scholarly journals The role of nimodipine and magnesium sulfate in the prevention and treatment of vascular spasm in patients in the acute rupture of cerebral aneurysms

2020 ◽  
Vol 10 (4) ◽  
pp. 53-60
Author(s):  
Aleksandr A. Kalinkin ◽  
A. G. Vinokurov ◽  
O. N. Kalinkina ◽  
G. М. Yusubalieva ◽  
S. M. Chupalenkov
Keyword(s):  
Magnesium Sulfate ◽  
Cerebral Arteries ◽  
Cerebral Aneurysms ◽  
Drug Action ◽  
Adverse Outcomes ◽  
Action Mechanisms ◽  
Prevention And Treatment ◽  
Acute Rupture ◽  
Vascular Spasm

Vascular spasm in patients with hemorrhage from rupture of cerebral aneurysms is the main cause of adverse outcomes of the disease. One way to treat persistent contraction of cerebral arteries is to use nimodipine and magnesium sulfate. This literature review presents studies on the use of nimodipine and magnesium sulfate in the treatment of vascular spasm, and highlights the main links of pathogenesis and drug action mechanisms.

scholarly journals Immune mechanisms of SARS-CoV-2 and potential drugs in the prevention and treatment of COVID-19

2020 ◽  
Vol 30 (5) ◽  
pp. 700-708
Author(s):  
M. P. Kostinov ◽  
E. V. Markelova ◽  
O. A. Svitich ◽  
V. B. Polishchuk
Keyword(s):  
Adverse Outcomes ◽  
The Body ◽  
Innate And Adaptive Immunity ◽  
Immune Mechanisms ◽  
Interferon Induction ◽  
Prevention And Treatment ◽  
Ifn Therapy ◽  
Coronavirus Infection ◽  
Spread Of Infection

The lack of specific vaccines against SARS-CoV-2, as well as chemotherapy, significantly affected the spread of infection and the number of adverse outcomes of COVID-19. With the discovery of the pathogenesis of coronavirus infection, especially immune mechanisms, the important role of the innate immunity system in interacting with the virus is obvious. The presence of comorbid conditions, as well as the aging of the body, lead to disturbances in the immune response mechanism, low interferon induction, depletion of CD8+ -lymphocytes and natural killers and suppression of the effectiveness of both innate and adaptive immunity. The review discusses various mechanisms of antiviral activity associated with the induction of interferon (IFN) production, the use of direct IFN therapy, the use of antiviral drugs, and immunotropic therapy (synthetic immunomodulators), as promising in the prevention and treatment of COVID-19.

The prevention of cerebral palsy in preterm infants – the potential role of magnesium sulfate

2019 ◽  
Vol 4 (67) ◽  
pp. 180
Author(s):  
Adelina Staicu ◽  
Adela Hanga ◽  
Ioana C. Rotar ◽  
Gabriela C. Zaharie ◽  
Daniel Mureşan
Keyword(s):  
Cerebral Palsy ◽  
Magnesium Sulfate ◽  
Preterm Infants ◽  
Potential Role

A Review on Melatonin’s Effects in Cancer: Potential Mechanisms

2018 ◽  
Vol 18 (7) ◽  
pp. 985-992 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Ertan Kucuksayan ◽  
Rana Cagla Akduman ◽  
Tomris Ozben
Keyword(s):  
Systematic Review ◽  
Antioxidant Activity ◽  
Membrane Receptors ◽  
Cancer Development ◽  
Secretory Product ◽  
Prevention And Treatment ◽  
G Protein Coupled

This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the changes occurring during cancer development and growth.

scholarly journals COVID-19: Up to 82% critically ill patients had low Vitamin C values

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Teresa Maria Tomasa-Irriguible ◽  
Lara Bielsa-Berrocal
Keyword(s):  
Vitamin C ◽  
Critically Ill ◽  
Potential Role ◽  
Plasma Vitamin ◽  
Single Center ◽  
Berlin Definition ◽  
Single Center Study ◽  
Prevention And Treatment ◽  
Center Study

AbstractThere are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.

scholarly journals The Role of Lifestyle, Eating Habits and Social Environment in the Prevention and Treatment of Type 2 Diabetes and Hypertension

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1460
Author(s):  
Kalliopi Karatzi ◽  
Yannis Manios
Keyword(s):  
Type 2 Diabetes ◽  
Social Environment ◽  
Eating Habits ◽  
Health Problems ◽  
Major Health ◽  
The Past ◽  
Prevention And Treatment

Type 2 diabetes (T2DM) and hypertension are major health problems, with an undisputed growth burden in the past decades [...]

The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review

Angiology ◽  
2021 ◽  
pp. 000331972110125
Author(s):  
Atalay Demiray ◽  
Baris Afsar ◽  
Adrian Covic ◽  
Masanari Kuwabara ◽  
Charles J. Ferro ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Adverse Outcomes ◽  
Narrative Review ◽  
Background Information ◽  
Pathophysiological Role ◽  
Artery Disease ◽  
Pathologic Processes

Increased serum uric acid (SUA) levels have been associated with various pathologic processes such as increased oxidative stress, inflammation, and endothelial dysfunction. Thus, it is not surprising that increased SUA is associated with various adverse outcomes including cardiovascular (CV) diseases. Recent epidemiological evidence suggests that increased SUA may be related to acute myocardial infarction (AMI). Accumulating data also showed that elevated UA has pathophysiological role in the development of AMI. However, there are also studies showing that SUA is not related to the risk of AMI. In this narrative review, we summarized the recent literature data regarding SUA and AMI after providing some background information for the association between UA and coronary artery disease. Future studies will show whether decreasing SUA levels is beneficial for outcomes related to AMI and the optimum SUA levels for best outcomes in CV diseases.

A comprehensive review of the role of microorganisms on texture change, flavor and biogenic amines formation in fermented meat with their action mechanisms and safety

2021 ◽  
pp. 1-18
Author(s):  
Tolulope J. Ashaolu ◽  
Ibrahim Khalifa ◽  
Matta A. Mesak ◽  
Jose M. Lorenzo ◽  
Mohamed A. Farag
Keyword(s):  
Biogenic Amines ◽  
Comprehensive Review ◽  
Action Mechanisms ◽  
Texture Change

Obesity as the 21st Century’s Major Disease: The Role of Probiotics and Prebiotics in Prevention and Treatment

2021 ◽  
pp. 101115
Author(s):  
Michał Włodarczyk ◽  
Katarzyna Śliżewska
Keyword(s):  
Major Disease ◽  
Prevention And Treatment

scholarly journals Inflammation as a determinant of healing response after coronary stent implantation

2021 ◽  
Author(s):  
Dorota Ochijewicz ◽  
Mariusz Tomaniak ◽  
Grzegorz Opolski ◽  
Janusz Kochman
Keyword(s):  
Cardiovascular Disease ◽  
High Risk ◽  
Inflammatory Response ◽  
Percutaneous Coronary Interventions ◽  
Coronary Stent Implantation ◽  
Percutaneous Coronary ◽  
Prevention And Treatment ◽  
Risk Patients ◽  
Excessive Inflammatory Response

AbstractCardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammation plays an important role in the development of atherosclerosis and is associated with adverse clinical outcomes in patients after percutaneous coronary interventions. Data on stent elements that lead to excessive inflammatory response, proper identification of high–risk patients, prevention and treatment targeting residual inflammatory risk are limited. This review aims to present the role of inflammation in the context of evolving stent technologies and appraise the potential imaging modalities in detection of inflammatory response and anti-inflammatory therapies.

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