scholarly journals Thromboelastometric evaluation of horses submitted to experimental thrombosis and jugular thrombectomy

2016 ◽  
Vol 36 (8) ◽  
pp. 677-686 ◽  
Author(s):  
Dietrich Pizzigatti ◽  
Daniele S. Gonçalves ◽  
Thays C. Trentin ◽  
Regina K. Takahira ◽  
Ana L.G. Alves ◽  
...  
Keyword(s):  
Platelet Count ◽  
Surgical Treatment ◽  
Alpha Angle ◽  
Fogarty Catheter ◽  
Significance Level ◽  
Treatment Groups ◽  
Significant Difference ◽  
Group 2 ◽  
The Moment ◽  
Α Angle

Abstract: Jugular thrombosis in horses occurs commonly in iatrogenic situations, secondary to endotoxemic clinical condition and disseminated vascular coagulation, potentially leading to death. Thus, hemostatic evaluation becomes necessary and extremely important for monitoring the risks of systemic hypercoagulability and for the efficiency of allopathic and surgical treatment. This paper describes the hemostatic behavior in experimental jugular thrombosis of ten healthy equines, subsequently submitted to two thrombectomy techniques and receiving heparin sodium as anti-rethrombosis therapy. These animals were evaluated for 20 days by thromboelastometry (TEM), platelet count, hematocrit and fibrinogen, at four moments: pre-induction to phlebitis (D0-MPF); three days after thrombophlebitis induction (D3-MFM); 6 days after, - moment of thrombophlebitis - (D9-MT); and 54 (D16) and 126 (D19) hours after thrombectomies (PTM). Thrombectomy was performed via a Vollmar Ring (group 1, n=5) and Fogarty catheter (group 2, n=5). All the animals received heparin (150 UI/kg, SC) every 12 hours, for ten days after the respective thrombectomies. Through the blood samples were evaluated TEM, activated partial thromboplastin time (aPTT) and prothrombin time (PT), dosing of fibrinogen, hematocrit and platelet count at the abovementioned moments. For comparison between groups and moments the t test was applied at 5% significance level. No significant difference was verified between treatment groups at any of the moments. There were reductions in clotting time (CT) and clot formation time (CFT), with increase in maximum lysis (ML) until the moment D9-MT. Evaluation through INTEM® reagent presented prolongations of CT and CFT with reduction of α angle and ML starting from D16 and D19. Similarly, aPTT presented significant differences between moments pre- (D0, 3 and 9) and post- (D16 and 19) anticoagulant and surgical treatment. The platelet numbers were diminished at moments D16 and D19. In evaluation with EXTEM® reagent, prolongation of CT and CFT occurred only between the moments D0 vs. D3 and vs. D9. O PT did not present significant differences. The results obtained demonstrate that experimental jugular thrombophlebitis leads to local clinical alterations, with impairment of tissue and of the extrinsic coagulation pathway (EXTEM® ), but without evidence of systemic hypercoagulability status, since there was no increase of the alpha angle or maximum clot firmness (MCF). Furthermore, TEM was shown useful and more sensitive than conventional coagulation tests (PT, aPTT and fibrinogen) for the monitoring of anticoagulant therapy, as demonstrated in other works.

scholarly journals Comparative Analysis of Biofilm Removal Efficacy by Multisonic Ultracleaning System and Passive Ultrasonic Activation

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3492 ◽  
Author(s):  
Hae Won Choi ◽  
Seong Yeon Park ◽  
Mo Kwan Kang ◽  
Won Jun Shon
Keyword(s):  
Negative Control ◽  
Ultrasonic Activation ◽  
Treatment Groups ◽  
Mandibular Molars ◽  
Maxillary Molars ◽  
Biofilm Removal ◽  
Significant Difference ◽  
Hematoxylin And Eosin ◽  
Group 3 ◽  
Group 2

The purpose of this study was to compare disinfection and the biofilm removal efficacy of the GentleWave System (Sonendo, Inc., Laguna Hills, CA, USA) with passive ultrasonic activation method. Forty-seven freshly extracted human molars were inoculated with Enterococcus faecalis and cultured for five weeks to establish biofilm. Eight molars were tested for confirmation of infection. Four of the eight teeth were not inoculated in order to provide a negative control. The remaining 39 inoculated molars were randomly separated into three treatment groups (n = 13 per group): Group 1—no treatment, Group 2—conventional rotary instrumentation and passive ultrasonic activation, and Group 3—minimal instrumentation and the GentleWave System treatment. Roots were subsequently prepared per standard histological tissue processing procedures. Modified Brown and Brenn stained sections and Hematoxylin and Eosin stained sections were visualized at 4× and 13.5× magnification using a stereomicroscope. The sections were scored and blindly analyzed by two independent evaluators, including a histopathologist, to evaluate the presence of biofilm on canal wall. A significant difference was found between Group 2 and Group 3 in both apical and middle regions (p = 0.001) of the mesial roots of mandibular molars and mesiobuccal roots of maxillary molars. Group 3 revealed significantly less biofilm than the controls (p = 0.003). The GentleWave System demonstrated significantly greater reduction in biofilm within the mesial roots of mandibular molars and mesiobuccal roots of maxillary molars than those treated with conventional rotary instrumentation and passive ultrasonic activation protocol.

scholarly journals Dentinal Microcrack Formation after Root Canal Instrumentation by XP-Endo Shaper and ProTaper Universal: A Microcomputed Tomography Evaluation

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Sarah M. Alkahtany ◽  
Ebtissam M. Al-Madi
Keyword(s):  
The Body ◽  
Micro Ct ◽  
Cross Sectional ◽  
Significance Level ◽  
Root Canals ◽  
Type Iv ◽  
Significant Difference ◽  
Before And After ◽  
Microcrack Formation ◽  
Group 2

Aim. To evaluate dentinal microcrack formation on root canals instrumented, continuously in the body temperature, with XP-endo shaper (XPES) and ProTaper Universal (PTU), by means of microcomputed tomographic (micro-CT) analysis. Methodology. Nineteen mesial roots with two separate canals (Vertucci Type IV) of extracted mandibular molars were used in this study. The root canals (N = 38) were divided into 2 groups. Group 1 (n = 19): all MB canals were instrumented with XPES. Group 2 (n = 19): all ML canals were instrumented with PTU. All roots were scanned with micro-CT before and after instrumentation. Two precalibrated examiners evaluated the cross-sectional images of each sample with DataViewer program. The dentinal microcracks (complete and incomplete) were counted in each third of the root for the preinstrumentation and the postinstrumentation images. Wilcoxin signed-rank and Mann–Whitney U tests were used for statistical analysis at a significance level of P<0.05. Results. The number of microcracks increased significantly (P<0.05) after instrumentation with XPES in the middle and cervical thirds. The number of microcracks increased significantly (P<0.05) after instrumentation with PTU in the cervical third only. There was no significant difference between the groups in the cervical and apical thirds. In the middle third, the XPES induced more incomplete microcracks than PTU (P<0.05). Conclusion. Within the limitations of this study, there was no significant difference in the dentinal microcrack formation between XPES and PTU in the apical and cervical thirds of the root. However, XPES instrumentation induced more incomplete microcracks than PTU in the middle third of human roots.

scholarly journals Impact of Medical and Surgical Treatment of Endometriosis on the Cure of Endometriosis and Pain

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Liselotte Mettler ◽  
R. Ruprai ◽  
Ibrahim Alkatout
Keyword(s):  
Surgical Treatment ◽  
Hormonal Therapy ◽  
Treatment Options ◽  
Combined Treatment ◽  
Treatment Strategies ◽  
Outcome Data ◽  
Deep Infiltrating Endometriosis ◽  
Cure Rate ◽  
Significant Difference ◽  
Group 2

This endometriosis study evaluates three different treatment strategies (hormonal medication, surgical, or combined treatment) and discusses the influence of endometriosis on the cure of this disease and pain relief. Four hundred and fifty patients with genital endometriosis, aged 18–44 years, were randomly distributed to three treatment groups at the first laparoscopy. They were reevaluated at a second-look laparoscopy (D 426/10), one to two months after the three-month hormonal therapy for groups 1 and 3 and five to six months later for group 2 (surgical treatment alone). Outcome data focussed on the recurrence of symptoms and pain. The three treatment options independent of the initial endoscopic endometriosis classification (EEC) stage including deep infiltrating endometriosis (DIE) achieved an overall cure rate of 50% or higher. The highest cure rate of 60% was achieved by the combined treatment, 55% by the exclusively hormonal therapy, and 50% by the exclusively surgical treatment. An overall pregnancy rate between 55% and 65% was achieved with no significant difference in relation to the therapeutical option.

Is the Preoperative Glycated Hemoglobin (HbA1c) Level Predictive of the Severity of Diabetic Hand Infection According to Surgical and Clinical Outcomes?

2019 ◽  
Author(s):  
Kaan Gürbüz ◽  
Yakup Ekinci
Keyword(s):  
Surgical Treatment ◽  
Hba1c Level ◽  
Surgical Techniques ◽  
Study Groups ◽  
Clinical Findings ◽  
Diabetic Patients ◽  
Hand Infection ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Abstract Objective We purposed to investigate whether preoperative HbA1c level is associated with the severity of surgical treatment in diabetic hand infection cases. Materials and Methods Between December 2015 and October 2018, 102 patients were surgically treated due to diabetic hand infection. Of the patients, 75 who met the criteria for diabetic hand infection were included in the study. The patients were divided into two groups: Group 1, < 8.5% HbA1c level (poorly controlled); and Group 2, 8.5% or higher HbA1c level (uncontrolled). Preoperative, intraoperative, and postoperative data were recorded. Drainage, VAC, ray/open amputation, and microsurgical reconstruction were performed according to the examination and clinical findings. p<0.05 was considered statistically significant. Results The study groups consisted of 41 patients (5 female/36 male; median age 59 years, range 32–68) in Group 1 and 34 patients (6 female/28 male; median age 62 years, range 28–67) in Group 2. The mean follow-up period was 21.14±10.42 months in Group 1 and 16.70±10.19 months in Group 2, which were not significantly different (p>0.05). The most common microbiological pathogen was polymicrobial in both study groups (39% in Group 1 and 41.2% in Group 2). Drainage was the most common surgical procedure in both groups and there was no significant difference between the groups in terms of the surgical techniques that were used (p>0.05). Conclusion Although HbA1c level is an important biomarker for monitoring glycemia in diabetic patients, it is not associated with the severity of surgical treatment in diabetic hand infections.

scholarly journals Effect of additional PGF2? dose on pregnancy rate in Nellore females subjected to FTAI

2020 ◽  
Vol 41 (6) ◽  
pp. 2669-2676
Author(s):  
Jorge Luís Ferreira ◽  
◽  
Matheus Henrique Dias Rodrigues ◽  
Shammara Noleto Santos ◽  
Rodolfo Olinto Rotoli Garcia de Oliveira ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Fixed Time ◽  
The State ◽  
Wilcoxon Test ◽  
Control Group ◽  
Additional Dose ◽  
Significance Level ◽  
Treatment Groups ◽  
Significant Difference ◽  
Nellore Cattle

This study examined the effect of administering an additional dose of prostaglandin F2 alpha (PGF2?), in a fixed-time artificial insemination protocol (FTAI), on the fertility of female Nellore cattle. Two experiments were carried out: the first (Experiment I) took place in the state of Tocantins and the second (Experiment II) in the state of Pará, Brazil. In Experiment I (E1), 80 cows were used in three treatments (T1, T2 and T3) in which all received the same FTAI protocol. In T1 (n = 29), the cows received 12.5 mg of Dinoprost on day 9; in T2 (n = 28), they received the additional dose on day 10; and in T3 (n = 23; control group), the animals did not receive the additional PGF2? dose. Experiment II consisted of 147 bovine females distributed into two treatment groups, namely, T1 - 72 animals receiving the same protocol as T1 of E1; and T2 - 75 animals receiving the same protocol as T3 of E1. Statistical analysis was performed using SAS software, applying the PROC NPARWAY procedure for E1, and means were compared by the Wilcoxon test at the 5% significance level. In Experiment II, the data were subjected to analysis of variance by PROC GLIMMIX and means were compared by the T test at the 5% significance level. The following pregnancy rates were obtained in Experiment I: T1 - 62.06% (18/29); T2 - 57.14% (16/28); and T3 - 52.17% (12/23), with no significant difference observed between treatments. In Experiment II, pregnancy rate in T1 was 66.67% (48/72), whereas in T2 it was 41.33% (31/75), with a significant difference detected (P < 0.05). An additional dose of PGF2? provides an increase in pregnancy rate in Nellore females.

scholarly journals Pengaruh Teknik Vulva Hygiene terhadap Jumlah Kuman Vulva pada Ibu Nifas di BPM Kota Bandar Lampung

2017 ◽  
Vol 8 (3) ◽  
pp. 465
Author(s):  
Nelly Indrasari ◽  
Purwati Purwati
Keyword(s):  
Degrees Of Freedom ◽  
Laboratory Data ◽  
Research Unit ◽  
Control Group ◽  
Chi Square ◽  
Significance Level ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
And Control

<p>The case of maternal mortality in Bandar Lampung city in 2013 is 19 cases, in 2014 there are 7 cases and all died during childbirth and there are 19 cases of maternal death by 2015. (Profile of Lampung Province Health Office 2014). Research Objectives to Detect the Influence of Vulva Hygiene Technique on Number of Vulva Germs In Nifas Mother In BPM Bandar Lampung City Year 2016. This research method using quasi-experiment design. This study compares between treated groups and control groups. Treatment group 1 was treated with vulvar hygiene by using 1 cotton, group 2 using 3 kinds of cotton, group 3 using 5 cotton and control group without treatment. Population in this research is mother Nanyang checking his health at BPM in Bandar Lampung city at the time of research. The sample of respondent's research is 120. Data collection with Teradata is done as much as 1 time then done culture and examination in a local laboratory. Data were processed and analyzed by independent T-test. The result showed that the average number of germs was 2277,37 germs (95% CI 7140,59-38402,16) with standard deviation 65553,94 germs. The lowest number of germs and pathogen bacteria still 0.35% of respondents on the vulva hygiene of a cotton with a duration of 26 days. The result of analysis with cruciate Wallis test is 3,498. Looking at the statistics of the table by looking at the Chi-square table, for df (degrees of freedom)=3 and the significance level (α) = 5%, then obtained statist table 2.32. Because of the count statistic (2.32&gt; 0.321), then Ho accepted, or no significant difference (significant). The research unit can utilize and apply vulva hygiene technique with antiseptic, so it can prevent the occurrence of infection in the postpartum mother.</p>

scholarly journals PLATELET COUNT INCREASES IN CHRONIC OTITIS MEDIA PATIENTS WITH BLOCKED EUSTACHIAN TUBE

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Okan DIKKER ◽  
Cem ALTINDAĞ ◽  
Güven YILDIRIM ◽  
Tolgar Lütfi KUMRAL
Keyword(s):  
Platelet Count ◽  
Otitis Media ◽  
Eustachian Tube ◽  
Chronic Otitis Media ◽  
Residual Pressure ◽  
Old Patients ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objectives: The aim of the present study was to examine the levels of complete blood count (CBC) parameters (Neutrophil, lymphocyte, platelets, MPV, NLR, and PLR) in patients with both perforated eardrums and dysfunctional eustachian tubes to determine which of these parameters might be reliable biomarkers of chronic otitis media prior to surgery, as inflammation is significant component of middle ear pathology. Materials and methods: In this study, we enrolled 95 patients with 18-65 years old. Patients with chronic otitis media (perforated tympanic membranes) more than three months in duration who have no draining ears, were enrolled in Okmeydani Training & Research Hospital. Patients were divided into three groups: Group 1 is “Open eustachian tube” group in which pressure changes (if evident) during swallowing were recorded on stepladder-type graphs; Group 2 is “Blocked” group, who could not neutralize the negative pressure even by repeated swallowing. Group 3 is “Partially blocked” group in whom some residual pressure persisted even after five swallows. The groups were compared in terms of laboratory tests. Results: There was a statistically significant difference between 3 groups in terms of platelet levels (p>0.05). We found that group 2 / blocked eustachian tube had significantly increased platelet counts values when compared to the group 1 and 3. There was no significant difference among group 1 and group 3.  There was no statistically significant difference between the 3 groups in terms of neutrophil, lymphocyte count, MPV, NLR, PLR levels, bone and air hearing thresholds. Conclusion: We found that the platelet count increased in chronic otitis media patients with blocked eustachian tube. This may be a simple and inexpensive biomarker with acustic impedencemeter tests supporting eustachian dysfunction before tympanoplasties. Key Words: Hematological biomarkers; eustachian tube dysfunction; chronic otitis media

scholarly journals Removal Torque Analyses of Two Self-drilling Orthodontic Temporary Anchorage Devices (TADs)

2019 ◽  
pp. 64-67 ◽  
Author(s):  
Mahfud F Mohamed
Keyword(s):  
Occlusal Plane ◽  
Coil Spring ◽  
Removal Torque ◽  
Temporary Anchorage Devices ◽  
Significant Difference ◽  
Maxillary Molar ◽  
Orthodontic Patients ◽  
Group 2 ◽  
The Stability ◽  
The Moment

Stability of miniscrews or Temporary Anchorage Devices (TADs) is an essential factor for successful application in orthodontics. Miniscrews removal torque can be used as an indicator of miniscrews stability. The objective of this work was to compare removal torque between self-drilling tapered mini-screws and cylindrical miniscrews. Materials and Methods: Two groups of TADs were inserted in the maxillae of orthodontic patients to provide stationary anchorage for front teeth retraction. Group 1: 20 tapered self-drilling miniscrews, Group 2: 20 cylindrical self-drilling miniscrew. Split mouth technique was used. All of the TADs were inserted parallel to the occlusal plane, between roots of the 2nd maxillary premolar and 1st maxillary molar. The TADs were immediately loaded with constant and continuous load using 8 mm long heavy short Nickel Titanium coil spring. The coil spring was stretched between the heads of the two types of TADs and crimpable hooks that fixed on arch wire just distal to the anterior six maxillary teeth. After complete retraction of the anterior maxillary teeth, TADs were removed using torque adjustable screw-removal. At the moment of movement of the TAD the torque was recorded in Newton Centimeter (Ncm). Results: Mann Whitney U Test resulted in a significant difference between the two groups, indicating that cylindrical TADs had significantly higher removal torque than tapered TADs (means were 3.20 Ncm ± 0.20 and 2.70 Ncm ± 0.10 respectively). Conclusion: Physical properties have a considerable influence on the stability of the TADs. Cylindrical TADs are showed more mechanical interlock into the bone.

scholarly journals Association between agenesis and root morphology of anterior teeth

2019 ◽  
Vol 48 ◽  
Author(s):  
Rodrigo BORALI ◽  
Carolina Carmo de MENEZES ◽  
Giovana Cherubini VENEZIAN ◽  
Silvia Amélia Scudeler VEDOVELLO ◽  
Viviane Veroni DEGAN
Keyword(s):  
Root Morphology ◽  
Third Molar ◽  
Tooth Agenesis ◽  
Chi Square ◽  
Significance Level ◽  
Exact Test ◽  
Anterior Teeth ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2

Abstract Introduction Tooth agenesis is likely to affect the root teeth and should be considerated in orthodontic tratament. Objective The aim of this study was to assess the association between agenesis and root morphology of anterior teeth. Material and method The anterior teeth of 51 individuals were evaluated on 102 periapical radiographs and then divided into three groups: Group 1 (n=16) – no tooth agenesis; Group 2 (n=17) – only third molar agenesis; and Group 3 (n=18) – tooth agenesis of premolars or lateral incisors. Root morphology of anterior teeth was evaluated and the roots were classified as short, blunt, apically bent, and pipette-shaped. Fisher’s exact test was used to compare root shapes, the chi-square test was used to obtain the distribution of sexes between the groups, and ANOVA was performed to compare the ages between the groups. The significance level was set at 5% for all analyses. Result There was significant difference in root shapes (P<0.05) between the groups. Blunt roots were the most prevalent in all groups, but their rate was higher in Group 3 (83%). Conclusion There was association between agenesis and root morphology of anterior teeth.

scholarly journals Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Tolga Yilmaz ◽  
Ahu Yilmaz
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Platelet Count ◽  
Large Cell ◽  
Distribution Width ◽  
Group 4 ◽  
Significant Difference ◽  
Group 2

Purpose. To investigate whether platelet morphology or function is altered in patients with diabetic retinopathy (DR).Methods. This prospective study enrolled 85 healthy controls (HCs) (group 1) and 262 patients with Type 2 diabetes mellitus (T2DM). Patients were subclassified into three groups according to ocular findings: no DR (group 2;n=88); nonproliferative DR (group 3;n=88), and proliferative DR (group 4;n=86). Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT) values, and platelet count were measured in the studied groups.Results. MPV, PDW, and PLCR levels were significantly altered in groups 2–4 compared with HCs (p<0.05,p<0.05,p<0.05). Compared with group 2, both DR groups had higher MPV and PDW levels, with a significant difference between groups 2 and 4 for both MPV (p=0.036) and PDW (p=0.006). PLCR correlated with retinopathy stage, but no significant difference was found between the DR groups. Platelet count and PCT values were not significantly different between the groups (p>0.05).Conclusion. Our findings suggest an association between mean platelet indices (MPI) (i.e., MPV, PDW, and PLCR) and DR stage. Therefore, MPI could be a beneficial prognostic marker of DR in patients with T2DM.

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