scholarly journals Susceptibility gene discovery for common metabolic and endocrine traits

2002 ◽  
Vol 28 (1) ◽  
pp. 1-17 ◽  
Author(s):  
MI McCarthy
Keyword(s):  
Molecular Basis ◽  
Susceptibility Gene ◽  
Gene Discovery ◽  
Premature Death ◽  
Susceptibility Genes ◽  
Disease Pathogenesis ◽  
Autoimmune Thyroid ◽  
History Of ◽  
The Individual ◽  
Almost All

Almost all major causes of ill-health and premature death in human societies worldwide - including cancer, cardiovascular disease, diabetes and many infectious diseases - are, at least in part, genetically determined. Typically, risk of succumbing to one of these illnesses is thought to depend on both the individual repertoire of variation within a number of key susceptibility genes and the history of exposure to relevant environmental factors. For many of these conditions, the molecular basis of disease pathogenesis remains obscure. This represents a major obstacle to development of improved, rational strategies for disease treatment, prevention and eradication. It is easy therefore to appreciate the importance attached to efforts to deliver more comprehensive understanding of the molecular basis of disease pathogenesis. Nor is it hard to understand that identification of major susceptibility genes should highlight those components of molecular machinery that are critical for the preservation of normal health. The benefits promised are great, but progress to gene identification in multifactorial traits has been rather disappointing to date. Why is this? This review aims to answer this question by describing current and future approaches to gene discovery in multifactorial traits. The examples quoted will mostly relate to type 2 diabetes, but the issues and approaches are generic, and apply equally to other multifactorial traits in the endocrine and metabolic arena - type 1 diabetes; obesity; hyperlipidaemia; autoimmune thyroid disease; polycystic ovarian syndrome - and beyond.

Means And Seas

2020 ◽  
Vol 2020 (46) ◽  
pp. 40-54
Author(s):  
Siegfried Zielinski
Keyword(s):  
Close Contact ◽  
The Other ◽  
Viable Alternative ◽  
World Community ◽  
Guiding Principle ◽  
History Of ◽  
The One ◽  
The Individual ◽  
Almost All ◽  
Bodies Of Water

In this article, the author examines the contrasting worldviews of specific philosophers, architects, and physicists in an attempt to identify a position that would represent a viable alternative to the concept of universalization. In the history of civilization, he asserts, almost all wars have been of a territorial nature. Territories tend toward uniformity and universalization. He contrasts this worldview with reflections on oceanic thinking, which perceives bodies of water such as the Mediterranean as mediators between continents as well as between opposing worldviews, connecting and dividing at the same time. The sea, however, does not connect in order to homogenize but rather creates distance as an important prerequisite for true communication, thus linking multiplicity in all its variety as a viable alternative to universalism. The author moves on to scrutinize the cosmopolitan attitude as a paradox that on the one hand is oriented to the particular individual and on the other hand to an imaginary world community, that is, the universal. Taking this notion further to consider today’s world that is saturated with the imaginary and symbolic power of the Internet, the author proposes that cosmopolitanism could be understood as an adequate expression for the technologically advanced world community by its capability to strike a balance between the individual and the world as a whole, on one side, and synthetic identity generated by culture and technology, on the other. Nevertheless, deviating from all of these worldviews, the author concludes with a short reflection, inspired by two films, on an alternative to cosmopolitanism that he calls cosmoethics, which employs ethics as the guiding principle of thought and action and commits to a practice that stays in close contact not only with real but also with diverse realities.

Opium and Social Control: Coolies on the Plantations of Peru and Cuba

2005 ◽  
Vol 1 (2) ◽  
pp. 169-183 ◽  
Author(s):  
Evelyn Hu-DeHart
Keyword(s):  
Social Control ◽  
Premature Death ◽  
The Pacific ◽  
Scant Attention ◽  
African Slaves ◽  
History Of ◽  
Contract Laborers ◽  
Human Trade ◽  
Coolie Trade ◽  
Almost All

AbstractThe place of opium in the history of the Chinese diaspora in Latin America and the Caribbean has received scant attention. This article is a preliminary attempt to look into this history, based on fragmentary evidence available. From 1847 to l874, as many as 225,000 Chinese indentured or contract laborers (coolies), almost all men, were sent to Cuba, still a Spanish colony, and newly independent Peru. Both the human trade itself, as well as work and life on the plantations, closely resembled slavery; indeed, the coolies in Cuba worked alongside African slaves. Opium was part of the coolie trade from its inception, distributed in the holding pens in South China ports, on the long, arduous voyages across the Pacific or Atlantic, as well as on the plantations. Cuban and Peruvian planters permitted, even encouraged, the sale, barter and consumption of opium by their coolies, in effect creating a mechanism of social control by alternately distributing and withholding this very addictive substance to desperate men. But this cynical use of opium might also have backfired on them, as sustained and massive ingestion lowered productivity, caused premature death (often by suicide), and resulted in high absenteeism.

A Comparative Study of Current Methods and Recent Advances in the Diagnosis and Assessment of Osteoporosis

2020 ◽  
Vol 2 (1) ◽  
pp. 3-17
Author(s):  
Hamidreza Shirzadfar ◽  
Narsis Gordoghli
Keyword(s):  
Family History ◽  
Bone Density ◽  
Early Diagnosis ◽  
Early Treatment ◽  
Sick People ◽  
Light Skin ◽  
History Of ◽  
Potential Risks ◽  
The Individual ◽  
Almost All

Osteoporosis is an abnormality that is manifested by a decrease in bone density. People with light skin, fine skeletons, a family history of osteoporosis, smokers, sedentary people and postmenopausal women are more likely to develop the disease. Early diagnosis of this disease can be of great help to improve one's future life course and prevent potential risks. There are currently ways to diagnose the disease that is discussed below. But what is important in this study is how to diagnose the disease further in this study and to use the tools that are least risky for the individual. In this case, almost all people in the community, including children and sick people, can also be tested. The person with the disease will receive early treatment.

scholarly journals Analysis of Http Cookie Hijacking in the Wild

2020 ◽  
Vol 9 (7) ◽  
pp. 859-863
Keyword(s):  
Customer Order ◽  
Home Address ◽  
In The Wild ◽  
History Of ◽  
The Individual ◽  
Session Hijacking ◽  
Mail Address ◽  
Almost All ◽  
E Mail ◽  
Vast Range

Because cookies act as the sole evidence of user identification, web sessions are especially vulnerable to attacks through session hijacking, where the server operated by a specific user sends users ' identity requests. If n > 1 cookies are used to execute a session, n sub-sessions that actually run on the same website where the individual cookies are used to access part of the session's state details. Our cookie hijacking analysis shows a range of significant defects; attackers may reach Google's home address and work address and websites that are accessed by Bing or Baidu, show the entire browsing history of the user, and Yahoo enables attackers to delete the list of contacts and upload emails from the account of the consumer. For fact, e-commerce providers such as Amazon and Ebay have a limited, complete customer order background, so almost all platforms have a user name so e-mail address on their page. Ad networks like Doubleclick will also expose pages accessed by the customer. In this article, we propose to improve the latest state-of - the-art HTTP(S) session control by utilizing user fingerprint.A vast range of functionalities of the new client tracking makes session identification on the server observable and dramatically increases the threshold for attackers. Furthermore, this paper describes HTML5 and CSS capabilities for client fingerprinting and the recognition or authentication of a device by using the UserAgent list.

Crises in Cephalopod Evolution

1985 ◽  
Vol 13 ◽  
pp. 202-214
Author(s):  
Curt Teichert
Keyword(s):  
Social Sciences ◽  
Evolutionary History ◽  
The Social ◽  
Short Period ◽  
History Of ◽  
Hierarchic Level ◽  
The Individual ◽  
Almost All ◽  
International Dictionary ◽  
Cephalopod Evolution

The 520 million year evolutionary history of the Cephalopoda is punctuated by a number of severe crises during each of which this class came very close to extinction. These are fully documented only for the externally shelled, or ectocochlian, cephalopods to which my remarks are, therefore, restricted. The word crisis should be defined narrowly in the sense in which it is used in medicine, business, and the social sciences: “a condition…. felt to endanger the continuity of the individual or his group “(Webster's Third International Dictionary). Within species, genus, and family groups evolutionary crises are, of course, commonplace, and even orders may disappear without threatening the extinction of an entire class. It is only when all, or almost all, taxa of family-group and lower hierarchic level disappear more or less simultaneously, or within a geologically very short period of time, that we may speak of a crisis, a situation that threatens the very survival of a class, or higher taxon, of organisms. It is the purpose of this presentation to study in some detail this kind of situation as it has affected the evolutionary history of the Cephalopoda.

Investigating the Relationship Between Self-Esteem and Stigma Among Young Adults With History of Suicide Attempts

Crisis ◽  
2016 ◽  
Vol 37 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Meshan Lehmann ◽  
Matthew R. Hilimire ◽  
Lawrence H. Yang ◽  
Bruce G. Link ◽  
Jordan E. DeVylder
Keyword(s):  
Young Adults ◽  
Suicide Attempts ◽  
Self Esteem ◽  
High Risk Population ◽  
High Functioning ◽  
People With Mental Illness ◽  
History Of ◽  
The Individual ◽  
The Impact ◽  
The Relationship

Abstract. Background: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. Aims: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. Method: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. Results: There was a significant stereotype awareness by attempt interaction (β = –.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (β = –.50, p = .013) compared with those without attempts (β = –.09, p = .037). Conclusion: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.

From the Tower of London to the Thomas More Society of Buenos Aires: “Give me thy grace, good Lord, to set the world at nought”

Moreana ◽  
2005 ◽  
Vol 42 (Number 164) (4) ◽  
pp. 187-206
Author(s):  
Clare M. Murphy
Keyword(s):  
Buenos Aires ◽  
Short History ◽  
Thomas More ◽  
Tower Of London ◽  
Hebrew Poetry ◽  
Prayer Book ◽  
The World ◽  
History Of ◽  
Book Of Hours ◽  
Almost All

The Thomas More Society of Buenos Aires begins or ends almost all its events by reciting in both English and Spanish a prayer written by More in the margins of his Book of Hours probably while he was a prisoner in the Tower of London. After a short history of what is called Thomas More’s Prayer Book, the author studies the prayer as a poem written in the form of a psalm according to the structure of Hebrew poetry, and looks at the poem’s content as a psalm of lament.

Victorian Pain

2017 ◽  
Author(s):  
Rachel Ablow
Keyword(s):  
Nineteenth Century ◽  
Victorian Literature ◽  
Social Life ◽  
Charles Darwin ◽  
Harriet Martineau ◽  
The Status ◽  
History Of ◽  
The Individual ◽  
Natural Philosophers ◽  
First Time

The nineteenth century introduced developments in science and medicine that made the eradication of pain conceivable for the first time. This new understanding of pain brought with it a complex set of moral and philosophical dilemmas. If pain serves no obvious purpose, how do we reconcile its existence with a well-ordered universe? Examining how writers of the day engaged with such questions, this book offers a compelling new literary and philosophical history of modern pain. The book provides close readings of novelists Charlotte Brontë and Thomas Hardy and political and natural philosophers John Stuart Mill, Harriet Martineau, and Charles Darwin, as well as a variety of medical, scientific, and popular writers of the Victorian age. The book explores how discussions of pain served as investigations into the status of persons and the nature and parameters of social life. No longer conceivable as divine trial or punishment, pain in the nineteenth century came to seem instead like a historical accident suggesting little or nothing about the individual who suffers. A landmark study of Victorian literature and the history of pain, the book shows how these writers came to see pain as a social as well as a personal problem. Rather than simply self-evident to the sufferer and unknowable to anyone else, pain was also understood to be produced between persons—and even, perhaps, by the fictions they read.

Queering Gender Identity Work: A Life History of a Black Transgender Woman

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Esethu Monakali
Keyword(s):  
Life History ◽  
Gender Identity ◽  
Public Spaces ◽  
Identity Work ◽  
Social Identities ◽  
Gender And Sexuality ◽  
Ongoing Effort ◽  
History Of ◽  
The Individual

This article offers an analysis of the identity work of a black transgender woman through life history research. Identity work pertains to the ongoing effort of authoring oneself and positions the individual as the agent; not a passive recipient of identity scripts. The findings draw from three life history interviews. Using thematic analysis, the following themes emerge: institutionalisation of gender norms; gender and sexuality unintelligibility; transitioning and passing; and lastly, gender expression and public spaces. The discussion follows from a poststructuralist conception of identity, which frames identity as fluid and as being continually established. The study contends that identity work is a complex and fragmented process, which is shaped by other social identities. To that end, the study also acknowledges the role of collective agency in shaping gender identity.

AN APPRAISAL OF SOURCE MATERIAL FOR THE STUDY OF TARGUM MINOR PROPHETS

2017 ◽  
Vol 24 (2) ◽  
pp. 451-469
Author(s):  
Gudrun Lier ◽  
Anna Fransina Van Zyl
Keyword(s):  
Source Material ◽  
Bible Translations ◽  
Integrated Research ◽  
Translation Techniques ◽  
Former Prophets ◽  
History Of ◽  
The Individual ◽  
History Of Biblical Interpretation ◽  
Work Done ◽  
Minor Prophets

The study of Aramaic Bible translations (Targumim) continues to be a valuable source of information, not only for uncovering the history of biblical interpretation but also for providing insights for the study of linguistics and translation techniques. In comparison with work done on the Pentateuchal Targumim and Targum Former Prophets, research on the individual books of Targum Minor Prophets has been scant. By providing an overview of selected source material this review seeks (i) to provide incentives for more focussed studies in the field of Targum Minor Prophets and (ii) to motivate new integrated research approaches which are now made possible with the assistance of highly developed software programmes.

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