scholarly journals Gender-based incidence, recovery period, and mortality rate of COVID-19 among the population of district Attock, Pakistan

2023 ◽  
Vol 83 ◽  
Author(s):  
R. Ejaz ◽  
M. T. Ashraf ◽  
S. Qadeer ◽  
M. Irfan ◽  
A. Azam ◽  
...  

Abstract COVID-19 is reported as an extremely contagious disease with common symptoms of fever, dry cough, sore throat, and tiredness. The published literature on incidence and gender-wise prevalence of COVID-19 is scarce in Pakistan. Therefore, the present study was designed to compare the distribution, incubation period and mortality rate of COVID-19 among the male and female population of district Attock. The data were collected between 01 April 2020 and 07 December 2020 from the population of district Attock, Pakistan. A total of 22,962 individuals were screened and 843 were found positive for RT-qPCR for SARS-CoV-2. The confirmed positive cases were monitored carefully. Among the positive cases, the incidence of COVID-19 was 61.7% among males and 38.2% among females. The average recovery period of males was 18.89±7.75 days and females were 19±8.40 days from SARS-CoV-2. The overall mortality rate was 8.06%. The death rate of male patients was significantly higher (P<0.05) compared to female patients. Also, the mortality rate was higher (P<0.05) in male patients of 40-60 years of age compared to female patients of the same age group. Moreover, the mortality rate significantly increased (P<0.05) with the increase of age irrespective of gender. In conclusion, the incidence and mortality rate of COVID-19 is higher in males compared to the female population. Moreover, irrespective of gender the mortality rate was significantly lower among patients aged <40 years.

2021 ◽  
Vol 27 ◽  
Author(s):  
Lilla Tamási ◽  
Krisztián Horváth ◽  
Zoltán Kiss ◽  
Krisztina Bogos ◽  
Gyula Ostoros ◽  
...  

Objective: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database.Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between January 1, 2011 and December 31, 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any cancer treatment other than lung cancer protocols were excluded.Results: Lung cancer incidence and mortality increased with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46–3.01 (p &lt; 0.0001) among the 70–79 age group. We found 2–11% decrease in male incidence rate at most age groups, while a significant 1–3% increase was observed in older females (&gt;60) annually during the study period.Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary decreased in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.


2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e21572-e21572
Author(s):  
Gabriella Galffy ◽  
Zoltan Kiss ◽  
Krisztina Bogos ◽  
Judit Moldvay ◽  
Nora Bittner ◽  
...  

e21572 Background: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database. Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between 1st January 2011 and 31th December 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any anti-cancer treatment different from lung cancer protocols were excluded. Results: In 2011, 4,522 new male lung cancer cases were registered in the NHIF database, while we found 4,176 incident patients in 2016. The number of female patients increased from 2,636 to 2,828 during the same period. The mean age at diagnosis was 64.51 years for men (SD±9.85) and 64.93 years for women (SD±11.19) in 2011, increasing steadily to 65.80 years (SD±9.41) and 65.99 years (SD±10.45), respectively. Lung cancer incidence and mortality increases with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46 to 3.01 (p < 0.0001) among the 70–79 age group. We found 2-11% decrease in male incidence rate at most age groups, while a significant 1-3% increase was observed in older females ( > 60) annually during the study period. Conclusions: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary is decreasing in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.


2020 ◽  
Author(s):  
Lilla Tamási ◽  
Krisztian Horvath ◽  
Zoltan Kiss ◽  
Krisztina Bogos ◽  
Gyula Ostoros ◽  
...  

Abstract Background: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database.Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between 1th January 2011 and 31th December 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any anti-cancer treatment different from lung cancer protocols were excluded. Results: Lung cancer incidence and mortality increases with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46 to 3.01 (p<0.0001) among the 70–79 age group. We found 2-11% decrease in male incidence rate at most age groups, while a significant 1-3% increase was observed in older females (>60) annually during the study period.Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary is decreasing in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.


2014 ◽  
Vol 56 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Larissa Rodrigues Fabris ◽  
Úrsulla Vilella Andrade ◽  
Aline Ferreira Dos Santos ◽  
Ana Paula da Costa Marques ◽  
Sandra Maria do Valle Leone de Oliveira ◽  
...  

With the objective to evaluate the behavior of paracoccidioidomycosis in the last three decades, clinical and epidemiological data of 595 patients admitted to clinical services of the Federal University of Mato Grosso do Sul from 1980 to 2009 were investigated. Gender, age distribution, clinical form, comorbidity with tuberculosis or AIDS, and mortality were compared by decades of clinical admission. It was shown that during the three decades there was a decrease in women percentage, and the same manner occurred a reduction in participants in the age group of 20 to 39 years. Moreover, the acute/subacute forms have been diminished in the period. These fluctuations are closely related and can be simultaneously analyzed. Increased AIDS co-infection prevalence from the first to the second decade was also revealed, coinciding with the appearance of the retroviral epidemic and stabilizing during the third decade. No change in the tuberculosis co-infection rate was observed (overall = 6.9%). It reinforces the importance of this co-morbidity. The overall mortality rate remained steady at 6.7%, not varying significantly from one decade to another. The persistent mortality rate calls attention to the importance of this neglected disease.


2020 ◽  
Vol 8 (2) ◽  
pp. 108-117
Author(s):  
Jihe Zhu ◽  
Blagica Arsovska ◽  
Kristina Kozovska

Lung cancer is one of the most common and deadly malignancies in the world, which is characterized by uncontrolled division and growth of malignant cells in the pulmonary parenchyma. For the purposes of this paper was used data from the clinical hospital “Dr. Trifun Panovski'' in the Municipality of Bitola, Republic of North Macedonia  in the period of 2015-2019. The results show that the most of the cases are male with the leading age of about 55-64 years. However, the disease is becoming more common in the female population at a later age. Regarding the number of male patients treated in the Municipality of Bitola, it can be noted that the highest number of male patients was in 2018, and the lowest in 2017. Most female patients were treated in 2016 and the least in 2018. From the analysis of the Institute of Public Health, the highest number of male deaths in Bitola occurred in 2014 and the lowest in 2015 and 2018, among female patients, the highest number of deaths was in 2014, but the lowest in 2018. Death outcomes in Bitola represent about 6-7% of total number of deaths in the Republic of North Macedonia.


2020 ◽  
Vol 6 (1) ◽  
pp. 81-93
Author(s):  
Mijala Bajracharya ◽  
S Nakarmi

Correction: The page numbers were changed from 98-100 to 81-93 on 31/08/2020. Background: Obesity is regarded as worldwide health problems which may put a person at a higher risk of serious health conditions leading to morbidity and mortality. Obesity is a risk factor for many diseases of which hypertension and type-2 diabetes mellitus are the most important. Hypertension, diabetes mellitus and obesity together form 24% of the global risk for mortality. Cardiovascular diseases related to these life-style disorders has major effect on life expectancy and impaired quality of life. Objectives: The study was done to evaluate the drug prescribing pattern of type - 2 diabetes and hypertension in both obese and non-obese patients. Along with it, this study also attempt to find the contributing factors associated with it and different types of drugs selected in those conditions respectively. Method: A descriptive cross-sectional study was conducted in 2074 at Manmohan memorial teaching hospital. A total of 101 out-patient were interviewed, measurements were done to calculate BMI and waist to hip ratio and their prescriptions were reviewed. For Treatment Guideline of HTN, JNC 8[20] was followed and Updated Treatment Guidelines for Type 2 Diabetes by the American Diabetes Association (ADA) [21] was followed in case of diabetes. Result: Among 101 patients studied, 58 were males and 43 were females. Regarding physical activity, only 26.7% of total patients were involved in morning walk and 3% in yoga, remaining 71% of study patients did not involve in any kind of physical exercise. Regarding food habits, 22.8% were smokers, 49.5% were alcoholics and 96% were non-vegetarians. Waist to hip ratio was also observed higher in both males (35.6%) and females (39.6%). Among the101 total participants, the age group of 41-55 years were found to be more obese than other age group (34 in numbers) followed by age group 56-70 which were 16 in numbers. Male patients were more obese (41) than female patients (31). Highest number (31) of the obese patients were diagnosed with type 2 diabetes mellitus, followed by second highest number (26) of patients diagnosed with hypertension and 15 patients with both the conditions. The commonly prescribed oral hypoglycemic drugs were metformin (35.60%) followed by glimepiride (24.80%). Among anti-hypertensive drugs, amlodipine (22.80%) was most common in prescriptions followed by losartan (18.80%) and Telmisartan (17.80%). Conclusion: The results of the present study show that higher number of male patients (41) were obese than female patients (31). About 30% of patients were found obese-diabetic, 26% were obese-hypertensive and 15% were with both obese diabetic and hypertensive condition. Among oral hypoglycemic drugs, metformin (35.60%) was mostly prescribed followed by glimepiride (24.80%). Among antihypertensives, amlodipine (22.8%) was mostly prescribed followed by losartan (18.80%). Atorvastatin (11.9%) was mostly prescribed oral hypolipidemic agent.


Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4517-4517
Author(s):  
Mutlu Arat ◽  
Pervin Topcuoglu ◽  
Meltem K. Yuksel ◽  
Klara Dalva ◽  
Gulhis Gultekin ◽  
...  

Abstract In EORTC-LCG AML-10 study patients with low CD34 mobilization profile showed a better outcome (Leukemia,2003,17:60-7). We hypothesized that patients with low pCD34 at the recovery period after RI therapy with de novo AML should have a better clinical outcome or vice versa and launched this prospective study. Between Jan 2002 and Oct 2004, 40 patients with AML (median age: 40 yrs, 17–60; 22M/18F) were enrolled to this study. Using flow cytometrical method CD34-expressing cells were measured in peripheral venous blood samples once WBC was between 1x10e9/L to 3x10e9/L at the recovery period after first RI therapy. Results: The median time for estimation of pCD34 was 23 days (7–35) after RI. The pCD34 cell count was lower in patients responding to first RI therapy (12x10e6/L vs 68x10e6/L, p=0.011). We observed a weak, but statistically significant positive correlation between CD34 expression of the blasts at diagnosis and pCD34 at recovery period (p=0.048, r2:0.322). We could not show any significant negative impact of CD34 expression of the blasts at diagnosis and response to first RI (p=0.059). Only two of 8 patients not responding to the 1st RI achieved a complete remission after re-induction. The two-year probability of OS, LFS, relapse incidence and mortality rates were 47.1%, 37.2%, 55% and 42.5%, respectively (fig 1,2). If we set up a cut-off value of 18x10e6/L for pCD34, we did not observe any impact of pCD34 on relapse incidence but the mortality rate was significantly increased in patients with high CD34+ cell count (p=0.025). Conclusion: We were able to show a positive impact of pCD34 estimations after first RI in AML patients on both remission and mortality rate. AML Patients with lower pCD34 after 1st RI tends to have a higher hematological remission rate and lower mortality. This impact of pCD34 as a predictive and prognostic marker in AML should be verified in large cohorts using multivariate analysis. Table 1: Distribution of risk factors at diagnosis according RI response Variables 1stCRafter1stRI (n=32 ) NoCR after 1stRI (n=8 ) P *p<0.05; Abbr: NS: Non-Significant; ND: Not-Done pCD34 (x10e6/L) 12.4 (0–268) 68.6 (4.4–3820) 0.011* CD34 expr at dx 12% (0%–94%) 44% (9–89) 0.059 Age, years 38.5 (17–57) 43 (20–60) NS WBC at dx (x10e9/L) 11.85 (0.7–175.0) 5.10 (2.7–114.7) 0.934 EM involvement (Y/N) 7/25 0/8 NS Table 2: The outcome of AML patients according to median pCD34 at recovery Variables pCD34<Med 18x10e6/kg (n=20 ) pCD34 ≥ Med 18x10.6/kg (n=20) p CR1 (Y/N) after 1st RI 19/1 13/7 0.044* Relapse incidence 44% 54.5% NS Mortality rate 25% 60% 0.025* DFS 46.19%±12.6% 29.2%±10.4 NS OS 64.95%±13.2% 35.6%±11.3 NS Figure Figure


Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 1269-1269 ◽  
Author(s):  
Mohammed N Kanaan ◽  
Utkarsh H Acharya ◽  
Haiyan Cui ◽  
Denise J Roe

Abstract Background: Acute Myelogenous Leukemia (AML) portends a poor prognosis accounting for substantial morbidity and mortality among hematologic malignancies. While studies have reported that older age, adverse cytogenetics, and molecular markers implicate survival, there is a considerable scarcity of epidemiologic literature to enhance our understanding of this disease. We aimed to study the epidemiology and survival outcome of AML and its correlation with the age, race, gender and region of diagnosis by reviewing the Surveillance, Epidemiology, and End Result Program (SEER database). Methods: The SEER database (version 8.1.5) was reviewed for patients with histologically confirmed non APL-AML (ICD-O-3) between 2004-2007. Age of included patients ranged from 15 years to 90 years. Collected variables in the analysis included: date of diagnosis, age at diagnosis, gender, ethnicity, location of diagnosis, reported intervals of follow up and 3- year overall survival (OS). Primary outcome was 3-year median OS correlation with age, race and gender. All SEER registries were included in the analysis. Data were analyzed using Kaplan Meier and Cox proportional hazard regression model. Results: A total of 13,238 pts with non APL-AML were included between 2004 and 2007. The mean age in was 61.6 years. The Caucasian to non-Caucasian race ratio was 5:1 and male to Female ratio was 7:6. The 3-year overall survival was statistically significant for ethnicity as non-Caucasian group had better 3 year OS (26.8%) compared with Caucasians (23.45 %, p = 0.0009). However, the association with overall survival based on ethnicity was not significant after adjusting for region, gender and age (p = 0.5881). When examining for gender, female patients demonstrated improved 3 year OS compared with male patients which held true irrespective of region, race, or age (p = 0.0036). OS was also associated with region of diagnosis as patients in East region had better survival when compared with patients in West region (HR 0.96). The patients in South and Midwest regions had poorer survival when compared with the West region (HR 1.01 and 1.13, respectively). This survival difference was statistically significant after adjusting for age, race and gender. Interestingly, when OS was analyzed according to age, the hazard ratio increased by 20% with every 5 year increment in age despite adjustments for region, race, and gender (p < 0.001). Conclusion: Non APL-AML OS was statistically associated with gender, race, age and region of diagnosis. Non-Caucasian group had better OS compared with Caucasians. However, this association was not significant after adjusting for region, gender and age. However, female patients demonstrated improved 3 year OS compared with male patients after adjusting for confounding factors. Association with region showed statistically significant difference according to region of diagnosis favoring those diagnosed in the East. Interestingly, when OS was analyzed according to age, the hazard ratio increased by 20% with every 5 year increment in age despite adjustments for region, race, and gender. This study suggest that female gender may serve as a favorable risk factor in AML and further confirms that advancing age may confer inferior survival in this disease population. Disclosures No relevant conflicts of interest to declare.


2018 ◽  
Vol 29 (1) ◽  
pp. 16-20
Author(s):  
MMR Khan ◽  
NK Sana ◽  
PM Basak ◽  
BC Sarker ◽  
M Akhtarul Islam ◽  
...  

Background: The impacts of socio-demographic characteristics on acute myocardial infarction (AMI) are not well understood and have not yet been studied much more in our country. Acute myocardial infarction is the most common form of coronary heart disease and the single most important cause of premature death worldwide.Objective: The aim of this study was to assess the impacts of the socio-demographic characteristics on AMI patients and to investigate the association between socioeconomic status and its various indicators and the risk of acute myocardial infarction (AMI). This study will help in awareness building in reducing AMI by early detection of socio-demographic variables.Patients and methods: This was a prospective observational study consisted of 325 persons of AMI patients who were aged >20 years. Patients with first time AMI arriving in Coronary Care Unit (CCU) of Rajshahi medical college during the period of 2012-2014, were included. Data were collected through interview.Results: Among the AMI patients, male were more sufferer than female (68.3% vs. 31.7%) and male and female ratio was 2.15:1.0. Highest percentage of education was up to primary level (53.85%). Most of studied subjects (92.0%) monthly income were ≤15000. More than half (59.38%) of the studied population were from rural area, mostly they were Muslim (94.46%) and smokers (50.15%). The mean±SD age of the acute Myocardial infarction patients was 53.75±11.64 years. Mean age of the female patients were a little bit higher than the male patients (female 54.28±11.78 vs. male 53.51±11.63). Highest percentage was in the age group 51-60 years (32%) followed by 41-50 (26.8%) and then age group >60 (23.7%). Among the male patients highest percentage was in the age group 51-60 years (31.1%) followed by 41-50 years (27%) and then age group >60 (24.3%). However, among the female patients, highest percentage were in the age group 51-60 years (34%) followed by 41-50 years (26.2%), and then age group >60 (22.3%). Acute Myocardial infarction patients was more in age group >40 years of age. Interestingly after 60 years of age occurrence of AMI was low in both sexes.Conclusion: Both sex and age influenced AMI. An association was also found among educational level, monthly income, residence area, religion, smoking habit and AMI.TAJ 2016; 29(1): 16-20


2021 ◽  
Vol 8 (8) ◽  
pp. 2324
Author(s):  
Devaprashanth M. ◽  
B. S. Ramesh ◽  
Pushpa Satish Kumar

Background: Diabetic foot is a severe public health issue. Nutrition is important in the repair of soft tissue injuries and wound healing and specific nutrients have been shown to enhance wound healing. Anemia and hypoalbuminemia are among the commonly encountered deficiencies in patients. Early detection of nutritional deficiencies and their prompt treatment is imperative for the effective management of diabetic foot ulcers. The aim of the study was to investigate the prevalence of anemia and hypoalbuminemia in diabetic foot patients presenting at our institution.Methods: Hemoglobin and albumin levels of 175 patients with diabetic foot were collected. Data was tabulated and analysed with descriptive statistics.Results: Hemoglobin varied from 6.5 g/dl to15 g/dl (10.5±2.3 g/dl). 116 (66.28%) patients had anemia. Among the 66 female patients, 43 (65.15%) had anemia. Among the 109 male patients, 73 (66.97%) had anemia. 11 of the 29 patients aged less than 40 had anemia (37.93%), while 105 of the 146 (71.91%) patients above 40 years had anemia. Albumin levels ranged from 1.6 g/dl to 5.4 g/dl (3.3±1.06 g/dl). 93 (53.14%) patients had hypoalbuminemia. 33 of the 66 female patients (50%) had hypoalbuminemia. 60 (55.04%) of the 109 male patients had hypoalbuminemia. 4 of the 29 (13.79%) patients below 40 years had hypoalbuminemia 89 of the 146 patients (60.9%) above 40 years had hypoalbuminemia.Conclusions: Anemia and hypoalbuminemia are common in patients with diabetic foot ulcers, with males being more commonly affected by both than females and older age group being more commonly affected than younger age group. 


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