scholarly journals Towards chemotherapy of tuberculosis: experiments with external use of copper salts in lupus

2021 ◽  
Vol 17 (2) ◽  
pp. 252-268
Author(s):  
S. Ya. Golosovker
Keyword(s):  
Chronic Diseases ◽  
Focus Of Attention ◽  
The Body ◽  
Copper Salts ◽  
Medicinal Substances

The question of the treatment of various chronic diseases, especially tuberculosis, with drugs with chemotherapeutic properties, has long been in the focus of attention of researchers. Chemotherapy seeks mainly to influence the body with certain medicinal substances, which, while destroying _ pathogens, do not harm the body itself.

scholarly journals Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Biology ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 287
Author(s):  
Yew Rong Kong ◽  
Yong Xin Jong ◽  
Manisha Balakrishnan ◽  
Zhui Ken Bok ◽  
Janice Kwan Kah Weng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Chronic Diseases ◽  
Carica Papaya ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
The Body ◽  
Health Conditions ◽  
Chemical Components ◽  
Impaired Wound Healing

Oxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases and cancers but these conditions can be managed properly with the aid of antioxidants. This review features various studies to provide an overview on how Carica papaya help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties and eventually improving the management of various oxidative stress-related health conditions. Carica papaya is a topical plant species discovered to contain high amounts of natural antioxidants that can usually be found in their leaves, fruits and seeds. It contains various chemical compounds demonstrate significant antioxidant properties including caffeic acid, myricetin, rutin, quercetin, α-tocopherol, papain, benzyl isothiocyanate (BiTC), and kaempferol. Therefore, it can counteract pro-oxidants via a number of signaling pathways that either promote the expression of antioxidant enzymes or reduce ROS production. These signaling pathways activate the antioxidant defense mechanisms that protect the body against both intrinsic and extrinsic oxidative stress. To conclude, Carica papaya can be incorporated into medications or supplements to help manage the health conditions driven by oxidative stress and further studies are needed to investigate the potential of its chemical components to manage various chronic diseases.

scholarly journals Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 588
Author(s):  
Hayden W. Hyatt ◽  
Scott K. Powers
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
Chronic Diseases ◽  
Muscle Mass ◽  
Cancer Chemotherapy ◽  
Muscle Wasting ◽  
The Body ◽  
Common Denominator ◽  
Skeletal Muscle Wasting ◽  
Vital Functions

Skeletal muscle is the most abundant tissue in the body and is required for numerous vital functions, including breathing and locomotion. Notably, deterioration of skeletal muscle mass is also highly correlated to mortality in patients suffering from chronic diseases (e.g., cancer). Numerous conditions can promote skeletal muscle wasting, including several chronic diseases, cancer chemotherapy, aging, and prolonged inactivity. Although the mechanisms responsible for this loss of muscle mass is multifactorial, mitochondrial dysfunction is predicted to be a major contributor to muscle wasting in various conditions. This systematic review will highlight the biochemical pathways that have been shown to link mitochondrial dysfunction to skeletal muscle wasting. Importantly, we will discuss the experimental evidence that connects mitochondrial dysfunction to muscle wasting in specific diseases (i.e., cancer and sepsis), aging, cancer chemotherapy, and prolonged muscle inactivity (e.g., limb immobilization). Finally, in hopes of stimulating future research, we conclude with a discussion of important future directions for research in the field of muscle wasting.

scholarly journals Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4426 ◽  
Author(s):  
Ming-Shun Wu ◽  
Levent Bless B. Aquino ◽  
Marjette Ylreb U. Barbaza ◽  
Chieh-Lun Hsieh ◽  
Kathlia A. De Castro-Cruz ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Sesamum Indicum ◽  
The Body ◽  
Anticancer Activities ◽  
Anticancer Properties ◽  
Pharmacological Significance ◽  
Anti Inflammatory ◽  
Natural Medicines

The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

scholarly journals The adaptive potential of workers in greenhouse farms in the Voronezh region

2021 ◽  
Author(s):  
L.A. Yatsenko ◽  
N.V. Dzen ◽  
N.V. Gabbasova ◽  
N.P. Mamchik
Keyword(s):  
Environmental Factors ◽  
Chronic Diseases ◽  
Human Body ◽  
The Body ◽  
External Factors ◽  
Adaptive Potential ◽  
Production Factors ◽  
Adaptive Capabilities ◽  
Voronezh Region ◽  
Integral Indicator

Adaptive potential is an indicator of the level of adaptability of the human body to various and changing environmental factors. The adaptive capabilities of the body are influenced not only by external factors, but also by internal - the state of the body as a whole, by the presence or absence of chronic diseases. Therefore, the adaptive potential was used as an integral indicator of a person's adaptability to production factors. The aim of the study was to assess the adaptive capabilities of the organism of workers in greenhouse farms in the Voronezh region. The study was carried out at the enterprises of the closed ground of the region by the method of questioning, the objects of the study were 125 women aged 27-45 years. In most cases, there are violations of the adaptive capabilities of the organism among the studied workers of greenhouse farms, and even a breakdown in adaptation was revealed in 0.8%. In less than half of the cases, the adaptive potential of the greenhouses was within the normal. The adaptive reserves of the greenhouses workers decrease with age.

scholarly journals Modern possibilities of herbal medicine in the treatment of acute inflammatory diseases of the upper respiratory tract

2021 ◽  
pp. 127-133
Author(s):  
A. V. Gurov ◽  
A. V. Muzhichkova
Keyword(s):  
Phenolic Compounds ◽  
Respiratory Tract ◽  
Inflammatory Diseases ◽  
The Body ◽  
Upper Respiratory Tract ◽  
Plant Materials ◽  
Pelargonium Sidoides ◽  
Medicinal Substances ◽  
Upper Respiratory ◽  
Tract Infections

The article provides data on the effectiveness of the use of the drug in the treatment of acute, chronic and recurrent diseases of the respiratory tract and ENT organs. The drug is an extract of Pelargonium sidoides. From the standpoint of modern pharmacology, it is known that the use of natural products based on plant materials ensures safety and the absence of pronounced side effects. The main active ingredients of pelargonium are phenolic compounds: coumarins, flavonoids and phenolic acids. The article details the biochemical and pharmacological properties of each of the above groups of compounds. It has been shown that the presence of several classes of phenolic compounds simultaneously contributes to the potentiation of the pharmacological effects of each group separately. Therefore, drug has a pronounced polytropic effect: antiviral, antibacterial, immunomodulatory, mucolytic, anti-inflammatory, antioxidant, cytoprotective. The article presents the results of numerous domestic and foreign randomized, placebo-controlled studies demonstrating its high efficacy and safety in the treatment of ENT diseases, upper respiratory tract infections and bronchitis, not only in adults, but also in children over 1 year old. On the basis of the analyzed and presented material, the authors concluded that the use of a natural-based drug in the treatment of acute respiratory infection is effective and safe, both as monotherapy and in combination with other medicinal substances. He is able to quickly eliminate not only the symptoms of inflammation, but also to support the body with any ailments of this type.

scholarly journals Radiolabelled cyanidin 3-O-glucoside is poorly absorbed in the mouse

2010 ◽  
Vol 103 (12) ◽  
pp. 1738-1745 ◽  
Author(s):  
Catherine Felgines ◽  
Stéphanie Krisa ◽  
Aurélie Mauray ◽  
Catherine Besson ◽  
Jean-Louis Lamaison ◽  
...  
Keyword(s):  
Small Intestine ◽  
Oral Administration ◽  
Chronic Diseases ◽  
The Body ◽  
Gi Tract ◽  
Major Fraction ◽  
Natural Pigments ◽  
Low Concentrations ◽  
Complex Chemistry

Anthocyanins are natural pigments abundant in various fruits and berries that are involved in the prevention of various chronic diseases. Their low concentrations in plasma and urine are explained in part by their complex chemistry and the formation of still uncharacterised metabolites. The aim of the present study was to follow the distribution of anthocyanins in the body using 14C-labelled cyanidin 3-O-glucoside (Cy3G) fed by gavage to mice. After the administration of 22·2 kBq 14C-Cy3G (0·93 mg), radioactivity was detected in most organs tested over the following 24 h with a peak observed in inner tissues at 3 h. The major fraction of the radioactivity (44·5 %) was found in the faeces collected 24 h after ingestion. At 3 h after oral administration of 141 kBq 14C-Cy3G (4·76 mg), most of the radioactivity (87·9 % of intake) was recovered in the gastrointestinal (GI) tract, especially in the small intestine (50·7 %) and the caecum (23 %). At this time, 3·3 % of the radioactivity was detected in urine. There was minimal accumulation (0·76 %) of radioactivity in tissues outside the GI tract. Distribution of radioactivity varied among organs, with liver, gallbladder and kidneys showing the highest radioactivity. Taken as a whole, these results show that Cy3G is poorly absorbed in the mouse.

scholarly journals Nutraceutical potentials of synergic foods: a systematic review

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Tharani Devi Natarajan ◽  
Janci Rani Ramasamy ◽  
Kirthika Palanisamy
Keyword(s):  
Chronic Diseases ◽  
Health Benefits ◽  
Nutrient Deficiency ◽  
Value Added ◽  
Well Being ◽  
Active Role ◽  
The Body ◽  
Health Food ◽  
Potential Health ◽  
Nutrition Research

AbstractFood synergy is a concept of linking foods to health. Food consists of mixtures of nutrients, serving as a fuel for the body. When synergistic foods are put together, the evidence for potential health benefits becomes stronger than individual foods. Nutrient deficiency is a known phenomenon in many individuals, and synergy plays a very important role in combating the nutritional deficiency. Today’s consumer expresses high interest to build knowledge on the active role of food in their well-being, as well as in the prevention of non-transmissible chronic diseases. Functional foods and their active compounds play a vital role in preventing chronic diseases, improving immunity, and decreasing infections. The concept of synergy is an overthinking in nutrition research which can enhance effective dietary planning value added to the forthcoming nutrition research. This paper gives an overview of various synergic combinations of food components and their interactions within the food and with the human system to attain ideal health benefits.

Immunology and Immunotherapy in Critical Care: An Overview

2019 ◽  
Vol 30 (2) ◽  
pp. 113-125 ◽  
Author(s):  
Nancy Munro
Keyword(s):  
Immune Response ◽  
Critical Care ◽  
Monoclonal Antibodies ◽  
Care Setting ◽  
Checkpoint Inhibitors ◽  
Focus Of Attention ◽  
The Body ◽  
Daily Functioning ◽  
Major Focus ◽  
Cellular Therapies

Until recently, immunology was not a major focus of attention in the acute and critical care setting. With the evolution of immunotherapy, however—including the development of monoclonal antibodies, checkpoint inhibitors, and adoptive cellular therapies—an in-depth understanding of the immune system has become necessary to properly care for acutely ill patients. Lymphocytes (ie, T cells and B cells) play a major role in the daily functioning of the immune response. The interaction of these cells in protecting the body against infection and foreign substances is complicated and is the basis for many of the innovations in immunology and cancer treatment. This article explores basic immunology concepts, new drug categories, and adoptive cellular therapies that are at the forefront of cancer therapy.

scholarly journals Urgensi dan Legitimasi Fatwa Majelis Permusyawaratan Ulama Aceh Nomor 3 Tahun 2018 tentang Penetapan Arah Kiblat

2020 ◽  
Vol 14 (1) ◽  
pp. 87-98
Author(s):  
Ismail Ismail
Keyword(s):  
Focus Of Attention ◽  
The Body ◽  
The Earth ◽  
Science Technology

When Muslims have settled on the earth, one of the problems which become a focus of attention is the Kiblah direction. For Muslims, the Kiblah direction is not only the need for prayer which is one of the legitimate conditions of prayer, but also includes other needs related to Kiblah such as the position of burying the body, establishing a mosque and musalla. This paper explains the position of the MPU Aceh’s fatwa Number 3 of 2018 concerning the determination of the direction of the MUI of the fatwa of MUI number 3 and 5 of 2010 concerning the direction of Kiblah and explaining its relevance to the context. With the approach of astronomy, the position of the MPU Aceh fatwa Number 3 of 2018 concerning the determination of the direction of Kiblah is complementary to the MUI fatwa Number 3 and 5 of 2010 concerning the Kiblah direction. Improvements to the integrity and intensity of fatwas are responsive, proactive and anticipatory. The presence of the MPU Aceh’s fatwa on Kiblah direction is able to solve the problem of Kiblah direction in Indonesia, both in the technical and the sociological domain, because the content of the fatwa is relevant with the context and it accommodates the dimensions of science, technology and Fiqh as a characteristic of collective diligence (Ijtihad Jama'i).

scholarly journals Overweight Effects on Metabolic Rate, Chronic Diseases, Time Perception, Aging, and Lifespan: a Systematic Review

2021 ◽  
Author(s):  
Kuat Oshakbayev ◽  
Gulnara Bedelbayeva ◽  
Meruyert Gazaliyeva ◽  
Bibazhar Dukenbayeva ◽  
Attila Tordai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Weight Loss ◽  
Food Intake ◽  
Metabolic Rate ◽  
Chronic Diseases ◽  
Time Perception ◽  
The Body ◽  
Low Calorie ◽  
Time Flow ◽  
The Impact

Abstract Background: The hypothesis that metabolic rate is inversely correlated with lifespan has long been debating. Another area of controversy is an evidence of a relationship between metabolic rate and time perception, and aging. Aim: to study the impact of overweight and food intake on metabolic rate, time-flow perception, chronic diseases, aging, lifespan; difficulties in weight loss.Methods: Design: a systematic review. Setting and Participants: Web of Science, Scopus, Science Direct, Kopernio, PubMed, Mendeley were searched for articles published from January 1979 until March 2020. The study bases on a viewpoint supported by a systematic literature review of 3612 articles published worldwide.Results: In total, 107 full-text articles were assessed for eligibility. From them, 25 articles were excluded with reasons. Overweight and food intake are the main causes of accelerating metabolic rate. By age, the body should less calorie intake due to decreasing metabolic rate. Body capability to gain weight is integral indicator of body energy reserve that depletes after weight gain. Increased metabolic rate creates a delayed time-flow perception and accelerates aging. Metabolic rate and lifespan are inversely correlated. Weight loss is a good tool to delay aging and increase lifespan. Very-low-calorie diets and to manage metabolic intoxication should use at weight loss.Conclusions: The findings support overweight with overeating increases metabolic rate that in turn delays time-flow perception, increases disease, accelerates aging, limits lifespan. For weight loss has to manage a very-low-calorie diet.

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