the most dominant factor (62.1%) with (OR Adj) 3.780 (1.000 – 3.168) after controlling for contact history with confirmed cases and sex. There were differences in the mean age and length of stay in patients with confirmed COVID-19 and not. Prevention of death in COVID-19 patients can be done by controlling comorbidities and contact history with positive cases of COVID-19.


2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Berliana Irianti ◽  
Ermawati Ermawati ◽  
Arni Amir

Abstrak Penyebab dismenore belum semuanya diketahui, ada dugaan peningkatan proses peroksida lipid yang akan mengaktivasi mediator inflamasi pada endometrium yang menimbulkan rasa nyeri haid (dismenore). Tujuan penelitian ini adalah menentukan perbedaan kadar malondialdehide dan tromboksan B 2  pada dismenore dan tanpa dismenore. Studi observasional ini menggunakan desain potong lintang komparatif. Subjek penelitian terdiri dari dua kelompok yaitu 23 remaja dismenore dan 23 remaja tanpa dismenore dengan waktu penelitian dari Juni sampai Juli 2014. Analisis sampel dilakukan di Laboratorium Biomedik dan Biokimia Universitas Andalas Padang. Pemeriksaan kadartromboksan B 2  menggunakan metode ELISA dan kadar malondialdehide menggunakan metode Asam Thiobarbiturat (TBA). Hasil penelitian diperoleh bahwa rerata kadar malondialdehid pada remaja dengan dismenore yaitu 2,60±0,63 µmol/ml, rerata remaja tanpa dismenore 1,98±0,12 µmol/ml dengan probabilitas p<0,05 (0,000), sedangkan reratakadar Tromboksan B 2  pada remaja dengan dismenore 20,043±9,56 ng/ml, rerata remaja tanpa dismenore 19,222±10,79 ng/ml, dengan probabilitas p>0,05 (0,786). Kesimpulan penelitian ini adalah terdapat perbedaan yang signifikan rerata kadar malondialdehid pada remaja dengan dismenore dan tanpa dismenore dan tidak terdapatperbedaan signifikan pada kadar tromboksan B 2 pada remaja dengan dismenore dan tanpa dismenore.Kata kunci: remaja, dismenore, malondialdehide, tromboksan B2 Abstract The precise cause of dysmenorrhea is still unclear, there may be increased lipid peroxidation process will activate the inflammatory mediators at endometrium that cause menstrual cramps (dysmenorrhea). The objective of this study was to determine the difference of malondialdehyde levels and thromboxane B 2  levels in dysmenorrhea and without dysmenorrhea. It was an observational study with comparative cross-sectional design. The subjects consisted of two groups, they are 23 adolescent with dysmenorrhea and 23 adolescents without dysmenorrhea, done in Juny -July 2014. Sample analysis was conducted in Laboratory of Biochemistry and Biomedical Laboratory of Andalas University Padang. The examination of Thromboxane B 2  levels used ELISA and the examination of malondialdehyde levels used a Thiobarbituric acid method. The results showed the mean of malondialdehyde levels in adolescents withdysmenorrhea was 2.60±0.63 µmol/ml, the mean level in adolescent without dysmenorrhea was 1.98±0.12 µmol/ml with probability p<0.05 (0.000), while the mean levels of thromboxane B 2  in adolescents with dysmenorrhea was 20.043±9.56 ng/ml, the mean level in adolescent without dysmenorrhea was 19.222±10.79 ng/ml, with probabilityp>0.05 (0.786). It can be concluded that there is a significant difference in the mean of malondialdehyde levels between adolescents with dysmenorrhea and without dysmenorrhea and there is no significant differences in thromboxane B 2 level between adolescents with dysmenorrhea and without dysmenorrheaKeywords: adolescent, dysmenorrhea, malondialdehyde, thromboxane B2


2021 ◽  
Vol 49 (1) ◽  
pp. 57-62
Author(s):  
Nendyah Roestijawati ◽  
Yudhi Wibowo

Cadmium (Cd) is one of the environmental factors that can cause prostate cancer. Cadmium can induces metallothionein (MT) in several tissues that functions to carry out an intracellular detoxification procession by binding to Cd. Exposure of Cd can cause an increase in reactive oxygen species which will cause lipid peroxidation with the end product being malondialdehyde (MDA). The research aims to determine the correlation between MT, MDA and prostate specific antigen (PSA) among auto body repair workers. The study used a cross sectional design involving 32 auto body repair workers and their ages ranged from 18 to 66 years. Measurement of MT, MDA and PSA using the ELISA method. We performed a multiple regression analysis to evaluate the relationships between MT, MDA with PSA for age and other covariates. The mean age of subjects was 38.88 ± 12.82 years. The mean levels of MT was 2.84 ± 1.18 ng/dL, MDA was 8.22 ± 20.06 ng / dL and PSA was 0.86 ± 1.79 ng / dL. The study found that MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) and MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) significantly predicted PSA. MDA (β = 0.827) has stronger relationship with PSA compared to MT (β =0.232). This results confirmed the role of MT and MDA on PSA synthesis. Metallothionein induce the process of lipid peroxidation with the end product being malondialdehyde (MDA) and increase PSA. Keywords : auto body repair workers, metallothionein, malondialdehyde, prostate Abstrak Kadmium (Cd) merupakan salah satu faktor lingkungan yang dapat menyebabkan kanker porstat. Kadmium dapat menginduksi metalotionin (MT) di beberapa jaringan yang akan berikatan dengan Cd untuk proses detoksifikasi. Pajanan Cd dapat meningkatkan ROS yang akan meyebabkan terjadinya peroksidase lipid dengan hasil akhir malondialdehid (MDA). Penelitian bertujuan untuk mengetahui hubungan antara MT, MDA dan PSA pada pekerja bengkel mobil. Penelitian menggunakan disain kros seksional dengan subyek sebanyak 32 pekerja bengkel mobil yang berusia 18 hingga 66 tahun. Pengukuran MT, MDA dan PSA menggunakan metode ELISA. Analisis statistik menggunakan analisis regresi berganda. Rata-rata usia subyek adalah 38.88 ± 12.82 tahun. Rata-rata kadar MT 2.84 ± 1.18 ng/dL, MDA 8.22 ± 20.06 ng / dL dan PSA 0.86 ± 1.79 ng / dL. Hasil uji didapatkan MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) dan MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) berpengaruh terhadap PSA secara signifikan. MDA (β = 0.827) mempunyai hubungan dengan PSA yang lebih kuat dibanding MT (β =0.232). Hasil penelitian mengkonfirmasi adanya peran MT dan MDA pada sintesis PSA. MT menginduksi proses peroksidase lipid dengan produk akhir MDA dan meningkatkan kadar PSA. Kata kunci : pekerja bengkel mobil, metalotionin, malondialdehid, prostat


2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Inri A. H. Oway ◽  
Sonny J. R. Kalangi ◽  
Taufik Pasiak

Abstract. Background. Triglycerides are a type of fat that can be found in blood which are stored the most in human body. Triglycerides are used as an energy source for various metabolic processes. High levels of triglycerides can lead to various health problems. Elevated triglycerides levels can be caused by various things, such as obesity. Obesity results when fat accumulates in body. Obesity and elevated triglycerides levels can affect human health. Objective. The aim for this research was to compare triglyceride levels of obese 1 and obese 2 students of Faculty of Medicine Sam Ratulangi University. Method. An observational method with cross sectional design research was done to compare triglyceride levels in obese 1 and obese 2 students of Faculty of Medicine Sam Ratulangi University  academic year 2010 and 2011. In the number of 49 people, (30 people were obese 1 and 19 people were obese 2). The data were analyzed using SPSS, test of hypothesis used Mann Whitney.  Result. The mean values of triglyceride levels in obese 1 students were 69,00 mg/dL and in obese 2 students were 85,53 mg/dL. Conclusion. There were significant differences on triglyceride levels in obese 1 and obese 2. Keyword: fat, obesity, triglyceride.   Abstrak. Latar Belakang. Trigliserida merupakan jenis lemak yang paling banyak pada tubuh manusia dan dapat ditemukan dalam darah. Trigliserida berguna sebagai sumber energi untuk berbagai proses metabolik tubuh. Akan tetapi jika kadar trigliserida terlalu tinggi maka dapat menimbulkan berbagai masalah kesehatan. Peningkatan kadar trigliserida dapat disebabkan oleh berbagai hal, salah satunya karena obesitas. Obesitas terjadi karena peningkatan akumulasi lemak dalam tubuh. Obesitas dan peningkatan kadar trigliserida dapat mempengaruhi tingkat kesehatan seseorang. Tujuan. Penelitian ini bertujuan untuk membandingkan kadar trigliserida pada mahasiswa obes 1 dan obes 2 Angkatan 2010 dan 2011 di Fakultas Kedokteran Universitas Sam Ratulangi. Metode. Penelitian ini dilakukan dengan metode observasional dan desain studi cross sectional untuk membandingkan kadar trigliserida pada mahasiswa obes 1 dan obes 2 Angkatan 2010 dan 2011 di Fakultas Kedokteran Universitas Sam Ratulangi. Jumlah sampel pada penelitian ini sebanyak 49 orang yang terdiri dari 30 orang obes 1 dan 19 orang obes 2. Analisis data dilakukan dengan menggunakan SPSS dan uji hipotesis menggunakan Uji Mann-Whitney. Hasil. Kadar trigliserida rata-rata pada obes 1 sebesar 69,00 mg/dL dan kadar trigliserida rata-rata pada obes 2 sebesar 85,53 mg/dL. Kesimpulan. Secara statistik terdapat perbedaan bermakna kadar trigliserida pada obes 1 dan obes 2. Kata Kunci: lemak, obesitas, trigliserida.


e-GIGI ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Princess Keloay ◽  
Christy N. Mintjelungan ◽  
Damajanty H. C. Pangemanan

Abstract: In Indonesia, children dental and mouth health is on the apprehensive level. The caries prevalence in children of 5 to 9 years old is 92.6% and the proportion of brushing their teeth properly is only 1.4%. The control and prevention of plaque forming can be done in a simple, effective, and practical way through brushing the teeth thoroughly and regularly. This study was aimed to obtain the tooth brushing technique and plaque index among students at SD GMIM Siloam Tonsealama (elementary school). This was a descriptive study with a cross sectional design. Study population consisted of elementary students og grade 3 to 5. We used total sampling method. There were 42 students as subjects. Data were obtained by observing their tooth brushing techniques. The results showed that all students used combination technique of tooth brushing. Most students had plaque index of moderate category. The mean plaque index of the subjects was 2.67. In conclusion, students at GMIM in Tonsealama used combination technique of tooth brushing, and their plaque index was categorized as moderate.Keywords: plaque index, brushing teeth technique Abstrak: Kesehatan gigi dan mulut anak di Indonesia masih sangat memrihatinkan. Prevalensi karies pada anak usia 5-9 tahun dilaporkan mencapai 92,6%, dan proporsi waktu menyikat gigi dengan benar sebesar 1,4%. Usaha untuk mengontrol dan mencegah pemben-tukan plak dapat dilakukan secara sederhana, efektif, dan praktis yaitu dengan cara menggosok gigi secara teliti dan teratur. Penelitian ini bertujuan untuk mengetahui gambaran teknik menyikat gigi dan indeks plak siswa SD GMIM Siloam Tonsealama. Jenis penelitian ialah deskriptif dengan desain potong lintang. Populasi penelitian terdiri dari siswa sekolah dasar kelas 3 sampai dengan 5. Pengambilan sampel menggunakan total sampling. Terdapat seba-nyak 42 siswa sebagai subyek penelitian. Pengumpulan data menggunakan formulir pemeriksaan. Hasil penelitian menunjukkan bahwa teknik menyikat kombinasi digunakan oleh seluruh subyek. Indeks plak paling banyak pada kategori sedang. Rerata nilai indeks plak yaitu 2,67. Simpulan penelitian ini ialah teknik menyikat gigi yang digunakan oleh siswa SD GMIM di Tonsealama ialah teknik kombinasi dengan indeks plak tergolong kategori sedangKata kunci: indeks plak, teknik menyikat gigi


2019 ◽  
Vol 12 (2) ◽  
pp. 183
Author(s):  
Ferawati Dakio ◽  
Nurlaily Idris ◽  
Mirna Muis ◽  
Andi Alfian ◽  
Hasyim Kasim ◽  
...  

Hidronefrosis dapat terjadi pada satu atau kedua ginjal yang menyebabkan aliran urine menjadi lemah dan mengganggu fungsi dari ginjal itu sendiri.Penelitian ini bertujuan mengetahui korelasi ketebalan korteks ginjal dan resistive index ginjal berdasarkan pemeriksaan ultrasonografi pada pasien hidronefrosis. Penelitian ini dilakukan di bagian Radiologi Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar dari Mei sampai dengan Agustus 2018. Desain penelitian yang digunakan adalah observasional dengan rancangan potong lintang.Sampel penelitian sebanyak empat puluh orang yang memiliki klinis hidronefrosis. Pemeriksaan ultrasonografi grayscale terhadap pasien dilakukan untuk mengukur ketebalan korteks ginjal yang dilakukan di bagian tengah ginjal pada potongan longitudinal dan diukur dari puncak piramid tegak lurus ke arah kapsul, kemudian dilanjutkan pemeriksaan ultrasonografi doppler di arteri interlobar atau arcuata pada pole superior, median, dan inferior ginjal untuk menilai  renal resistiveindex. Data dianalisis dengan analisis statistik melalui uji korelasi Spearman dan Pearson.Hasil penelitian menunjukkan bahwa rerata sampel penelitian mengalami hidronefrosis derajat ringan. Mean tebal korteks ginjal kanan pada penelitian ini 0,9 cm (0,26-1,79cm) dan ginjal kiri 0,84 cm (0,22-1,57cm). Terdapat korelasi yang bermakna antara derajat hidronefrosis dengan ketebalan korteks ginjal kanan dan kiri dengan arah korelasi negatif (p=0,0001). Kecenderungan peningkatan derajat hidronefrosis, meningkatkan nilai resistive index meskipun secara statistik tidak bermakna. Tidak terdapat korelasi antara ketebalan korteks dan resistive index  ginjal berdasarkan pemeriksaan ultrasonografi.   Hydronephrosis can occur in one or both kidneys which causes the flow of urine to become weak and interfere with the function of the kidney. This research aimed to investigate the correlation between the cortex thickness and the resistive index of kidney based on the ultrasonography examination in hydronephrosis patients.  The research was conducted in Radiology Department of Dr. Wahidin Sudirohusodo General Hospital, Makassar from May through August 2018. The research design used was observational using the cross sectional design. The total samples comprised 40 samples with clinical hydronephrosis. The examination of ultrasonography grayscale was carried out in order to measure the cortex thickness of the kidneys in the central parts of kidneys and the longitudinal cut was measured from the pyramid top straight down the capsule, then it was continued with the Doppler ultrasonography examination in the interlobare artery or arcute at superior pole, median and inferior kidney in order to evaluate the renal resistive index. The data were analyzed using the statistical analysis through the correlation tests of Spearman and Pearson. The research results indicated that the mean research samples had experienced the light hydronephrosis. The mean cortex thickness of the right kidney was 0.9 cm (0.26 - 1.79 cm), and that of the left kidnet was 0.84 cm (0.22 - 1.57 cm). There was a significant correlation between the degree of hydronephrosis and the cortex thickness of the right and the left kidneys, with the direction of the negative correlation (p=0.0001). There was a tendency of the increase of hydronephrosis degree to increase the value of resistive index, though statistically it was insignificant. There was no correlation between the cortex thickness and the resistive index of kidney based on the ultrasonogrphy examination.  


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