scholarly journals Effects of different hormonal contraceptives in women's blood pressure values

2018 ◽  
Vol 71 (suppl 3) ◽  
pp. 1453-1459 ◽  
Author(s):  
Cristiane Crisp Martins Ribeiro ◽  
Antonieta Keiko Kakuda Shimo ◽  
Maria Helena Baena de Moraes Lopes ◽  
José Luiz Tatagiba Lamas

ABSTRACT Objective: To identify evidence in the literature of the relationship between the use of different hormonal contraceptive methods and alterations in women's blood pressure values. Method: This is an integrative literature review, consisting of ten scientific articles published in PubMed and BVS, between 2012 and 2016, selected by keywords, available fully and free of charge, in English, Portuguese, or Spanish. Results: The articles showed that exogenous estrogen helps in the activation of the renin-angiotensin-aldosterone system causing hypertensive effects even in small doses; and that combined use with drospirenone reduces these effects. Routes of administration without passage through the liver and use of isolated progestin showed promising results in reducing the effects on blood pressure. Conclusion: There is evidence in the literature of pressure alterations associated with different hormonal contraceptives and that personal history of morbidities are to be considered in an attempt to reduce the effects on the cardiovascular system.

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Cari J Clark ◽  
Susan A Everson-Rose ◽  
Resnick Michael ◽  
Iris Borowsky ◽  
Sonya S Brady ◽  
...  

Introduction: Women are more likely to experience distress and injury from intimate partner violence (IPV), and may also be at greater risk of higher blood pressure than male victims. However, most prior epidemiologic research has not included men and has not examined perpetation, despite the predominance of mutually violent relationships. Therefore, this study investigates sex differences in the relationship between exposure to IPV victimization and perpetration and systolic blood pressure (SB). Methods: The study included 3447 (52% female; mean(sd) age=22(3)) participants of Waves 3 (2001–2002) and 4 (2007) of the publically-available subset of the National Longitudinal Study of Adolescent Health. Frequency of psychological, physical, sexual IPV and IPV-related injury were ascertained with the Revised Conflict Tactics Scales at Wave 3. Exposure to IPV was categorized as no IPV victimization or perpetration (ref), only low victimization and / or perpetration, high victimization and low/no perpetration, high perpetration and low/no victimization, and both high victimization and perpetration. SBP was measured at Wave 4 using standard procedures. Potential confounders (age, educational attainment, race, history of child abuse) and mediators (depressive symptoms, breakfast consumption, moderate physical exercise, BMI, smoking, alcohol consumption) were recorded at Wave 3. Multivariable weighted linear regression was used to test the relationship between SBP and IPV by adjusting for confounders then by adjusting for the proposed mediators. Analyses were stratified by sex and a multiplicative term was tested. Results: Approximately 30% of the sample reported IPV exposure (n=2050), of which 23% (n=831) experienced low victimization and or perpetration, 5% (n=157) high victimization, 6% (N=203) high perpetration, 6% (n=206) both high victimization and perpetration. Women were slightly more likely to report high perpetration and both high victimization and high perpetration (p<0.01). In separate models controlling for confounders, experiencing both high victimization and perpetration was associated with 4.02 mmHg SBP higher in men (95% CI: 0.32, 7.72) and 2.51 mmHg SBP higher in women (95% CI: 0.18, 4.84) compared to those with no IPV. In addition, reporting high perpetration was associated with 3.83 mmHg higher SBP in men (95% CI: –0.72, 8.38), while high victimization was associated with 2.94 mmHg higher SBP for women (95% CI: –0.61, 6.49). Further adjustment for the hypothesized mediators slightly attenuated the findings. The multiplicative term (IPV X sex) was marginally significant (p=0.09). Conclusions: Exposure to high levels of victimization and perpetration is associated with higher levels of SBP for men and women. High victimization alone is related to higher SBP for women while high perpetration is related to higher SBP for men.


2019 ◽  
Vol 48 (Supplement_3) ◽  
pp. iii17-iii65
Author(s):  
Giulia Rivasi ◽  
Rose Anne Kenny ◽  
Andrea Ungar ◽  
Roman Romero-Ortuno

Abstract Background Older people taking benzodiazepines (BDZs) have higher risk of falling, which is mainly attributed to unfavorable drug-related effects on cognition and psychomotor functioning. BDZs may also have hypotensive effects, but evidence concerning the relationship between BDZs and orthostatic blood pressure (BP) behaviour in older people is scarce. We investigated the effects of BDZs on BP response to an orthostatic active stand test. Methods We performed a retrospective analysis of data from an outpatient research clinic in an Irish university hospital, where people aged 60 or older underwent a comprehensive geriatric assessment between August 2007 and May 2009. Non-invasive beat-to-beat orthostatic BP was measured during active stand, with systolic BP assessed at each 10-second interval. Information on regular BDZs use was collected. Factors independently associated with orthostatic systolic BP were investigated using multiple linear regression. Results Of 624 community-dwelling people who underwent a clinic assessment, orthostatic active stand data was collected in 541. Information on regular BDZs use was available in 538 people. Of 538 participants, mean age was 72.7±7.2, 67.7% were female and 33 (6.1%) reported regular use of BDZs. History of falls (p=0.027) and fear of falling (p<0.001) were more prevalent in this subgroup. During active stand, participants on BDZs showed a significantly greater systolic BP drop 10 seconds after the posture change (“immediate” BP drop). No significant differences were detected in orthostatic systolic BP in the latter phases of the active stand. After adjusting for possible confounders, BDZs use was independently associated with a mean immediate systolic BP drop of 12 mmHg after standing. Conclusion BDZs may confer higher risk of an immediate systolic BP drop after standing in older people, which may contribute to their known falls risk. BDZ should be avoided in older people at risk of falling.


2019 ◽  
Vol 8 (1) ◽  
pp. 54-57
Author(s):  
Eva Santi Hutasoit ◽  
Yessi Azwar

Hypertension is a condition when blood pressure in blood vessels increases chronically (Suiraoka, 2012). The risk of increasing this blood pressure is related to race, family history of hypertension, obesity, diet / food intake, smoking and the length of time the combination hormonal contraceptive is used. Family acceptors who use hormonal contraception over a period of time often complain of health problems, one of the health problems that are often experienced by hormonal contraceptive acceptors is hypertension or high blood pressure. Hormonal contraception can cause high blood pressure (hypertension) in approximately 4-5% of women who have normal blood pressure before taking the drug, and can increase blood pressure in 9-16% of women who have suffered hypertension before. The type of research used in this study is quantitative, with analytic research design and with a cross sectional approach, namely research conducted simultaneously. The number of samples is 54 mothers who are KB KBtor. From the results of the study, it was found that respondents who used hormonal contraception experienced an increase in blood pressure by 37 people (84.1%), while those who did not experience a rise in blood pressure were 7 people (15.9%). Respondents who did not use hormonal contraception experienced an increase in blood pressure by 5 people (50.0%), while those who did not experience an increase in blood pressure were 5 people (50.0%). From the Chi-square test results obtained a value of 0,045 (Pvalue 0,045 <α 0,05) and OR 5,286. This shows that Ha is accepted which means that there is a relationship between the use of hormonal contraception and an increase in blood pressure. OR = 5,286 showed that the use of hormonal contraception 5 times was associated with increased blood pressure.


Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Yangmei Li ◽  
Xinxue Liu ◽  
Robert N Luben ◽  
Amanda I Adler ◽  
Nicholas J Wareham ◽  
...  

Background and Objectives: An elevated white blood cell (WBC) count has been reported to be associated with all-cause mortality and risk of cardiovascular diseases. While the relationship between leukocyte count and coronary heart disease has been well documented, evidence on the association with risk of stroke has been less consistent. The aim of this study was to investigate the relationship between WBC count and incidence of stroke in a large cohort of disease-free men and women, and to assess how far any associations might be explained by traditional risk factors for stroke. Methods: We examined the prospective association between full blood WBC count and incident stroke in 7,392 men and 9,049 women from the general population participating in the European Prospective Investigation into Cancer-Norfolk Study. Participants were aged 39-79 years, without known heart attack, stroke, and cancer at the baseline examination in 1993-1997 and were followed up for incident stroke till March 2008. Results: During the median follow-up of 12 years, 542 incident stroke cases were observed. The age- and sex- adjusted risk of incident stroke increased with the increase of WBC count. Compared to the lowest quartile of WBC count, the age- and sex- adjusted hazard ratios (HRs) and 95% CIs for stroke were 1.11 (0.86-1.45), 1.40 (1.10-1.79), and 1.65 (1.29-2.09) in the second, third, and fourth quartile, respectively. Adjusting for smoking attenuated the results, while further adjustment for socioeconomic and lifestyle risk factors changed the association very little. The association was further attenuated after adjustment for biological risk factors such as systolic blood pressure and a history of diabetes at baseline, but people with the highest quartile of WBC count still had a higher risk of stroke than those in the lowest quartile (HR 1.32, 95% CI 1.02-1.71). Every 2*10 9 /L increase in WBC count was associated with a hazard ratio of 1.14 (95% CI 1.02-1.26) for stroke in the fully-adjusted model which included age, sex, smoking status, BMI, social class, educational level, alcohol intake, physical activity, systolic blood pressure, a history of diabetes at baseline, and total serum cholesterol. Conclusions: A positive association between WBC count and stroke was observed in these middle-aged and older men and women. Adjustment for smoking attenuated the association while multivariate adjustment for other risk factors did not further change the results.


Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Sarah A Hale ◽  
Carole McBride ◽  
Ira M Bernstein

Blood pressure (BP) and arterial stiffness are known to be correlated and have independent value in assessing risk for future cardiovascular disease. The objective of the current study was to evaluate the relationship between arterial stiffness, as measured by pulse wave velocity (PWV), and BP, in nulliparous women (CTL) as compared to women with a history of preterm preeclampsia (PE). Twenty-eight nulliparous women and 19 PEs were evaluated during the follicular phase of the menstrual cycle. There were no differences in age: CTL: 30.9 ± 0.9 vs. PE: 31.3 ± 1.1 yrs, p = 0.78. BMI was significantly lower in CTL: 24.4 ± 1.1 vs. PE: 28.5 ± 1.6 kg/m 2 , p = 0.02. Time interval from delivery to evaluation in PE was 2.46 ± 0.29 yrs. PWV was measured using simultaneous electrocardiographic tracings and ultrasound determined arterial flow waveforms and calculated as the estimated distance divided by the time interval between EKG r-wave peak and ultrasound derived peak popliteal artery flow. Beat to beat BPs were measured in the seated position using the Finapres Pro and averaged over one minute. The data are expressed as mean ± SE. P < 0.05 accepted for significance. MAP was significantly lower in CTLs than in PEs: 87.7 ± 1.4 vs PE: 94.4 ± 2.4, p = 0.02. There was no difference in PWV between CTL and PE: CTL: 2.51 ± 0.05, PE: 2.52 ± 0.06, p = 0.88. Pulse pressure was significantly correlated with PWV in PEs, but not in CTLs, CTL: r = 0.26, p = 0.18, PE: r = 0.54, p = 0.02. Systolic BP was significantly correlated in both CTL and PE with PWV: CTL: r = 0.43, p = 0.02, PE: r = 0.53, p = 0.02. There was a trend for a significant positive correlation between diastolic BP and PWV in the PE group, but not in the CTL: r = 0.11, p = 0.57, PE: r = 0.44, p = 0.06. The same trend existed in the PE for MAP and PWV: CTL: r = 0.27, p = 0.17, PE: 0.44, p = 0.06. For women who have had previous PE, a significant relationship exists between BP and arterial stiffness, while women who have not had a pregnancy do not exhibit this relationship. Pregnancy likely unmasks subclinical cardiovascular derangement resulting in PE, and persisting years beyond delivery. Our observations suggest that for women who have had prior PE evaluating the relationship between arterial stiffness and BP may be more informative for cardiovascular risk than assessing PWV alone.


2014 ◽  
Vol 54 (4) ◽  
pp. 202
Author(s):  
Desy Aswira Nasution ◽  
Rusdidjas Rusdidjas ◽  
Supriatmo Supriatmo ◽  
Rafita Ramayati ◽  
Oke Rina Ramayani ◽  
...  

Background A family history of hypertension is a risk factor forhypertension in children. Past studies have reported a significantrelationship between elevated blood pressure in children andhypertensive parents.Objective To assess for an association between blood pressure inchildren and that of their parents.Methods A cross-sectional study was conducted in 90 childrenaged 6-18 years in Baringin Village, Panyabungan, from May toJune 2010. Subjects were collected by consecutive sampling.Classification of hypertension was based on Fourth Task ForceGuidelines by measuring blood pressure, height, and weight. Weused Student's T-test to analyze numerical data. Simple linearregression was used to investigate the relationship between bloodpressures of children and their parents.Results Of the 90 participants recruited, 24 boys and 17 girlshad hypertensive parents. The mean systolic (SBP) , diastolic(DBP) and arterial blood pressure (MABP) were significantlyhigher in children with hyperten sive parents than in childrenwith normotensive parents [ (SBP 116. 7 (SD 7 .07) vs. 87 .1 (SD13.57) mmHg; P=0.0001), (DBP 77.8 (SD 8.33) vs. 51.8 (SD11.70) mmHg; P=0.0001), (MABP 90.7 (SD 7.41) vs . 63 .6(12.10) mmHg; P=0.000 1] . There was a significant relationshipbetween elevated SBP in boys and their fathers, as indicated bythe correlation coefficient (r =0.806; P=0.0001).Conclusion The blood pressure is significantly higher in childrenwith hypertensive parents than in those with normotensiveparents. There is a correlation between SBP in boys and that oftheir fathers.


Author(s):  
Yusrawati Yusrawati ◽  
Delmi Sulastri ◽  
Desmawati Desmawati

Objective: This study aimed to investigate the correlation between nutritional status and estradiol level with telomere length in premenopausal women with and without hormonal contraceptive history. Methods: This cross-sectional study was conducted in Padang city to 115 premenopausal Minangkabau ethnic 40–54 years old. Height examined using stature meter, waist circumference (WC) using measuring tape, and body weight using body scale were performed by trained people. Blood sample analysis was performed using O’Callaghan and Fenech’s technique to measure telomere length. Estradiol level was measured by enzyme-linked immunosorbent assay technique. Results: This research indicated that an average telomere length was 552.96±422.57 bp, body mass index (BMI) was 26.12±4.84, WC was 85.66±10.28 cm, and estradiol level was 148.24±54.03 pg/ml. The proportion of subjects who have hormonal contraceptives history was 65.2% with the most method of contraceptive used injection (75%). There were no correlations between BMI, WC, and estradiol level with telomere length (p>0.005). However, there was a positive significant correlation between estradiol levels and telomere length in women with no history of hormonal contraceptive use (p=0.025). Conclusion: A history of hormonal contraceptive used influences the correlation between estradiol levels and telomere length in premenopausal women. 


2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Yasi Anggasari

Event hyperemesis gravidarum viewed from use of history when pre hormonal contraception BPM Kusmawati Surabaya. Nausea vomiting in pregnancy is a physiological state occurs in pregnant women on a trimester 1. But still many pregnant women who experienced nausea vomiting excess accompanied the decline of appetite .The purpose of this research know the incidence of hyperemesis gravidarum seen from the history of the use of hormonal contraception during pre conception in BPM Kusmawati Surabaya. Analytic research design.The population of all pregnant women a trimester 1 visit in BPM Kusmawati Surabaya February 2015 of 22 people , large sample of 21 of respondents.Simple tekhnik random sampling, the independent variable research is the use of hormonal contraceptive and the dependent variable is hyperemesis gravidarum.Instrument of the questionnaire, data processing by means of coding, editing,tabulating and analyzed by test Chi square, with the level of kemaknaan = 0,05 . The results of research most ( 72.7 %) mother who use hormonal contraception had hyperemesis gravidarum. Fisher found the results of the value of statistical test excat =0,008 significance.Significant value < then rejected it means there is the relationship between the use of hormonal contraceptive with hyperemesis gravidarum incident in BPM Kusmawati Surabaya.


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